ライフサイエンスコーパス: transendothelial migration

1 neutrophil adhesion to endothelial cells and transendothelial migration.

2 rins CD11b/CD18 (Mac-1), specifically during transendothelial migration.

3 of calcium fluxes and Rac1 during leukocyte transendothelial migration.

4 , S730, or S737 were necessary for leukocyte transendothelial migration.

5 RNA completely blocked bradykinin-stimulated transendothelial migration.

6 ancer cell-endothelial cell interactions and transendothelial migration.

7 L-selectin, function to facilitate leukocyte transendothelial migration.

8 ing sequentially induce PECAM-1-mediated PMN transendothelial migration.

9 cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration.

10 eceptors that bind to chemokines and trigger transendothelial migration.

11 tep 1) into firm adhesion (step 3), yielding transendothelial migration.

12 phosphorylation events are indispensable for transendothelial migration.

13 junction formation, leukocyte adhesion, and transendothelial migration.

14 f adhesion molecules, monocyte adhesion, and transendothelial migration.

15 ; and regulation of cellular recruitment via transendothelial migration.

16 necessary, but not sufficient for increased transendothelial migration.

17 resulted in increased E-cadherin and reduced transendothelial migration.

18 e endothelial surface for potential sites of transendothelial migration.

19 SIRPgamma, play an important role in T-cell transendothelial migration.

20 tion of early cellular processes involved in transendothelial migration.

21 esion molecule-1 (ICAM-1)-dependent monocyte transendothelial migration.

22 igration of PMN or evoke a role for JAM-C in transendothelial migration.

23 0.01) increase in IL-8-induced migration and transendothelial migration.

24 ssed ligand for PMN beta(2) integrins during transendothelial migration.

25 r transition to shear-resistant adhesion and transendothelial migration.

26 g monocyte adhesion to endothelial cells and transendothelial migration.

27 d the ability of CCL2 to stimulate monocytic transendothelial migration.

28 n molecule (JAM)-C plays a role in leukocyte transendothelial migration.

29 , compound 4 nonetheless inhibits lymphocyte transendothelial migration.

30 ells to endothelium from flow but also drove transendothelial migration.

31 s particularly important for steps involving transendothelial migration.

32 ial barrier function and reducing neutrophil transendothelial migration.

33 nt component in the regulation of neutrophil transendothelial migration.

34 s, aggregation, adhesion to endothelium, and transendothelial migration.

35 ll junctions is ligated by leukocytes during transendothelial migration.

36 d primarily to mediate stronger adhesion and transendothelial migration.

37 be an essential element in chemokine-induced transendothelial migration.

38 tent inducer of CXCR3 down-regulation and of transendothelial migration.

39 m tethering to firm adhesion, spreading, and transendothelial migration.

40 of RhoA, we found that RhoA was required for transendothelial migration.

41 receptors such as CXCR4, MMP-9, followed by transendothelial migration.

42 cell-cell contacts and facilitates leukocyte transendothelial migration.

43 t ~10% underwent spontaneous basal to apical transendothelial migration.

44 s a relevant negative regulator of leukocyte transendothelial migration.

45 hibited PMN adhesion, arrest under flow, and transendothelial migration.

46 ak through matrix barriers during tumor cell transendothelial migration.

47 ed human monocyte recruitment, adhesion, and transendothelial migration.

48 from the primary tumor, stromal invasion and transendothelial migration.

49 of CLL cell binding to PEX9, chemotaxis, and transendothelial migration.

50 catenins out of the junction at the site of transendothelial migration.

51 l ligands and support leukocyte adhesion and transendothelial migration.

52 ctins but impaired intraluminal crawling and transendothelial migration.

53 ls roll on the endothelium to initiate their transendothelial migration.

54 ty integrin activation and chemokine-induced transendothelial migration.

55 cruitment was assessed based on adhesion and transendothelial migration.

56 MMP-1 regulates endothelial permeability and transendothelial migration.

57 eir presentation to leukocytes and leukocyte transendothelial migration.

