ライフサイエンスコーパス: translate

1 critically their likelihood to be clinically translated.

2 small open reading frames within lncRNAs are translated.

3 e transcribed into RNAs that are spliced and translated.

4 ape nonsense-mediated decay are not actively translated.

5 when all expressed ribosomes are constantly translating.

6 Here, we translate 3D-microscopy techniques (focused ion beam nan

7 elivers aminoacyl tRNAs to the A-site of the translating 80S ribosome.

8 pe transcriptome, and thus are programmed to translate a bloodstream-form type proteome upon entry in

9 rates are dominated by the time required to translate a given transcript.

10 echanism by which a common signaling pathway translates a specific nutrient signal into physiological

11 pt to solve both problems simultaneously, by translating a given set of mechanisms into the state var

12 That is, the efficiency of translating a particular codon is influenced by the natu

13 IV GagPol involves a proportion of ribosomes translating a U6A shift site at the distal end of the ga

14 These results are therefore essential for translating abnormalities of human WM and effects of DBS

15 and female) either pursued a small spot that translated across a screen, or fixated it as it remained

16 ns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) study between April 1, 2010, and October

17 y support a mechanism wherein CTCF serves to translate alphaKG-sensitive metabolic changes into conte

18 um computers require appropriate software to translate and optimize applications (toolflows) and abst

19 ations, including nascent polypeptides being translated and post-translationally modified proteins.

20 acetylcholine receptor 4 (M4) is excessively translated, and synthesis of M4 downstream of mGlu5 acti

21 ch, it represents an essential first step in translating animal data into the clinic.

22 Gland cells translate APs into touch-inducible JA signaling that pro

23 In addition, the number of differentially translated APs was elevated following stress.

24 his we found that our recombinant mRNAs were translated as efficiently as the host cell transcriptome

25 o inosine (I) residues that are subsequently translated as G.

26 pombe Both fission yeast and human Sde2 are translated as inactive precursor proteins harbouring the

27 different mRNAs within the NDT80 regulon are translated at different times during sporulation.

28 we demonstrate that many human proteins are translated at noncanonical TISs.

29 a 50% reduction of a transcription factor is translated at the cis-regulatory level into a malignant

30 ieved that they had a good understanding for translating basic science research into clinical practic

31 etection presents itself as a major means of translating biological data into clinical applications.

32 r discovery studies, while the role of MS in translating biomarker candidates to clinical diagnostics

33 , we addressed how cytokine-responsive cells translate brief cytokine exposure into phenotypic change

34 These data were translated by assessing human neutrophil-endothelial int

35 ggest that Ca(2+) -sensitive SK channels can translate changes in cellular Ca(2+) into a repolarizing

36 Their Ca(2+) -dependent activation translates changes in cellular Ca(2+) into a repolarizin

37 sine represents an endogenous mechanism that translates changes of the brain state into a shift of th

38 sical Rosetta Stone, the Hechtian Hypothesis translates classical AGP function as a Ca(2+) capacitor,

39 at are both significantly enriched in slowly translated codons and evolutionarily conserved.

40 e results provide further evidence that fast-translating codons can be as biologically important as p

41 hese features allow presynaptic terminals to translate complex firing frequencies and tune the amount

42 dditive manufacturing (AM) alias 3D printing translates computer-aided design (CAD) virtual 3D models

43 ction of off-target effects is important for translating CRISPR-Cas9 nucleases into human therapeutic

44 to understand the mechanisms by which TRPV1 translates diverse stimuli into channel opening.

45 G binding proteins play an essential role in translating DNA methylation marks into a downstream tran

46 redicts both eye movements and perception of translating dot patterns.

47 aders are expressed that are not efficiently translated due to the presence of multiple small open re

48 Cells use biochemical networks to translate environmental information into intracellular r

49 the structure of a quaternary complex of the translating Escherichia coli ribosome, the SRP-SR in the

50 antagonism) of mGluR5 modulation required to translate existing knowledge into improved therapies.

51 or 828 of these annotations were analyzed by translating experimentally known fragmentation rules of

52 ubstrate and by catalyzing the reaction that translates external cues into biological responses.

53 ensure prompt appropriate clinical action to translate faster diagnostic test results in the laborato

54 A critical challenge to translating field effect transistors into biochemical se

55 st range specificity, making it difficult to translate from animal models to humans.

56 for mitochondrial disorders are beginning to translate from bench to bedside along the paths of neuro

57 The putative alternative proteins translated from altORFs have orthologs in many species a

58 apparatus in which the food could be rapidly translated from the center of the arena.

