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1 ssed for function in cultured cells and in a transgenic mouse.
2 we used an autoimmune-prone T-cell receptor transgenic mouse (2D2) and a mouse-adapted human influen
7 man basophils and the human FcepsilonRIalpha transgenic mouse bone marrow-derived mast cells via driv
8 onal differences between Tau aggregates from transgenic mouse brain and in vitro assembled recombinan
9 tions and ex vivo autoradiography studies in transgenic mouse brain sections show cortical Abeta bind
10 ring protocols with the FACT protocol, using transgenic mouse brains with fluorochrome expression in
14 study, we generated a Notch gain-of-function transgenic mouse by conditionally overexpressing the Not
15 wnstream components in early symptomatic R9C transgenic mouse cardiomyocytes compared with wild type
19 algorithms using single cells from Etv2-EYFP transgenic mouse embryos and reveal specific molecular p
20 r second heart field (pSHF) of Tbx5 and Osr1 transgenic mouse embryos, a time-course gene expression
22 imately 4000 copies of the ERV-9 LTRs and in transgenic mouse erythroblasts carrying a single copy of
23 sangial cells and in an inducible human Nox5 transgenic mouse exposed to streptozotocin-induced diabe
24 ic cells and their progenies by generating a transgenic mouse expressing a chimaeric protein in which
25 this article, we report the development of a transgenic mouse expressing human CD22 (hCD22) in B cell
30 filament protein into adulthood in the ssTnI-transgenic mouse heart induced downregulation of the gen
34 brain slices or in vivo Here, we describe a transgenic mouse in which expression of Optopatch constr
38 d Ca(2+) fluxes were all markedly reduced in transgenic mouse islets, whereas glucose-induced oxygen
42 duced CNS alphaS pathology in another alphaS transgenic mouse line (M20), albeit less robustly in the
43 eding the hypomorphic mutant with a rescuing transgenic mouse line bearing a 662-kb Gata3 yeast artif
46 is the first time overexpression of AS in a transgenic mouse line has shown an ability to induce HP.
50 ral sclerosis pathogenesis by crossing a new transgenic mouse line that overexpresses OXR1 in neurons
53 advantage of the cell-type specificity of a transgenic mouse line, the GN220-Ntsr1 Cre line, to mani
55 ression in unintentionally targeted cells in transgenic mouse lines can confound the interpretation o
56 tersectional strategies to generate multiple transgenic mouse lines expressing high levels of novel g
57 To address this hypothesis, we generated transgenic mouse lines harboring a Gata1 bacterial artif
58 g ERK1/2 activity in myelinating cells using transgenic mouse lines in which ERK1/2 activation was up
59 ere T cells derived from two independent TCR transgenic mouse lines recognize the same melanoma antig
60 munoblotting studies of selectively bred and transgenic mouse lines revealed a positive correlation b
61 f EYFP(Vglut2) , EYFP(Vgat) , and GFP(Gad67) transgenic mouse lines revealed that, like GnRH neurons,
62 of the GARPs, we have characterized several transgenic mouse lines selectively restoring GARPs on a
64 al expression system, here we generated Plk1 transgenic mouse lines to examine the role of Plk1 in tu
67 is review includes a list of the various Cre transgenic mouse lines used to achieve tooth root format
68 e pathogenesis of these diseases, we created transgenic mouse lines using human CFH bacterial artific
69 ndrogenesis, myelination, and remyelination, transgenic mouse lines were generated in which a modifie
70 ead occlusion model of glaucoma to different transgenic mouse lines, each expressing green fluorescen
74 of programmed death-ligand 1 (PD-L1) in Her2 transgenic mouse mammary tumors, with high expression li
76 hy, the retina of the P301S mutant human tau transgenic mouse, mild tau pathology results in function
77 ire breadth to a non-self-antigen, a TCRbeta transgenic mouse model (EF4.1) expressing a limited, yet
79 ified a beneficial taxonomic repertoire in a transgenic mouse model (RIP140mvarphiKD) which resists t
