ライフサイエンスコーパス: transfuse

1 ntain 1.2 HCV RNA copies/mL (60 copies/50 mL transfused).

2 A total of 7054 units blood were transfused.

3 ient-specific Tregs are expanded ex vivo and transfused.

4 in or hematocrit level below which RBCs were transfused.

5 fusion were compared with those who were not transfused.

6 nt years) were included, of which 58.8% were transfused.

7 renal failure with dialysis, with less blood transfused.

8 the rebleeding rate, and the amount of blood transfused.

9 cquisition, after control for units of blood transfused.

10 s of plasma and platelets to red blood cells transfused.

11 s of plasma and platelets to red blood cells transfused.

12 ay affect the number of red blood cell units transfused.

13 t mechanism, 47% severe TBI, 20.5% massively transfused.

14 n patients with blood group A and O who were transfused.

15 d and 117 total units of blood products were transfused.

16 nd IFNgamma (P = 0.035) at 24 hours in those transfused.

17 Twenty of 51,440 platelet units transfused (0.004%; 389 per million) were bacterially co

18 sfusion events that occurred within 4 years, transfusing 16569 U of RBCs, 13933 U of FFP, 5228 U of c

19 in 9.6%, with increased transformation among transfused (24.6%; P < .001).

20 2 mm Hg; P < 0.05) but did not change after transfusing 3-day blood (17 +/- 2 to 18 +/- 2 mm Hg; P =

21 40-day plus nitric oxide blood but not after transfusing 3-day blood.

22 or the mean (+/-SD) number of red-cell units transfused (4.5+/-4.6 units in the epoetin alfa group an

23 nsthoracic echocardiography, increased after transfusing 40-day blood (18 +/- 2 to 23 +/- 2 mm Hg; P

24 fused 545 units of FWB and 685 patients were transfused 5,294 units of RBCs with a mean age at transf

25 t support hospital in 2004, 87 patients were transfused 545 units of FWB and 685 patients were transf

26 The immediate aim should be to avoid transfusing a small number of RBC units for general mala

27 of storage), and the other "older" unit was transfused after 40 to 42 days of storage.

28 16.5]; P < .001), cumulative volume of blood transfused among the patients in each group who received

29 red aspiration, and volume of blood products transfused and fluids administered.

30 njury cases (n=16) were randomly assigned to transfused and nontransfused cardiac surgery controls in

31 The plasma from transfused and nontransfused patients with severe sepsis

32 hemoglobin was 88 +/- 7 and 99 +/- 12 g/L in transfused and nontransfused patients.

33 ransplant antibodies was similar in patients transfused and not transfused, and only 1 of 12 patients

34 Exploratory subgroups included massively transfused and severe TBI patients.

35 gy to reduce the volume of allogeneic plasma transfused and to support storage following pathogen red

36 renal failure-free days, and blood products transfused) and compliance with each guideline, as well

37 dications for transfusion, dose of platelets transfused, and methods of treating alloimmunised recipi

38 s was similar in patients transfused and not transfused, and only 1 of 12 patients who received more

39 ile range 9-26]; 25% were in shock; 28% were transfused; and 6% died within 24 hours.

40 HbG-transfused animals also showed increased astrocytic glia

41 Two-photon microscopy in live transfused animals revealed that extracellular mitochond

42 Of the 15 million red blood cell components transfused annually in the United States, approximately

43 e approximately 2 million units of platelets transfused annually within the United States, if impleme

44 million units of red blood cells (RBCs) are transfused annually worldwide, transfusion practices var

45 than 81 million units of red blood cells are transfused annually.

46 tate to fall on ECLS and volume of platelets transfused are independent predictors of mortality.

47 g/dL with 67%, 36%, 15%, and 5% of patients transfused at >7, >8, >9, and >10 g/dL, respectively.

48 enrolled in a randomized crossover study of transfusing autologous, leukoreduced blood stored for ei

49 mitant blockade of inhibitory FcgammaRIIB on transfused basophils further substantially increased bas

50 e 129 blood components, 62 of which had been transfused before identification of the infected donatio

51 nd that patients with both nontransfused and transfused beta-thalassemia have very high serum ERFE le

52 A widespread approach today is to transfuse bleeding trauma patients with RBC concentrates

53 a wide range of doses for the vCJD agent in transfused blood and plasma derivatives.

