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1 with cognitive improvements in an AD APP/PS1 transgenic mouse model.
2 impaired decidualization in both women and a transgenic mouse model.
3 progression of retinal pathology in a PD/DLB transgenic mouse model.
4 was further demonstrated in vivo using a CLL transgenic mouse model.
5 different EAE models, including the 2D2 TCR-transgenic mouse model.
6 and elicit functional improvement in an aged transgenic mouse model.
7 ing breast cancer progression in a MMTV-PyMT transgenic mouse model.
8 etworks and inhibited tumor progression in a transgenic mouse model.
9 U2AF1 mutation using a doxycycline-inducible transgenic mouse model.
10 intracerebroventricular infusion in an aged transgenic mouse model.
11 eractions to induce leukemia in the Emu-TCL1 transgenic mouse model.
12 I and circulates as free plasma species in a transgenic mouse model.
13 and prevents mammary cancer development in a transgenic mouse model.
14 vel cardiac-specific TetON-miR-133 inducible transgenic mouse model.
15 hesis that PAD2 promotes oncogenesis using a transgenic mouse model.
16 profiles and behavioral changes in a G72/G30 transgenic mouse model.
17 utant HTT expression in vivo in the N171-82Q transgenic mouse model.
18 autoimmune cascade of PV in a humanized HLA-transgenic mouse model.
19 tient samples and the RIP1-Tag2 (RT2) PanNET-transgenic mouse model.
20 constructed an adipose tissue-specific G0S2 transgenic mouse model.
21 metabotropic glutamate receptor 1 (Grm1(Tg)) transgenic mouse model.
22 ed Jagged1 using osteoblast-specific Jagged1 transgenic mouse model.
23 stemic anaphylaxis in human FcepsilonRIalpha transgenic mouse model.
24 ase (SCD) in a NRF2 knockout (SCD/NRF2(-/-)) transgenic mouse model.
25 apoptosis mediated by the p53 pathway in our transgenic mouse model.
26 cells, using a unique T cell receptor (TCR) transgenic mouse model.
27 ed this hypothesis, using highly replicative transgenic mouse models.
28 using tetracycline- and tamoxifen-inducible transgenic mouse models.
29 of Interleukin (IL)-10 in the brains of APP transgenic mouse models.
30 ain and in Abeta precursor protein (AbetaPP) transgenic mouse models.
31 een greatly accelerated by the generation of transgenic mouse models.
32 rming activity of sTAg in vivo in a panel of transgenic mouse models.
33 set of focal and vascular amyloid in AD-like transgenic mouse models.
34 osition was analyzed in 12 different AD-like transgenic mouse models.
35 tau protein aggregation both in vitro and in transgenic mouse models.
38 diomyocyte-specific, doxycycline-regulatable transgenic mouse model aggravated cardiac hypertrophy, f
39 riggers, could prevent disease symptoms in a transgenic mouse model and a knockin mouse model of the
40 urther generated a corresponding betaH1-eGFP transgenic mouse model and demonstrated the presence of
42 interstitial fluid (ISF) and CSF from an AD transgenic mouse model and postmortem ventricular and an
43 We generated a cardiomyocyte-targeted Nox2-transgenic mouse model and studied the effects of in viv
44 Using various inducible and site-specific transgenic mouse models and pharmacological validation e
45 mmary gland tumors in a ErbB2-overexpressing transgenic mouse model, and in-vitro evidence that PKCde
46 tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically
47 heir functions in prostate, we established a transgenic mouse model (AR3Tg) with targeted expression
48 s decreased in the brains of AD patients and transgenic mouse model, as well as Abeta-treated cells.
