ライフサイエンスコーパス: translation

1 es in maintaining the accuracy of mRNA codon translation.

2 CD200(+) leukemia cells, supporting clinical translation.

3 e repression and thereby facilitates VAR2CSA translation.

4 ce protein and a gene-specific inhibition of translation.

5 rgy production and the regulation of protein translation.

6 s full-length eIF2Bepsilon to inhibit global translation.

7 localization by altering their length and/or translation.

8 n shown to have a negative effect on protein translation.

9 lacking regulatory elements that guide local translation.

10 localization by providing local control over translation.

11 and have high potential for future clinical translation.

12 E. coli gene regulation, transcription, and translation.

13 ntribute to the coupling of transcription to translation.

14 ll activation are controlled at the level of translation.

15 -controlled Ca(2+) release as well as active translation.

16 tion factor 2alpha to inhibit global protein translation.

17 rapidly growing cells does not contribute to translation.

18 ting and was therefore selected for clinical translation.

19 timely tRNA and mRNA binding and error prone translation.

20 for maturation of functional tRNAs and mRNA translation.

21 relieves its inhibitory activity on RP mRNA translation.

22 n in Proteobacteria without interfering with translation.

23 wn to require RPL10A/uL1 for their efficient translation.

24 ies-specific specialization of mitochondrial translation.

25 nd highlights how it can accelerate clinical translation.

26 UTR), which affect both mRNA copy number and translation.

27 1 (Sin1), which resulted from enhanced Sin1 translation.

28 originated primarily in the pioneer round of translation.

29 s before being exported to the cytoplasm for translation.

30 of acquisition are key barriers to clinical translation.

31 global effects on mRNA repair and ribosomal translation.

32 through the regulation of mRNA stability and translation.

33 mTOR inhibitors by inducing cap-independent translation.

34 es (RNPs) that form the substrate for axonal translation.

35 5'UTR is necessary for Pdcd4 to inhibit Sin1 translation.

36 these should be incorporated more to enhance translation.

37 nd are presumably recycled for new rounds of translation.

38 c acids therapeutics for successful clinical translation.

39 ds TOP mRNAs, regulating their stability and translation.

40 and revealing novel modes of cap-independent translation.

41 ced degradation of the mRNA or inhibition of translation.

42 N2-methylguanosine (m2G) moderately impeded translation.

43 e levels of mRNA stability, localization and translation.

44 ulating energy-consuming processes including translation.

45 ism of action suggest that compound 8 blocks translation.

46 o depth that commonly arises during observer translation.

47 ally occurs via changes in transcription and translation.

48 hanges in poly(A) tail length influence mRNA translation.

49 systems science, with an emphasis on science translation.

50 ucleocapsid protein (CCHFV-NP) augments mRNA translation.

51 nimize their toxicity in the future clinical translation.

52 ty but little is known about their impact on translation.

53 livery and could further facilitate clinical translations.

54 leting 4EBP1, an mTORC1 target that inhibits translation, alleviated the dependence of HH signaling o

55 rate a connection between the elevated Adcy1 translation and abnormal ERK1/2 signalling and behaviour

56 ctivity links development with maternal mRNA translation and ensures irreversibility of the oocyte-to

57 maining approximately 80% of the variance in translation and explains approximately 5% of the varianc

58 Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling.

59 eIF2alpha), leading to repression of general translation and latency induction.

60 d activation of dHSCs by restricting protein translation and levels of reactive oxygen species (ROS)

61 the mechanism by which FMRP mediates protein translation and neural network activity, we demonstrated

62 -2 (Mdm2), is required for Gp1 mGluR-induced translation and neural network activity.

63 these upstream sites, differentially skewing translation and protein expression.

64 e central dogma panel include transcription, translation and protein maturation and folding.

65 e show that despite widespread reductions in translation and protein synthesis, certain oncogenic mRN

66 ch invert the programmed local speed of mRNA translation and provide direct evidence for the central

67 e a cellular environment that promotes viral translation and replication.IMPORTANCE RNA viruses encod

68 hat IRF5 re-expression inhibited HCV protein translation and RNA replication.