54 ed erythrocytes in a culture, distinguishing transfused blood cells from a patient's own blood, ident

55 ytomegalovirus nucleic acid testing (NAT) of transfused blood components and breast milk was performe

56 identical parasites in the recipient and the transfused blood confirmed transfusion-transmitted malar

57 Phenotypically matching transfused blood has been shown to decrease alloimmuniza

58 uently demonstrated that Kell differences on transfused blood induce antibody responses and hemolytic

59 thesized that preimmunization to antigens on transfused blood may prime BMT rejection.

60 le unit, the risk increases as the number of transfused blood products increase.

61 man neutrophil antigen antibodies present in transfused blood products, and predisposing factors such

62 than 10 mg Fe/g dry weight, and more than 50 transfused blood units.

63 The prevalence of P. falciparum malaria in transfused blood was 4.7% (21/445) by microscopy, 13.7%

64 The mean age of transfused blood was 5.1 (SD, 2.0) days in the fresh RBC

65 om information about the storage duration of transfused blood was missing and one patient whose sex w

66 %) was the parasite identical to that in the transfused blood.

67 e genotyped and compared to parasites in the transfused blood.

68 isk of in-hospital mortality associated with transfusing blood stored longer than 35 days.

69 Fewer platelets were transfused but more frequent transfusions were required.

70 blood (treated) or whole blood prepared and transfused by standard local practice (untreated).

71 alent severity who are infrequently or never transfused can still develop serious complications of ir

72 gations to define the biological fate of the transfused cells in recipients.

73 A single transfusion in the chronically transfused cohort improved FMD.

74 of hospital stay was significantly longer in transfused compared with nontransfused patients (17.8 +/

75 ed time to hemostasis, blood product volumes transfused, complications, incidence of surgical procedu

76 of this study was to evaluate the effect of transfusing components from male-only vs. female donors

77 sion-related acute lung injury compared with transfused controls.

78 ic medical centers enrolled 89 cases and 164 transfused controls.

79 immunoglobulins or monoclonal antibodies, we transfused convalescent-phase blood from EBOV-immune mon

80 can Association of Blood Banks on outcome of transfused critically ill patients.

81 nts, and the total amount of red blood cells transfused did not differ between groups (1.80 U versus

82 number of units of blood products that were transfused during hospitalization was 4331 in the tranex

83 of infection per unit of fresh frozen plasma transfused equal to 1.039 (1.013-1.067).

84 ce to the foreign antigens on the surface of transfused erythrocytes if the animal has not been given

85 Adherence to a strict policy of transfusing exclusively ABO-identical platelets may lead

86 venous thromboembolism; (2) do not routinely transfuse for chronic anemia or uncomplicated pain crise

87 ation groups, ranging from 91.1% among those transfused for a malignant disease without surgery to 1.

88 A total of 5901 PRBC units were transfused for a median of 2 (interquartile range 2-4) u

89 A total of 5901 PRBC units were transfused for a median of 2 (interquartile range 2-4) u

90 sease without surgery to 1.7% among patients transfused for obstetrical bleeding.

91 infarcts occur among children with SCD being transfused for secondary stroke prevention.

92 The influence of transfusing fresh vs. stored blood on the liver has not

93 One unit was autologously transfused "fresh" (3-7 days of storage), and the other

94 he odds ratio (OR) for 10 years mortality in transfused group was 2.92 and after adjusting for preope

95 let Dose Study, which included 1272 platelet-transfused hematology-oncology patients who received 603

96 The AABB recommends transfusing hospitalized adult patients with a platelet

97 deletion was associated with engraftment of transfused HSPC without any toxic conditioning of the ho

98 restrictive red-cell transfusion threshold (transfuse if hemoglobin level was <7.5 g per deciliter,

99 or a liberal red-cell transfusion threshold (transfuse if hemoglobin level was <9.5 g per deciliter i

100 Blood products were transfused in 72 (64%) patients within the first 24 hour

101 00 units of warm fresh whole blood have been transfused in Afghanistan and Iraq by U.S. medical provi

