ライフサイエンスコーパス: transferrin saturation

1 M significantly increased serum ferritin and transferrin saturation.

2 els, and serum iron correlated strongly with transferrin saturation.

3 -off value was used to define elevated serum transferrin saturation.

4 higher ferritin/transferrin levels and lower transferrin saturation.

5 re correlated positively with maternal serum transferrin saturation.

6 eived iron depletion therapy; all had normal transferrin saturation.

7 epcidin, accompanied by a major reduction in transferrin saturation.

8 rum ferritin and normal to slightly elevated transferrin saturation.

9 ations were proportional to the increment in transferrin saturation.

10 ygous for TFR2 mutations, all with increased transferrin saturation.

11 245X) mutant mice also demonstrated elevated transferrin saturations.

12 1.83 (95% CI: 1.21, 2.76; P < 0.01); HR for transferrin saturation: 1.68 (95% CI: 1.18, 2.38; P < 0.

13 : 2.45 (95% CI:1.12, 5.34; P < 0.05); HR for transferrin saturation: 1.90 (95% CI:1.02, 3.56; P < 0.0

14 ntrol (ferritin=628+/-367 ng/ml [mean+/-SD]; transferrin saturation=30%+/-12%; P<0.001 for both).

15 eters (ferritin=899+/-488 ng/ml [mean+/-SD]; transferrin saturation=39%+/-17%) versus subjects on act

16 pared with HFE+/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated l

17 high-sensitivity C-reactive peptide), higher transferrin saturation (a marker of iron stores), and th

18 tivation of the Smad1/5/8 signaling pathway, transferrin saturation activates the downstream Smad1/5/

19 cular volume increased after conversion, but transferrin saturation and ferritin did not change.

20 Screening for transferrin saturation and ferritin levels does not dete

21 ipants with HFE mutations, the average serum transferrin saturation and ferritin levels were slightly

22 A (average 7.7-fold), despite their elevated transferrin saturation and hepatic iron content.

23 normal ALT levels (P < 0.05) included higher transferrin saturation and iron and selenium concentrati

24 fe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumulation.

25 We demonstrated that both transferrin saturation and liver iron content independen

26 erythropoiesis, and significantly decreased transferrin saturation and lung iron stores after 2 week

27 /fl);Cre(+) mice exhibited approximately 90% transferrin saturation and massive liver iron overload,

28 C326Y, which can be associated with greater transferrin saturation and more prominent iron depositio

29 The balance between serum transferrin saturation and serum transferrin-receptor co

30 he latter category of FPN mutation have high transferrin saturation and tend to deposit iron througho

31 roots of the proportion with the lowest mean transferrin saturation and the proportion with the highe

32 rom all three strains demonstrated increased transferrin saturations and liver iron concentrations co

33 Single measurements of serum transferrin saturations and serum ferritin levels.

34 associated with increases in iron transport (transferrin saturation) and stores (serum ferritin) amon

35 um iron, total iron binding capacity (TIBC), transferrin saturation, and ferritin in a Hispanic/Latin

36 We measured serum iron, transferrin saturation, and ferritin in all heterozygote

37 Plasma TAS, serum ferritin, serum iron, transferrin saturation, and hemoglobin were measured at

38 study-wise type 1 error for serum ferritin, transferrin saturation, and intravenous iron and erythro

39 haracterized by high serum ferritin, reduced transferrin saturation, and macrophage iron loading.

40 er operator curve analysis of CHr, ferritin, transferrin saturation, and MCV demonstrates that CHr ha

41 es of iron status (including serum ferritin, transferrin saturation, and non-transferrin-bound iron)

42 rtal distribution and increased plasma iron, transferrin saturation, and non-transferrin-bound iron,

43 atory tests, including complete blood count, transferrin saturation, and other chemistries; serum fer

44 ical data, including hemoglobin, serum iron, transferrin saturation, and serum ferritin concentration

45 t group had significantly higher hemoglobin, transferrin saturation, and serum ferritin values and a

46 ded determination of hemoglobin, hematocrit, transferrin saturation, and serum ferritin values.