59 Herein I show that, translated from the dynamic nanoscale assemblies in cell

60 the narrow therapeutic index drug tacrolimus translates from healthy volunteers to individuals receiv

61 e marker NeoR to be a highly transcribed and translated gene.

62 bacterial extracts used for transcribing and translating gene sequences into proteins as well as the

63 ing CRPAs to each patient is a new method of translating genotype to phenotype.

64 The internally translated GJA1-20k isoform stabilizes actin filaments,

65 toxicological impact and the limitations in translating graphene materials into advanced clinical to

66 dscape controlled by mTORC1 to integrate and translate growth signals into an oncogenic metabolic pro

67 vitro-in vivo extrapolation (IVIVE) analyses translating high-throughput screening (HTS) data to huma

68 CYCB transcripts can be exported and translated; however, CDC20 and CCS52B mRNAs are confined

69 om the phototransduction pathway in the skin translates illumination differences and generates retino

70 c understanding, these findings were reverse translated in a mouse model of acute social defeat stres

71 efine candidate transcripts that are locally translated in astrocyte processes.

72 where we identify a subset of mRNAs that are translated in dendrites by neuronal ribosomes.

73 from the surface and endocytosed NPs, which translated in enhanced proteasome inhibition and robust

74 Ribosomal proteins are translated in the cytoplasm and imported into the nucleu

75 ociated with loss of global DNA methylation, translating in decreased fitness.

76 to provide a more objective perspective when translating in vitro or in vivo observations into the cl

77 ugs in tumors using PET has the potential to translate into a clinically useful imaging tool for indi

78 w gaining a deeper understanding of GxEs may translate into a therapeutic practice with more targeted

79 In order for human microbiome studies to translate into actionable outcomes for health, meta-anal

80 id leukemia (AML) progression, which did not translate into an OS difference.

81 ng this near-source chemical feature did not translate into better downwind peak estimates of single

82 f several transcription factor networks that translate into cell division activity during the early d

83 y to determine if these physiologic benefits translate into clinical improvement and outweigh the ris

84 warranted to see if our preliminary findings translate into clinical outcomes.

85 that promote nutritious foods alone may not translate into clinically meaningful diet-related health

86 tain stem-like and niche cell phenotypes can translate into effective anti-cancer therapies.

87 , respectively, at C/10 and C/5 rates, which translate into high areal, gravimetric, and volumetric c

88 nefits observed in these 48-week trials will translate into improvements in bone and renal health in

89 mputational or experimental-this ability may translate into informed prediction of improved catalysts

90 in the management of immune thrombocytopenia translate into more women contemplating pregnancy while

91 difications to the inter-ionic forces, which translate into nuclear stopping power well above the adi

92 is unclear whether volume changes over time translate into predictable outcome changes.

93 r, increased transcript levels do not always translate into protein production, and therefore simulta

94 bivalirudin arm of the EUROMAX trial did not translate into reduced cardiovascular or all-cause death

95 control of remote sites of inflammation may translate into reduced coronary artery disease risk.

96 optimizing immunotherapy, which will in turn translate into remission and long-term survival in this

97 enchmark service, we show that these changes translate into substantial improvement on multiple empir

98 rent, conductive, capacitive electrodes, and translate into technologically viable devices for next-g

99 top codon read-through allowing ribosomes to translate into the 3-end of mRNAs.

100 The failure of this system in ALS may translate into the split hand presentation, gait disturb

101 derstand how genetic signatures of selection translate into variation in fitness and phenotypes.

102 ve symptoms in the discovery study, which is translated into 3.8% of the total estimated heritability

103 line in ROS production and a G1/S block that translated into a 2-3-fold increase in tumor cell doubli

104 d, the favorable energetic effects in the WG translated into a 92-kcal/d (95% CI: 28, 156-kcal/d) hig

105 d with the "fluoride-rebound" mechanism, was translated into a protocol for the synthesis of (18)F-ra

106 enesulfonate (3-NBS) were optically trapped, translated into a solution containing cytochrome c, and

107 penetration of the tumor extracellular fluid translated into a strong anti-tumor effect prolonging su

108 blueshift of the absorbance of CaSPA, which translated into an accompanying decrease of the peak pho

109 e with SAFIRE than with FBP (P = .03), which translated into an estimated radiation dose reduction po

110 me apparent nanoscale roughness that was not translated into an increased electrochemical active surf

111 , weather variations in 103 source countries translated into asylum applications to the European Unio

112 wn about how exposure to childhood trauma is translated into biological risk for psychopathology.

113 s by which localized biochemical signals are translated into cell-level responses is poorly understoo

114 , and other cardiovascular diseases, must be translated into changes in food patterns, aiming to incr

115 er, few nanomedicines have been successfully translated into clinical application.

