ライフサイエンスコーパス: translation initiation

1 to facilitate mTORC1-dependent induction of translation initiation.

2 gulate gene expression through inhibition of translation initiation.

3 nditions, suggesting that HPFSa may suppress translation initiation.

4 upted on the ribosome at different stages of translation initiation.

5 functional implications of such noncanonical translation initiation.

6 l processes by controlling mRNA turnover and translation initiation.

7 tem, an intricate reaction network regulates translation initiation.

8 results in a coincident global reduction in translation initiation.

9 ectly occludes ribosome binding and prevents translation initiation.

10 nteraction with eIF2.GTP at an early step in translation initiation.

11 F5B are being continuously rearranged during translation initiation.

12 ioral alterations caused by exacerbated mRNA translation initiation.

13 or of the mRNA-ribosome recruitment phase of translation initiation.

14 in insulin-resistant conditions by impairing translation initiation.

15 nits and participates in nearly all steps of translation initiation.

16 en important steps in cancer development and translation initiation.

17 to autism models involving exacerbated mRNA translation initiation.

18 /DEAH box RNA helicase, DHX33, promotes mRNA translation initiation.

19 bosomal subunits apart and prevent them from translation initiation.

20 ribosome assembly at the late stage of mRNA translation initiation.

21 ich may be essential for its function during translation initiation.

22 ing the SD sequence for ribosome binding and translation initiation.

23 s to unwind mRNA secondary structures during translation initiation.

24 lts in altered mRNA stability and/or altered translation initiation.

25 l subunit during the subunit-joining step of translation initiation.

26 or m(6)A modification of mRNA in stimulating translation initiation.

27 iency and fidelity of subunit joining during translation initiation.

28 al elongation in coupling mRNA structures to translation initiation.

29 nd the function of the PABP-eIF4G complex in translation initiation.

30 uggesting a regulatory role of processing on translation initiation.

31 ory formation was blocked by an inhibitor of translation initiation.

32 ) 5' cap to promote ribosome recruitment and translation initiation.

33 adjacent probable RNA-binding domain mediate translation initiation.

34 unctional structure involved in noncanonical translation initiation.

35 predicted to regulate mostly at the level of translation initiation.

36 During eukaryotic translation initiation, 43S complexes, comprising a 40S

37 (Eif4ebp2), encoding the suppressor of mRNA translation initiation 4E-BP2, leads to an imbalance in

38 ere, we show that a combination of inhibited translation initiation and accelerated protein degradati

39 ariety of biological processes by inhibiting translation initiation and by destabilizing target mRNAs

40 on of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in p

41 substitutions of these residues reduce bulk translation initiation and diminish initiation at near-c

42 by activating downstream targets critical to translation initiation and elongation and are known to c

43 synthesis with descriptions of the roles of translation initiation and elongation factors that assis

44 Dynamic regulation of mRNA translation initiation and elongation is essential for t

45 ctly image and quantify, for the first time, translation initiation and elongation kinetics with sing

46 hesis is blocked at several steps, including translation initiation and elongation.

47 , Mss116 is required for efficient COX1 mRNA translation initiation and elongation.

48 osomes, participating in the biochemistry of translation initiation and functioning as a counterion f

49 ogram relies on a subset tiRNAs that inhibit translation initiation and induce the assembly of stress

50 bacterial RNA binding protein that regulates translation initiation and mRNA stability of target tran

51 Leucine plays a key role in stimulating translation initiation and muscle protein anabolism and

52 conserved DEAD-box RNA helicase involved in translation initiation and other processes of RNA metabo

53 bunit of eIF2 (eIF2alpha-P), which represses translation initiation and reduces influx of newly synth

54 43S scanning, leading to premature, upstream translation initiation and reducing protein expression f

55 o determine whether leucine, a stimulator of translation initiation and skeletal muscle protein synth

56 otein synthesis, with widespread alternative translation initiation and termination, robust discrimin

57 multiple aspects of RNA metabolism including translation initiation and the assembly of stress granul

58 matically studying the general principles of translation initiation and the development of computatio

59 f transfer RNA fragments that interfere with translation initiation and thereby alleviate ER stress.

60 PABP has been found to stimulate translation initiation and to inhibit nonsense-mediated

61 plicing, stop codon readthrough, alternative translation initiation, and C-terminal truncation.

62 ajectory of IRES translocation, required for translation initiation, and provide an unprecedented vie

63 how that two distinct modes of cap-dependent translation initiation are active during physioxia and a

64 s that mediate splicing, nuclear export, and translation initiation are recruited to the transcript v

65 regates that are directly connected with the translation initiation arrest response to cellular stres

66 oping new-in-class small molecules targeting translation initiation as antineoplastic agents.

67 n factor 2 (eIF2) plays an important role in translation initiation as it selects and delivers the in

68 tors but is primarily considered to activate translation initiation as part of the PABP-eIF4G-eIF4E c

69 recise quantification of the rules governing translation initiation at N-terminal coding regions, imp

70 all, this study provides evidence of protein translation initiation at noncanonical TISs and argues t

71 '-BTE) in its 3'-UTR essential for efficient translation initiation at the 5'-proximal AUG.

