ライフサイエンスコーパス: transgenic rat

1 the albumin-SV40 large T antigen (Alb-SV40) transgenic rat.

2 es isolated from an alb-SV40 large T-antigen transgenic rat.

3 ion using a diphtheria toxin receptor (hDTR) transgenic rat.

4 reducing light-induced retinal damage in all transgenic rats.

5 ulation that became expanded in diseased B27 transgenic rats.

6 y prevented but did not treat colitis in B27 transgenic rats.

7 ry tissue from certain lines of mid-pregnant transgenic rats.

8 notypes are observed in female MMTV-TGFalpha transgenic rats.

9 estinal and systemic inflammation in HLA-B27 transgenic rats.

10 m inflammatory disease characteristic of B27 transgenic rats.

11 leasing (GRF) neurons in the hypothalamus of transgenic rats.

12 ce and orexin neuron-ablated orexin/ataxin-3 transgenic rats.

13 leted from the mesenteric lymph nodes of B27-transgenic rats.

14 ell differentiation would be aberrant in B27-transgenic rats.

15 tially reversible, at least in mutant TDP-43 transgenic rats.

16 from the spinal cord of SOD1-overexpressing transgenic rats.

17 on in naive and cocaine-sensitized cfos-lacZ transgenic rats.

18 B27/human beta(2)-microglobulin (Hubeta(2)m)-transgenic rats.

19 ent receptor occupancy in the CNS of hBK B 1 transgenic rats.

20 stigated in INS-1 cells and human IAPP (HIP) transgenic rats.

21 /human beta(2)-microglobulin-transgenic (B27-transgenic) rats.

22 SD) of parietal cells; in inflamed areas of transgenic rats 21 +/- 5.2% (P < 0.0001) of parietal cel

23 n 1) an experimental uveitis model, 2) SOCS1 transgenic rats, 3) insulin-deficient diabetic rats, 4)

24 For this purpose we used S334ter-line-3 transgenic rats, a transgenic model developed to express

25 ley (SD) and retinal degenerate S334Ter(+/-) transgenic rats aged 1 to 180 days.

26 Transgenic rats also displayed a low-level plasma viremi

27 The spinal cord of transgenic rats also exhibited a progressive depletion o

28 ecific expression of EGFP makes this line of transgenic rats an excellent novel tool to study germ ce

29 uman beta2-microglobulin transgenic (HLA-B27 transgenic) rats, an animal model of spondyloarthritis,

30 HLA-B27 transgenic rat and mouse models have provided a new tool

31 ion of EGFP in Prox1-expressing cells of the transgenic rats and allowed a convenient visualization o

32 e transgene was undetectable in the TGFalpha transgenic rats and could not be induced when the animal

33 nidazole significantly attenuated colitis in transgenic rats and DSS-treated mice, it had no therapeu

34 ers and cerebrospinal fluid (CSF) from BACHD transgenic rats and from human HD subjects can seed muta

35 s less abundant in beta-cells in both h-IAPP transgenic rats and humans with type 2 diabetes.

36 mooth muscle cells from cocaine injected HIV-transgenic rats and in total lung extracts from HIV infe

37 we selectively activated TH(VTA) neurons in transgenic rats and measured resulting changes in whole-

38 The authors generated SOCS1 transgenic rats and mice (SOCS1-Tg), induced experimenta

39 -in mice and Period1::luciferase (Per1::luc) transgenic rats and recorded bioluminescence as a real-t

40 etina, is validated in retina-specific SOCS1 transgenic rats and retinal cells overexpressing SOCS1/S

41 a way to silence gene expression in vivo in transgenic rats and shows a role of Nogo-A in regulating

42 ne in mammary carcinomas from the HrHr, HrKr transgenic rats and their non-transgenic littermates was

43 d NspA to cause invasive disease in human fH transgenic rats and to survive in wild-type infant rat s

44 t green fluorescent protein (GFP)-expressing transgenic rats and transplanted into a sciatic nerve cr

45 ssion SCI was induced in SOD1-overexpressing transgenic rats and wild-type littermates.

