ライフサイエンスコーパス: transgene

1 in oligodendrocyte glycoprotein-specific TCR transgene.

2 but instead carries the human MX1 locus as a transgene.

3 uctural proteins expressed from an exogenous transgene.

4 prisingly not with transcription of the hTNF transgene.

5 ep expressing a human CAG-expansion HTT cDNA transgene.

6 or to the nucleus to drive expression of any transgene.

7 correlated with the expression level of the transgene.

8 ited wihin tissues that express a repetitive transgene.

9 -specific, latency-resistant TGF-beta mutant transgene.

10 salivary gland specific promoter-driven hNGF transgene.

11 ld 1Ax1 that had similar expression level of transgene.

12 e transfected with LNA-anti-uc.173 or uc.173 transgene.

13 ying an inducible human tetherin (hTetherin) transgene.

14 to mice expressing the inducible Pdx1CreERT transgene.

15 ression of large and/or multiple therapeutic transgenes.

16 d gap junctions with dominant-negative unc-1 transgenes.

17 ment of viral vectors expressing problematic transgenes.

18 levels from bacterial artificial chromosome transgenes.

19 ike silencing of canola-biased PUFA synthase transgenes.

20 rapeutic products of different serotypes and transgenes.

21 ssion cassettes affect expression of the two transgenes?

22 quence to increase the expression of the two transgenes?

23 verexpression of prolyl-hydroxylase 2 (PHD2) transgene, a predominant isoform of PHDs in renal tubule

24 chromosomes and permanently express encoded transgenes, a process known as stable transformation.

25 Using a transgene activation system, the human sex-determining g

26 codes inducible KRAS (G12D) and TP53 (R167H) transgenes, allowing for STS modeling in a spatial and t

27 ther show that a combination of Gal4 and Cre transgenes allows intersectional expression of a fluores

28 retion compared with mice expressing the Cre transgene alone; however, when compared with wild-type m

29 in stromal cells with a mesenchymal Prx1-Cre transgene also promoted this phenotype.

30 We successfully express the transgene and one mirtron together from a single constru

31 e2 and H3K79me2 levels at the Ccnb1 promoter transgene and the native Ccnb1 gene indicated that the e

32 reported NOD mouse line expressing an Ealpha transgene and, thereby, the Ealpha:Ebeta complex.

33 signal that can alter the expression of both transgenes and endogenous loci.

34 specifically integrated single-copy promoter transgenes and measuring their expression to indicate pr

35 mmalian and bacterial cells expressing P1-3C transgenes and retained the ability to process P1 polypr

36 ommon polymorphism not incorporated into the transgene, and were restricted by a rare HLA class I C a

37 s, report an inhibitory effect of repetitive transgenes, and discover conditions for cell-autonomous

38 utilizes specific primers to amplify target transgenes, and endogenous reference genes in a single d

39 in C. reinhardtii We demonstrate its use in transgene- and selection-free generation of sequence-spe

40 aneously arising Emu-Myc lymphomas to define transgene architecture, somatic mutations, and structura

41 to be locally expressed in the tissues where transgenes are active and associated with phenotypic alt

42 nteractions (PPIs) into stable expression of transgenes are powerful tools for PPI discovery, screens

43 ffect, we combined mice carrying the APP/PS1 transgene array that develop plaques with rTg4510 mice c

44 d provides a method for the use of other Cre transgenes associated with a similar LoxP inhibition eve

45 Metoprolol significantly reduced transgene-associated mortality (n>/=29; P<0.001), attenu

46 omoter and factor IX Padua (factor IX-R338L) transgene at a dose of 5x10(11) vector genomes per kilog

47 mice that express only 1 copy of human REG3A transgene but were fed feces from control mice (not expr

48 efficiently map the integration site of any transgene, but also provide additional information regar

49 gy that combines both essential signals in 1 transgene by expressing the nonlymphoid hematopoietic gr

50 tilizes a translational block of one or more transgenes by employing the bacterial tryptophan RNA-bin

51 Integration of a transgene can disrupt an endogenous gene, potentially in

52 e, hypodermis, or neurons using a repetitive transgene can enable silencing also in unrescued tissues

53 e of larval midgut copper cells and that the transgene can rescue a normally early lethal ATP7 deleti

54 However, expression of therapeutic transgenes can often adversely affect vector titres due

55 otocol based on a doxycycline-inducible Cas9 transgene carried on a piggyBac transposon to enable rob

56 Conversely, the BACHD transgene carries a floxed, synthetic exon 1 sequence.

57 melanogaster However, we found that a large transgene carrying the entire D. erecta eve locus drives

58 multiplexed orthogonal activation of several transgenes carrying cognate variable activating sequence

59 ammalian gastrointestinal tract resulting in transgene-carrying wild type bacteria.