53 st time Pcdh10 up-regulation in tissues from transgenic mouse models, cultured Schwann cells, and hum
54 tution of bone marrow cells into a TGF-alpha transgenic mouse model demonstrated that fibrocytes do n
57 ire breadth to a non-self-antigen, a TCRbeta transgenic mouse model (EF4.1) expressing a limited, yet
60 first report of a newly generated humanized transgenic mouse model engineered to express human NRG1-
67 c alleviated S. pyogenes-induced sepsis in a transgenic mouse model expressing human FH (S. pyogenes
69 er mammals and humans, but not in rodents, a transgenic mouse model expressing the complete human MOG
73 impact of TDP-43 dysfunction, we generated a transgenic mouse model for a partial loss of TDP-43 func
74 he advantages and limitations of the HLA-DR4 transgenic mouse model for evaluating human C. trachomat
79 t composition in the skin, we have generated transgenic mouse models for tamoxifen-inducible de novo
80 ) and previously undescribed (G2-Gata4(Cre)) transgenic mouse models for the study of coronary vascul
81 ue expression in Tg32, a human FcRn knock-in transgenic mouse model, for which a strong correlation o
83 rmacodynamic and pharmacokinetic assays in a transgenic mouse model harboring the human receptors, no
84 of IR-induced DSBs to GBM development using transgenic mouse models harboring brain-targeted deletio
88 n the majority of Rett Syndrome (RTT) cases, transgenic mouse models have played a critical role in o
90 ine phosphatases Shp1 and Shp2, knockout and transgenic mouse models have revealed distinct phenotype
92 in prostatic tissues of TRAMP (autochthonous transgenic mouse model), human CaP patients, and in cell
94 severative behaviors, we characterized a new transgenic mouse model in which inducible ablation of SC
95 cted CC, a toxin-driven model in rats, and a transgenic mouse model in which p53 deletion is targeted
97 V-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter
102 injury pharmacologically and genetically in transgenic mouse models in which microglia and systemic
104 morigenesis, we developed an inducible Nanog transgenic mouse model, in which the expression of Nanog
105 receptors has been characterized in anti-DNA transgenic mouse models including 3H9, 3H9/56R, and thei
107 ation and improves survival in a calcineurin transgenic mouse model, indicating that COUP-TFII may se
111 ow for the first time that, unlike other tau transgenic mouse models, minimal expression of a human d
115 to investigate brain copper trafficking in a transgenic mouse model of AD by PET imaging with (64)Cu,
116 that reducing endogenous alpha-syn in an APP transgenic mouse model of AD prevented the degeneration
122 ould exert beneficial effects in the Tg19959 transgenic mouse model of AD; Tg19959 mice express the h
123 pening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD
125 rovements in synaptic plasticity on a triple transgenic mouse model of Alzheimer's disease (3xTg-AD)
126 genous alpha-synuclein (alpha-syn) in an APP transgenic mouse model of Alzheimer's disease (AD) preve
127 S)-induced microglia activation in vivo in a transgenic mouse model of Alzheimer's disease (APP/PS1)
128 subsequent fluorescent amyloid staining in a transgenic mouse model of Alzheimer's disease (tgSwe).
131 d in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis
133 are antipruritic against acute itch and in a transgenic mouse model of atopic dermatitis produced by
134 D8+ T cells are implicated as effectors in a transgenic mouse model of autoimmune GFAP meningoencepha
135 elerated lymphoma development in the Emu-Myc transgenic mouse model of B lymphoma and that silencing
137 of CaSR-PTHrP interactions in the MMTV-PymT transgenic mouse model of breast cancer and in human bre
143 igated the impact of gammadelta T cells in a transgenic mouse model of carcinogenesis induced by HPV1
145 in C57BL/6 mice, guinea pigs, and in an APP transgenic mouse model of cerebral amyloidosis (Tg2576).
148 used patient samples and the Emu-TCL1 (TCL1) transgenic mouse model of CLL, which results in spontane
149 vivo relevance of this pathway in our IL-15 transgenic mouse model of CTCL by showing that interfere
152 logical approaches, we have shown that, in a transgenic mouse model of dementia, the functional prope
154 GMP signaling.SIGNIFICANCE STATEMENT In DYT1 transgenic mouse model of dystonia, PDE10A, a key enzyme
162 ilin degradation and rescued phenotypes in a transgenic mouse model of hereditary primary open-angle
165 rogression of carcinogenesis in the K14E6/E7 transgenic mouse model of human papillomavirus-associate
166 Here we report novel findings in the R6/2 transgenic mouse model of Huntington's disease (HD) by d
167 p and electroencephalogram disturbances in a transgenic mouse model of Huntington's disease (R6/2 mic
168 duced in striatal output neurons of the R6/2 transgenic mouse model of Huntington's disease, at an ag
170 Using a human islet amyloid polypeptide transgenic mouse model of islet amyloidosis, we show ARC
173 y used on tumor tissue extracts from a K-ras transgenic mouse model of lung cancer to enhance our und
175 ymal transition and metastasis, an MMTV-PyMT transgenic mouse model of mammary tumour progression and
176 Here, we further characterized a lethal transgenic mouse model of MERS-CoV infection and disease
183 our results show in an aggressively growing transgenic mouse model of PDAC that the coordinated acti
185 n early pathological stage, in the THY-Tau22 transgenic mouse model of progressive AD-like tau pathol
186 se hypotheses were tested using cells from a transgenic mouse model of prostate cancer infected with
192 mtDNA genomes on the background of the PyMT transgenic mouse model of spontaneous mammary carcinoma.
