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1 owth factor, keratinocyte growth factor, and transforming growth factor alpha).
2 ctor, glial-derived neurotrophic factor, and transforming growth factor-alpha).
3 ation with either epidermal growth factor or transforming growth factor alpha.
4 heparin-binding epidermal growth factor and transforming growth factor alpha.
5 EGFR) pathway due to increased expression of transforming growth factor alpha.
6 7, including tumor necrosis factor alpha and transforming growth factor alpha.
7 the expression of mRNAs for amphiregulin and transforming growth factor alpha.
8 B1, p-ErbB2, p-Erk1/2, p-Akt, cyclin D1, and transforming growth factor alpha.
9 se of many transmembrane proteins, including transforming growth factor-alpha.
10 24 h with a potent fetal hepatocyte mitogen, transforming growth factor-alpha.
11 phatase 5 and positive feedback by autocrine transforming growth factor-alpha.
13 ased mRNA levels of EGFR (6.0 +/- 1.7-fold), transforming growth factor-alpha (14.4 +/- 5.0-fold), he
15 mRNAs for interleukin 1alpha (IL-1alpha) and transforming growth factor alpha (8 of 8); transforming
16 DAM17 as the major convertase of epiregulin, transforming growth factor alpha, amphiregulin, and hepa
17 gens, such as epidermal growth factor (EGF), transforming growth factor alpha, amphiregulin, and hepa
18 s of plasma gastrin; increased expression of transforming growth factor-alpha, amphiregulin, and gast
19 in the neck and base, secrete HCl as well as transforming growth factor-alpha, amphiregulin, heparin-
20 e of additional EGF receptor (EGFR) ligands (transforming growth factor-alpha, amphiregulin, hereguli
23 wever, calcium influx-stimulated shedding of transforming growth factor alpha and amphiregulin does n
24 ion of conditioned medium with antibodies to transforming growth factor alpha and EGF significantly i
26 orted E2-inducible autocrine growth factors, transforming growth factor alpha and stromal cell-derive
27 cells secrete a number of factors including transforming growth factor alpha and tenascin, which whe
28 ently into skin wounds and that they express transforming growth factor-alpha and -beta 1 mRNAs and p
30 2 prototype experimental models, i.e., c-myc/transforming growth factor-alpha and c-myc/E2F-1 mice, f
32 unsuspected autocrine circuits activated by transforming growth factor-alpha and interleukin-1alpha,
33 e rat gastric epithelial cell line RGM1 with transforming growth factor-alpha and interleukin-1beta l
35 progesterone or epidermal growth factor plus transforming growth factor-alpha and p53 responses to ga
36 of autocrine growth factor ligands, such as (transforming growth factor alpha) and TNF-alpha, followi
37 Mice lacking epidermal growth factor (EGF), transforming growth factor alpha, and amphiregulin were
39 s of heparin-binding EGF-like growth factor, transforming growth factor-alpha, and amphiregulin mRNA
40 ent glands expressed increased amphiregulin, transforming growth factor-alpha, and betacellulin mRNA
41 ansforming growth factor-alpha, E2F-1, c-myc/transforming growth factor-alpha, and c-myc/E2F-1 mice.
43 ine gastrins, insulin-like growth factor-II, transforming growth factor-alpha, and endocrine gastrins
44 ncluding vascular endothelial growth factor, transforming growth factor-alpha, and erythropoietin.
45 t genes, vascular endothelial growth factor, transforming growth factor-alpha, and Glut-1 was abrogat
46 ifferent polypeptide ligands, including EGF, transforming growth factor-alpha, and heparin-binding EG
47 Addition of basic fibroblast growth factor, transforming growth factor-alpha, and hepatocyte growth
48 n in response to epidermal growth factor and transforming growth factor-alpha, and increased phosphor
49 a result of the additive effects of hypoxia, transforming growth factor-alpha, and interleukin-1beta.