60 are well-suited for stable delivery of large transgene cassettes and warrant further investigation fo

61 t is restricted to Tregs via a Cre-inducible transgene causes an autoimmune syndrome.

62 demonstrate that the sequence composition of transgene CDSs can directly impact silencing, providing

63 esizes a unique small peptide arising from a transgene composed of a randomized nucleic acid sequence

64 Analysis of the wild type ATP7-GFP transgene confirmed that ATP7 is expressed at the basola

65 oralis, we observed expression patterns of a transgene construct encoding green fluorescent protein u

66 rated via pronuclear microinjection of a Cre transgene construct, the integration site is random and

67 lentiviral vector incorporating the HA-1 TCR transgene construct.

68 ombinations of elements that are typical for transgene constructs.

69 lr(-/-)) bone marrow chimeras that express a transgene containing an engineered latent membrane prote

70 Analysis of the gATP7-GFP transgenes containing pathogenic mutations showed that t

71 However, combining RNPs with transgene-containing donor templates for targeted gene a

72 The Lshid transgene contains a sex-specific intron and as a conseq

73 ing the simple and accurate determination of transgene copy number in these six important crop specie

74 Currently, transgene copy number is estimated by either Southern bl

75 loped a droplet digital PCR-based method for transgene copy number measurement in an array of crops:

76 e TG increased with input dose, and multiple transgenes could be co-delivered to TG neurons by separa

77 alter promoter DNA methylation level of the transgene d35S::LUC, although the DNA demethylase ROS1 i

78 However, extrapolation of the transgene data to endogenous L1s suggests that it is unl

79 novel and atraumatic technique for inner ear transgene delivery in early postnatal mice.

80 a rationally designed synthetic vector, for transgene delivery to the mouse cochlea.

81 Transgene-derived factor IX coagulant activity enabled t

82 ively stable and dose-dependent increases in transgene-derived wild-type AAT after local intramuscula

83 erized in plants; thus, we evaluated several transgene design parameters as means to reduce heritable

84 et, mice carrying one copy of KD-mTOR mutant transgene developed glucose intolerance and beta-cell in

85 enic soybean lines overexpressing three WRKY transgenes displayed increased resistance to SCN.

86 ne disruption abrogated thermotaxis; a PKC-2 transgene, driven by endogenous pkc-2 promoters, restore

87 The BAC transgene drives cell-type-specific transcription of an

88 man and mouse hepatocytes independent of the transgene, driving promoter, or AAV serotype and was sub

89 ce that display stage-specific activation of transgenes during odontoblast differentiation.

90 Simple enhancer-effector transgenes employing lepb-linked sequences upstream of p

91 le-specific rescue of rde-4 using repetitive transgenes enables silencing in other tissues.

92 or T-DNA insert stability and consistency of transgene encoded protein accumulation through commercia

93 reprogramming a patient's own T cells with a transgene encoding a chimeric antigen receptor to identi

94 ither genetic (i.e., the INK-ATTAC 'suicide' transgene encoding an inducible caspase 8 expressed spec

95 Expression of a transgene encoding p65 or p50 in IECs led to significant

96 ell differentiation, whereas expression of a transgene encoding TAZ or activation of TAZ directed TH1

97 Analyses of Arabidopsis plants with transgenes encoding a microalgal polyunsaturated fatty a

98 developed mice with inducible expression of transgenes encoding small hairpin RNAs (shRNAs) against

99 eedy, stable and marker-free introduction of transgenes encoding the DiCre recombinase into genomic l

100 A 55-kb transgene encompassing the human renin locus was crossed

101 reover, elevating PEX5 levels via a 35S:PEX5 transgene exacerbated pex26 defects and ameliorated the

102 geted genome editing and concurrent scarless transgene excision.