46 or human islet amyloid polypeptide (h-IAPP) transgenic rats, and pancreatic tissue from rats and hum

47 When two such lines of either type of transgenic rat are subjected to repeated cycles of pregn

48 disease manifestations in HLA-B27/Hubeta(2)m-transgenic rats arise in the absence of any functional C

49 Using the McGill-R-Thy1-APP transgenic rat as a model of selective Abeta pathology,

50 Our paper introduces the c-fos-GFP transgenic rat as a new tool to study unique synaptic ch

51 ression of ASBT in wild-type mice and in the transgenic rat ASBT promoter reporter, while paradoxical

52 adapted photoreceptors in all three lines of transgenic rats at advanced stages of retinal degenerati

53 this disease, we depleted these cells in B27 transgenic rats before the onset of disease by adult thy

54 not detectable in mammary tissue from virgin transgenic rats but is detected in mammary tissue from c

55 Injection of DT into transgenic rats but not wild-type rats resulted in dose-

56 All three lines of transgenic rats carrying rhodopsin mutations show an inc

57 uman HLA-B27 and beta(2) -microglobulin (B27-transgenic rats), colitis and peripheral inflammation de

58 Only transgenic rats colonized with defined bacterial cocktai

59 the hypothalamus and brainstem of the renin transgenic rat compared with its normotensive control.

60 with HIV-1, lymphatic organs from hCD4/hCCR5 transgenic rats contained episomal 2-long terminal repea

61 od used allowed the generation of homozygous transgenic rats containing one copy of the transgene per

62 crease until late-stage disease in human and transgenic rat cortex, and p-tau was elevated in individ

63 e findings indicate that the orexin/ataxin-3 transgenic rat could provide a useful model of human nar

64 microglia, but not lymphocytes, from double-transgenic rats could be productively infected by variou

65 In the specific B27/hbeta(2) m-transgenic rat cross-strain (21-3 x 382-2)F(1) , only th

66 istological analysis of testes from neonatal transgenic rats demonstrated that gonocytes are the only

67 Light-induced retinal damage in transgenic rats depends on the time of day of exposure t

68 Transgenic rats designed to ubiquitously express either

69 B27 transgenic rats develop a spontaneous disease resembling

70 HLA-B27 transgenic rats develop chronic gastritis at age 3 month

71 Transgenic rats develop early changes in novelty-seeking

72 us lesions, and ulcers; however, whereas the transgenic rats died within 6 days, only very mild intes

73 BACHD transgenic rats display a robust, early onset and progre

74 (2 months) and aged (24-26 months) Per1-luc transgenic rats, entrained to light-dark cycles, were ki

75 HLA-B27 transgenic rats exhibit generalized, severe inflammatory

76 Aged (18-21 months) G2019S and R1441C mutant transgenic rats exhibit L-DOPA-responsive motor dysfunct

77 At 17 weeks of age, the transgenic rats exhibited postnatal loss of orexin-posit

78 The transgenic rats exhibited prominent schizophrenia-like b

79 Here, we report the generation of transgenic rats expressing a human ataxin-3 fragment wit

80 erated LRRK2 bacterial artificial chromosome transgenic rats expressing either G2019S or R1441C mutan

81 Through the use of donor cells from transgenic rats expressing GFP exclusively in the germli

82 Thus, transgenic rats expressing the appropriate human recepto

83 In this study, we explored transgenic rats expressing the HIV-1 receptor complex as

84 One line of transgenic rats expressing the PEPCK-TAg transgene devel

85 ines were established from the livers of two transgenic rats expressing the simian virus protein larg

86 Retinas from transgenic rats expressing truncated rhodopsin (Ser334te

87 Here, we used cFos-lacZ and pCAG-lacZ transgenic rats for activity-dependent or nonselective i

88 ypothesis, we validated the use of Per-1:LUC transgenic rats for continuous longitudinal assessment o

89 rhodopsin slow photoreceptor degeneration in transgenic rats for up to 3 months of age when injected

90 enerated for the first time, human SIRPA BAC transgenic rats, for which the gene is faithfully expres

91 Three lines of transgenic rats, GPR-2, -4, and -5, were established.

92 % of the NMU-induced carcinomas in these Ras transgenic rats had an activating ras mutation in their

93 The P23H transgenic rat has a slow rod degeneration with initiall

94 c strategies, difficulties of generating BAC transgenic rats have hindered progress.

95 Transgenic rats homozygous for the wild-type Rab38 BN al

96 Utilizing a transgenic rat in which an enhanced green fluorescent pr

97 By using anterograde tracing in a transgenic rat in which neurons express a dendritically-

98 Through use of a transgenic rat in which rhythmicity in transcription of

99 Raising Ser334ter transgenic rats in darkness resulted in minimal rescue f

100 we report the creation of multiple lines of transgenic rats in which expression of ALS-associated mu

101 Heterozygous transgenic rats, including P23H sublines 2 and 3 and S33

102 In unmanipulated transgenic rats, inflammation was first evident in the d

103 We have generated transgenic rat insulin promotor (RIP)-CXCL10 mice expres

104 The inflammatory disease of B27 transgenic rats is thus T cell-dependent.

105 type 2 diabetes, isolated islets from h-IAPP transgenic rats, isolated human islets, and INS 832/13 c

106 etyl-D-mannosamine (ManNAc) to NPHS2-Angptl4 transgenic rats it increased the sialylation of Angptl4

107 ubretinal delivery of AAV5 expressing BiP to transgenic rats led to reduction in CHOP and photorecept

108 A transgenic rat line carrying the alb-SV40A transgene has

109 Breeding to homozygosity resulted in a novel transgenic rat line exclusively producing chimeric Abs w

110 and were observed in any of the HrHr or HrKr transgenic rat line heterozygotes.