50 regulation of epidermal growth factor (EGF), transforming growth factor-alpha, and nuclear oncogenes
51 tin-1, angiogenin, hepatocyte growth factor, transforming growth factor-alpha, and tumor necrosis fac
52 nectin 1; keratins 14, 18, and 19; vimentin; transforming growth factor alpha; and autocrine motility
54 and its ligands, epidermal growth factor and transforming growth factor alpha, as well as several tum
55 arious RAS mutant colon carcinoma lines, the transforming growth factor-alpha autocrine loop differen
57 stimulus for fibroblasts than natural EGF or transforming growth factor alpha because of its altered
59 sidues for epidermal growth factor (EGF) and transforming growth factor alpha binding to the EGF rece
60 fibroblast growth factor 2, IL-7, IL-15, and transforming growth factor alpha) but lower levels of th
62 exogenous epidermal growth factor (EGF) and transforming growth factor-alpha, but not by isoforms of
65 transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR
66 growth factor receptor-1, p70 S6 kinase, and transforming growth factor alpha compared with nonrespon
68 to basic fibroblast growth factor, IL-7, and transforming growth factor alpha, coupling strength and
69 ing metaplasia (SPEM), amphiregulin (AR) and transforming growth factor-alpha-deficient mice and thei
71 carcinoma nodules that develop in the c-myc/transforming growth factor-alpha-driven and the hepatiti
72 nic models of liver cancer, including c-myc, transforming growth factor-alpha, E2F-1, c-myc/transform
73 ther promoted the expression and activity of transforming growth factor alpha, EGFR and AP1 transcrip
75 nding to tyrosine kinase receptors including transforming growth factor-alpha, epidermal growth facto
77 n oogenesis, Gurken protein, a member of the transforming growth factor alpha family, is produced by
79 CK cells after administration of AR, but not transforming growth factor-alpha, further supporting a s
80 formed a meta-analysis of the association of transforming growth factor alpha gene (TGFA) polymorphis
81 umors from mice bitransgenic for the neu and transforming growth factor-alpha genes (both driven by t
82 ce other EGF-related peptides including EGF, transforming growth factor alpha, heparin-binding EGF-li
83 ates, including tumor necrosis factor alpha, transforming growth factor alpha, heparin-binding epider
84 epidermal growth factor (EGF) receptor, EGF, transforming growth factor-alpha, heparin-binding EGF-li
85 v-rasHa (HK1.ras), v-fos (HK1.fos), or human transforming growth factor alpha+HK1.TGFalpha) exclusive
86 tumor necrosis factor-alpha, IFN-gamma, and transforming growth factor-alpha in cultured keratinocyt
87 , granulocyte colony-stimulating factor, and transforming growth factor-alpha in response to gluten t
88 important in distinguishing between EGF and transforming growth factor-alpha in their recognition by
89 ound by several activating ligands including Transforming Growth Factor-alpha in vertebrates, and its
90 207%, and prostaglandin E2 by 240%, whereas transforming growth factor alpha increased by 225% and v
92 sted, two [epidermal growth factor (EGF) and transforming growth factor-alpha] induced expression of
93 ion/repair, whereas epidermal growth factor, transforming growth factor alpha, insulin, IGF-1, and IG
94 ession of a wide variety of genes, including transforming growth factor-alpha, insulin-like growth fa
95 cyte growth factor, epidermal growth factor, transforming growth factor-alpha, interleukin-6, tumor n
96 gnalling pathway, which includes a localised transforming growth factor-alpha like molecule, Gurken,
97 nds, Gurken (Grk) and Spitz (Spi), which are transforming growth factor alpha-like proteins, Vn has b
98 ffects the accumulation of Gurken protein, a transforming growth factor alpha-like signaling molecule
99 kpoint activity regulates translation of the transforming growth-factor-alpha-like Gurken signaling m
100 arin resulted in a significant inhibition of transforming growth factor alpha-mediated activation of
101 epithelial chloride secretion as a result of transforming growth factor-alpha-mediated EGFR transacti
102 enomic instability (exemplified by the c-myc/transforming growth factor-alpha mouse) and activation o
104 In addition, PGE(2), in collaboration with transforming growth factor-alpha or K-Ras oncogene, syne
105 kin that is distinct from that of transgenic transforming growth factor-alpha or other cytokines, and
107 ting ligands [epidermal growth factor (EGF), transforming growth factor alpha, or heparin-binding EGF
109 heparin-binding EGF-like growth factor, and transforming growth factor-alpha phosphorylated both rec
110 d epithelial cells significantly upregulated transforming growth factor alpha precursor expression, s
112 bstrates of the general shedding system, the transforming growth factor-alpha precursor, pro-TGF-alph
113 e, pH, bicarbonate, epidermal growth factor, transforming growth factor alpha, prostaglandin E2, muci
114 ory cytokines, such as interleukin-1 beta or transforming growth factor alpha, protects carcinomas fr