116 microfluidic point-of-care testing has been translated into clinical applications to support a promp

117 erapeutic approaches have been validated and translated into clinical practice.

118 of D1R stimulation in the dlPFC that can be translated into clinical practice.

119 he algorithms presented here can be directly translated into clinical-use with any quantitative data,

120 vide actionable insights that can be rapidly translated into CSC-specific therapies.

121 Sensory information is translated into ensemble representations by various popu

122 These findings were translated into health burdens using a dose-response cur

123 bsorption coefficient of graphitic CDs to be translated into high charge extraction for efficient pho

124 t them by violently depriving them of it-has translated into hundreds of health workers killed, hundr

125 positive effects of training have not always translated into improved cognitive functioning and often

126 of NP-mediated drug delivery has not always translated into improved survival of cancer patients, in

127 These effects translated into inhibition of superantigen-induced Th1 c

128 The Moral Distress Scale-Revised was translated into Italian and administered along with a me

129 This progress has translated into major advances in the treatment of advan

130 re at a point that they can be realistically translated into novel diagnostic tests and treatments.

131 w complex developmental-genetic networks are translated into organs with specific 3D shapes remains a

132 be accounted for before such insights can be translated into policy.

133 of some upregulated antioxidant genes to be translated into protein.

134 This translated into reduced energy intake in a breakfast buf

135 The signaling defect translated into reduced induction of Bcl-xL and IkappaBa

136 nitric oxide and TNFalpha production, which translated into reduced microglial toxicity towards dopa

137 n about how cues from fluid shear stress are translated into responses that pattern artery developmen

138 nd 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated

139 Because these risk levels can be readily translated into standard drink equivalents per day of di

140 9 on sleep-wake states indicated long RT was translated into sustained inhibition of rapid eye moveme

141 These findings are now being translated into the clinic in several trials currently u

142 to refine their activity before they can be translated into the clinic.

143 Thus, how detection of U:G mismatches is translated into the single-strand nick required for erro

144 hat increases in photosynthesis are directly translated into yield at subambient levels of Ca .

145 rbation provided by the pyrene functionality translates into a 150 mV lower overpotential for 2(2-) w

146 CG models which retain chemical specificity translates into a direct path to the rational design of

147 The multitude of bioinformatic work also translates into a multitude of credit-distribution arran

148 w that the resulting enhanced coherence time translates into a significantly enhanced precision for q

149 ition towards a defective fluorite structure translates into a tunable density of anion Frenkel disor

150 d sustained NOTCH1-receptor signaling, which translates into activation of a broad transcriptional pr

151 nterest since their rich phase diagram often translates into an equally rich out-of-equilibrium behav

152 However, how neuronal irregularity actually translates into behavioural variability is unclear.

153 her and how knowledge of genetic relatedness translates into differential neurocognitive evaluation o

154 n CRF is in excess, sex-biased CRF1 coupling translates into divergent cell signaling that is express

155 a-arrestin recruitment is mandatory and this translates into efficient reduction of the number of cir

156 r cases than limited screening, whether this translates into improved patient outcomes remains unclea

157 Anatomical transcriptional diversity translates into joint-specific synovial fibroblast pheno

158 so decreases cold ischemia time, potentially translating into a higher success rate.

159 and more appropriately sized stents, perhaps translating into lower risk of subsequent stent thrombos

160 a mix of baseline and periprocedural factors translating into poorer clinical outcomes.

161 Translating IR/DR regulation to in vitro evolution yield

162 egrate information from multiple sources and translate it into an appropriate response sequence.

163 anisms by which cells sense ECM geometry and translate it into changes in shape and migration directi

164 dentified a mechanotransduction pathway that translates laminar flow-induced shear stress to activati

165 However, non-AUG uORFs are translated less efficiently than AUG-uORFs and are less

166 alysis based on protein sequences showed the translated MBF1 proteins of the newly isolated mbf1 gene

167 Translated MBP exhibits extreme microheterogeneity with

168 NOMPC architecture underscores the basis of translating mechanical force into an electrical signal w

169 Block polymer self-assembly typically translates molecular chain connectivity into mesoscale s

170 ver, there is little understanding of how to translate monomer sequence to physical material properti

171 optimal for gene expression because they are translated more slowly than common codons.

172 organoids grew larger, setting the stage to translate mouse model findings to precision medicine in

173 re the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and

174 We found that the expression of astroglial translating mRNAs closely follows the dorsoventral axis,

175 host shutoff by analyzing total and actively translating mRNAs in a genome-wide manner.