58 In contrast, during transendothelial migration, a form of active deformation

59 stimulatory effect of platelets on leukocyte transendothelial migration, a key mediator of atheroprog

60 (INV) expression are required for tumor cell transendothelial migration, a necessary step during intr

61 are not inherently toxic to neurons but that transendothelial migration across IL-1-stimulated brain

62 , we demonstrated that monocyte adhesion and transendothelial migration across inflamed endothelium w

63 In vitro, T lymphocyte transendothelial migration across PECAM-KO endothelial c

64 on the endothelial surface before undergoing transendothelial migration, also called diapedesis.

65 vidity to coordinate adhesion and subsequent transendothelial migration, although the sequential sign

66 in the processes of neutrophil and monocyte transendothelial migration, an analogous function of VE-

67 othelial cells and fibroblasts and prevented transendothelial migration, an effect rescued by the for

68 entation on endothelial cells and subsequent transendothelial migration, an essential step for lympho

69 Leukocyte transendothelial migration and adhesion to RA ST require

70 nts are inhibited by antibodies that prevent transendothelial migration and are reversed following tr

71 es that have been reported to play a role in transendothelial migration and asks why so many molecule

72 d to increased intravasation, the details of transendothelial migration and detachment into circulati

73 on of primary human monocytes promotes their transendothelial migration and differentiation into proi

74 60% of HIV-1-infected patients, to stimulate transendothelial migration and drive productively infect

75 early metastatic seeding, including arrest, transendothelial migration and early micrometastases for

76 il but endothelial LSP1 regulates neutrophil transendothelial migration and extravascular directional

77 sequential steps of lymphocyte adhesion and transendothelial migration and facilitates lymphocyte mi

78 ytoskeletal rearrangements abrogated CD34(+) transendothelial migration and impaired CD34(+) cell hom

79 ults extend the role of EMT in metastasis to transendothelial migration and implicate ZEB1 and N-cadh

80 regulates human polymorphonuclear leukocyte transendothelial migration and is anti-inflammatory.

81 Thus, transendothelial migration and lung metastasis developme

82 primary HCMV infection of monocytes induces transendothelial migration and monocyte-to-macrophage di

83 These results implicate defects in both PMN transendothelial migration and PMN DAG kinase alpha sign

84 stop human polymorphonuclear leukocyte (PMN) transendothelial migration and PMN infiltration in sever

85 n the regulation of Mena(INV) expression and transendothelial migration and provide mechanistic infor

86 treatment can potentially decrease leukocyte transendothelial migration and reduce angiogenesis assoc

87 sions that interacted with leukocytes before transendothelial migration and removal of HS reduced thi

88 To this end, PMN transendothelial migration and superoxide anion generati

89 sions, important for tumor cell invasion and transendothelial migration and tumor cell dissemination.

90 APCs in draining lymph nodes as well as for transendothelial migration and tumor cell recognition at

91 foci formation, mechanotransduction, T cell transendothelial migration, and homing to lymph nodes, a

92 vage fluid cells, inhibited bone marrow cell transendothelial migration, and inhibited endothelial ce

93 le-1 expression, polymorphonuclear leukocyte transendothelial migration, and leukocyte sequestration

94 adhesion to microvascular endothelial cells, transendothelial migration, and metastatic retention in

95 activity including cell invasion, migration, transendothelial migration, and proliferation were incre

96 lly required for Axl-mediated cell invasion, transendothelial migration, and resistance against TGF-b

97 an occur without polymorphonuclear leukocyte transendothelial migration, and that polymorphonuclear l

98 bone marrow (BM) are recruited to tissues by transendothelial migration, and we found that CCL2 is ch

99 L-selectin; HEV expression of molecules for transendothelial migration; and metabolic programs for l

100 JAM-C has been implicated in leukocyte transendothelial migration, angiogenesis, cell adhesion,

101 integrin-mediated firm adhesion followed by transendothelial migration - are dependent on the activa

102 pecific cellular processes (phagocytosis and transendothelial migration) are enriched for transcripts

103 A transendothelial migration assay was used to determine t

104 Angiogenesis and transendothelial migration assays were performed in cons

105 12 both in transwell migration assays and in transendothelial migration assays.

106 alysis, inflammatory stimulation assays, and transendothelial migration assays.

