ライフサイエンスコーパス: transitional B-cell

1 ity via direct, TACI-dependent activation of transitional B cells.

2 This was due to a decrease in naive and transitional B cells.

3 B cells leave the bone marrow as transitional B cells.

4 ) spleen, there is an accumulation of type 1 transitional B cells.

5 biased by IS regimens, which also influenced transitional B cells.

6 secretion as was observed in healthy control transitional B cells.

7 enic B cells and a further pronounced one in transitional B cells.

8 FF promotes the expansion of TACI-expressing transitional B cells.

9 ance via positive selection of self-reactive transitional B cells.

10 ells were CD27(-)/CD10(+), characteristic of transitional B cells.

11 ated level of IRF8 promoted apoptosis in the transitional B cells.

12 ed and Notch hindered the differentiation of transitional B cells.

13 morphisms in BLK are restricted to naive and transitional B cells.

14 venting 2F5 V(H)/V(L) expression by immature/transitional B cells.

15 capacity to purge autoreactive immature and transitional B cells.

16 B cells, as well as IL-10-producing CD27(+) transitional B cells.

17 BAFF-mediated survival of the Act1-deficient transitional B cells.

18 In the periphery transitional B cells accumulated under ERT, and the defe

19 erapy was characterized by a predominance of transitional B cells and a lack of memory B cells.

20 nctionally immature, with a preponderance of transitional B cells and a paucity of memory B cells.

21 actin caused a decrease in the population of transitional B cells and an increase in mature follicula

22 A transient increase in transitional B cells and cells with phenotypic character

23 Both late splenic transitional B cells and cells within this uncharacteriz

24 igen-dependent negative selection of splenic transitional B cells and is required for activation of t

25 Both the percentage of immature/transitional B cells and levels of IL-7 were inversely c

26 tion was not evident in interactions between transitional B cells and preactivated CD4-expressing T c

27 se delta (PI3Kdelta) lead to accumulation of transitional B cells and senescent T cells, lymphadenopa

28 marrow of adult mice enter the periphery as transitional B cells and subsequently differentiate into

29 ctive immature B cells to differentiate into transitional B cells and to be positively selected into

30 ion of nonautoreactive immature B cells into transitional B cells and to promote their positive selec

31 4(high) B10 cells, CD24(hi)CD38(hi) immature transitional B cells, and CD73(-)CD25(+)CD71(+) BR1 cell

32 pitope (SP62): in C57BL/6 mice, SP62-binding transitional B cells are readily identified in bone marr

33 In vitro, AID deficient immature/transitional B cells are significantly more resistant to

34 for WP ontogeny, and CXCL13-responsive late transitional B cells are the initiating subset.

35 In the absence of Rac1 and Rac2, transitional B cells are unable to migrate in response t

36 in A/WySnJ B cells decreased the turnover of transitional B cells, as determined by 5-bromo-2'-deoxyu

37 r, breakage of tolerance, increased immature/transitional B cells, B cell malignancies, as well as a

38 n receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or fol

39 the differentiation of CD23(-) into CD23(+) transitional B cells both in vitro and in vivo through a

40 We report that transitional B cells can process and present Ag as pepti

41 demonstrate that B cells, and in particular transitional B cells, can promote prolongation of graft

42 In contrast to early transitional B cells, CD21(int) T2 B cells exhibit augme

43 th increasingly elevated Flt3L, depletion of transitional B cells, CD56(bright) NK cells, naive T cel

44 effect against anti-IgM apoptotic signals on transitional B cell checkpoint, not observed with BAFF.

45 ing, as indicated by the increased number of transitional B cells coexpressing kappa/lambda light cha

46 Bregs were identified in both the naive and transitional B-cell compartments and suppressed T-cell p

47 od, and spleen in mice and humans shows that transitional B cells comprise a much smaller fraction in

48 The lack of dsDNA breaks in transitional B cells contrasts with their increased expr

49 In the current study, when transitional B cells developed in the presence of donor

50 appa recombination signal sequences, whereas transitional B cells did not.

51 for sustained p100 production emerged during transitional B cell differentiation, the stage at which

52 tory molecule CD86 (B7.2) and are activated, transitional B cells do not and undergo apoptosis.

53 d role in purging self-reactive immature and transitional B cells during their maturation in the bone

54 the first time, the study reveals that human transitional B cells encompass not only transitional typ

55 pment is arrested at the same T0 stage, with transitional B cells excluded from the white pulp.