111 mammalian circadian system, we constructed a transgenic rat line in which luciferase is rhythmically

112 d disease-prone and healthy HLA-B27/Hubeta2m-transgenic rat lines with a healthy line, 283-2, carryin

113 es also occurred in the respective CD8a(-/-)-transgenic rat lines.

114 a cell line, L25, derived from the Alb-SV40 transgenic rat liver tumors, whereas another cell line,

115 to enhanced green fluorescent protein (EGFP)-transgenic rat LTx with 18-hour cold preservation in Uni

116 Anti-H-Y CTL generated in cima B27 transgenic rats lysed male B27 cimb/b targets significan

117 of extracellular glutamate in the G93A SOD1 transgenic rat may account for a dampened effect of rilu

118 re lowering effects in a hypertensive double-transgenic rat model after oral administration.

119 In this study, we created a transgenic rat model and investigated the transgeneratio

120 This transgenic rat model enables us to study physiological r

121 nvestigated the neuroanatomical changes in a transgenic rat model for a subset of sporadic chronic me

122 stating disease, we sought to create a first transgenic rat model for SCA17 that carries a full human

123 itro destruction of P23H mutant mRNAs from a transgenic rat model of ADRP.

124 e transport activity in a recently developed transgenic rat model of amyotrophic lateral sclerosis (A

125 Previous studies of the HLA-B27-transgenic rat model of ankylosing spondylitis (AS) sugg

126 proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.

127 e unlikely to serve as effector cells in the transgenic rat model of HLA-B27-associated disease, in o

128 matory agent, as demonstrated in the HLA-B27 transgenic rat model of inflammatory bowel disease.

129 y models) and yet were active in the HLA-B27 transgenic rat model of inflammatory bowel disease.

130 ion on retinal disease process in the P23H-1 transgenic rat model of retinal degeneration.

131 therapy for photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.

132 so observed in the 2-year-old P23H rhodopsin transgenic rat model of retinitis pigmentosa.

133 We evaluated the HIP rat, a human IAPP transgenic rat model that develops islet pathology compa

134 Here, we generated an HD transgenic rat model using a human bacterial artificial

135 We have generated a transgenic rat model using RNAi and used it to study the

136 We used a transgenic rat model whose tissues express luciferase in

137 We demonstrate that a novel transgenic rat model, modestly overexpressing the full-l

138 nd assessed their progression over time in a transgenic rat model, which allows for a finer spatial r

139 mammary carcinogenesis were examined using a transgenic rat model.

140 ood pressure lowering activity in the double-transgenic rat model.

141 These transgenic rat models confirm the conclusions reached in

142 ens opportunities for expansion of humanized transgenic rat models in the future to advance biomedica

143 testinal inflammation in gnotobiotic HLA-B27 transgenic rats monoassociated with either B. vulgatus o

144 f photo-switchable fluorescent mitoDendra in transgenic rat motor neurons expressing mutant or wild-t

145 SMBs or BMCs derived from male GFP-transgenic rats, or PBS were injected intramyocardially

146 or mediated apoptotic pathway, as shown in a transgenic rat overexpressing tumor necrosis factor-alph

147 ined with varied approaches including use of transgenic rats overexpressing STPB-C which were studied

148 lands, extensive pathologies, whereas virgin transgenic rats produce no such abnormalities.

149 Therefore, B27-transgenic rats provide a model of spondylarthritis.

150 These transgenic rats provide a valuable resource to pursue ex

151 The GPR-4 line of transgenic rats provides a genetic model for the underst

152 expression of PDE4D1 (P) to GnRH neurons in transgenic rats (R) by using the GnRH gene promoterenhan

153 Retinal degeneration in transgenic rats raised in darkness was evaluated by quan

154 Gnotobiotic transgenic rats raised in Trexler isolators were selecti

155 The HIV-1 transgenic rat recapitulates many key features of human

156 HLA-B27 transgenic rats received antibiotics (ciprofloxacin, met

157 Germfree transgenic rats reconstituted with enteric bacteria grow

158 enous renin-angiotensin system in Cyp1a1Ren2 transgenic rats reduced cortical tissue PO2.