115 nzyme (ADAM17), which cleaves membrane-bound transforming growth factor alpha (proTGF-alpha) and rele
117 M1-IT4 cells with epidermal growth factor or transforming growth factor alpha resulted in increased c
118 e tumors, basic fibroblast growth factor and transforming growth factor alpha RNA expression was dete
119 the embryonic axes is initiated by Gurken, a transforming growth factor alpha signal from the oocyte
120 MDLC with a toll-like receptor 2 agonist or transforming growth factor-alpha significantly increases
121 n probe, whereas epidermal growth factor and transforming growth factor-alpha stimulate the expressio
122 Fyn, and Lyn were expressed and activated by transforming growth factor-alpha stimulation in all four
123 Tumor necrosis factor-alpha (TNF-alpha) or transforming growth factor-alpha stimulation of human ep
124 ived from MPM patients express both EGFR and transforming growth factor alpha, suggesting an autocrin
125 Recently, we have shown that PGE(2) and transforming growth factor-alpha synergistically induces
126 contrast, at least one oncogene combination, transforming growth factor alpha/T-antigen, was sufficie
127 4-Hydroxytamoxifen is a full agonist at a transforming growth factor alpha target gene in situ in
128 o MDA-MB-231 cells and the activation of the transforming growth factor alpha target gene in situ tha
129 The epidermal growth factor receptor ligands transforming growth factor alpha (TGF alpha) and amphire
133 have examined mRNAs for Kgf receptor (KgfR), transforming growth factor alpha (Tgf alpha), epidermal
134 locks completely the binding of both EGF and transforming growth factor alpha (TGF-a) to various EGFr
135 eated with HGF, epidermal growth factor, and transforming growth factor alpha (TGF-alpha) alpha showe
138 oma of the head and neck (SCCHN) overexpress transforming growth factor alpha (TGF-alpha) and its rec
139 wing that expression of the genes coding for transforming growth factor alpha (TGF-alpha) and platele
140 kinase (MAPK) pathway activation by E2, and transforming growth factor alpha (TGF-alpha) as a positi
141 ivation in part via extracellular release of transforming growth factor alpha (TGF-alpha) by matrix m
142 hepatocyte growth factor (HGF), induction of transforming growth factor alpha (TGF-alpha) expression,
143 ovel assay in vitro was used to activate the transforming growth factor alpha (TGF-alpha) gene in sit
144 uced by epidermal growth factor (EGF) and by transforming growth factor alpha (TGF-alpha) in NIH3T3 c
145 ently shown that overexpression of c-myc and transforming growth factor alpha (TGF-alpha) in the live
146 Transgenic mice with ectopic expression of transforming growth factor alpha (TGF-alpha) in the panc
150 by determining their ability to up-regulate transforming growth factor alpha (TGF-alpha) mRNA in MDA
151 er due to expression in mammary epithelia of transforming growth factor alpha (TGF-alpha) or c-myc.
153 MEK activity in vitro in immortalized murine transforming growth factor alpha (TGF-alpha) transgenic
155 expressed the epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), EGF recept
156 AG1478 was able to prevent TCDD-, EGF-, and transforming growth factor alpha (TGF-alpha)-dependent c
157 ce that miR-8-positive glia express Spitz, a transforming growth factor alpha (TGF-alpha)-like ligand
160 One candidate is the hepatocyte mitogen transforming growth factor alpha (TGF-alpha); in HBV-inf
161 idermal growth factor (EGF) family including transforming growth factor-alpha (TGF alpha) and EGF are
163 al growth factor receptor (EGFR), its ligand transforming growth factor-alpha (TGF alpha), the downst
165 wn to abrogate transcriptional activation of transforming growth factor-alpha (TGF-alpha) and epiderm
166 Among the various growth factors examined, transforming growth factor-alpha (TGF-alpha) and insulin
167 been shown to stimulate autocrine release of transforming growth factor-alpha (TGF-alpha) and interle
168 imary astrocytes requires stimulation of the transforming growth factor-alpha (TGF-alpha) and of the
169 okines were increased, whereas the levels of transforming growth factor-alpha (TGF-alpha) and platele
172 investigation demonstrated that cleavage of transforming growth factor-alpha (TGF-alpha) by matrix m
175 eptor (EGFR) and ErbB2 by elevated autocrine transforming growth factor-alpha (TGF-alpha) expression
176 We have previously reported that the human transforming growth factor-alpha (TGF-alpha) gene encode
179 induced by epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) has been st
180 Despite constitutive expression of autocrine transforming growth factor-alpha (TGF-alpha) in growth f
181 were assessed in transgenic mice expressing transforming growth factor-alpha (TGF-alpha) in pulmonar
184 o determine the molecular mechanism by which transforming growth factor-alpha (TGF-alpha) is a more p
185 The level of activation of this receptor by transforming growth factor-alpha (TGF-alpha) is controll
188 binding of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) ligands.