56 eased frequency of autoreactive new emigrant/transitional B cells exiting the BM, indicating that the

57 When modeled as a time-dependent covariate, transitional B cell frequencies (but not total B cells o

58 BAFF-mediated humoral autoimmunity, TACI(+) transitional B cells from BAFF-transgenic mice spontaneo

59 In addition, we found that transitional B cells from both healthy controls and IFN-

60 at IL-4 stimulated the generation of CD23(+) transitional B cells from CD23(-) B cells, and this effe

61 vity of antibodies expressed by new emigrant/transitional B cells from IPEX patients were similar to

62 ing immune response might rescue Ag-specific transitional B cells from negative selection.

63 We found that new emigrant/transitional B cells from patients with XLP were enriche

64 y, we examined the responses of immature and transitional B cells from V(H)12Vkappa1A Ig transgenic m

65 We found enrichment of transitional B cell genes in systemic lupus erythematosu

66 Whereas naive and transitional B cells have been associated with long-term

67 Human transitional B cells have previously been variably ident

68 nse, (2) transient preponderance of immature/transitional B cells in all lymphoid organs, (3) impaire

69 y low frequency of polyreactive new emigrant/transitional B cells in DOCK8-deficient patients.

70 on mature B cells, the expansion of immature/transitional B cells in patients with ICL occurred at th

71 Here, we report the expansion of immature/transitional B cells in patients with ICL, which is asso

72 number of regulatory CD19(+)CD24(++)CD38(++) transitional B cells in peripheral blood relative to tre

73 We identified transitional B cells in rabbits and classified them into

74 he bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha

75 is dispensable for the generation of CD23(-) transitional B cells in the bone marrow, but it is impor

76 ns is maintained by continuous production of transitional B cells in the bone marrow.

77 cisely downmodulated upon culture of splenic transitional B cells in the presence of BAFF.

78 d for optimal survival and TLR7 responses of transitional B cells in the spleen and was overexpressed

79 Further, we show that transitional B cells in the spleen are latently infected

80 one marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2

81 at shares multiple characteristics with late transitional B cells in the spleen.

82 evated numbers of peripheral blood naive and transitional B cells in tolerant participants compared w

83 l maturation to delineate refined subsets of transitional B cells, including a late transitional B ce

84 Later transitional B cells, including T2 and T3, are found at

85 y damage, lymphopenia, increased circulating transitional B cells, increased immunoglobulin M, and re

86 ight on a new alternative mechanism by which transitional B-cells inhibit T-cell proliferation and cy

87 pt maturation and prevent differentiation of transitional B cells into marginal zone and follicular B

88 ts receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thomps

89 A substantial influx of CXCR5(+) transitional B cells into the spleen occurred 18 h befor

90 f naive follicular mature cells produced per transitional B cell is 3- to 6-fold higher across tissue

91 t that the gain of survival potential within transitional B cells is dependent on the ability to prod

92 Moreover, the fraction of transitional B cells is doubled in the cord blood of car

93 ells is reduced and the frequency of CD27(+) transitional B cells is increased in patients with autoi

94 the same signal induces receptor editing in transitional B cells is not clear.

95 Finally, we identified transitional B cells isolated from CV facilities as poss

96 Our results support the idea that transitional B cells lose the capacity to edit, but are

97 Transitional B cells mark the crucial link between bone-

98 cquisition of resistance to apoptosis during transitional B cell maturation is achieved by integratio

99 Additional studies demonstrate that transitional B cells mature across a developmental conti

100 lly resistant to apoptosis, whereas immature transitional B cells more commonly expressed Ki67, the l

101 est at the T0 stage at least in part because transitional B cells need to migrate into the white pulp

102 What determines whether transitional B cells newly emerged from the bone marrow

103 B cells, with especially robust increases in transitional B cell number, marginal zone B cell prolife

104 Blood transitional B-cell numbers were normal, but naive matur

105 mory B cells, with a concomitant increase in transitional B-cell numbers.