69 cap-independent translation element-mediated translation and show that the functional core domain of

70 MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and pla

71 ot affected by inhibition of eIF4E-dependent translation and such expression was dependent on a conti

72 ge repeatability 'r') from computed pairwise translations and then minimizes stitching errors by opti

73 es not bind to eIF4A, failed to inhibit Sin1 translation, and consequently failed to repress mTORC2 a

74 monitoring, analysis, integration, knowledge-translation, and data archiving phases of CAN-BIND proje

75 We provide the PLatform for the Analysis, Translation, and Organization of large-scale data (PLATO

76 ctor 4A (eIF4A), sufficiently inhibited Sin1 translation, and thus suppressed mTORC2 kinase activity

77 al protein synthesis and increased uORF mRNA translation are followed by normalization of protein syn

78 nscriptional factors, genes involved in mRNA translation are highly represented in our interactome re

79 ds due to defects in pigment biosynthesis or translation are known to repress photosynthesis-associat

80 The signals controlling differential translation are poorly understood.

81 osphorylation-mediated inhibition of protein translation as a critical mediator of the antileukemic e

82 vels were increased, suggesting impaired ECD translation as the mechanism for reduced protein levels.

83 ormative mixed methods design with knowledge translation as the theoretical framework.

84 A cell-free in vitro translation assay containing human cell lysate and purif

85 N184X mutation triggers the reinitiation of translation at a third start codon in SPAST, resulting i

86 A leaky-scanning model of translation based on Kozak translation initiation sequen

87 omous clocks are composed of a transcription-translation-based autoregulatory feedback loop.

88 e glutaminolysis is necessary for early gene translation but not transcription.

89 editing alters gene expression by modulating translation (but not RNA stability or localization).

90 sions of (52g)Mn are prohibitive to clinical translation, but the short-lived (51)Mn (t1/2: 46 min, b

91 proteins that are initially cytosolic after translation, but then become stably attached to the cell

92 cation of natural compounds that induce Nrf2 translation by a mechanism independent of Keap1-mediated

93 trate that eIF4E regulates HAV IRES-mediated translation by two distinct mechanisms.

94 This suggests that kinetic properties of translation can determine the spatial organization of th

95 ependent and that mechanisms regulating mRNA translation, cell cycle progression, and gene expression

96 These findings imply a mode of translation control whereby, as an upstream effector of

97 The effects of methylated ribonucleosides on translation could be attributed to the methylation-elici

98 We reasoned that translation could be specifically enhanced using trans-a

99 erent functional states during transcription-translation coupling.

100 Excessive mRNA translation downstream of group I metabotropic glutamate

101 Ribosomes can stall during translation due to defects in the mRNA template or trans

102 red for both the early and late phase of Arc translation during mGluR-LTD, through a mechanism involv

103 ting the uORFs results in markedly increased translation efficiencies in luciferase reporter assays.

104 l, RiboDiff, to detect genes with changes in translation efficiency across experimental treatments.

105 Messages with high translation efficiency were more robustly repressed.

106 ed predicted SD-aSD interactions and reduced translation efficiency.

107 es translational repression by affecting the translation efficiency.

108 r the helicase complex in 3' cap-independent translation element-mediated translation and show that t

109 n speed in fungal systems, but its effect on translation elongation speed in animal systems is not cl

110 Codon optimality has been shown to regulate translation elongation speed in fungal systems, but its

111 resents two parallel kinetic pathways during translation elongation, underscoring the ability of E-si

112 this study, we report that the P. falciparum translation enhancing factor (PTEF) relieves upstream op

113 nisms intervene appropriately when defective translation events occur, in order to preserve the integ

114 n aminoacyl tRNA synthetase, AspRS, and in a translation factor needed for efficient proline-proline

115 The translation factors, elongation factor G and ribosome re

116 ore of the mammalian circadian transcription/translation feedback loop.

117 ress response and differential regulation of translation, fermentation, and amino acid biosynthesis.

118 One reason for such poor translation from drug candidate to successful use is a l

119 ents in stroke has been a notable failure of translation from medical research into clinical practice

120 Rapid translation from neurodevelopmental discovery to clinica

121 The translation from numerous successful animal experiments

122 We examined the potential translation function of suppressor tRNA species in Esche

123 being designed renal clearable for clinical translation, fundamental understanding of their transpor

124 tially lead to enhancement of transcription, translation, gene regulation, and other aspects of cellu

125 udy of ribosome structure and the process of translation in bacteria since the development of this te

126 een documented their effect on authentic HIV translation in cellulo has remained elusive until now.