80 riven tumor progression, we generated triple-transgenic mouse model (tetO-EGFR(L858R); CCSP-rtTA; Mal
82 riggers, could prevent disease symptoms in a transgenic mouse model and a knockin mouse model of the
83 urther generated a corresponding betaH1-eGFP transgenic mouse model and demonstrated the presence of
85 interstitial fluid (ISF) and CSF from an AD transgenic mouse model and postmortem ventricular and an
87 first report of a newly generated humanized transgenic mouse model engineered to express human NRG1-
92 c alleviated S. pyogenes-induced sepsis in a transgenic mouse model expressing human FH (S. pyogenes
94 er mammals and humans, but not in rodents, a transgenic mouse model expressing the complete human MOG
96 he advantages and limitations of the HLA-DR4 transgenic mouse model for evaluating human C. trachomat
100 severative behaviors, we characterized a new transgenic mouse model in which inducible ablation of SC
101 cted CC, a toxin-driven model in rats, and a transgenic mouse model in which p53 deletion is targeted
102 V-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter
108 to investigate brain copper trafficking in a transgenic mouse model of AD by PET imaging with (64)Cu,
109 that reducing endogenous alpha-syn in an APP transgenic mouse model of AD prevented the degeneration
115 genous alpha-synuclein (alpha-syn) in an APP transgenic mouse model of Alzheimer's disease (AD) preve
116 S)-induced microglia activation in vivo in a transgenic mouse model of Alzheimer's disease (APP/PS1)
117 subsequent fluorescent amyloid staining in a transgenic mouse model of Alzheimer's disease (tgSwe).
119 d in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis
121 are antipruritic against acute itch and in a transgenic mouse model of atopic dermatitis produced by
122 D8+ T cells are implicated as effectors in a transgenic mouse model of autoimmune GFAP meningoencepha
124 of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in human bre
128 igated the impact of gammadelta T cells in a transgenic mouse model of carcinogenesis induced by HPV1
131 vivo relevance of this pathway in our IL-15 transgenic mouse model of CTCL by showing that interfere
133 logical approaches, we have shown that, in a transgenic mouse model of dementia, the functional prope
134 GMP signaling.SIGNIFICANCE STATEMENT In DYT1 transgenic mouse model of dystonia, PDE10A, a key enzyme
137 ilin degradation and rescued phenotypes in a transgenic mouse model of hereditary primary open-angle
140 duced in striatal output neurons of the R6/2 transgenic mouse model of Huntington's disease, at an ag
142 Using a human islet amyloid polypeptide transgenic mouse model of islet amyloidosis, we show ARC
146 ymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progression and
152 our results show in an aggressively growing transgenic mouse model of PDAC that the coordinated acti
158 emporal structure of SWRs was disrupted in a transgenic mouse model of tauopathy (one of the major ha
161 To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenes
162 in DIV7 cortical cultures of either from E18 transgenic mouse model or from rat E18 embryos that were
167 Previous studies described a TDP-43(A315T) transgenic mouse model that develops progressive motor d
172 In this issue of the JCI, Pham et al. use a transgenic mouse model to demonstrate that STAT5BN642H i
173 gionally restricted and temporally regulated transgenic mouse model to investigate the behavioral, mo
176 ediated skin cancer by interbreeding an HPV8 transgenic mouse model with a conditional disruption of
177 of TRAF3IP2 in heart disease, we generated a transgenic mouse model with cardiomyocyte-specific TRAF3
178 ere, we report the generation of a claudin-1 transgenic mouse model with doxycycline-inducible transg
179 s phenomenon, we have developed an inducible transgenic mouse model with expression of the most commo
180 p52 expression in vivo, we generated a novel transgenic mouse model with inducible expression of p52
181 ional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a
183 s decreased in the brains of AD patients and transgenic mouse model, as well as Abeta-treated cells.