102 ctive effects of fresh vs. stored blood when transfused in anemic rats after acute myocardial infarct

103 esting of 2,831 samples from FWB donor units transfused in Iraq and Afghanistan between May 2003 and

104 was an increased use of plasma and platelets transfused in the 1:1:1 group, no other safety differenc

105 These data demonstrate that RBCs transfused in the absence of inflammation can induce tol

106 ream infections occur in 15 (20.8%) of those transfused in the first 24 hours, compared with 1 patien

107 Three hundred sixty-five (45%) patients were transfused in the first 24 hours.

108 s of PRBCs (range, 0-167 units/patient) were transfused in the intraoperative (1581 units [39.5%]) an

109 A median of 2 units of red cells were transfused in the liberal-strategy group and none in the

110 s of anti-hGPA immunoglobulins, unlike those transfused in the presence of polyinosinic:polycytidylic

111 more than 1.5 million platelet products are transfused in the USA each year, 2.9 million products in

112 nor), although nonirradiated components were transfused in the vast majority of these (97.6%).

113 Although many transfused incompatible RBCs are cleared, some remain in

114 ls did not reduce the proportion of patients transfused (interaction p = 0.01).

115 Of these, 16 RNA-positive units transfused into 16 susceptible recipients were identifie

116 C virus (HCV) RNA negative to positive were transfused into 2 chimpanzees to assess infectivity duri

117 Overall, 42 DENV RNA-positive units were transfused into 35 recipients.

118 from 105 donors (of 12 529 tested donations) transfused into a population of surgical patients with a

119 s from such mice were rapidly destroyed when transfused into C3-sufficient mice.

120 so exhibits markedly prolonged survival when transfused into FVIII-deficient mice, the cotransfused F

121 ovalbumin-human transmembrane Duffy(b)) were transfused into naive mice alone or together with select

122 sgenic (hGPA-Tg) or wild-type (WT) mice were transfused into non-Tg recipients passively immunized wi

123 pheresed red cells, divided and autologously transfused into the forearm brachial artery 5 and 42 day

124 large numbers in vitro, and autologous MSCs transfused into tuberculosis patients have been found to

125 ANH patients were less often transfused intraoperatively (n = 1, 1.6%) compared with

126 ng number of units of packed red blood cells transfused intraoperatively (odds ratio=1.2, 95% confide

127 injury of the right carotid artery and were transfused intravenously with ECs (total, 1.5x10(6) cell

128 is associated with iron overload due to both transfused iron and increased iron absorption, the latte

129 te that the amount of fresh warm whole blood transfused is independently associated with improved 48-

130 chanistic pathways involving the presence of transfused leukocytes.

131 aracteristics of acute endothelial injury in transfused lungs in vivo.

132 ), and mortality was further increased among transfused MDS (P < .01).

133 CI -35 to 11]; p=0.23), with fewer RBC units transfused (mean 1.2 [SD 2.1] vs 1.9 [2.8]; difference -

134 red blood cell sequestration in the lungs of transfused mice in vivo.

135 end points were the number of red-cell units transfused, mortality, and the change in hemoglobin conc

136 The recruitment of SF1670-pretreated transfused neutrophils to the inflamed peritoneal cavity

137 hosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, provi

138 t with those derived from a risk analysis of transfused nonleukoreduced red blood cells in the United

139 n of blood component ratios in the massively transfused nontrauma demographic.

140 Among 601 massively transfused nontrauma patients, cardiothoracic surgery an

141 Massively transfused nontrauma patients.

142 S (HbS) containing red blood cells (RBCs) by transfusing normal blood units containing hemoglobin A (

143 V-C RNA acquisition increased with each unit transfused (odds ratio, 1.09; 95% confidence interval, 1

144 transfusions must be balanced with those of transfusing old RBCs in patients with life-threatening t

145 ) are lifesaving in neonatal intensive care, transfusing older RBCs may result in higher rates of org

146 n-bound iron derived from rapid clearance of transfused, older stored RBCs may enhance transfusion-re

147 pido and colleagues evaluated the effects of transfusing one unit of blood close to the storage limit

148 24 hours, compared with 1 patient (2.5%) not transfused (OR = 10.3 [1.3-81], P = 0.008).