127 al profiling provides valuable insights into translation in CHO cells and can guide efforts to enhanc

128 Local mRNA translation in growing axons allows for rapid and precis

129 ZA is entirely independent of RpsA and trans-translation in M. tuberculosis.

130 s, suggesting that MPF is required for their translation in mouse oocytes.

131 Local translation in neuronal processes is key to the alterati

132 We show that R-motif regulates translation in response to pattern-triggered immunity in

133 ro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31.

134 strate SynapTRAP's efficacy and report local translation in the cortex of mice, where we identify a s

135 ective erythropoiesis, highlighting heme and translation in the regulation of erythropoiesis.

136 sforming growth factor (TGF)-beta1 to -beta3 translation in vitro and in vivo.

137 duce tRNA fragments that function to repress translation in vivo.

138 on therapies deemed immediately tractable to translation included ABT-263/crizotinib, ABT-263/paclita

139 ural plasticity likely underlie this form of translation-independent memory.

140 d sensitivity of the double rnhAB mutants to translation inhibition points to R-loops as precursors f

141 site with other imide-based natural product translation inhibitors, CL engages in a particularly int

142 ge for the structure-guided design of better translation inhibitors.

143 ed using ASOs designed to hybridize to other translation inhibitory elements in 5' UTRs.

144 We find that C9RAN translation initiates through a cap- and eIF4A-dependent

145 The development of the translation initiation (TI) sequencing (TI-seq) techniqu

146 substitutions of these residues reduce bulk translation initiation and diminish initiation at near-c

147 all, this study provides evidence of protein translation initiation at noncanonical TISs and argues t

148 has been shown that non-AUG or noncanonical translation initiation can also occur.

149 ntly increases phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in

150 out (PERK-KO) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse e

151 h activating pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

152 d4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently i

153 ate the importance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production

154 rget of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-bind

155 e based on mutations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their

156 fold, which was not observed before in other translation initiation factors.

157 In the human genome, translation initiation from non-AUG codons plays an impo

158 Translation initiation generally occurs at AUG codons in

159 Translation initiation is a key step in the regulation o

160 Global reductions in translation initiation resulting from mutations in the t

161 scanning model of translation based on Kozak translation initiation sequences alone does not adequate

162 e Shine-Dalgarno sequence towards a stronger translation initiation signal.

163 protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha.

164 functional implications of such noncanonical translation initiation.

165 nd the function of the PABP-eIF4G complex in translation initiation.

166 adjacent probable RNA-binding domain mediate translation initiation.

167 ors of pre-mRNA splicing, nuclear export and translation-interact with RNA in different cellular comp

168 A testing and monitoring, and to promote its translation into clinical bedside practice for stroke ma

169 cal PET imaging agents and the potential for translation into human patients.

170 types and presents a promising approach for translation into the clinical setting.

171 l analyses indicate that astrocyte-localized translation is both sequence-dependent and enriched for

172 Taken together, dysregulation of mRNA translation is emerging as a unifying mechanism underlyi

173 eurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production

174 es that demonstrate that holistic multiscale translation is essential to biomimetic design.

175 COX1 mRNA can occur, activation of COX1 mRNA translation is impaired.

176 Conversely, Ccnb2 translation is insensitive to Cdk1 inhibition.

177 A key mechanism for modulating translation is through phosphorylation of the alpha subu

178 e results indicate that Pdcd4-inhibited Sin1 translation is through suppressing eIF4A, and functional

179 Eukaryotic translation is tightly regulated to ensure that protein

180 Translation is typically not thought to initiate from th

181 rt domain (55 degrees in rotation and 8 A in translation) lead to access of the substrate binding sit

182 bosomal protein S1 (RpsA) and inhibits trans-translation leading to accumulation of stalled ribosomes

183 ined UGA opal codon by means of Sec-specific translation machineries.

184 esses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-binding

185 ns mRNAs coding for proteins involved in the translation machinery, known to be highly codon biased a

186 ation due to defects in the mRNA template or translation machinery, leading to the production of inco

187 Shutdown of this translation mechanism might selectively impact viral pro

188 latomes is incompatible with cap-independent translation mediated by internal ribosome entry sites (I

189 e applied beyond Immunology, and serve as a "translation method" for the biochemical characterization

190 ed analysis of this naturally occurring post-translation modification in neurodegenerative diseases a

191 ndoplasmic reticulum (ER) supports dendritic translation, most dendrites lack the Golgi apparatus (GA

192 artefacts caused by the use of inhibitors of translation (notably cycloheximide).