47 >/=2 of 3 tests (erythrocyte protoporphyrin, transferrin saturation, and serum ferritin) and a low he

48 sed indicators, such as serum ferritin (SF), transferrin saturation, and soluble transferrin receptor

49 uration subpopulation and support the use of transferrin saturation as an inexpensive screening test

50 testinal (59)Fe uptake, lower serum iron and transferrin saturation, but no change in liver non-heme

51 yed the decrease in hepcidin until after the transferrin saturation, but not the ferritin concentrati

52 Increased transferrin saturation correlated positively with the se

53 low iron levels (cutoff 10.5 mumol/mL), low transferrin saturation (cutoff 55%), and high serum tran

54 Statistical mixture modeling was applied to transferrin saturation data for African Americans and Ca

55 In previous analyses of transferrin saturation data in African Americans and Cau

56 arrow iron depletion in patients with normal transferrin saturations, elevated serum ferritins, eleva

57 Diet did not affect hemoglobin, transferrin saturation, erythrocyte protoporphyrin, or s

58 no significant difference between groups in transferrin saturation, erythrocyte zinc protoporphyrin

59 At initial diagnosis, fasting transferrin saturation, ferritin level, routine chemistr

60 creases in serum iron levels, percentages of transferrin saturation, ferritin levels, elevations in h

61 3 +/- 5.6 mumol/L (P < 0.0001) and increased transferrin saturation from 35.7 +/- 16.3% to 45.4 +/- 1

62 ID) diet for 24 hours, the rapid decrease of transferrin saturation from 71% to 24% (control vs ID di

63 versus 37.5% of compound heterozygotes with transferrin saturation > 50%; p = 0.003), serum ferritin

64 on, serum ferritin levels of 300-2000 ng/mL, transferrin saturation >/= 45%, and no known history of

65 300 mug/L in men and >200 mug/L in women and transferrin saturation >45% in women and 50% in men.

66 tely 11% to 22% of those with elevated serum transferrin saturation had concurrently elevated serum f

67 a whole, these subpopulations of increasing transferrin saturations had progressively increasing mea

68 hromatosis screening program that uses serum transferrin saturation has been proposed, but few data e

69 ther with serum ferritin, serum transferrin, transferrin saturation, hemoglobin, and alanine aminotra

70 symptomatic Australians to estimate the mean transferrin saturation in hemochromatosis heterozygotes

71 aims of this study were to estimate the mean transferrin saturation in hemochromatosis heterozygotes

72 The prevalence of elevated serum transferrin saturation in non-Hispanic black persons and

73 The prevalence of elevated serum transferrin saturation in persons 20 to 49 years of age

74 with Kupffer-cell iron deposition and normal transferrin saturation in vivo, whereas patients with th

75 that was seen at both high and low levels of transferrin saturation in white women should be confirme

76 To determine if transferrin saturations in African Americans may reflect

77 addition, only after the older transfusion, transferrin saturation increased progressively over 4 ho

78 groups initially had 30% declines in plasma transferrin saturation, increases in plasma ferritin con

79 icantly, but it had no discernible effect on transferrin saturation, iron-deficient erythropoiesis, h

80 To test the hypothesis that relatively high transferrin saturation is associated with increased stro

81 An elevated transferrin saturation is the earliest phenotypic abnorm

82 aditional population screening measuring the transferrin saturation is unlikely to be cost-effective

83 nked to clinically relevant indices, such as transferrin saturation level.

84 males showed differences across genotypes in transferrin saturation levels (100% of homozygotes versu

85 e marrow iron stores are absent, even though transferrin saturation levels are normal.

86 ablished primary hematopoietic cultures with transferrin saturation levels that restricted erythropoi

87 Consistent with this, iron, ferritin, and transferrin saturation levels were reduced and red cell

88 Initial transferrin-saturation levels exceeding the threshold as

89 erum ferritin at a level of < 150 ng/mL, and transferrin saturation < 21%.

90 nsferrin receptors > or = 8.4 microg/mL, and transferrin saturation < or = 13.2%).

91 o 30 ml/min, 46% of women and 19% of men had transferrin saturation <20%, and 47% of women and 44% of

92 <100 ng/ml or ferritin 100 to 300 ng/ml with transferrin saturation <20%.

