ライフサイエンスコーパス: transketolase

1 phoribulokinase), and part of cbbT (encoding transketolase).

2 tion by ribokinase and further metabolism by transketolase.

3 or substrate binding were examined for human transketolase.

4 vered a mechanism by which null mutations in transketolase A (tktA) and glycerol-3-phosphate (G3P) de

5 ate cyclase two-hybrid system, we found that transketolase A (TktA) interacts with MarR.

6 ldtype strain by the presence of an isozyme, transketolase A (TktA).

7 crease in the fraction of ribose derived via transketolase, a thiamine-dependent enzyme in the pentos

8 Transketolase activity is required in cells to make eryt

9 eveal the crucial importance of the level of transketolase activity to provide the precursor for synt

10 atic testing confirmed significantly reduced transketolase activity.

11 m microtubules by washing with salt included transketolase, alpha-enolase, and betaB2-crystallin.

12 ns with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosp

13 , three- to fivefold increased expression of transketolase and glutathione reductase.

14 de in genes encoding phosphoribulokinase and transketolase and in the gene encoding the LysR-type tra

15 ethyl thiamine pyrophosphate intermediate of transketolase and inactivating this enzyme.

16 PAGE (-DTT) resolved mouse serum albumin and transketolase and indicated that serum albumin was 13% o

17 bears homology to the equivalent domains in transketolase and the E1 subunit of pyruvate dehydrogena

18 abel in the glucose moiety was scrambled via transketolase and transaldolase activities of the pentos

19 Separate transketolase and transaldolase fluxes could be distingu

20 n assumptions about the reversibility of the transketolase and transaldolase reactions in the nonoxid

21 represent a novel class of highly conserved transketolases and likely plays a key role in the biosyn

22 tion factor 2, glucose-regulated protein 78, transketolase, and succinyl-CoA transferase were primari

23 ent functional pathway that operates through transketolase B (TktB), and which is 'buffered' in wildt

24 Serum albumin from cornea was separated from transketolase by SDS-PAGE (+/-dithiothreitol [DTT]) and

25 ional protein domains was examined using the transketolase C-terminal (TKC)-domain as an example.

26 ced nucleic acid production through impaired transketolase catalysis is the underlying biochemical di

27 mposed of a full-length Arabidopsis thaliana transketolase cDNA under the control of the cauliflower

28 ase multienzyme complex E1 subunit and yeast transketolase crystal structures indicates a general str

29 Transketolase deficiency is one of a growing list of inb

30 Transketolase deficiency reduces NADPH synthesis and nuc

31 utosomal-recessively inherited deficiency of transketolase, encoded by TKT, on chromosome 3p21.

32 thiamine and benfotiamine therapy increased transketolase expression in renal glomeruli, increased t

33 s increased further by knockdown of nrf2 and transketolase expression.

34 ng mediation by nrf2 and related increase of transketolase expression.

35 ulate the three individual transaldolase and transketolase extents of reversibility.

36 glucose, fructose induces thiamine-dependent transketolase flux and is preferentially metabolized via

37 or the in vitro determination of activity of transketolase from Escherichia coli (TKec) using commerc

38 perglycemia in which increased expression of transketolase has a pivotal role.

39 The enzyme transketolase has been employed as a catalyst for asymme

40 systems, scale-up of the reaction and use of transketolase in multi-enzyme experiments.

41 histidine is distinct from its role in yeast transketolase in which it aids in binding donor substrat

42 a brief overview of the use of aldolases and transketolases in the synthesis of sugars, sugar analogs

43 t activation of the nonoxidative PPP enzyme, transketolase, in imatinib-resistant CML cells.

44 and II in the same monomer, whereas that of transketolase is located at the interface of the dimer.

45 i pyruvate dehydrogenase and His263 in yeast transketolase, is on a largely ordered phosphorylation l

46 Finally, inhibiting the transketolase isoenzyme transketolase-like 1 (TKTL1) by

47 se) or leucine (the corresponding residue in transketolase) led to greatly diminished kcat values, sh

48 ally, inhibiting the transketolase isoenzyme transketolase-like 1 (TKTL1) by siRNA reversed theses ef

49 e from a YAC in Xp22, the recently described transketolase-like gene in a YAC from Xq28 and a putativ

50 s been associated with overexpression of the transketolase-like-1-gene (TKTL1), which encodes an esse

51 and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine syntheta

52 in M. jannaschii as endoglucanase (MJ0555), transketolase (MJ0681), thiamine biosynthetic protein th

53 tabolic enzymes, including transaldolase and transketolase of the nonoxidative pentose pathway, malat

54 evated expression of the TKL1 gene, encoding transketolase of the pentose phosphate pathway.

55 investigate the effect of increased plastid transketolase on photosynthetic capacity and growth, tob

56 active centers of the E. coli E1 subunit and transketolase on the basis of the parallels in the ligat

57 ere complemented by germinating the seeds of transketolase-overexpressing lines in media containing e

58 ls in the seeds and cotyledons were lower in transketolase-overexpressing lines than in wild-type pla

59 When transketolase-overexpressing plants were supplemented wi

60 led a major and unexpected effect of plastid transketolase overexpression as the transgenic tobacco p

61 The mechanism determining transketolase protein levels remains to be elucidated, b

62 ana tabacum) plants with increased levels of transketolase protein were produced.

63 versus untreated mice: fatty acid synthase, transketolase, pulmonary surfactant-associated protein C

64 A transketolase reaction was catalyzed by cyanide ion unde

65 Since the analogous transketolase reaction, being involved in the carbohydra

66 ing regions of the color pigment genes and a transketolase-related gene.

67 both the pyruvate dehydrogenase complex and transketolase, resulted in enhanced imatinib sensitivity

68 ted to another enzymatic reaction with yeast transketolase that changes the mass of the products to b

69 s is suppressed by overexpression of TKL1, a transketolase that generates NADPH, which balances redox

70 drogenase (G6PD) catalyzed oxidative and the transketolase (TK) catalyzed nonoxidative pentose cycle

71 volution of the mechanism and specificity of transketolase (TK) has been minor, and that the smallest

72 d on thiamine pyrophosphate (ThDP)-dependent transketolase (TK)-catalyzed reaction, followed by the o

73 ithin the flexible loops of Escherichia coli transketolase (TK).

74 incident with a more than 90% loss of tissue transketolase (TKT) and aldehyde dehydrogenase (ALDH) cl

75 undantly express two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1

76 The transketolase (TKT) gene is expressed 30-50 times more h

77 Transketolase (TKT) is a ubiquitous enzyme used in multi

78 y and Akt association and phosphorylation of transketolase (TKT), a key enzyme of the nonoxidative pe

79 nase 2 (GLUD2), adenylate kinase 2 (AK2) and transketolase (TKT).

80 tors inducing loss of the corneal crystallin transketolase (TKT).

81 Here, we demonstrate that this protein is transketolase (TKT; EC 2.2.1.1), an enzyme in the nonoxi

82 r two proteins, phosphoglucomutase (Pgm) and transketolase (TktA), are enzymes involved in carbohydra

83 hosphate and triose phosphate and reversible transketolase velocity were similar to net glycolytic fl

84 The S385Y/D469T/R520Q variant of E. coli transketolase was evolved previously with three successi

85 Coamplification with transketolase, which increases d-erythrose 4-phosphate a