190 ibition of matrix metalloproteinases (MMPs), transforming growth factor-alpha (TGF-alpha) or c-Src bl
191 xpression of wild-type EGFR ligands, such as transforming growth factor-alpha (TGF-alpha) or heparin-
192 n of insulin-like growth factor (IGF)-II and transforming growth factor-alpha (TGF-alpha) over IGF-I
193 erting enzyme (TACE/ADAM17) is a physiologic transforming growth factor-alpha (TGF-alpha) sheddase, a
195 rogen receptor modulator, is an agonist at a transforming growth factor-alpha (TGF-alpha) target gene
196 t mice possess a defect in the production of transforming growth factor-alpha (TGF-alpha) that leads
199 ) c-kit, hepatocyte growth factor (HGF), and transforming growth factor-alpha (TGF-alpha) was observe
200 line of double transgenic mice that express transforming growth factor-alpha (TGF-alpha), a liver mi
202 th polymorphisms in the gene (TGFA) encoding transforming growth factor-alpha (TGF-alpha), an epiderm
203 insulin-like growth factor-1 (IGF-1), IGF-2, transforming growth factor-alpha (TGF-alpha), and epider
204 tor (EGF) family hormones amphiregulin (AR), transforming growth factor-alpha (TGF-alpha), and hepari
205 rowth factor (EGF) receptor ligands, EGF and transforming growth factor-alpha (TGF-alpha), but not by
206 hat recognize epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), EGF recept
208 ung disease induced by the overexpression of transforming growth factor-alpha (TGF-alpha), establishe
209 ulin 1-beta (NRG1-beta), betacellulin (BTC), transforming growth factor-alpha (TGF-alpha), heparin bi
210 nd indirectly, via the sequential release of transforming growth factor-alpha (TGF-alpha), interleuki
211 rowth factor (HB-EGF), neuregulin (NRG), and transforming growth factor-alpha (TGF-alpha), is importa
212 eration with the well-characterized oncogene transforming growth factor-alpha (TGF-alpha), PRL induce
213 f the integral membrane precursor to soluble transforming growth factor-alpha (TGF-alpha), pro-TGF-al
214 A variety of transmembrane proteins, such as transforming growth factor-alpha (TGF-alpha), tumor necr
220 colon carcinoma cells are stimulated by the transforming growth factor-alpha (TGF-alpha)/epidermal g
221 enerated transgenic mice that express either transforming growth factor (alpha) (TGF(alpha)) or epide
222 are applied to test for association between transforming growth factor alpha (TGFA) gene and cleft p
225 deleted fibroblasts had higher expression of transforming growth factor-alpha (Tgfa) mRNA and secrete
226 onment interaction between maternal smoking, transforming growth factor-alpha (TGFa), and clefting ha
227 ough the epidermal growth factor receptor by transforming growth factor alpha (TGFalpha) and found th
230 (EGFR) signaling pathway due to the enhanced transforming growth factor alpha (TGFalpha) expression p
231 in (AREG), heparin-binding EGF (HB-EGF), and transforming growth factor alpha (TGFalpha) from tumor c
232 y of 351 mutant ERs and antiestrogens at the transforming growth factor alpha (TGFalpha) gene in situ
233 of a neutralizing monoclonal antibody versus transforming growth factor alpha (TGFalpha) had no effec
234 ative, neurogenic, and behavioral effects of transforming growth factor alpha (TGFalpha) in a 6-OHDA
235 s when co-expressed with the potent oncogene transforming growth factor alpha (TGFalpha) in bitransge
236 (HGF/SF), epidermal growth factor (EGF), and transforming growth factor alpha (TGFalpha) in the prese
237 onal agent-based approach with an integrated transforming growth factor alpha (TGFalpha) induced EGFR
238 nigra dopaminergic neurons and infusions of transforming growth factor alpha (TGFalpha) into forebra
244 ously validated assay using the induction of transforming growth factor alpha (TGFalpha) mRNA in situ