193 ockdown/knockout significantly increased the translation of 5'Sin1-Luc but not the control luciferase

194 unction downstream of mTORC1 to regulate the translation of 5'TOP mRNAs such as those encoding riboso

195 consequence of linear models is that faster translation of a given mRNA is unlikely to generate more

196 phorylation of ser209 on eIF4E regulates the translation of a subset of mRNAs.

197 2 to lower the stability of and suppress the translation of ACOT7 mRNA.

198 er RNAs (mRNAs) and selectively enhances the translation of activating transcription factor 4 (ATF4)

199 d to the added tetracycline, which represses translation of aptamer-containing mRNAs.

200 me profiling reveals that m(6)A promotes the translation of c-MYC, BCL2 and PTEN mRNAs in the human a

201 asome pathways might synergistically inhibit translation of c-Myc.

202 The MSI2 RBP is a central regulator of translation of cancer stem cell programs.

203 sulin processing by regulating cap-dependent translation of carboxypeptidase E in a 4EBP2/eIF4E-depen

204 re CGG RNA sequesters specific proteins, and translation of CGG repeats into a polyglycine-containing

205 To further explore the translation of closed-loop TES for treatment of epilepsy

206 The prevailing model was that the slow translation of codons decoded by rare tRNAs reduces effi

207 essory protein STRAP, needed for coordinated translation of collagen mRNAs.

208 etic variant in the 5' UTR of DDX39B reduces translation of DDX39B mRNAs and increases MS risk.

209 transcriptional induction more strongly than translation of DNA replication, survival, and DNA damage

210 We find that translation of dyrk1a, a Down syndrome- and autism spect

211 les within computational workflows limit the translation of existing methods to the clinic.

212 ts outnumbering mechanistic studies and slow translation of experimental results obtained in animal m

213 s eIF2alpha (eIF2alphaP), which inhibits the translation of globin messenger RNAs (mRNAs) and selecti

214 three introns (TPL 1-3), is critical to the translation of HAdV late mRNA.

215 d levels of miR-126 and consequently reduced translation of Irs1 mRNA, the effects of a post-weaning

216 ts and DPP-4 inhibitors, with a focus on the translation of mechanisms derived from preclinical studi

217 The data also confirmed translation of miRNA target mimics and lncRNAs that prod

218 Queen dynamics emerge in our setup, and the translation of model terms and phenomenology into genera

219 t not Aurora A kinase activity, prevents the translation of Mos or Ccnb1 reporters, suggesting that M

220 However, the translation of neuromodulatory OXT effects to novel trea

221 the community to assist in the discovery and translation of new therapeutic approaches for cancer.

222 evant populations are necessary steps in the translation of non-traditional biomarkers in nephrology

223 trate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall a

224 so, the initial production of IFN-gamma uses translation of preformed mRNA.

225 roduction of L-malic acid, which affects the translation of RecN, the first protein recruited to DNA

226 in the Salmonella flgM gene, the effects on translation of replacing codons Thr6 and Pro8 of flgM wi

227 Moreover, these data facilitate the translation of results across different species and acro

228 teps that need to be made to facilitate this translation of science to the clinic.

229 otein synthesis coincident with preferential translation of select mRNAs that participate in stress a

230 A can be reassigned to selenocysteine during translation of selenoproteins by a mechanism involving a

231 ic initiation factor eIF2alpha, enabling the translation of stress response genes; among these is GAD

232 recruitment of mRNAs to heavy polysomes and translation of subsets of genes.

233 In an effort to hasten and streamline the translation of the DSM-5 criteria for PMDD into terms co

234 Here we monitored translation of the mammalian genome as cells become spec

235 low to mild doses of oxidants induce de novo translation of the NRF2 protein.

236 , indicating that Pum1 and Pum2 regulate the translation of their target mRNAs.

237 Clinical translation of therapies based on small interfering RNA

238 immunological disease and to accelerate the translation of these insights into therapies.

239 vs. oxidized graphenes) is essential for the translation of this material into clinical assays.