107 genes and other genes involved in leukocyte transendothelial migration at the vaccine injection site

108 tubulin binding returned cell migration and transendothelial migration back to control levels, indic

109 onocyte ADAM17 facilitates the completion of transendothelial migration by accelerating the rate of d

110 ge in vivo, despite interruption of in vitro transendothelial migration by CD177 ligation.

111 We conclude that Trio promotes leukocyte transendothelial migration by inducing endothelial docki

112 data show that annexin A2 limits neutrophil transendothelial migration by organizing the spatial dis

113 nts in understanding regulation of leukocyte transendothelial migration by small GTPase signaling.

114 d chemokine receptor expression and enhanced transendothelial migration capacity in patients with CKD

115 a-forming cell (CAFC) capacity and augmented transendothelial migration capacity, which was abrogated

116 s firm adhesion to the vascular endothelium, transendothelial migration, chemotaxis, and phagocytosis

117 alis-stimulated monocytes displayed enhanced transendothelial migration compared with monocytes stimu

118 is factor alpha, and supported higher immune transendothelial migration compared with PAECs.

119 esulting increase in lymphocyte and monocyte transendothelial migration could be blocked with soluble

120 Intravital imaging demonstrated a transendothelial migration defect into DAP12-deficient l

121 d diminished support for B16F10 adhesion and transendothelial migration, diminished B16F10-induced pe

122 egrins have been shown to mediate neutrophil transendothelial migration during systemic and local inf

123 by signaling through activating FcRs before transendothelial migration has occurred.

124 fficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependen

125 romoting the adhesion of monocytes and their transendothelial migration in a Mac-1-dependent manner.

126 e candidate targets for inhibiting leukocyte transendothelial migration in heart disease and chronic

127 Measurement of transendothelial migration in response to CCL5 demonstra

128 CR2 and CD62L levels and underwent efficient transendothelial migration in response to fractalkine (F

129 ng stathmin expression significantly reduced transendothelial migration in two different neuroblastom

130 Notably, transendothelial migration in vitro and extravasation in

131 y neutrophil arrest, adhesion, crawling, and transendothelial migration in vitro and in vivo.

132 ver, this mutant chemokine failed to promote transendothelial migration in vitro and inhibited the ha

133 Niflumic acid-treated PMNs also had impaired transendothelial migration in vitro, whereas migration i

134 d an increased chemotaxis, chemokinesis, and transendothelial migration in vitro.

135 priming impaired priming-enhanced eosinophil transendothelial migration in vitro.

136 mal cells and fibronectin along with reduced transendothelial migration in vitro.

137 nt role in mediating neutrophil and monocyte transendothelial migration in vivo.

138 ic interactions play a key role in leukocyte transendothelial migration, in allowing PECAM-1 to serve

139 ed permeability and increased naive monocyte transendothelial migration include the disruption of act

140 s have been shown to play a critical role in transendothelial migration including signals derived fro

141 Several mechanisms play a critical role in transendothelial migration, including signals derived fr

142 ICAM-1 is also involved in transendothelial migration, independently of its role in

143 ers, proportionally fewer MO-MDSCs underwent transendothelial migration, indicating that the final st

144 (1 unit/mL) tumor necrosis factor-alpha and transendothelial migration induced by high-dose (100 uni

145 contacts culminate in cooperative, step-wise transendothelial migration into bone is not known.

146 Leukocyte transendothelial migration involves the active participa

147 The process of intravasation involving transendothelial migration is a key step in metastatic s

148 d in cell-cell interactions during leukocyte transendothelial migration is a prerequisite for designi

149 of metastasis (TMEM), facilitates tumor cell transendothelial migration is not completely understood.

