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1 dicating that all four groups have a role in transition state stabilization.
2 network of charged residues is essential for transition state stabilization.
3 be carefully investigated for their role in transition state stabilization.
4 l hydrogen bonding interaction necessary for transition state stabilization.
5 and that Arg-131 and His-200 are involved in transition state stabilization.
6 indicating that this arginine is critical in transition state stabilization.
7 site can contribute to rate acceleration via transition state stabilization.
8 more effective substrate preorganization and transition state stabilization.
9 rm a network of hydrogen bonds necessary for transition state stabilization.
10 n of dephosphorylation by nucleotide-induced transition state stabilization.
11 , indicating contributions to E2 binding and transition state stabilization.
12 d reveals contacts that likely contribute to transition state stabilization.
13 Both of these residues might be involved in transition state stabilization.
14 ion in a manner that allows it to assist in transition state stabilization.
15 ate discrimination results from differential transition state stabilization.
16 ontributed approximately 4.5 kcal/mol toward transition state stabilization.
17 ial catalytic groups for ubiquitin adenylate transition state stabilization.
18 alysis, and R92 plays a critical role in the transition state stabilization.
19 ns from a change in the solvation effect and transition state stabilization.
20 that the anionic backbone of DNA is used in transition state stabilization.
21 be ground state destabilization rather than transition state stabilization.
22 e of electron delocalization in reactant and transition state stabilization.
23 by creating a more favorable environment for transition-state stabilization.
24 acid/base catalysis, substrate binding, and transition-state stabilization.
25 eaction and is likely to be a key residue in transition-state stabilization.
26 plexes may be good models of enzyme-mediated transition-state stabilization.
27 is probably involved in maltooligosaccharide transition-state stabilization.
28 portant for high-affinity AdoMet binding and transition-state stabilization.
29 e conformations and in part by electrostatic transition-state stabilization.
30 ibutions to ground-state destabilization and transition-state stabilization.
31 idity and provides an overall 14-17 kcal/mol transition-state stabilization.
32 mine makes a modest contribution to chemical transition state stabilization (1.0 kcal.mol-1 relative
33 Through protonation of the leaving group and transition-state stabilization, activated MKP3 catalyzes
34 ting alphaD335 to alphaS337 are important to transition state stabilization and catalytic function th
35 tentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal te
36 ue of the hammerhead complex is critical for transition state stabilization and efficient cleavage ac
37 ribozyme/substrate complex are critical for transition state stabilization and efficient cleavage ac
38 We surmise that Arg-130 plays dual roles in transition state stabilization and general acid catalysi
39 us studies implicated Arg-223 and His-265 in transition state stabilization and Lys-167 in proton don
40 catalysis may be derived from electrostatic transition state stabilization and the opposing view tha
41 an oxyanion hole), which is crucial for the transition state stabilization and, therefore, on the en
42 of the active site permits us to suggest how transition-state stabilization and a general base may ca
43 on ( K m (D)) correlated with ATP hydrolysis transition-state stabilization and ATP occlusion (EC 50
44 se effects can be extended to ATP hydrolysis transition-state stabilization and ATP occlusion at a si
45 the previously proposed roles for Arg L96 in transition-state stabilization and for His L91 as the nu
46 binding energy) and are the key factors for transition-state stabilization and molecular recognition
47 central to the H-bond network that provides transition-state stabilization and tight binding of the
48 oth metals participate in substrate binding, transition state stabilization, and the hydrolysis react
49 eighboring group electrostatic interactions, transition-state stabilization, and leaving group activa
50 xygen at C2 on the nucleobase contributes to transition-state stabilization, and thus acts as a posit
51 r these residues include nucleotide binding, transition-state stabilization, and triggering protein c
52 ation of charges (using differential product/transition state stabilization approach) followed by cal
54 implicated in phosphohydrolase chemistry via transition state stabilization (Arg308, Arg648, Gln275),
56 demonstration of stereoelectronic effects in transition state stabilization as well as a separation o
57 hich differ with respect to the mechanism of transition state stabilization, as dictated by differenc
59 only is important for providing the optimal transition state stabilization but also ensures correct
60 in betaR246A caused almost complete loss of transition state stabilization, but partial rescue was a
61 t CTA gains catalytic efficiency from modest transition-state stabilization, but DTA and PTA catalyze
62 lfate on the alpha-phosphate of ATP involves transition state stabilization by Arg-248, Asn-249, His-
63 hat the 2'-OH may play an additional role in transition state stabilization by donating a hydrogen bo
64 arer understanding of the forces involved in transition state stabilization by Escherichia coli cytid
65 core a common catalytic mechanism, entailing transition state stabilization by manganese and the phos
66 The proposed catalytic mechanism implicates transition state stabilization by PPAT without involving
67 alysis are interpreted to be consistent with transition state stabilization by solvent being primaril
68 an allosteric effect, which includes a major transition state stabilization by the electrostatic effe
69 catalytic role of zinc ion, and improve the transition state stabilization by the enzyme environment
70 s of antibodies, catalyze hydrolysis through transition state stabilization by tyrosine or histidine
71 etal cofactor appears to be mediated through transition-state stabilization by outer-sphere complex f
72 the course of loop closure, as expected for transition-state stabilization by the side chain ammonio
73 up conformations are shown to be critical to transition-state stabilization (by up to 15 kcal/mol), a
75 oth substrate organization and electrostatic transition state stabilization contribute to catalysis.
