ライフサイエンスコーパス: translatable

1 in vivo effects; hence, it may be clinically translatable.

2 not all treatments and outcomes are directly translatable.

3 cortical NMDA function that is also robustly translatable.

4 ogression in model bacteria are not directly translatable [1, 2, 6-8].

5 on did not increase expression of a directly translatable, 5'-proximal gene in RNA3, implying that 1a

6 easy-to-implement apparatus that is readily translatable across sites.

7 This clinically translatable agent could noninvasively detect inflammati

8 r a scaffold for the synthesis of clinically translatable agents.

9 ridine, making messenger RNAs (mRNAs) highly translatable and non-immunogenic is one such feature tha

10 to play a role in partitioning mRNAs between translatable and nontranslatable pools, and our results

11 s, which indicates that these biomarkers are translatable and relevant to human disease.

12 e recovery of 3' fragments revealed that the translatable and the AUG-deficient mRNAs are both degrad

13 al grade and hence this approach should be a translatable and universal modification of hydrogels.

14 e normal degradation of CYC1 mRNAs, and that translatable and untranslated mRNAs are degraded by the

15 es such as 3 mug/L or 20% are measurable and translatable and would substantially increase detection

16 ch infections is needed, as are relevant and translatable animal models to identify and test concepts

17 new pharmacological agents developed through translatable animal research over the past few decades h

18 A highly novel and translatable approach to assess the efficacy of cell the

19 ompatible, semi-quantitative, and clinically translatable approach to evaluate the tumor targeting of

20 we propose that this drug might represent a translatable approach to limit organ injury in septic pa

21 with KGF represents a novel and potentially translatable approach to promote rapid and durable thymi

22 trating the therapeutic merit of this highly translatable approach.

23 rge open reading frame (ORF) of 3,494 codons translatable as a polyprotein and two embedded shorter O

24 Viroids are non-translatable, autonomously replicating circular RNAs tha

25 findings to pathological mechanisms that are translatable back to the patient.

26 results from our studies appear to be highly translatable because we discerned an inverse relationshi

27 Fear extinction offers a tractable and translatable behavioral readout of individual difference

28 d we have endeavored to develop a clinically translatable, belatacept-based regimen that could obviat

29 rotein analysis showed that betah0 encodes a translatable beta-like globin protein that can pair with

30 A translatable biomarker of MMP activity would enable deve

31 this assay for nitrotyrosine as a clinically translatable biomarker was demonstrated by quantifying b

32 nce our understanding of EEG recordings as a translatable biomarker.

33 To identify translatable biomarkers for an off-the-shelf responsive

34 To identify clinically translatable biomarkers of SU11248 activity, expression

35 of preclinical models to identify clinically translatable biomarkers.

36 the use of electrophysiological measures as translatable biomarkers.

37 e unlikely to be both condition-specific and translatable but consistent with the possibility of biol

38 formation in NHPs, and offers a potentially translatable calcineurin inhibitor-free protocol inclusi

39 l transcript elongation capable of producing translatable carAB transcripts.

40 ncoding phenylalanine in position 508 of the translatable CFTR sequence (accompanied by a C to T repl

41 ing site II were investigated by introducing translatable chimeric minigenes containing sequence -20

42 as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functi

43 tions offer the prospect of a novel, rapidly translatable, disease-modifying, and neuroprotective tre

44 r anatomical target for the development of a translatable drug treatment.

45 reduce research waste and provide clinically translatable evidence.

46 feasibility of this concept as a clinically translatable experimental therapeutic.

47 d by ribosomes under conditions that are not translatable for most mRNAs.

48 s of current therapies and may be clinically translatable for patients with therapy-sensitive and the

49 and minimal sample preparation, making this translatable for point-of-care applications.

50 If translatable from mice to humans, these data have import

51 d for neuroimaging findings to be clinically translatable, future studies need to focus on a-priori h

52 d here offers high potential as a clinically translatable genetic modification strategy for cell ther

53 Superinfecting BVDV failed to deliver a translatable genome into acutely infected cells, indicat

54 ant HD protein by decreasing the quantity of translatable HD mRNA.

55 y lifestyles, but few studies have developed translatable health behavior change interventions.

56 that transcriptional induction of a readily translatable HuR mRNA may be driven by a mechanism known

57 uggest that HP DHA, a potentially clinically translatable imaging agent, holds special promise in ima

58 for the design of excretable and thus highly translatable imaging agents.

59 spectroscopic imaging (MRSI) is a clinically translatable imaging method that allows noninvasive moni

60 lthough clinically relevant, is not directly translatable in animal models.

61 Ex vivo results were translatable in vivo, confirming that intercellular adhe

62 As more translatable information about the larger adipokine-CV-l

63 vailable, this approach should be clinically translatable, insofar as it may assess the efficacy of i

64 system for developing potentially clinically translatable interventions for suppressing diabetogenic

65 two editing strategies that are potentially translatable into clinical application.