150 a separate step in leukocyte extravasation, transendothelial migration is regulated by molecules tha

151 Transendothelial migration itself can be dissected into

152 t resolvins directly act on PMN to attenuate transendothelial migration, less is known about the infl

153 Compared to PMN transendothelial migration, little is known about how PM

154 emained static before a proportion underwent transendothelial migration mediated by a combination of

155 migration, the effects of Pak1 knockdown on transendothelial migration (microinvasion), tumor growth

156 nd evidence suggests that initial neutrophil transendothelial migration modifies endothelial cell phe

157 ase-PI(3,4)P2 signaling axis while augmented transendothelial migration occurs in a vascular endothel

158 okine expression, proliferation, and delayed transendothelial migration of allogeneic memory, but not

159 ion that cognate recognition of ECs enhanced transendothelial migration of antigen-specific T lymphoc

160 CD40-stimulated tumor cells also support the transendothelial migration of autologous CCR4(+) antileu

161 ascular leakage in tumors, and inhibited the transendothelial migration of cancer cells.

162 igen was necessary for the firm adhesion and transendothelial migration of CD8+ effector T cells spec

163 estational age newborns, then minimizing the transendothelial migration of circulating cells by pharm

164 Transendothelial migration of effector memory CD4 T cell

165 Bradykinin stimulated transendothelial migration of EPCs in a concentration-de

166 The ability of FNf to stimulate transendothelial migration of HIV-1-infected MNLs may he

167 reased endothelial permeability and elevated transendothelial migration of HIV-infected monocytes acr

168 -1 inhibition enhanced vitronectin-dependent transendothelial migration of human bone marrow-derived

169 -docosahexaenoic acid, and they both stopped transendothelial migration of human neutrophils (EC(50)

170 To study this process further, we analyzed transendothelial migration of human PC-3 prostate cancer

171 nce across the in vitro BBB and the enhanced transendothelial migration of immunocompetent cells acro

172 BBB permeability using TEER measurements and transendothelial migration of immunocompetent cells.

173 2 deficiency impaired the integrin-dependent transendothelial migration of innate leukocytes and rest

174 essed on the endothelial barrier can promote transendothelial migration of KSHV-infected cells.

175 lectin, and breakdown of the BRB, leading to transendothelial migration of leukocytes and recruitment

176 ressure, vascular permeability, clotting and transendothelial migration of leukocytes and tumor cells

177 on of blood-brain barrier (BBB) function and transendothelial migration of leukocytes are essential c

178 on endothelium and other cells as well as to transendothelial migration of leukocytes in the microcir

179 d flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed t

180 Transendothelial migration of leukocytes is a critical e

181 g the molecules and mechanisms that regulate transendothelial migration of leukocytes, or diapedesis,

182 alysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

183 own that stanniocalcin-1 (STC1) inhibits the transendothelial migration of macrophages and T cells, s

184 was reduced by blocking WASP binding to WIP, transendothelial migration of macrophages, the most cruc

185 osome formation, thereby mediating efficient transendothelial migration of macrophages.

186 duced proliferation and superantigen-induced transendothelial migration of memory T cells, indicating

187 ivation, which led us to investigate whether transendothelial migration of monocytes across HSECs inf

188 These data point to a role of MMP-14 during transendothelial migration of monocytes and T-cell attra

189 Transendothelial migration of monocytes is the process b

190 We found that MCP-1-dependent transendothelial migration of monocytes markedly acceler

191 nocyte adhesion to ECs, EC migration and the transendothelial migration of monocytes, while the over-

192 othelial cells increased the recruitment and transendothelial migration of monocytes.

193 thelial and BBB hyperpermeability as well as transendothelial migration of monocytic cells.

194 tactic Protein 1 (MCP-1), play a key role in transendothelial migration of mononuclear cells during t

195 ecruitment with a predominant enhancement of transendothelial migration of neutrophilic granulocytes.

196 is an adhesion molecule believed to mediate transendothelial migration of neutrophils and other leuk

197 9 regulate distinct, sequential steps in the transendothelial migration of neutrophils during inflamm

198 Transendothelial migration of neutrophils in postcapilla

199 se brain endothelial cells and supported the transendothelial migration of neutrophils in vitro.

200 Furthermore, RAP inhibited transendothelial migration of neutrophils induced by fib

201 Conditioned medium harvested after transendothelial migration of neutrophils or supernatant

202 own that TSG-6 inhibits chemokine-stimulated transendothelial migration of neutrophils via a direct i

203 that is needed to facilitate the early-onset transendothelial migration of PMN.