149 manage iron overload in children chronically transfused over 7 years before enrollment.

150 To evaluate the impact of transfused packed red blood cell (PRBC) age on periopera

151 th liberal practices were twice as likely to transfuse patients and had higher risk-adjusted mortalit

152 cm H2O, p < .001), and in the percentage of transfused patients (63% to 38%, p < .001) after the int

153 By day 5, 785 of 977 transfused patients (80.4%) had received at least one RB

154 y rates were 24.7% in bloodless and 24.5% in transfused patients (odds ratio, 1.01; 95% CI, 0.68-1.52

155 st common complications are iron overload in transfused patients and syndrome-specific malignancies i

156 comprehensive descriptions of the massively transfused patients and their outcomes.

157 ropathy, and graft loss was slightly more in transfused patients but the differences were not statist

158 In comparison, 143 transfused patients had more severe injury, prolonged pr

159 Also, 50% of massively transfused patients in hemorrhagic shock demonstrated SD

160 Transfused patients received a mean (sd) of 5 (6) RBC un

161 l, 71 (58%) chronic and 9 (15%) episodically transfused patients were alloimmunized.

162 lidated the 7 g/dL threshold, but previously transfused patients were excluded.

163 At any time after their operations, transfused patients were less likely to have been discha

164 One-third of transfused patients were not bleeding and had no planned

165 Transfused patients were older, had higher hemoglobin le

166 -five (45%) chronic and 7 (12%) episodically transfused patients were Rh immunized.

167 We recruited 31 chronically transfused patients with beta-thalassemia major and coll

168 erasirox pharmacokinetics (PK), comparing 10 transfused patients with inadequate deferasirox response

169 hown promise in recent trials in chronically transfused patients with sickle cell disease and may pro

170 eans to prevent iron overload in chronically transfused patients with sickle cell disease.

171 s responsible for iron overload in minimally transfused patients with this disease.

172 Among transfused patients, 228 (46.7%) had died by day 90 when

173 less patients appeared to be comparable with transfused patients, albeit the latter group had older a

174 Galacomannans were found in transfused patients, pooled platelet concentrates, fresh

175 the increased risk of ARDS in critically ill transfused patients.

176 anifestations, and cardiovascular events) in transfused patients.

177 nsfusion safety in severely ill or massively transfused patients.

178 actice that appears to occur in about 50% of transfused patients.

179 ctice which appears to occur in about 50% of transfused patients.

180 racteristics, and the mortality of massively transfused patients.

181 efficient thymic entry of endogenous or i.v. transfused pDCs.

182 usion led to a decreased number of platelets transfused per patient but an increased number of transf

183 A mean (SD) of 0.5 (1.3) RBC unit was transfused per patient for the 500 OLTs, and 79.6% of th

184 The mean number of red blood cell transfused per patient was reduced from 1.21 +/- 0.05 to

185 A mean of 18 packed RBC units (U) were transfused per patient.

186 median of 2 (interquartile range 2-4) units transfused per patient.

187 median of 2 (interquartile range 2-4) units transfused per patient.

188 ntly reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejec

189 ell units (0.27 vs 0.29; P=.55) or number of transfused platelet units (0.26 vs 0.29; P=.31).

190 Here, we demonstrate that immunity to transfused platelets contributes to subsequent BMT rejec

191 rophages rapidly removed a large fraction of transfused platelets independent of their storage condit

192 ed bone marrow because, although immunity to transfused platelets is best characterized in relation t

193 However, some patients rapidly clear transfused platelets, preventing the desired therapeutic

194 only 2 of 10 (20%) recipients accepting the transfused platelets.

195 d in this analysis of a nontrauma, massively transfused population.

196 fewer patients in the restrictive group were transfused postrandomization (p<0.001) and received a me

197 with the addition of the highly significant transfused PRBC variable (P<0.0001; OR=1.23/transfused P

198 transfused PRBC variable (P<0.0001; OR=1.23/transfused PRBC) to the model attenuates the purported i

199 ried out with, and without, consideration of transfused PRBC.

200 Instead, transfused pRBCs remained in circulation longer in acute

201 The AABB recommends that platelets should be transfused prophylactically to reduce the risk for spont

202 aluated after exclusion of patients who were transfused proximate to the time of rejection.