245 ith an ERE3-luciferase reporter, and second, transforming growth factor alpha (TGFalpha) mRNA was use
246 r sensory epithelia, as does the infusion of transforming growth factor alpha (TGFalpha) plus insulin
248 ave shown that intrathecal administration of transforming growth factor alpha (TGFalpha) to the contu
250 proTGFalpha, the transmembrane precursor of transforming growth factor alpha (TGFalpha), as a model
251 r epithelial cells constitutively expressing transforming growth factor alpha (TGFalpha), c-Met is co
252 or receptors (EGF-R) by its ligands, EGF and transforming growth factor alpha (TGFalpha), causes MUC5
253 t cancers, that for c-erbB-2 (HER-2) and for transforming growth factor alpha (TGFalpha), have been c
255 ransfected RIE-1 cells, as well as exogenous transforming growth factor alpha (TGFalpha), promoted mo
256 mutant EGFR signaling or lack of its ligand transforming growth factor alpha (TGFalpha), suggesting
257 17 proteolytic targets, amphiregulin (AREG), transforming growth factor alpha (TGFalpha), syndecan-1
258 or without epidermal growth factor (EGF) or transforming growth factor alpha (TGFalpha), which are k
259 vivo, we assessed the effects of estrogen on transforming growth factor alpha (TGFalpha)- and prolact
261 ets, we investigated secreted molecules from transforming growth factor alpha (TGFalpha)-stimulated h
265 ity of hepatocytes to growth factors such as transforming growth factor alpha (TGFalpha); however, th
267 ligands, epidermal growth factor (EGF), and transforming growth factor-alpha (TGFalpha) elicit diffe
268 f shedding epidermal growth factor (EGF) and transforming growth factor-alpha (TGFalpha) from the pla
270 t, a signal from the oocyte (Gurken (Grk), a transforming growth factor-alpha (TGFalpha) homolog) is
274 Sprague-Dawley rats expressing either human transforming growth factor-alpha (TGFalpha) or simian vi
275 t mammary branching morphogenesis induced by transforming growth factor-alpha (TGFalpha) requires PI3
276 ling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes i
277 f human BDNF, rat CNTF, human FGF2, or human transforming growth factor-alpha (TGFalpha), and immunoh
278 gainst potential EGFR ligands suggested that transforming growth factor-alpha (TGFalpha), but not the
279 he erbB receptor-activating ligands, such as transforming growth factor-alpha (TGFalpha), NRG1alpha,
280 t the EGFR ligands EGF, heparin-binding-EGF, transforming growth factor-alpha (TGFalpha), or amphireg
281 ed by a variety of ligands including EGF and transforming growth factor-alpha (TGFalpha), whereas no
284 sion of epidermal growth factor receptor and transforming growth factor-alpha than distant mucosa.
286 NIKS cells express steady-state levels of transforming growth factor-alpha, transforming growth fa
289 ivated EGFR, the release of amphiregulin and transforming growth factor alpha, two ligands of the EGF
290 In epidermis of transgenic mice expressing transforming growth factor alpha under control of the ke
293 wo EGFR ligands, epidermal growth factor and transforming growth factor-alpha, we found that activate
294 actor 2, platelet-derived growth factor, and transforming growth factor alpha were altered due to lac
295 n-like growth factor-I (IGF-I), insulin, and transforming growth factor-alpha were assayed in organo-
297 dermal growth factor-like growth factor, and transforming growth factor-alpha) were up-regulated in t
298 andard medium or in medium supplemented with transforming growth factor-alpha when compared with cont
299 activation of ERK activity induced by either transforming growth factor-alpha, which links extracellu
300 ha accumulation, which induces expression of transforming growth factor alpha, with consequent activa
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