204 d with cobra venom factor and intrapulmonary transendothelial migration of PMNs into the bronchoalveo

205 f TRPM2 expressed in ECs in the mechanism of transendothelial migration of PMNs.

206 lled F. tularensis LVS for 24 h promoted the transendothelial migration of subsequently added neutrop

207 Our results provide visualization of transendothelial migration of T cells into lymphatic sin

208 in reduced microvilli formation and impaired transendothelial migration of T cells.

209 costimulatory conditions, and inhibition of transendothelial migration of T cells.

210 xpress CXCR3 and reduced the IP-10-dependent transendothelial migration of T helper cells under condi

211 neutrophils would also modify the subsequent transendothelial migration of T lymphocytes across cytok

212 thway in brain EC is essential for efficient transendothelial migration of T lymphocytes into the bra

213 c G-protein-mediated signaling in supporting transendothelial migration of T lymphocytes.

214 examine the effects of B. burgdorferi on the transendothelial migration of T lymphocytes.

215 pression of VLA-4 also resulted in increased transendothelial migration of Tck cells, which could be

216 pain as a critical driver of T. b. gambiense transendothelial migration of the human BBB.

217 as well as on endothelial cells promoted the transendothelial migration of the melanoma cells.

218 Transendothelial migration of these cells depended on ex

219 Monocytes promoted transendothelial migration of tumor cells through the in

220 Far less is known about the impact of transendothelial migration on eosinophil survival, in pa

221 /Rap1 GTPase signaling pathway, resulting in transendothelial migration on stimulated human umbilical

222 se VCAM-1 signals are required for leukocyte transendothelial migration on VCAM-1.

223 sion to HUVEC, but significantly reduced PMN transendothelial migration (P < 0.0001) and fMLP-induced

224 Here, we show that the leukocyte transendothelial migration pathway is activated in the o

225 resulting in enhanced monocyte motility and transendothelial migration, prolonged monocyte survival,

226 by expression of Rap1GAP increased leukocyte transendothelial migration, providing physiological rele

227 to the regulation of leukocyte adhesion and transendothelial migration remains poorly understood.

228 r, a complete mechanism governing tumor cell transendothelial migration remains unclear.

229 ell arrest on the EC surface, preventing the transendothelial migration response to IP-10.

230 cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver m

231 Ex vivo analyses of transendothelial migration revealed that Nef disrupted T

232 ost defense cell responsiveness to GM-CSF at transendothelial migration sites while suppressing it in

233 through a dense three-dimensional matrix and transendothelial migration, suggesting that tyrosine pho

234 In addition, we addressed the transendothelial migration (TEM) activity of bone marrow

235 lecule, is required for CLL cells to undergo transendothelial migration (TEM) and enter the prolifera

236 e and clustering) is required for lymphocyte transendothelial migration (TEM) and entry into lymph no

237 Leukocyte crawling and transendothelial migration (TEM) are potentiated by shea

238 trol efflux of small molecules and leukocyte transendothelial migration (TEM) between blood and tissu

239 previously reported that the TCR-stimulated transendothelial migration (TEM) depends on fractalkine

240 ar requirements of chemokine- and TCR-driven transendothelial migration (TEM) differ significantly.

241 Leukocyte transendothelial migration (TEM) has been modeled as a m

242 e EM CD4+ T cells, but fail to support their transendothelial migration (TEM) in response to TCR enga

243 Leukocyte transendothelial migration (TEM) is a critical event dur

244 Transendothelial migration (TEM) is a tightly regulated

245 Leukocyte transendothelial migration (TEM) is a tightly regulated,

246 Lymphocyte transendothelial migration (TEM) is critically dependent

247 In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial c

248 essential role in the CXCL12/CXCR4-mediated transendothelial migration (TEM) of CXCR4(+)CXCR7(+) hum

249 ability of several C-C chemokines to induce transendothelial migration (TEM) of eosinophils in vitro

250 hat regulate the endothelial response during transendothelial migration (TEM) of invasive cancer cell

251 Transendothelial migration (TEM) of normal lymphocytes i

252 Transendothelial migration (TEM) of polymorphonuclear le

253 This rapid process, called transendothelial migration (TEM) or diapedesis, is compl

254 Leukocyte transendothelial migration (TEM) requires two major even

255 The transendothelial migration (TEM) step is poorly understo

256 distributed chemokines and their effects on transendothelial migration (TEM) under hydrodynamic shea

257 PECAM-1/CD31 is required for leukocyte transendothelial migration (TEM) under most inflammatory

258 helial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a luminal-to-ablumi

259 designated as chemokine-driven or TCR-driven transendothelial migration (TEM), respectively.