176 X syndrome (FX); however, the differentially translating mRNAs that contribute to altered neural func

177 transcripts, particularly those that will be translated (mRNAs) from the class of long non-coding RNA

178 d astroglial ribosome-associated (presumably translating) mRNAs in major cortical and subcortical bra

179 g targets redistribute from polysomes to non-translating mRNPs, and recapping is all that is needed f

180 ected through the channel are compressed and translated orthogonally to the channel length, while sof

181 ceptor potential vanilloid 4 (TRPV4) channel translates osmotic stress into ion flux.

182 To translate our findings into a therapeutic strategy, we k

183 We translated our findings to two murine models of lung can

184 As a proof of concept, we translated our murine data to the transcriptome data of

185 pathogenesis, and support the feasibility of translating pioglitazone as a novel pharmacotherapy of P

186 s all that is needed for their return to the translating pool.

187 In this work, we introduce a new concept for translating radioactive decays occurring stochastically

188 The transmitted silver signal is translated rapidly into a dramatic speed change associat

189 The platform was rotated or translated relative to the room frame of reference.

190 nd to find implementation interventions that translate research evidence into clinical practice.

191 , or survival highlighting the challenges of translating results between in vitro and in vivo models.

192 ntology, adult-brain gene lists generated by Translating Ribosome Affinity Purification (TRAP) and CR

193 Translating ribosome affinity purification (TRAP) and in

194 We used translating ribosome affinity purification (TRAP) and RN

195 Furthermore, translating ribosome affinity purification and single-ce

196 y and further show that PRV circuit-directed translating ribosome affinity purification can be broadl

197 Translating ribosome affinity purification is a method i

198 gnal recognition particle (SRP) binds to the translating ribosome displaying the signal sequence to d

199 we measured the absolute abundance of RPs in translating ribosomes and profiled transcripts that are

200 f Molecular Cell, Shi et al. (2017) identify translating ribosomes which lack specific proteins and a

201 As and rRNAs, thereby placing the protein on translating ribosomes.

202 rowth, indicating that it is accommodated by translating ribosomes.

203 These results translate risk into potential mechanisms of pathogenesis

204 A few proteins are translated selectively and influence cell fate.

205 icking and that Cx43 has a 20 kDa internally translated small C terminus isoform, GJA1-20k (Gap Junct

206 The prediction of translated small ORFs (sORFs) by quantitation of transla

207 investigators have questioned the ability to translate SPRINT results into routine clinical practice,

208 ribosomes with differential selectivity for translating subpools of transcripts, including those con

209 r pathways that control palatogenesis and to translate such information for the development of noninv

210 the inner membrane are generally less highly translated than other genes.

211 to understand their biologic function and to translate that knowledge into clinical practice.

212 esenting processed visuospatial information, translates that information into programs for particular

213 technologies create opportunities to rapidly translate the analysis of DNA into tools that can identi

214 To translate the findings from SPRINT to clinical practice,

215 Therefore, this study aimed to translate the Gastrointestinal Symptom Rating Scale for

216 e this phenomenon, a method to appropriately translate the nanojet on top of a region of interest is

217 lenges that must be overcome to successfully translate the reviewed technologies from research platfo

218 nd genetic mouse models of NAFL and NASH and translated the results to humans by correlating the spat

219 After translating the CAM-ICU into Arabic language, the Arabic

220 ce of a conceptual framework and toolkit for translating the evidence into practice.

221 Translating the genetic and epigenetic heterogeneity und

222 pursued for various targets, the progress on translating the proof-of-concepts to commercially viable

223 Translating the readily available genomic data into usef

224 E-EK approach, which holds great promises in translating the use of cultured CEnCs into the clinic.

225 volution of triphosphorylating ribozymes and translate their fitnesses into absolute estimates of cat

226 use internal ribosome entry sites (IRESs) to translate their genomes into protein.

227 e genetic code-the language used by cells to translate their genomes into proteins that perform many

228 roteins (GBPs) recognize specific glycans to translate their structures to functions in various physi

229 nal evidence to map disease associations and translate them into clinical applications.

230 rthermore, they establish a feasible path to translate these findings against clinically relevant dis

231 The aim of the present study was to translate these findings into preclinical applications u

232 To translate these findings to a more relevant cell type, w

233 In this fMRI study, we attempted to translate these findings to humans.

234 t sequencing, better methods are required to translate these human genetic findings into improvements

235 The main goal of our response is to translate these issues into testable empirical predictio

236 exhibited preclinical efficacy, attempts to translate these studies to the clinic have failed thus f

237 Radiomics is an emerging field that translates these medical images into quantitative data t

238 n animal models, which will be a key step to translating these findings into clinical practice.