77 ective enhancement effect are: (a) increased transition-state stabilization due to hydrogen bonding i
78 er alignment of sLys (downward orientation), transition-state stabilization (due to the protein envir
80 d residues involved in aspartate binding and transition state stabilization during the formation of b
81 rate and that, in this case, at least 70% of transition state stabilization energy can be achieved us
82 hich are important for substrate binding and transition state stabilization for both of the chemical
83 nalyses indicated roles for the arginines in transition state stabilization for catalysis but not in
84 nal reorganization while maintaining optimal transition state stabilization for every step during cat
85 esidue that is important in both binding and transition state stabilization for the activity with (S)
86 ity with (S)-mandelate, is also critical for transition state stabilization for the esters, but not f
87 sential activator, providing 3.2 kcal/mol of transition state stabilization for the truncated substra
89 of 3 x 10(10) M(-1), which corresponds to a transition-state stabilization for deuterium exchange of
90 nstrated the importance of charge balance in transition-state stabilization for phosphoryl transfer e
91 e conclude that a large portion of the total transition-state stabilization for the decarboxylation o
93 examined in this work, which enables strong transition state stabilization from enzyme-phosphodianio
94 abolishes both functions, R130K permits the transition state stabilization function (via contact of
95 test the contribution of this interaction to transition-state stabilization, Glu-91 was converted to
96 ous transition state inhibitors supports the transition state stabilization hypothesis for enzymatic
97 al residue involved in phosphate-binding and transition state stabilization in ATP synthase catalytic
100 d active site mutants underscore the role of transition state stabilization in the evolution of this
101 pproach was used to examine the differential transition state stabilization in the papain mutant rela
103 contribute 10 to 20 kilocalories per mole to transition-state stabilization in enzymatic catalysis.
105 d through a mechanism that is similar to the transition-state stabilization in the general acid-base
106 ed by the results of experiments testing how transition state stabilization is affected by the trunca
107 rgues against the model in which substantial transition state stabilization is derived from a water m
108 eneral acid-base or electrostatic catalysis, transition state stabilization is likely to be an import
110 the positive charge is the main effector of transition state stabilization is shown by the construct
111 K25V the removal of the charge and resultant transition state stabilization is the main origin of the
113 190 in orienting the substrate for effective transition-state stabilization is consistent with rate r
114 e thermodynamic perturbation, in addition to transition-state stabilization, is required for the larg
115 42) hypothesized to be key for electrostatic transition state stabilization (K42A, K42Q, K42E, and K4
116 s favorable polar interactions important for transition state stabilization leading to efficient aden
117 ces is that catalysis occurs via a different transition state stabilization mechanism in HcTrpRS with
122 everal other arginines likely participate in transition state stabilization of the transferred phosph
123 anisms: pre-steady state bursts, significant transition-state stabilization of both amino acid activa
125 of protein side chain functional groups, and transition-state stabilization of the S(VI) exchange rea
126 ey suggest instead that something other than transition-state stabilization or tunneling is responsib
127 affect substrate carboxyl binding (R71N) and transition state stabilization (R63N) also yielded wild-
128 he SRL structure, which imparts 4.3 kcal/mol transition state stabilization relative to a single-stra
129 significantly, it accounts for 9kcal/mol of transition state stabilization relative to the reactant
130 combination with biochemical data, support a transition-state stabilization role for the P(1) residue
131 of KSHV Pr, (Ser114, His46, and His157) and transition-state stabilization site are arranged as in o
132 pling of substrate-dependent arch motions to transition-state stabilization suppresses inappropriate
133 binding interactions and through additional transition state stabilization that may arise from compl
134 ions of these side chains may play a role in transition state stabilization; the observed line broade
135 e ribofuranosyl contacts to ground state and transition state stabilization, Thr-100 and Asp-37 were
136 lts indicate that R277 plays a major role in transition state stabilization through its positive char
137 DeltaG(cat)()) for the CI mechanism involves transition-state stabilization through general-acid cata
139 the enzyme works by providing electrostatic transition state stabilization (TSS), by applying steric
141 n bond (LBHB), may account for the "missing" transition state stabilization underlying the catalytic
143 cules rather that to the more common mode of transition state stabilization used by naturally evolved
144 atalysis, that Gly65 and Gln58 contribute to transition-state stabilization via hydrogen bond formati
145 ground state binding and the P4 position for transition state stabilization was identified through si
147 assembled beta-hairpin as a key template in transition state stabilization with the beta-turn playin
149 ribution of each substrate hydroxyl group to transition-state stabilization with the wild type and ea
150 y combining ground-state destabilization and transition-state stabilization within the cavity of an e
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