103 opies of a kinase-dead mTOR mutant (KD-mTOR) transgene exclusively in beta-cells.

104 The transgenes exhibit initially broad patterns of transcrip

105 ana) as a model system, we discovered that a transgene exogenously expressing histone 3 Lys-36 to Met

106 months-long protection of vector-transduced, transgene-expressing cells from microglial phagocytosis.

107 evious work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stron

108 tigated the biomass, exogenous Bt toxins, Bt-transgene expression and methylation status in Bt rice e

109 ences (CDSs) with higher GC content improved transgene expression and resulted in a remarkable trans-

110 choice of transcriptional promoters to drive transgene expression and the best ways to sink existing

111 ansion, oncogenic transformation, variegated transgene expression and transcriptional silencing.

112 wn that reliability of the A2UCOE in driving transgene expression can be attributed to its resistance

113 oses required to reach therapeutic levels of transgene expression caused liver inflammation in some p

114 These results indicate that long term transgene expression consistency and T-DNA insert stabil

115 Long term transgene expression consistency and T-DNA insert stabil

116 s study addresses T-DNA insert stability and transgene expression consistency in multiple cycles of f

117 s study addresses T-DNA insert stability and transgene expression consistency in multiple cycles of f

118 The Tet-On/Off system for conditional transgene expression constitutes state-of-the-art techno

119 H-driven medulloblastoma, animals with Atoh1 transgene expression developed highly penetrant medullob

120 flanking sequences that can be used to drive transgene expression for any organism where transcriptom

121 -repeat enhancers have proven safe; however, transgene expression from cellular promoters is often in

122 Suppression of therapeutic transgene expression from retroviral gene therapy vector

123 .3- to 8-fold or 91- to 125-fold increase of transgene expression from the same batch of materials, d

124 e versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic acid-CD44 independe

125 Transgene expression in hPSCs is tightly regulated in re

126 Flcn H255Y mutant transgene expression in kidney-targeted Flcn knockout mi

127 igh-level stable gene transfer and sustained transgene expression in multiple primary human somatic c

128 tively and specifically drives Cre-dependent transgene expression in selected postsynaptic neuronal t

129 uronal-specific promoters were able to drive transgene expression in TG neurons.

130 ic injection of different rat brain regions; transgene expression in the hippocampus lasted up to 6 m

131 Transgene expression in these cells, however, can be sta

132 enous Bacillus thuringiensis (Bt) toxins and transgene expression in transgenic rice under different

133 Chlamydomonas RPL23 sequences also enabled transgene expression in Volvox carteri.

134 ply, while, to some extent, the exogenous Bt-transgene expression is reduced at sub-N levels (1/4 and

135 , providing design strategies for increasing transgene expression levels and reducing risks of herita

136 iple promoters and terminators, and variable transgene expression levels.

137 We therefore exploited the power of targeted transgene expression of mutant hDAT in Drosophila to exp

138 In mice, fibroblast-specific Il11 transgene expression or Il-11 injection causes heart and

139 conventional nanocomplexes, or DNA-CN), and transgene expression reached beyond the tumor edge, wher

140 tion site-independent, copy number-dependent transgene expression restricted to macrophages, we demon

141 genic mouse model with doxycycline-inducible transgene expression specifically in the glomerular podo

142 , which was critical to achieving widespread transgene expression throughout orthotopic rat brain tum

143 ated sequences could drive stable luciferase transgene expression to significantly higher levels than

144 a vitreous component, in adenoviral-mediated transgene expression was examined.

145 hCD39 transgene expression was localized to the vascular endot

146 on by food intake), recombinant AAV-mediated transgene expression was markedly reduced, both in vitro

147 Transgene expression with the PBAE/PBAE-PEG blended nano

148 of integrated T-DNA molecules likely affect transgene expression, and control of integration is cons

149 of undefined T-cell mixtures, variability of transgene expression, and terminal differentiation of ce

150 -DZ cells results in a similar activation of transgene expression, and treatment with dasatinib, an i

151 cellular promoters result in relatively low transgene expression, often leading to inadequate diseas

152 se, which was associated with a reduction in transgene expression, was characterized more thoroughly

153 In order to achieve kidney-specific transgene expression, we tested direct hydrodynamic inje

154 ce of versican respond with an activation of transgene expression.