203 immunized SCD CD16+ monocytes in response to transfused RBC breakdown products promote an anti-inflam

204 o better assess when and how aggressively to transfuse RBCs in neurosurgical patients.

205 association between the length of storage of transfused RBCs and patient mortality.

206 association between the length of storage of transfused RBCs and patient mortality.

207 rovide additional insight into the nature of transfused RBCs as an immunogen and provide a mechanism

208 murine models of humoral alloimmunization to transfused RBCs have been described.

209 imilar biology regulates alloimmunization to transfused RBCs in humans.

210 nts treated with immunoprophylaxis, with the transfused RBCs remaining in circulation having minimal

211 e report that in the noninflamed state, most transfused RBCs were consumed by splenic macrophages, wi

212 Rapid clearance of essentially all transfused RBCs with detectable KEL glycoprotein antigen

213 fusions can trigger alloimmunization against transfused RBCs with serious clinical sequelae.

214 In contrast, transfused RBCs with the KEL glycoprotein antigen fully

215 cell subsets and participate in clearance of transfused RBCs, we tested the hypothesis that in respon

216 ke inflammation enhances alloimmunization to transfused RBCs.

217 Because of the potential adverse outcomes of transfusing RBCs of increased storage age to combat-rela

218 e to specific clinical questions; (2) do not transfuse red blood cells in hemodynamically stable, non

219 ces were noted in the median daily number of transfused red blood cell units (0.27 vs 0.29; P=.55) or

220 ects humoral alloimmunization to antigens on transfused red blood cells (RBCs).

221 I study of deferasirox, including volumes of transfused red blood cells and changes in liver iron con

222 cy in adenosine-5'-triphosphate release from transfused red blood cells may promote or exacerbate mic

223 key secondary end point was total number of transfused red blood cells.

224 thologies, or studies using small volumes of transfused red blood cells.

225 ity after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks.

226 The age of transfused red cells did not affect 90-day mortality amo

227 l monitoring for venous thromboembolism when transfusing red blood cells through multi-lumen PICCs se

228 '-triphosphate and adhesion in responses to (transfused) red blood cells.

229 into the possible mechanisms of clearance of transfused refrigerated platelets.

230 We then compared the ability of transfused resting and degranulated platelets to prevent

231 control study, DNA samples from 2 cohorts of transfused SCD patients were combined (France and The Ne

232 Th1 (IFN-gamma(+)) cytokines in chronically transfused SCD patients with alloantibodies as compared

233 TR jet, and FMD were measured in chronically transfused SCD pre- and posttransfusion (N = 25), in non

234 These correlations improved for transfused, shocked or head injured patients.

235 The immediate aim should be to avoid transfusing small numbers of RBC units for general malai

236 ase of pulmonary artery pressure produced by transfusing stored blood.

237 been raised about the safety and efficacy of transfusing stored blood.

238 y and also the potential untoward effects of transfusing stored RBCs of different ages and storage co

239 Transfused subjects received a median of 5 transfusions.

240 and cardiomyopathy are common in chronically transfused thalassemia major patients, occurring in the

241 Hemoglobin at randomization was lower in transfused than in nontransfused patients (94 vs 111 g/L

242 fusion according to the standard practice of transfusing the oldest available blood.

243 iven well before 10 units of PRBCs have been transfused; the early use of recombinant Factor VIIa; an

244 (1.09-2.95; p=0.022) compared with patients transfused through a peripheral intravenous line.

245 For every red blood cell unit transfused through a PICC, there was a significantly inc

246 Similarly, patients transfused through a right-sided PICC were more likely t

247 We evaluated the risks of FWB and RBCs transfused to combat-related casualties.

248 RBC transfusion and the number of RBC units transfused to describe the effect of restrictive transfu

249 e blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospi

250 ies to prevent HTRs, WBC-reducing components transfused to patients undergoing cardiac surgery, reduc

251 in the United States, approximately 40% are transfused to patients undergoing elective surgical proc

252 ison of average units of fresh frozen plasma transfused to patients with and without infectious compl

253 Finally, we demonstrate that T cell-transfused TRAF1(-/-) recipient mice demonstrated impair

254 ctive cohort study, we assembled data on 741 transfused trauma patients at a large trauma center.