93 itin <or= 450 pmol/L or <or= 675 pmol/L with transferrin saturation <or= 19%) receiving subcutaneousl

94 rin receptor >or=8.4 or >10.0 microg/mL, and transferrin saturation <or=13.2% or <10.0%, respectively

95 ron measures, including serum ferritin (SF), transferrin saturation, mean cell volume, and hemoglobin

96 icant difference in baseline serum ferritin, transferrin saturation, mean cell volume, mean cell hemo

97 a for iron overload using serum ferritin and transferrin saturation measurements and HFE genotyping.

98 ciated positively with increasing deciles of transferrin saturation (odds ratio [OR] per decile, 1.10

99 In practice, a fasting transferrin saturation of > or = 45% identifies virtuall

100 Participants with a transferrin saturation of >55% or >45% and an elevated s

101 When erythropoietin resistance is present, transferrin saturation of < 27% or serum ferritin < 300

102 .2% of the truncated sample had a lower mean transferrin saturation of 24.1%, whereas 11.8% had an in

103 f 24.1%, whereas 11.8% had an increased mean transferrin saturation of 37.3%.

104 Patients with a serum transferrin saturation of 45% or more on initial testing

105 A transferrin saturation of 50% had a sensitivity of only

106 Those who had a fasting serum transferrin saturation of 55% or more and a serum ferrit

107 hemochromatosis; and 23 patients had a serum transferrin saturation of 55% or more with no identifiab

108 opulation with a mean +/- standard deviation transferrin saturation of 63.4% +/- 5.7% (postulated hom

109 ation, and 65 of the 66 patients (98%) had a transferrin saturation of at least 45%.

110 erum ferritin level of 101 to 299 ng/mL with transferrin saturation of less than 20%.

111 t erythropoiesis as judged by the NKF-K/DOQI transferrin saturation or serum ferritin targets.

112 Higher transferrin saturation or serum iron concentrations were

113 a high-iron diet revealed no differences in transferrin saturation or tissue iron stores between WT

114 =2 of 3 abnormal concentrations in ferritin, transferrin saturation, or erythrocyte protoporphyrin (t

115 ion in hematocrit value, reticulocyte count, transferrin saturation, or ferritin level in the experim

116 h levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change =

117 but little effect on hemoglobin, hematocrit, transferrin saturation, or plasma iron.

118 iding with a 50% reduction in serum iron and transferrin saturation over the 24-hour period.

119 wth rates were very strongly correlated with transferrin saturation (p < 0.0001 in all cases).

120 increases in AUC for serum iron (P < 0.01), transferrin saturation (P < 0.001), and nontransferrin-b

121 oots of the proportions with the lowest mean transferrin saturation (P = .925) and the highest (q = 0

122 tate significantly reduced tHcy (P = 0.017), transferrin saturation (P = 0.027), and ferritin (P = 0.

123 Serum transferrin saturations (percent saturation of serum tra

124 or length gain or in hemoglobin, hematocrit, transferrin saturation, plasma zinc, or erythrocyte ribo

125 who ingested 65 mg of iron, the increase in transferrin saturation preceded by hours the increase in

126 , older age, higher urea reduction ratio and transferrin saturation, prescription of intravenous iron

127 NTBPI values in TM correlated with transferrin saturation (r = .6, P = .03) but not with se

128 The prevalence of initially elevated serum transferrin saturation ranged from 1% to 6%.

129 Cut-off values used to define elevated serum transferrin saturation ranged from greater than 45% to g

130 Determination of transferrin saturation remains the most useful noninvasi

131 s more severe in the restrictive group (peak transferrin saturation: restrictive group 83.9+/-13.0%,

132 tion studies for serum iron, serum ferritin, transferrin saturation (SAT) and total iron binding capa

133 To evaluate potential transferrin saturation screening levels, modeling result

134 normal individuals and to evaluate potential transferrin saturation screening levels.

135 Serum transferrin saturation screening tests were offered to a

136 Transferrin saturation (serum iron concentration divided

137 um ferritin, total iron-binding capacity and transferrin saturation), serum hepcidin and genome-wide

138 y was defined as > or =2 abnormal values for transferrin saturation, serum ferritin, and erythrocyte

139 The transferrin saturation, serum ferritin, and liver iron b

140 nces in hematocrit, mean corpuscular volume, transferrin saturation, serum ferritin, and serum iron.