155 blasts into integration-free iCMs via robust transgene expression.

156 from methylation, thereby conferring stable transgene expression.

157 or the ability to drive heterologous nuclear transgene expression.

158 tein isoforms, relying instead on cDNA-based transgene expression.

159 vels and reducing risks of heritable loss of transgene expression.

160 rprisingly sensitive reporters of off-target transgene expression.

161 is, site-of-action experiments and exogenous transgene expression; and we provide a basic driver and

162 dated in functional rescue experiments using transgenes expression in EPCs from retroviral vectors.

163 mbiguously proven by the characterization of transgene flanking regions and the combinations of eleme

164 es, but this could require steps to mitigate transgene flow to wild populations.

165 Nicotiana tabacum L.) to reduce pollen-borne transgene flow.

166 le, we engineered a CREB-luciferase reporter transgene for noninvasive bioluminescence monitoring of

167 tably inherited to the next generations, and transgene-free mutants of rice MPK genes were readily ob

168 e selection and fixation of novel alleles in transgene-free plants and fine manipulation of yield com

169 ry proteins expressed in GM crops containing transgenes from the soil bacterium Bacillus thuringiensi

170 ofructo-2-kinase/fructose-2,6-bisphosphatase transgene (Glyco(Lo) mice) lowered glycolytic rate and r

171 le phiC31 integrase mediated introduction of transgenes has been generated.

172 Moreover, mice expressing an FGF19 transgene have been shown to develop HCC.

173 D, having two full-length, genomic human HTT transgenes heterozygous for the HD mutation and polymorp

174 mice have two full-length, genomic human HTT transgenes heterozygous for the HD mutation and polymorp

175 Notably, expression of the Flcn K508R mutant transgene in heterozygous Flcn knockout mice resulted in

176 imaging of a single-copy, estrogen-inducible transgene in human cells.

177 n mice can be prevented by an additional SRM transgene in macrophages.

178 including confirmation of expression of the transgene in midbrain dopamine neurons and validation of

179 Expressing the G0 or G1 APOL1 transgene in nephrocytes also impaired the acidification

180 Selective expression of the APOL1 G0 or G1 transgene in nephrocytes, fly cells homologous to mammal

181 ted a mouse model with an inducible tetherin transgene in order to study how tetherin affects retrovi

182 quently results in random integration of the transgene in the genome and its stable transmission thro

183 Expression of the TBK1 transgene in the retinae of these mice was demonstrated

184 nd carry the diptheria toxin subunit A (DTA) transgene in the Rosa26 locus (Plp1(CreER);Rosa26(DTA) m

185 ing both the wild-type and the mutant PDGFRA transgenes in cells of neural crest origin.

186 chmark for strong constitutive expression of transgenes in Chlamydomonas, and develops a general appr

187 Additionally, both transgenes in Hu128/21 mice match the human HTT exon 1 r

188 report a novel approach for delivering large transgenes in lentiviruses, in which we demonstrate proo

189 y stable and support long-term expression of transgenes in non-dividing cells, exhibiting a decreased

190 new molecular tools to incorporate multiple transgenes in nuclear and plastid genomes with computati

191 ids (1) , indirect effects of BAR-containing transgenes in planta, including modified amino acid leve

192 hich enables parallel expression of multiple transgenes in spatially distinct tissues in vivo.

193 mpletely rescued by expression of respective transgenes in sweet GRNs.

194 insulator does promote the expression of two transgenes in transgenic plants.

195 strategy and the potential for the spread of transgenes in vivo in the mammalian gastrointestinal tra

196 creasing levels of uc.173 by expression of a transgene increased growth of intestinal epithelial cell

197 The Mcl-1 transgene increased oxygen consumption rates and mROS ex

198 The TRiP system is transgene-independent and will be a particularly useful

199 Further experiments in maize with transgenes individually expressing three crystal (Cry) p

200 ne-related genes (n = 45) for changes in tau transgene-induced behavioral defects.

201 Notably, macrophage-specific ABHD5 transgene-induced CRC growth in mice can be prevented by

202 Standard strategies for transgene induction involve the use of viral vectors pro

203 We conclude that expression of an APOL1 transgene initially enhances nephrocyte function, causin

204 h binds its target RNA sequence close to the transgene initiation codon.