72 PRS mRNA 5'-leader serve to dampen levels of translation initiation at the EPRS coding region.

73 RNAs carrying PTCs in close proximity to the translation initiation AUG codon escape NMD.

74 a subset of RGG-motif proteins in repressing translation initiation by binding eIF4G1.

75 all polyadenylated mRNAs, and is involved in translation initiation by interaction with eukaryotic tr

76 up to three protein isoforms via alternative translation initiation by re-initiation and leaky scanni

77 Phosphorylation of eIF2alpha controls translation initiation by restricting the levels of acti

78 ation factor (IF) 2 controls the fidelity of translation initiation by selectively increasing the rat

79 1 (mTORC1) that represses cap-dependent mRNA translation initiation by sequestering the translation i

80 e Emi1, we find strong overall repression of translation initiation by specific 5' UTR sequences, but

81 has been shown that non-AUG or noncanonical translation initiation can also occur.

82 addition to a primary defect at the level of translation initiation caused by DDX3X mutation, SG asse

83 ssion of a large number of genes involved in translation initiation, cell cycle, DNA damage and prote

84 cripts are also produced that lack the first translation initiation codon and rely on a second in-fra

85 we demonstrate that a c.2T>C mutation in the translation initiation codon of KDM5C results in transla

86 The presence of two translation initiation codons in SPAST allows synthesis

87 ting protein sequence by providing alternate translation initiation codons.

88 educed by inhibition of mTOR or Pim kinases, translation initiation complex assembly, or eIF4A functi

89 disturbs the assembly of the eIF4F-mediated translation initiation complex on the mRNA cap through d

90 to a decrease in arginine methylation of the translation initiation complex, thereby disrupting its a

91 s organelles that are condensates of stalled translation initiation complexes and mRNAs.

92 large macromolecular aggregates that contain translation initiation complexes and mRNAs.

93 hat are multimolecular aggregates of stalled translation initiation complexes formed to aid cell reco

94 action network can promote remodeling of the translation initiation complexes, and the roles in the p

95 ssion and the mutational effects influencing translation initiation efficiency.

96 ained intron (RI) in the master regulator of translation initiation, EIF2B5.

97 cellular regulatory pathways that influence translation initiation, elongation, and termination.

98 Among the three phases of mRNA translation-initiation, elongation, and termination-init

99 , our model reveals that all three stages of translation-initiation, elongation, and termination/rein

100 SG formation is triggered by both eukaryotic translation initiation factor (eIF) 2alpha phosphorylati

101 thways convergently signal to the eukaryotic translation initiation factor (eIF) 4F complex to regula

102 The eukaryotic translation initiation factor (eIF) 4G is required durin

103 phosphate mRNA cap analogues with eukaryotic translation initiation factor (eIF4E).

104 Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimer

105 nse in the liver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylat

106 ntly increases phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in

107 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates s

108 hosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) to activate

109 orylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), is an impor

110 hat, translational control by the eukaryotic translation initiation factor 2 alpha (eIF2alpha) bidire

111 kinase R (PKR) and its substrate eukaryotic translation initiation factor 2 alpha (eIF2alpha).

112 d activation (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3,

113 hereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF

114 result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or

115 mmaTE treatment increased phosphorylation of translation initiation factor 2, IkappaBalpha, and JNK,

116 Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protei

117 Phosphorylation of translation initiation factor 2alpha (eIF2alpha) attenua

118 tein levels in the heme-regulated eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase

119 out (PERK-KO) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse e

120 Ppp1r15b, a regulatory subunit of eukaryotic translation initiation factor 2alpha (eIF2alpha) phospha

121 The eukaryotic translation initiation factor 2alpha (eIF2alpha) phospho

122 -dependent phosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced transl

123 h activating pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

124 inding protein and phosphorylated eukaryotic translation initiation factor 2alpha unchanged.

125 ons in genes encoding subunits of eukaryotic translation initiation factor 2B (eIF2B).

126 nce 03 (retr03), an allele of the eukaryotic translation initiation factor 2B-beta (eIF2Bbeta).

127 Eukaryotic translation initiation factor 3 (eIF3) is a central play

128 nslation, a process that involved eukaryotic translation initiation factor 3 subunit b as a P311 bind

129 addition, mTOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the

130 DEAD-box RNA helicases eukaryotic translation initiation factor 4A (eIF4A) and Ded1 promot

131 d4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently i

132 -, beta-, and gamma-subunits) and eukaryotic translation initiation factor 4A (three isoforms), altho

133 rary profiling, we identified the eukaryotic translation initiation factor 4B (eIF4B) as a MELK-inter

134 Eukaryotic translation initiation factor 4B (eIF4B) is a cofactor f

135 loid leukemia (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation.