193 emporal structure of SWRs was disrupted in a transgenic mouse model of tauopathy (one of the major ha
197 To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenes
199 ortem brain tissue samples from AD patients, transgenic mouse models of AD, and neuronal cells were u
202 low-up of beta-amyloid (Abeta) deposition in transgenic mouse models of Alzheimer disease (AD) would
203 was activated in reactive astrocytes in two transgenic mouse models of Alzheimer's disease and in a
204 hese results were confirmed in vivo by using transgenic mouse models of Alzheimer's disease in which
208 derived tumor xenograft (PDX) and MYC-driven transgenic mouse models of breast cancer by inhibiting t
210 a result of tumor formation in two different transgenic mouse models of cancer (RIP1-Tag2 model of in
212 oglia are associated with amyloid plaques in transgenic mouse models of cerebral amyloidosis and in h
213 slocation, MCL has not been recapitulated in transgenic mouse models of cyclin D1 overexpression alon
215 olysis events observed in vivo, we generated transgenic mouse models of HD representing five distinct
216 Here, we use bacterial artificial chromosome transgenic mouse models of LRRK2 to explore potential no
217 f Nrf2/ARE genes is neuroprotective in other transgenic mouse models of neurodegenerative diseases an
218 breast cancer metastasis in two conditional transgenic mouse models of PyMT-induced breast cancer.
219 emonstrate a significant analgesic effect in transgenic mouse models of SCD and cancer as well as com
221 Disappointingly, the initial enthusiasm for transgenic mouse models of the disease has not been foll
224 G30 genomic region was used to establish the transgenic mouse model, on which gene expression studies
225 in DIV7 cortical cultures of either from E18 transgenic mouse model or from rat E18 embryos that were
230 in LTP/LTD magnitude seen across ages in AD transgenic mouse models reflect the inability to undergo
231 nfection model and a lethal model makes this transgenic mouse model relevant for advancing MERS resea
232 IL-1alpha in prostatic epithelial cells in a transgenic mouse model resulted in increased prostate si
233 turely terminated MHC-TCR/CD4 interaction in transgenic mouse models results in lineage redirection,
234 ified a beneficial taxonomic repertoire in a transgenic mouse model (RIP140mvarphiKD) which resists t
238 riven tumor progression, we generated triple-transgenic mouse model (tetO-EGFR(L858R); CCSP-rtTA; Mal
239 e therapeutic profile of CpG ODN in a triple transgenic mouse model, Tg-SwDI, with abundant vascular
240 r type 3 (NTRK3) in both PAND patients and a transgenic mouse model (TgNTRK3) may have a role in PAND
243 , here we generate an RNA interference-based transgenic mouse model that allows tetracycline-dependen
245 rance of prion aggregates in the muscle of a transgenic mouse model that develops profound muscle deg
246 Previous studies described a TDP-43(A315T) transgenic mouse model that develops progressive motor d
248 on in vivo, we generated and characterized a transgenic mouse model that expresses a non-glycosylated
254 study, we show in a humanized HLA-DRB1*04:02-transgenic mouse model that HLA-DRB1*04:02-restricted T
256 newly generated mThy-1 alpha-synuclein E57K transgenic mouse model that is prone to forming oligomer
257 g electrophysiology, cellular markers, and a transgenic mouse model that specifically labels GABA cel
261 Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT
262 and prepubertal development we generated two transgenic mouse models that permit controlled, cell-spe
265 In this issue of the JCI, Pham et al. use a transgenic mouse model to demonstrate that STAT5BN642H i
267 gionally restricted and temporally regulated transgenic mouse model to investigate the behavioral, mo
269 ystrophin with utrophin and analyzed several transgenic mouse models to identify phenotypes of the md
273 ntioxidants in patient cell cultures and the transgenic mouse model, we believe that preventing forma
274 d precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model, we found that inhibition of RIPK
276 ne-targeting approach to delete TNFRII in AD transgenic mouse model, we found that, in the brain of A
286 yl-D-aspartate receptors are reduced in this transgenic mouse model, which might underlie the observe
287 ectrophysiological recordings in the rTg4510 transgenic mouse model, which overexpresses a mutant for
288 ed sialylation during kidney maturation in a transgenic mouse model, which was restricted to glomerul
290 ediated skin cancer by interbreeding an HPV8 transgenic mouse model with a conditional disruption of
291 on of a novel herpes-susceptible HLA-A*02:01 transgenic mouse model with ASYMP epitopes, but not with
293 of TRAF3IP2 in heart disease, we generated a transgenic mouse model with cardiomyocyte-specific TRAF3
294 ere, we report the generation of a claudin-1 transgenic mouse model with doxycycline-inducible transg
295 s phenomenon, we have developed an inducible transgenic mouse model with expression of the most commo
296 p52 expression in vivo, we generated a novel transgenic mouse model with inducible expression of p52
298 ional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a
299 er-induced choroidal neovascularization, and transgenic mouse models with deficient or spontaneous re
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