205 CR revealed that line 474 contained a single transgene insert.

206 0% of the selected WA09 clones harboring the transgene inserted at the targeted genomic locus.

207 NSC lines, including: (1) efficient targeted transgene insertion at safe harbour loci (Rosa26 and AAV

208 efficient method for identifying single-copy transgene insertion events from a population of independ

209 In all lines, transgene insertion was associated with structural chang

210 te the value of sequence-level resolution of transgene insertions and transcription analysis to infor

211 hereby eliminating any positional effects of transgene insertions.

212 ood source and the favored target tissue for transgene integration and genome editing, friable embryo

213 provide additional information regarding the transgene integration events.

214 sed at negligible levels in mouse brain, but transgene integration has resulted in cortical expressio

215 ansposon-mediated transgenesis, where random transgene integration into the host genome results in in

216 of a partial fragment (exons 8-11) 3' to the transgene integration site in R6/2.

217 at the introgression of Bcl-xL-coding Bcl2l1 transgene into NF-kappaB signalling-deficient IkappaBDel

218 Accordingly, introgression of the Bcl2l1 transgene into PKC-theta null mouse failed to rescue NKT

219 more, ectopic integration of ASAR6 or ASAR15 transgenes into mouse chromosomes resulted in delayed re

220 Posttranscriptional gene silencing (PTGS) of transgenes involves abundant 21-nucleotide small interfe

221 In addition, knowledge of where the transgene is integrated is important for planning of cro

222 expression or introduction of an IL-7Ralpha transgene is not sufficient to correct the defect in iNK

223 The mRNA-based expression of itga4 transgene is potentially sufficient for diapedesis after

224 Only six days were required for detecting transgene-labeled markers in a 1-mm thick brain slice fr

225 CTL019 transgene levels were measurable up to 780 days in perip

226 s amplification (TLA) to efficiently map the transgene location in seven previously published Cre and

227 in pcdh15a-null mutants by assessing Pcdh15a transgene-mediated rescue of auditory/vestibular behavio

228 mice that overexpress the ErbB2/Neu-IRES-Cre transgene (NIC) specifically in the mammary epithelium.

229 luble apyrase and mice expressing human CD39 transgene) on acute and chronic renal outcomes were exam

230 otease, we screened 3C mutants for increased transgene output in comparison to wild-type 3C using a G

231 However, expression of the Flcn K508R mutant transgene partially, but not completely, abrogated the p

232 Hemizygous Tg-TBK1 mice (with one TBK1 transgene per genome) had a 13% loss of RGCs by 18 month

233 ftment and expansion of a polyclonal pool of transgene-positive functional T cells and sustained gene

234 known concerning structural integrity of the transgene, precise site of integration, or its impact on

235 CTL responses to the transgene product remain an active area of concern for t

236 may render the subject tolerant to wild-type transgene products.

237 region remained silent, indicating that the transgene promoter and/or insertion site are critical fo

238 showed that the T-DNA inserts are stable; no transgene rearrangements were observed.

239 T-DNA inserts are stable; no transgene rearrangements were observed.

240 poor and inconsistent expression of nuclear transgenes remains an obstacle for basic and applied res

241 RNA is sufficient to confer methylation of a transgene reporter in Nicotiana benthamiana.

242 Here, we exemplify the novel 'Transgene Repression In vector Production' (TRiP) system

243 tablished that de novo methylation of the L1 transgene required the intact piRNA pathway.

244 e-specific or global overexpression of SLP-2 transgenes rescued parkin mutant phenotypes, in particul

245 expressed in the C. elegans pharynx, and its transgene rescues the sms-1 mutant phenotype.

246 nd Pol II firing rates of the Ccnb1 promoter transgene resembled those of the native Ccnb1 gene both

247 Mice with two copies of the transgene [RIPCre;KD-mTOR (Homozygous)] develop glucose

248 Nur77-GFP transgenes serve as specific TCR and BCR signaling repor

249 d reduction of H3K9me2 at meiotic onset, the transgene showed 1,400-fold increase in RNA expression a

250 The DGAT transgenes significantly reduced the soluble carbohydrat

251 e unpredictable and stochastic occurrence of transgene silencing and epigenetic alternations remains

252 mRNA export factor that is indispensable for transgene silencing and the production of trans-acting s

253 studies have highlighted great challenges of transgene silencing for transgenic plants facing climate

254 r protein declined across generations and no transgene silencing was observed in three commercial sug

255 PMI protein levels across generations and no transgene silencing was observed.

256 sign parameters as means to reduce heritable transgene silencing.