66 ing, identify interventions that are readily translatable into clinical practice, and cost less than

67 potential points on the endocardial surface translatable into electrograms or color-coded activation

68 evolutionarily conserved, our results may be translatable into new immunotherapies for the treatment

69 All potentially translatable lncRNA ORFs had only a single peptide match

70 The translatable MALDI-IMS glycan profiling workflow describ

71 osttranscriptionally into pre-mRNA to create translatable messages.

72 uridylate insertions and deletions, creates translatable messenger RNAs (mRNAs) out of nonsense pre-

73 With the aim of improving the discovery of translatable metabolite biomarkers, we present search an

74 signaling in DCs, suggesting an immediately translatable method to empower DC vaccination approaches

75 ER stress utilizing PBA can be a clinically translatable method to treat systemic cGVHD.

76 icular rate by adenosine might be clinically translatable methods for improving stem cell engraftment

77 a strong Shine-Dalgarno element (SD2) and a translatable mini-ORF of six codons.

78 RNA (kRNA) editing is a process that creates translatable mitochondrial mRNA transcripts from cryptog

79 l mechanism(s), and to identify a clinically translatable model to assess the drug-drug interaction (

80 tion, this has not been tested in clinically translatable models of hypoxia-reoxygenation injury.

81 Thus, we report a translatable modular biomolecular approach with which to

82 This may provide a clinically translatable molecular imaging approach to characterize

83 an approach for the discovery of robust and translatable molecular signatures in GBM.

84 ect of intron content on the rate of mature, translatable mRNA degradation has not been demonstrated.

85 They were similar in the ability to produce translatable mRNA except in the cases of NS1 and NS2, wh

86 l for mitochondrial respiration, but only if translatable mRNA for NRF-1 is available.

87 ling ribosome recruitment to a fully edited, translatable mRNA.

88 The mechanism by which ribosomes select translatable mRNAs from the complex mixture of incomplet

89 ucleotides in many preedited mRNAs to create translatable mRNAs in the mitochondria of the parasite T

90 ines from precursor-mRNAs to produce mature, translatable mRNAs.

91 s uridines from pre-mRNAs to produce mature, translatable mRNAs.

92 c function and thus offers a more clinically translatable neovasculogenic therapy.

93 main effect of prenatal nutrition on highly translatable neurodevelopmental outcomes.

94 esults also provide the basis for clinically translatable noninvasive imaging markers for predicting

95 educing dietary BCAAs may represent a highly translatable option for the treatment of obesity and ins

96 esistant transgenic plants expressing either translatable or nontranslatable versions of the coat pro

97 d >95% by induction of constructs for either translatable or untranslatable PLGA RNAs.

98 ading frame, arguing that only elements with translatable ORFs can be incorporated into the chromosom

99 This approach provides a translatable paradigm to investigate the mode and mechan

100 ration microbubbles (SonoVue) and clinically translatable PEGylated VEGFR2-targeted microbubbles (BR5

101 xis as a target for a potentially clinically translatable pharmacological approach that can block T1D

102 r growth insofar as it offers a biologically translatable picture of how local and global action may

103 osclerotic lesions and suggests a clinically translatable platform for the detection of atherosclerot

104 DCs of highly potent toxins thus introduce a translatable platform that may be exploited to maximize

105 oustic imaging has evolved into a clinically translatable platform with the potential to complement e

106 ctivates this process, allowing synthesis of translatable polyadenylated TNF-alpha mRNA.

107 s in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processin

108 rch and accelerate the generation of readily translatable preclinical data that could ultimately infl

109 te-specific recombination system to create a translatable reading frame by excision of a blocking seq

110 1 cells cDNA library, a clone of most of the translatable region of HDGF was obtained and used to syn

111 uirements for transparent, reproducible, and translatable research are accelerated by the rapid growt

112 appropriate and a high-priority platform for translatable research in host-microbiome interactions.

113 g signals but not to easily interpretable or translatable results.

114 empirical approaches without consistent and translatable results.

115 ibosomes which are converted to cold-adapted translatable ribosomes by the association of cold-shock

116 e inducing signal for the cold-unadapted non-translatable ribosomes which are converted to cold-adapt

117 In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to

118 confers tropism to bone and unveil a readily translatable roadmap for programming cellular traffickin

119 LT-1 possesses promising characteristics for translatable ROS detection and provide a general approac

120 A transgene encoding a translatable sense-strand RNA from the 5' end of iaaM si

121 h methods can promote functional recovery in translatable settings.

122 Many tissues also produce translatable spliced transcript (SpORF2).

123 constructed around sense, antisense and non-translatable-stop strategies (pGRsensehph, pGRantihph an

124 ibrinolytic cotherapy is therefore a rapidly translatable strategy for improving therapeutic effectiv

125 Thus, our results demonstrate a potentially translatable strategy for restoring cortical dependent f

126 after transplantation and described a novel translatable strategy for targeted complement inhibition

127 -target exposure and represents a clinically translatable strategy in myocardial regenerative therape

128 Our findings also provide a rapidly translatable strategy to enhance the outcome of anti-VEG

129 tion in the niche, but also define a rapidly translatable strategy to enhance transplantation therape

130 reclinical validation of a novel and readily translatable strategy to improve cancer therapy.