159 ptor functional protection in P23H rhodopsin transgenic rat retina.

160 rs compacta dopamine neurons in R1441C LRRK2 transgenic rats reveal an age-dependent reduction in bur

161 In adult Fos-lacZ transgenic rats, selective inactivation of nicotine-cue-

162 In Fos-lacZ transgenic rats, selective inactivation of relapse test-

163 We generated a transgenic rat stably expressing the green fluorescent p

164 podocyte depletion and glomerulosclerosis, a transgenic rat strain in which the human diphtheria toxi

165 stable fluorescence reporter from an inbred transgenic rat strain provides an important new resource

166 The transgenic rat system will be useful in further defining

167 smid construct used to generate two lines of transgenic rats, termed JP17 and JP59.

168 Here, a transgenic rat (TgF344-AD) expressing disease-causing mu

169 The HD transgenic rat (tgHD), which contains the human HD mutat

170 was administered by subretinal injection to transgenic rats (TgN S334ter-4) at postnatal day 15 (P15

171 of genetically engineered hypertension, the transgenic rat TGR (mREN2)27, provides a unique opportun

172 aggressive colitis and gastritis in HLA-B27 transgenic rats than did the other five bacteria without

173 eptor degeneration was examined in a line of transgenic rats that carry a rhodopsin mutation S334ter.

174 otrophin (CT)-1 on photoreceptor survival in transgenic rats that carry the rhodopsin mutation S334te

175 Here, we created novel lines of transgenic rats that express a mutant form of human TDP-

176 We have also generated transgenic rats that express GFP at high levels, suggest

177 We created a line of transgenic rats that produce epitope-tagged human SREBP-

178 aun02 inactivation procedure in male FosLacZ-transgenic rats to ablate selectively Fos-expressing PLC

179 We then used male FosGFP-transgenic rats to assess selective alterations of intri

180 d light damage and the susceptibility of the transgenic rats to light damage.

181 sors revealed a defect in the ability of B27-transgenic rats to produce DCs of the migratory phenotyp

182 We trained c-fos-lacZ transgenic rats to self-administer cocaine in Context A

183 We trained c-fos-lacZ transgenic rats to self-administer heroin and 11 d later

184 We generated transgenic rats (TR) with targeted expression of IFN-gam

185 ls, we studied four additional groups of B27 transgenic rats treated with: 1) continuous anti-CD8alph

186 In FUS transgenic rats, ubiquitin aggregation and FUS mislocali

187 m is operative in photoreceptor death in the transgenic rats under investigation.

188 e that, like their human counterparts, HIV-1 transgenic rats undergo severe osteoclastic bone resorpt

189 fore, an efficient generation of human SIRPA transgenic rats using piggyBac opens opportunities for e

190 Using circuit perturbations in transgenic rats, we demonstrate that switching between s

191 neurons in prelimbic cortex (PLC) of FosGFP-transgenic rats, we found that operant food self-adminis

192 in choline acetyltransferase (ChAT)::Cre(+) transgenic rats, we selectively labeled cholinergic neur

193 ds isolated from hepatocellular neoplasms in transgenic rats were aneuploid.

194 Subsequently, germfree transgenic rats were colonized with groups of five to ei

195 Germfree transgenic rats were colonized with specific-pathogen-fr

196 Transgenic rats were created, wherein soluble OPG was ov

197 Five lines of PEPCK-TGFalpha transgenic rats were established, each genetic line cont

198 nic spinal cord of alkaline phosphatase (AP) transgenic rats were grafted acutely into a DC lesion at

199 , macrophages, and microglia from hCD4/hCCR5 transgenic rats were highly susceptible to infection by

200 Hepatocytes from transgenic rats were isolated by a two-step perfusion pr

201 c-fos-GFP transgenic rats were then used to assess glutamatergic s

202 Marked testis cells from transgenic rats were transplanted to the testes of immun

203 Opsin P23H transgenic rats were treated with light at P28 and analy

204 Transgenic rats with a high level of expression of the h

205 By using transgenic rats with a luciferase (luc) reporter, we ass

206 common final cell death, apoptosis, we used transgenic rats with a P23H or S334ter rhodopsin mutatio

207 nfluenced by chromosomal context, leading to transgenic rats with different pigmentation that enabled

208 Transgenic rats with high expression of HLA-B27 develop

209 vation of macrophages from premorbid HLA-B27 transgenic rats with IFN-gamma increases HLA-B27 express

210 ages derived from the bone marrow of HLA-B27 transgenic rats with inflammatory disease.

211 at lcn2 is induced in reactive astrocytes in transgenic rats with neuronal expression of mutant human

212 Our FUS transgenic rats would be useful to the mechanistic study