141 Measurement of serum ferritin, transferrin saturation, serum soluble transferrin recept

142 emochromatosis heterozygotes form a distinct transferrin saturation subpopulation and support the use

143 of this new study was to determine if these transferrin saturation subpopulations have different lev

144 consistent with the concept that population transferrin saturation subpopulations reflect different

145 ritin concentrations were determined for the transferrin saturation subpopulations that were identifi

146 1) to encourage laboratories to provide the transferrin saturation test as part of routine laborator

147 f 45% or more on initial testing had a serum transferrin saturation test done under fasting condition

148 eening for hemochromatosis done by using the transferrin saturation test has been advocated by expert

149 screening for hemochromatosis done by using transferrin saturation testing can be recommended, labor

150 parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availabi

151 e in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic ani

152 serum ferritin, total-iron-binding capacity, transferrin saturation, the ratio of enzymatic to immuno

153 A transferrin saturation threshold of 45% identified 98% o

154 d evaluation of iron status (ferritin level, transferrin saturation, transferrin receptor level, reti

155 hereditary hemochromatosis (HHC) by means of transferrin saturation (TS) levels has been advocated an

156 t possible to assess the association between transferrin saturation (TS) subpopulations and HFE mutat

157 globin, mean corpuscular volume (MCV), serum transferrin saturation (TS), serum ferritin, and white b

158 end maintaining ferritin > or =100 ng/ml and transferrin saturation (TSAT) > or =20% to ensure adequa

159 Thirteen patients with serum transferrin saturation (TSAT) < 25% received ITDI, and 1

160 rritin levels between 500 and 1200 ng/ml and transferrin saturation (TSAT) < or = 25%.

161 One-half of them (10 of 22) proposed transferrin saturation (TSAT) as an alternative or compl

162 dose, intravenous (IV) iron dose, ferritin, transferrin saturation (TSAT) concentration, parathyroid

163 Subjects on FC had increased ferritin and transferrin saturation (TSAT) levels compared with subje

164 occurs with serum ferritin >500 ng/ml and/or transferrin saturation (TSAT) of 20 to 30%.

165 dialysis patients with high ferritin and low transferrin saturation (TSAT).

166 ents who are responsive to erythropoietin, a transferrin saturation value < 18% or serum ferritin lev

167 atosis be defined by repeated elevated serum transferrin saturation values(with or without DNA test r

168 The mean serum iron concentrations and transferrin-saturation values were higher in heterozygot

169 ptoms of hemochromatosis or who had elevated transferrin-saturation values.

170 n value was 62 +/- 4.8 percent, and the mean transferrin saturation was 20 +/- 9 percent.

171 The median baseline transferrin saturation was 8% (range, 2-58%).

172 Transferrin saturation was also associated with a greate

173 ion and the proportion with the highest mean transferrin saturation was approximately 1.

174 However, transferrin saturation was decreased more with chromium

175 ated with overexpression of hepcidin and low transferrin saturation was found to be associated with b

176 The prevalence of elevated serum transferrin saturation was lower in women than in men wh

177 matocrit was measured weekly for four weeks, transferrin saturation was measured, and coexisting illn

178 a standard diet, by 10 weeks of age, fasting transferrin saturation was significantly elevated compar

179 Transferrin saturation was significantly lower in C57BL/

180 of septic ICU subjects, low iron levels and transferrin saturation went along with a nonlethal outco

181 ancer), higher serum iron concentrations and transferrin saturation were associated with increased ri

182 ncreasing weight, urea reduction ration, and transferrin saturation were associated with lower EPO do

183 ochromatosis homozygotes, two populations of transferrin saturation were identified in asymptomatic A

184 t for diurnal variation, 3 subpopulations of transferrin saturation were identified in each racial gr

185 Three subpopulations based on transferrin saturation were present (P < .0001) and the

186 results indicated a close correlation of low transferrin saturation with decreased hepcidin mRNA.

187 served a significant U-shaped association of transferrin saturation with risk of incident stroke (> 4

188 total-iron-binding capacity and increase in transferrin saturation (%) with resistive training are l

189 For transferrin saturation, with 6194 CHD cases in 5 studies

190 demonstrated strain-dependent differences in transferrin saturation, with the highest values in AKR m

191 ansferrin receptor (sTfR) concentrations and transferrin saturation without affecting hemoglobin conc

192 of greater than 60% to define elevated serum transferrin saturation would identify an estimated 1.4 t