106 a significant increase in naive, memory, and transitional B cells on day 30 after vaccination, wherea

107 ch that excess expression pushes the A/WySnJ transitional B cells past the apoptosis checkpoint to ce

108 lopment in the spleen abruptly halted at the transitional B cell population 1 to 2 stage, a block tha

109 Here we show that transitional B-cells produced more IL-10 and expressed h

110 An increased percentage of peripheral transitional B cells producing IL-10 has been observed i

111 No association between transitional B cell proportions and either de novo donor

112 A) formation was evident, although preserved transitional B cell proportions were associated with red

113 et of B-cell reconstitution characterized by transitional B-cell recovery occurred either early (mont

114 Transitional B cells represent a target of negative sele

115 CD24(high)CD38(high) transitional B cells represent cells at a key stage in t

116 Estradiol enhances transitional B cell resistance to apoptosis and expands

117 The fundamental role of BLyS in transitional B cell selection, coupled with the relative

118 Moreover, enriched transitional B cells showed a cell-autonomous defect lea

119 were relatively unperturbed, WASp-deficient transitional B cells showed enhanced proliferation in vi

120 cells were rescued at both the immature and transitional B cell stage in E2-treated mice.

121 c B cells that differentiatively arrest at a transitional B cell stage in the spleen.

122 2, B cell development is arrested at an IgD- transitional B cell stage that we term transitional type

123 tive and negative selection occur within the transitional B cell stage.

124 of B cells that fail to progress beyond the transitional B cell stage.

125 Data point to the late transitional B-cell stage as a crucial juncture at which

126 ed selective advantage beginning at the late transitional B-cell stage; and (3) a similar in vivo sel

127 were occupied by GPI, operated mainly at the transitional B cell stages in the spleen, preventing the

128 They arise from within the transitional B-cell subpopulation and are characterised

129 The characterization of multiple transitional B cell subpopulations provides important in

130 transplantation, the peripheral CD19CD24CD38 transitional B cell subset strongly declined, regardless

131 ts of transitional B cells, including a late transitional B cell subset with a phenotype intermediate

132 We have characterized a distinct, late transitional B cell subset, CD21(int) transitional 2 (T2

133 Flow cytometry analysis of the splenic transitional B cell subsets demonstrated that MZ B cell

134 late calcium mobilization in each of the two transitional B cell subsets.

135 study indicates that altered distribution of transitional B-cell subsets highlights different regulat

136 +)CD27(+) memory and CD19(+)CD24(hi)CD38(hi) transitional B-cell subsets in healthy human donors.

137 B-cell progenitors in the bone marrow and of transitional B-cell subsets in the spleen.

138 ides evidence for the existence of different transitional B-cell subsets, each displaying unique phen

139 ow levels of AID in bone marrow immature and transitional B cells suppress the development of autorea

140 1 plays a critical role in the regulation of transitional B cell survival and maturation.

141 TNFRSF13C gene, is critically important for transitional B cell survival to maturity.

142 ation in the spleen and other IgD-expressing transitional B cells that express lower levels of CD21 a

143 We describe herein a population of immature/transitional B cells that is overly represented in the p

144 sic apoptosis was observed in CD10+ immature/transitional B cells that likely arise as a result of HI

145 s and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow,

146 ow and results in the generation of immature transitional B cells that transit to the spleen to compl

147 The process of maturation from immature transitional B cell through to mature naive B cell inclu

148 s underlying the differential sensitivity of transitional B cells to apoptosis remain unclear.

149 The ability of transitional B cells to process and present Ag to CD4 T

150 Despite the relatively small contribution of transitional B cells to the human nonmemory pool, the nu

151 prolonged expansion of functionally immature transitional B cells, tonsil biopsy tissues revealed act

152 Transitional B cells transiently increased 2 mo posttran

153 s and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B ce

154 Transitional B cells turn over rapidly in vivo and are s

155 Finally, type 1 transitional B cells uniquely produce MMP9 in response t

156 In addition, the number of 564Igi transitional B cells was increased in Rasgrp1-deficient

157 his stimulatory condition, CD86 expressed by transitional B-cells was down regulated and T-cell proli

158 at the down-regulation of CD86 expression by transitional B-cells was due to the autocrine effect of

159 BCR)-mediated apoptosis and proliferation of transitional B cells were analyzed by flow cytometry.

160 sion, although the percentages of mature and transitional B cells were normal.

161 Splenic immature transitional B cells were significantly expanded both in

162 ations, namely mature activated and immature transitional B cells, which are overrepresented in untre

163 Furthermore, treatment of transitional B cells with high concentrations of anti-Ig