257 eptide are considered more likely to mount a transgene-specific T cell response because of a lack of

258 In this report we describe the appearance of transgene-specific T-cell responses in two subjects that

259 d X receptor (FXR), mice that express an FXR transgene specifically in the intestine, and ABCG8-knock

260 human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identi

261 Using a transgene strategy to express and stimulate designer rec

262 argeted sequencing approaches to reconstruct transgene structure and integration sites in models of H

263 introduce silent mutations into an ataxin 7 transgene such that it is resistant to their effect.

264 The molecular basis of transgene susceptibility to silencing is poorly characte

265 enerated from a 35S promoter::GU-US reporter transgene targeted by CRISPR/Cas9.

266 We generated KO mice harboring a transgene, TgAC1, consisting of Clrn1-UTR (Clrn1 cDNA in

267 inducible human tumor necrosis factor (hTNF) transgene than wild-type mice.

268 Lentiviral vectors can package larger transgenes than adeno-associated viruses, yet lentiviral

269 510 mice carrying the P301L mutant human tau transgene that develop extensive tau pathology with age.

270 Here, we developed a codon-optimized L1 transgene that is controlled by an endogenous mouse L1 p

271 body tissues, we generated a GFP-tagged-cry transgene that rescues light-induced behavioral phase re

272 the expression of H3K9M, a histone H3 mutant transgene that reverses the effect of Kdm4d on H3K9 meth

273 Using in vivo inducible transgenes that can sense or modify Rac activity, we dem

274 Single-copy transgenes that express rde-4(+) in body-wall muscles or

275 dditionally show, using photoactivatable Rac transgenes, that it is the level of Rac activity that de

276 of gene-editing reagents bypasses the use of transgenes, this method is potentially applicable to a w

277 e that carried a hepatitis B surface antigen transgene-this to model the multiplicative effects of af

278 phage colony-stimulating factor receptor GFP transgene throughout the mononuclear phagocyte system),

279 single Bacterial Artificial Chromosome (BAC) transgene to direct sparse labeling of genetically-defin

280 mpted to use the germline-expressed Vasa-Cre transgene to engineer a mouse mutation, but observe a dr

281 he intestine and transfected with the uc.173 transgene to increase uc.173 levels.

282 due to the inability of the Twist2-IKKbetaca transgene to induce inflammasome activity.

283 Using a conditionally inactivatable transgene to rescue vri developmental lethality, we show

284 nts of cells expressing the alphaSMA-CreERT2 transgene to the odontoblast lineage.

285 le adenovirus (SC-Ad) vectors that replicate transgenes to amplify protein production and immune resp

286 The transgene toolkit and the strain set described here will

287 a narrow window of time at TE insertion (or transgene transformation) is key for establishing the tr

288 Using mice carrying a DTR/EGFP transgene under the control of the Foxp3 promoter (DEREG

289 initiation of epigenetic silencing of a new transgene, virus, or transposable element (TE) remains e

290 However, hCD39 transgene was more widespread at 4 weeks post-IRI and wa

291 Unexpectedly, Pol II transcription of the transgene was required for efficient diRNA production an

292 lines with variable copy numbers of an EGFP transgene, we discovered that CRISPR knockout is relativ

293 (-/-)) and carrying a human stem cell factor transgene were engrafted with human hematopoietic stem c

294 y, DNA methylation dynamics of a single-copy transgene were indistinguishable from those of endogenou

295 (CAR) T cells expressing EGFRvIII targeting transgene were labeled with a perfluorocarbon (PFC) emul

296 ll immunotherapy, we developed a therapeutic transgene with 4 components: (1) a TCR specific for the

297 ease model, that integration of a rearranged transgene with coincident deletion of 5,444 bp of host g

298 Transgenes with higher GC content exhibited increased tr

299 ery of loss-of-function and gain-of-function transgenes with precise spatial-temporal resolution in v

300 the whiskerpad into TG neurons and expressed transgenes within cell bodies and axons of sensory neuro