260 leukocytes and transmit signals required for transendothelial migration (TEM).

261 sion (TEP) by the T cell but fails to induce transendothelial migration (TEM).

262 tes subsequent signaling that promotes their transendothelial migration (TEM).

263 n, and azithromycin, in an in vitro model of transendothelial migration (TEM).

264 ecycling compartment (LBRC), is critical for transendothelial migration (TEM).

265 s primary human monocytes actively engage in transendothelial migration (TEM).

266 adhesion, crawling towards EC junctions and transendothelial migration (TEM).

267 to form short-lived "gaps" during leukocyte transendothelial migration (TEM); however, whether these

268 ss endothelium [referred to as diapedesis or transendothelial migration (TEM)] is a critical step in

269 nocyte-to-myeloid fibroblast formation after transendothelial migration (TEM; 3-fold, P < 0.01).

270 cells were found to be independent of VEGF, transendothelial migration through CNS microvascular end

271 wice as many CD14++CD16+ monocytes underwent transendothelial migration through hepatic endothelial c

272 easured using in vitro chemotaxis assays and transendothelial migration through human umbilical vein

273 ma cells highlighted that stathmin regulates transendothelial migration through ROCK signaling.

274 ion pathways may lead to PECAM-1-independent transendothelial migration through the pulmonary or the

275 nderlying mechanisms that regulate leukocyte transendothelial migration through the vascular endothel

276 We found that the increased transendothelial migration (TM) of MDA-MB-231 cells resu

277 i showed that inflammation-induced leukocyte transendothelial migration to peritoneum or lungs was si

278 )CD28- T cells enhanced their chemotaxis and transendothelial migration toward the chemokine CCL5.

279 d for the induction of monocyte motility and transendothelial migration, two biological events requir

280 integrins, leading to defective adhesion and transendothelial migration under conditions of physiolog

281 n of CXCR 3 promotes lymphocyte adhesion and transendothelial migration under flow and that human hep

282 results in increased neutrophil adhesion and transendothelial migration under flow conditions and red

283 okines, promote mononuclear leukocytes (MNL) transendothelial migration, up-regulate monocyte CD11b a

284 diated both leukocyte adhesion and leukocyte transendothelial migration upon oxLDL treatment of endot

285 the lung, but acted by inhibiting neutrophil transendothelial migration upstream of interstitial migr

286 , which facilitates endothelial adhesion and transendothelial migration via an ICAM1-fibrinogen-ICAM1

287 cell proliferation, migration, adhesion, and transendothelial migration via increased expression of I

288 Furthermore, T lymphocyte transendothelial migration was inhibited by treatment of

289 Transendothelial migration was not observed in CD14(dim)

290 The reduction in T lymphocyte transendothelial migration was not observed using a diff

291 In vitro chemotaxis and transendothelial migration were examined in a Transwell

292 within endothelial cells decreased leukocyte transendothelial migration, whereas inhibiting Rap1 acti

293 and P3/P3a/P3b peptides inhibited B-CLL cell transendothelial migration, whereas the mutated peptide

294 hocytes, the malignant cells did not undergo transendothelial migration, which could explain why lymp

295 l gap formation, the first step during tumor transendothelial migration, which is mediated by both ad

296 ed breast cancer cell adhesion to HUVECs and transendothelial migration, which were repressed by ET-1

297 ing leaves open a possible role in leukocyte transendothelial migration, which would be consistent wi

298 resence of activated neutrophils and reduces transendothelial migration without affecting adhesion of

299 neutrophils, with alpha2-agonists decreased transendothelial migration, without affecting neutrophil

300 (SDF-1alpha [CXCL12])-mediated T lymphocyte transendothelial migration, without reducing accumulatio