240 nd target biology, which facilitate exciting translation of this research to many areas of drug devel

241 To illustrate clinical translation of this strategy, we allometrically scaled m

242 Two fundamental challenges plague clinical translation of vaccine-adjuvants: reducing acute toxicit

243 Here, we show that translation of VEGFA mRNA in human myeloid cells is dict

244 RACK1, phosphorylation of which selects for translation of viral or reporter mRNAs with 5' untransla

245 We found that, for these viruses, translation of viral proteins is the most energetically

246 'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor ma

247 cause of excessive head motion (ie, > 0.8 mm translation per repetition time of 1.6 seconds throughou

248 transcription and mTOR-induced cap-dependent translation, pre-treatment with AR antagonists including

249 Here we measured the host mRNA translation rate during a vaccinia virus-induced host sh

250 llular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

251 substitutions have been selected to optimize translation rates at specific locations within genes.

252 We found that the mRNAs' translation rates were repressed, by up to 530-fold, whe

253 omplex is often targeted to regulate overall translation rates, and also by mRNA-specific translation

254 ificant implications on the understanding of translation regulation and the design of therapeutic mol

255 Thus, HRI coordinates 2 key translation-regulation pathways, eIF2alphaP and mTORC1,

256 tor of TOR, ROP2 coordinates TOR function in translation reinitiation pathways in response to auxin.

257 OR inactivation abolishes ROP2 regulation of translation reinitiation, but not its effects on cytoske

258 e proteins can bypass the general control of translation remains unknown.

259 mbined with a promoter-specific, fluorescent translation reporter confirmed clusters are the function

260 erlapping structure controlled the extent of translation repression.

261 However, unexpectedly, without translation reprogramming an ATF4-high/MITF-low state is

262 levels of coordination of transcription and translation responses to energy stress.

263 ng and RNA-seq uncover the impact of CsrA on translation, RNA abundance, and RNA stability.

264 these findings indicate that in prokaryotes, translation start signals are subject to weak but signif

265 highly likely that CCHFV uses an NP-mediated translation strategy for the rapid synthesis of viral pr

266 in synthesis, suggesting that an NP-mediated translation strategy is a target for therapeutic interve

267 structures using cell-based assays, in vitro translation systems, and in vivo ribosome profiling of l

268 both Escherichia coli and wheat germ extract translation systems, whereas N2-methylguanosine (m2G) mo

269 3), casein kinase 1alpha (CK1alpha), and the translation termination factor GSPT1] whose ubiquitylati

270 of the yeast prion [PSI (+)], formed by the translation termination factor Sup35.

271 sure as a result of aggregation of the Sup35 translation termination factor, which increases stop cod

272 ribosomal particles due to a dysfunction in translation termination.

273 the only example where three 3'CITEs enhance translation: the eIF4E-binding Panicum mosaic virus-like

274 is evidence for polycistronic expression via translation through an internal ribosome entry site (IRE

275 biotics that target the essential process of translation through impairment of EF-Tu function.

276 Translation through space produces one global pattern of

277 Here we use a simple stochastic model of translation to characterize the effect of mRNA propertie

278 etter prognosis for patients, but successful translation to clinical practice is hindered by the lack

279 r activity for further mechanistic study and translation to clinical trials.

280 Finally, cancer cells upregulate translation to facilitate KRAS(G12)-driven acquired resi

281 xtremely long duration of action) that limit translation to human studies.

282 To enable translation to humans, we developed baboon offspring coh

283 a1-deficient dog model to evaluate potential translation to patients.

284 entified; these were closely associated with translation, transcription, and replication.

285 f beta-cell dysfunction at the level of mRNA translation under such conditions.

286 ts beta-actin mRNA and releases it for local translation upon phosphorylation.

287 Models of mRNA translation usually presume that transcripts are linear;

288 we show that the OrzO sRNA can inhibit zorO translation via base pairing to the of the EAP region.

289 orking model of strong inhibition of protein translation via interactions of G4 with potential RNA-bi

290 east and worms was observed to increase when translation was globally slowed down, possibly due to in

291 chemically distinct macrolide inhibitors of translation, we have identified a key difference in thei

292 is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K a

293 To optimize translation, we need to assess the effect of experimenta

294 to show how this method can catalyze medical translation, we show that dosage time can temporally seg

295 l changes in steady-state mRNA abundance and translation were observed for all but 265 annotated prot

296 lved in information processing, particularly translation, which are maintained by strong selection, t

297 ng transcript localization, stability and/or translation, while changes in the coding sequences lead

298 itionally conserved sORF of TAS3a linked its translation with tasiRNA biogenesis.

299 es of cell population growth and global mRNA translation, with peak rates occurring at normal physiol

300 minimizes stitching errors by optimizing the translations within a (4r)(2) square area.