131 med at augmenting ApoE may serve as a novel, translatable strategy to promote functional recovery in

132 on tumor immunity and propose a potentially translatable strategy to re-engineer the tumor-immune mi

133 ress SHP-1-specific small interfering RNA, a translatable strategy, also exhibited enhanced antitumor

134 d represents a novel, potentially clinically translatable, strategy for the attenuation of GVHD.

135 In this clinically translatable study, we explored the critical role of zin

136 meric antigen receptors (CAR) are clinically translatable synthetic fusion proteins that can redirect

137 novel approach is the first truly clinically translatable system to unlock the therapeutic potential

138 ther diseases, motivating the development of translatable technologies for biological ROS imaging.

139 ific artificial microRNA is an effective and translatable therapeutic approach for ALS.

140 T: There is a need for developing clinically translatable therapy for preventing fetal origins of car

141 There is a need for developing clinically translatable therapy for preventing fetal origins of car

142 treat kidney disease and shows promise as a translatable therapy.

143 collagen hydrogel could produce a clinically translatable thermoresponsive hydrogel to attenuate post

144 ese magnetic resonance methods is clinically translatable, these markers could contribute to early di

145 The intervention is translatable through existing telephone cancer support a

146 potential biomarkers and therapeutic targets translatable to all CKDs.

147 -scale measurements, a response not directly translatable to canopies.

148 ll be used to illustrate how modeling can be translatable to clinical applications.

149 The lessons from NAT are translatable to clinical oncology and may help to promot

150 the recipient and is intended to be directly translatable to clinical use.

151 A mutation detection method should be easily translatable to electrophoretic analyses on microfluidic

152 structural tunability of these electrodes is translatable to functional tunability as the density of

153 ys and suggest that CR mechanisms are likely translatable to human health.

154 scriptional changes in the macaque model are translatable to human M. tuberculosis infection and offe

155 e disease in an animal model and is directly translatable to human patients is critical.

156 If these findings are translatable to human patients, they will have important

157 ro or in vivo, have been problematic and not translatable to human patients.

158 s on confirming that the rodent findings are translatable to human physiology and to diseases such as

159 These doses are scalable and translatable to humans and may provide the foundation fo

160 r imaging reporter gene labeling is directly translatable to humans and provides useful information o

161 If translatable to humans, a subset of migraine auras may b

162 of effort-related decision-making are highly translatable to humans, and an emerging body of evidence

163 Assuming our results are translatable to humans, they raise concerns that analges

164 s that the behavior of CRLX101 in animals is translatable to humans.

165 observed ex vivo and in vivo in mice is also translatable to humans.

166 ed protocol, make this technique potentially translatable to humans.

167 ar stress, these advantages seem not readily translatable to in vivo models.

168 The nanoparticles are readily translatable to in vivo studies on animals and ultimatel

169 approach is environmentally friendly, fully translatable to industry and thus represents a significa

170 These findings may be particularly translatable to medical device applications.

171 ith the added advantage that the approach is translatable to MRI.

172 ression of Ube3a isoform 2 causes phenotypes translatable to neurodevelopmental disorders.

173 od-production systems and these concepts are translatable to other built environments.

174 hods and results presented herein are likely translatable to other mammalian cell systems.

175 ensure that these experiments are optimally translatable to patient care.

176 This transduction protocol may be directly translatable to patients with sickle cell disease who ca

177 iption of such networks in a simple language translatable to Systems Biology Markup Language would al

178 s in cynomolgus monkeys (cynos) is generally translatable to that in humans.

179 This combination should be translatable to the clinic and other immunosuppressive c

180 Moreover, our device is easily translatable to the clinic, as the ergonomics, visual ou

181 c brain regions, this neuroimaging approach, translatable to the clinic, promises to be useful in exp

182 , with special emphasis on advances that are translatable to the clinic.

183 localized bacterial infections that could be translatable to the clinic.

184 mor hypoxia noninvasively and is immediately translatable to the clinic.

185 hroughput, are expensive, and are not easily translatable to the clinic.

186 nt implications in understanding ICV and are translatable to the clinical setting.

187 These efforts are directly translatable to the development of sensitive detection o

188 This promise, however, is not directly translatable to the growing liver, where high rates of h

189 e to demonstrate so far that this finding is translatable to the human receptor.

190 y of purposes, these results are immediately translatable to the treatment of pancreatic cancer patie

191 Our findings are relevant, but not directly translatable, to human male infertility cases.

192 ing is a powerful new minimally invasive and translatable tool that can be used to track and quantify

193 burden in atheromata, providing a clinically translatable tool to identify inflamed plaques and to mo

194 ed increased expression of the shorter, more translatable transcript and decreased expression of the

195 ltrasound molecular imaging using clinically translatable vascular endothelial growth factor receptor

196 geting myelinating Schwann cells that can be translatable, we delivered a lentiviral vector using a s

197 Furthermore, accumulation of translatable zygotic mRNAs is minimal in 1-cell embryos