185 ue expression in Tg32, a human FcRn knock-in transgenic mouse model, for which a strong correlation o
187 ation and improves survival in a calcineurin transgenic mouse model, indicating that COUP-TFII may se
188 e therapeutic profile of CpG ODN in a triple transgenic mouse model, Tg-SwDI, with abundant vascular
190 d precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model, we found that inhibition of RIPK
194 ectrophysiological recordings in the rTg4510 transgenic mouse model, which overexpresses a mutant for
208 tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically
209 Using various inducible and site-specific transgenic mouse models and pharmacological validation e
212 t composition in the skin, we have generated transgenic mouse models for tamoxifen-inducible de novo
213 ) and previously undescribed (G2-Gata4(Cre)) transgenic mouse models for the study of coronary vascul
214 n the majority of Rett Syndrome (RTT) cases, transgenic mouse models have played a critical role in o
215 ine phosphatases Shp1 and Shp2, knockout and transgenic mouse models have revealed distinct phenotype
217 injury pharmacologically and genetically in transgenic mouse models in which microglia and systemic
219 ortem brain tissue samples from AD patients, transgenic mouse models of AD, and neuronal cells were u
223 derived tumor xenograft (PDX) and MYC-driven transgenic mouse models of breast cancer by inhibiting t
224 a result of tumor formation in two different transgenic mouse models of cancer (RIP1-Tag2 model of in
227 Here, we use bacterial artificial chromosome transgenic mouse models of LRRK2 to explore potential no
228 breast cancer metastasis in two conditional transgenic mouse models of PyMT-induced breast cancer.
229 emonstrate a significant analgesic effect in transgenic mouse models of SCD and cancer as well as com
234 in LTP/LTD magnitude seen across ages in AD transgenic mouse models reflect the inability to undergo
237 Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT
240 er-induced choroidal neovascularization, and transgenic mouse models with deficient or spontaneous re
243 st time Pcdh10 up-regulation in tissues from transgenic mouse models, cultured Schwann cells, and hum
244 ow for the first time that, unlike other tau transgenic mouse models, minimal expression of a human d
256 the E-box element was confirmed in the hGH1 transgenic mouse pituitary in situ Occupancy was reduced
257 rom neural stem cells that were derived from transgenic mouse pre-labeled with enhanced green fluores
259 eam effectors Grp78/BiP and eIF2alpha in ERG transgenic mouse prostate glands indicate the presence o
261 characterize these changes further, we used transgenic mouse reagents to delineate neuronal circuitr
263 NF-kappaB signalling-deficient IkappaBDeltaN transgenic mouse rescues NKT cell development and differ
264 reduced inhibition of cGMP production in the transgenic mouse retinas at the free calcium concentrati
266 del we used wild-type MMTV mice and a triple transgenic mouse SPC-rtTA(+/-)TetoCre(+/-)LoxP-VEGF-A(+/
267 ma by transfer of Th2 cells from a novel TCR transgenic mouse, specific for the major B. tropicalis a
268 BZ protein alone in vivo, we generated a new transgenic mouse strain that expresses HBZ mRNA altered
273 (CLL) is the most common human leukemia, and transgenic mouse studies indicate that activation of the
276 this study, we analyzed these processes in a transgenic mouse system in which TCR-transgenic Th cells
284 nvolved in isotype switching, we generated a transgenic mouse that over-expressed RNase H1, an enzyme
286 g, imaging and mass spectrometry, we use our transgenic mouse to label and analyze proteins in excita
287 eaky tetracycline promoter system in the Tat-transgenic mouse to show that a chronic very low-level e
288 4.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germs using transcriptome sequenc
289 d, TGFbeta2 was high in four MMTV-Hoxb7/Her2 transgenic mouse tumor cell lines and two breast cancer
290 we generated a doxycycline suppressible Cre transgenic mouse under the regulation of the Nkx2.5 enha
291 Furthermore, expressing FGFR3b-S243C in transgenic mouse urothelium expressing SV40T converted c
293 earing, or retrograde tracing in a MET(EGFP) transgenic mouse, we identify three novel subpopulations
294 a causative role in OA, we used the p16-3MR transgenic mouse, which harbors a p16(INK4a) (Cdkn2a) pr
295 te these results in vivo by generating a BAC transgenic mouse, which overexpresses Cyfip1 under the e
298 address this, we have developed "mito-QC," a transgenic mouse with a pH-sensitive fluorescent mitocho
299 ted gene-1(AEG-1)/metadherin in NASH using a transgenic mouse with hepatocyte-specific overexpression
300 and secondary hepatic damage, we generated a transgenic mouse with liver-selective expression of NPC1
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