255 s in the transfusion management of massively transfused trauma patients, focusing on the use of fixed

256 tide polymorphisms (SNPs) to characterize 59 transfused trauma patients, with MC (n=30) and without M

257 at low concentrations, is well documented in transfused trauma patients.

258 0.81 (95% CI, 0.44-1.49) in 2009 per 10 000 transfused units (P = .002).

259 phase, intraoperative blood loss, number of transfused units of blood, and postoperative morbidity.

260 Leukoreduced status of transfused units was not associated with GBV-C transmiss

261 ue to a failure to account for the timing of transfused units.

262 Because transfusing units of incompatible blood is potentially l

263 The AABB recommends transfusing up to a single apheresis unit or equivalent.

264 More than 1 in 10 units of PRBCs were transfused using a liberal Hb trigger.

265 ceived a transfusion, 456 units (11.4%) were transfused using a liberal trigger (intraoperative, 122

266 516) and ischemic outcomes (832 of 8518) for transfused versus nontransfused patients were 3.38 (95%

267 mean age 61 + 0.4 yr and median RBCs volume transfused was 1700 mL (interquartile range 800-3150 mL)

268 The number of RBC units transfused was lower in the restrictive transfusion grou

269 fusion for each packed red blood cell (PRBC) transfused was recorded, in minutes, for all patients.

270 The median number of platelets transfused was significantly lower in the low-dose group

271 Mean number of PRBCs and FFP transfused were 7.7 +/- 12 U, 6 U, and 5 +/- 12 U, respe

272 n morning hemoglobin level and amount of RBC transfused were prospectively collected in the Randomize

273 ing HLA antibody if they had been previously transfused when compared with those who did not have a h

274 Sixty-three hospitals (70%) could transfuse whole blood but only 7 (7.4%) could separate a

275 Volunteers were transfused with 3-day blood, 40-day blood, and 40-day bl

276 ased pulmonary artery pressure in volunteers transfused with 40-day blood (17 +/- 2 to 12 +/- 1 mm Hg

277 in one pretransfusion seropositive recipient transfused with a component containing greater than 10(1

278 d)/D(d)) heart transplant and were passively transfused with anti-donor MHC class I Ab.

279 ermined a rate of transmission to recipients transfused with B19V DNA-positive components.

280 Most patients transfused with contaminated platelets do not show immed

281 phylococcus aureus pneumonia, were exchanged-transfused with either 7- or 42-day-old washed or unwash

282 Nearly one-half of patients transfused with FFP during the postoperative period had

283 tened FVIII survival in FVIII-deficient mice transfused with FVIII and VWF D'D3/D'D3-Fc is due to ine

284 Of 1092 recipients, 471 (43.1%) were transfused with HHV-8 antibody-positive blood.

285 STR occurred only in neutropenic patients transfused with high bacterial loads.

286 renal patients awaiting transplantation when transfused with HLA selected units of blood compared wit

287 of the recipient strain, because B10.BR mice transfused with membrane-bound hen egg lysozyme antigen-

288 trast, no grafts were rejected by recipients transfused with Mirasol-treated platelets.

289 226 to 348 mL and the proportion of patients transfused with packed red blood cells over placebo.

290 of Rh alloimmunization in patients with SCD transfused with phenotypic Rh-matched African American R

291 a greater than twofold higher odds of being transfused with RBCs [adjusted odds ratio (AOR) = 2.41;

292 FVB mice transfused with RBCs expressing transgenic human glycoph

293 ients whose RBCs lacked the antigen and were transfused with Rh-matched RBCs.

294 All four deer transfused with the blood mononuclear cell fraction from

295 Mice transfused with these red blood cells are resistant to h

296 Wild-type (WT) recipients transfused with transgenic KEL2 RBCs generated anti-KEL

297 nts alloimmunization in wild-type recipients transfused with transgenic murine RBCs expressing the hu

298 Rats were transfused with trauma-sham shock (T/SS), or T/HS whole

299 hospital length of stay, and red blood cells transfused within 48 hours.

300 s associated with fewer red blood cell units transfused without adverse associations with mortality,