239 Before translating these findings into routine clinical practic

240 However, translating these laboratory findings into effective cli

241 d for visual scene recognition, but ants can translate this acquired directional information into a h

242 In order to safely translate this approach to humans, a more in-depth knowl

243 Here we translate this concept into an operational definition at

244 iring through changes in calcium influx, and translates this into compensatory changes in excitatory

245 ere is currently no systematic framework for translating this information into patient-specific predi

246 f asthma to understand causal mechanisms and translating this knowledge into personalized prevention

247 brain updates specific goals on the fly, and translates those updates into choices, have remained unk

248 In practical spectroscopy, this can translate to advantages, which include a high selectivit

249 erstanding of how changes at single synapses translate to an entire population of neurons.

250 isk point scores, assuming that those scores translate to fixed stroke rates.

251 script gradients, and demonstrate that these translate to gradients in protein accumulation and gradu

252 selective fungal culture media, and this may translate to important clinical decisions.

253 ra- and intermolecular interactions that can translate to improved pharmacological profiles.

254 xpressions of these tumor suppressive miRNAs translate to patient survival were not investigated in l

255 That sex-biased exposure might translate to sex-specific adverse outcomes such as behav

256 tency of site II-specific antibodies did not translate to significant in vivo dose sparing.

257 microstructural changes in the dentate gyrus translate to the severity of hippocampal sclerosis and s

258 We also show that tension stimulation can be translated to a human cell source to generate anisotropi

259 easing experience of operators/centers, have translated to a major reduction in periprocedural compli

260 ure to increased serum calcium levels can be translated to a risk associated with short-term to mediu

261 alphabeta and gammadelta TCRs, which in turn translated to a stronger, and more polyfunctional, respo

262 ation of internally valid causal effects are translated to apply to the identification of externally

263 er, how chirality at one length scale can be translated to asymmetry at a different scale is largely

264 ent in cancer therapy, and how this could be translated to clinical practice.

265 al and practical frameworks that can then be translated to conditions that permit replicating systems

266 ive development in Arabidopsis that could be translated to crops for increased agricultural productiv

267 a patients; however, this theory needs to be translated to humans.

268 These strategies can be translated to improve the performance of computational s

269 cular imaging approach we developed could be translated to investigate these imaging biomarkers for t

270 This translated to lower cumulative and annual healthcare cos

271 at mechanisms intrinsic to glioma cells have translated to only limited success; effective therapeuti

272 ing action of ES on AR and GR can be further translated to PCa therapy.

273 ich known related structures are rotated and translated to provide an initial atomic model for the ne

274 a cell frequencies postinfection and if this translated to reduced viremia.

275 the open-water season and how these changes translated to the growth and condition of individual fis

276 The importance of these findings translated to the natural host, where the AddAB system w

277 enal clearance and high compatibility can be translated to the non-human primates: no adverse effects

278 e complete revascularization, a finding that translates to 8 and 21 events per 100 patients, respecti

279 se in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potent

280 eased consumption of nitrate-rich vegetables translates to a lower risk of atherosclerotic vascular d

281 g in a quick burst of flower production that translates to an early yield.

282 This finding translates to an estimated variability in population pre

283 Whether this translates to an increased risk is unknown and requires

284 This incidence translates to approximately 4 (2-6) additional stillbirt

285 ter understand how in vivo targeting of CD22 translates to human disease are needed.

286 ubular sodium reabsorption, but whether this translates to human DR is unknown.

287 Intriguingly, this finding also translates to large networks of type-II phase oscillator

288 Activity also translates to M. tuberculosis, with a lead compound from

289 , dendritic cells, and innate lymphoid cells translates to T-cell outcomes, with an emphasis on the a

290 oss the thalamus, but whether this diversity translates to thalamic functions beyond relaying informa

291 at 7 years with ezetimibe/simvastatin, thus translating to a number-needed-to-treat of 16.

292 peat expansion in the Huntingtin (HTT) gene, translating to an elongated glutamine tract in the hunti

293 th poorer mental and physical health (7,8) , translating to high economic burden (9) .

294 perties on industrial device performance and translating unique nanoscale properties to the macroscal

295 t prophase, and the cognate proteins are not translated until the redistribution of the mRNAs to the

296 ing external milieu, human cells efficiently translate upstream signals into post-translational modif

297 ds to isosmolar cell swelling and osmolarity translated via different aquaporins.

298 s replication in hepatocytes, likely because translated viral proteins are unable to transfer from th

299 effectively captures population dynamics and translates well to a predictive framework.

300 The codon-optimized mMOMP gene was co-translated with Delta49apolipoprotein A1 (Delta49ApoA1),