136 Eukaryotic translation initiation factor 4E (eIF4E) is overexpresse

137 iation of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a

138 Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic

139 lated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing bin

140 e analogues were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-subs

141 ed expression of the translational repressor translation initiation factor 4E (eIF4E)-binding protein

142 d translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding protein

143 inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein

144 ockade of its downstream effector eukaryotic translation initiation factor 4E activity equally reduce

145 ate the importance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production

146 educe the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.

147 rget of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-bind

148 APK-interacting kinase (MNK), and eukaryotic translation initiation factor 4E, which is a critical re

149 rget of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

150 revealed hyperphosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

151 first, it preferentially targets eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

152 Eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

153 ibosomal protein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 durin

154 Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-B

155 the translation repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein).

156 (eIF4G), the scaffold subunit of eukaryotic translation initiation factor 4F (eIF4F), preferentially

157 are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and ini

158 MNK binds eukaryotic translation initiation factor 4G (eIF4G) and phosphoryla

159 Remarkably, depleting eukaryotic translation initiation factor 4G (eIF4G), the scaffold s

160 on initiation by interaction with eukaryotic translation initiation factor 4G (eIF4G), we investigate

161 to bind the poly(A) tail of mRNA, as well as translation initiation factor 4G and eukaryotic release

162 rently known hypusinated protein, eukaryotic translation initiation factor 5A.

163 Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is invol

164 ng is controlled by the G-protein eukaryotic translation initiation factor 5B (eIF5B).

165 anslation initiation via an interaction with translation initiation factor 5B (eIF5B).

166 nduced protein kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2alpha) phosphor

167 doplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor alpha (eIF2alpha)-CEBP hom

168 omitant with elevated phosphorylation of the translation initiation factor alpha subunit of eukaryoti

169 udies suggest that the reduced activity of a translation initiation factor called eIF2alpha might be

170 tion between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmar

171 factors such as ribosomal protein RPS-1 and translation initiation factor EIF-3.J to reduce infectio

172 Here we report that translation initiation factor eIF1A directly interacts w

173 phosphorylation of the alpha subunit of the translation initiation factor eIF2 (eIF2alpha) can promo

174 ase (OAS), which respectively inactivate the translation initiation factor eIF2 and stimulate RNA cle

175 eIF2B GEF activity toward its substrate, the translation initiation factor eIF2, in vitro.

176 nslational control by phosphorylation of the translation initiation factor eIF2alpha (p-eIF2alpha) ac

177 gene product, phosphorylates the eukaryotic translation initiation factor eIF2alpha and causes trans

178 study, we found that reduced activity of the translation initiation factor eIF2alpha underlies the hy

179 s (MRV) infection induces phosphorylation of translation initiation factor eIF2alpha, which promotes

180 otein translation via phosphorylation of the translation initiation factor eIF2alpha.

181 s MITF via ATF4 in response to inhibition of translation initiation factor eIF2B.

182 Moreover, overexpression of translation initiation factor eIF4A, a helicase, enhance

183 e regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppress

184 Eukaryotic translation initiation factor eIF4AI, the founding membe

185 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, dri

186 d the calcineurin regulator Rcn2, the 4E-BP (translation initiation factor eIF4E-binding protein) tra

187 s its association with and inhibition of the translation initiation factor eIF4E.

188 A translation initiation by sequestering the translation initiation factor eIF4E.

189 ltiple ribosome biogenesis genes and the key translation initiation factor eIF4E.

190 It relies on its ability to compete with the translation initiation factor eIF4F to specifically reco

191 ated in splicing, interacts with the general translation initiation factor eIF4G and promotes transla

192 untranslated region that interacts with host translation initiation factor eIF4G.

193 carcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the

194 Eukaryotic translation initiation factor eIF5A promotes protein syn

195 es the eukaryotic initiation factor 2 (eIF2) translation initiation factor upon binding to viral doub

196 osphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation fac

197 arrest mediated by the phosphorylation of a translation initiation factor, the alpha subunit of euka

198 g mRNA-binding proteins, ribosomal proteins, translation initiation factors and translation elongatio

199 was associated with increased expression of translation initiation factors eIF4A and eIF4GI, and red

200 d activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well

201 he ASOs appear to improve the recruitment of translation initiation factors to the target mRNA.

202 election by 5' upstream open reading frames, translation initiation factors, and primary and secondar

203 ing proteins (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key r

204 e based on mutations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their

205 that the W73V mutant could not interact with translation initiation factors.

206 oskeletal organization, and the abundance of translation initiation factors.

207 t of a 5' cap and some/all of the associated translation initiation factors.

208 fold, which was not observed before in other translation initiation factors.

209 ng and plays a prominent role in maintaining translation initiation fidelity.

210 al mRNAs likely contribute to differences in translation initiation frequencies between mRNAs.

211 In the human genome, translation initiation from non-AUG codons plays an impo

212 Translation initiation from non-canonical start codons m

213 TITER extracts the sequence features of translation initiation from the surrounding sequence con

214 The cap-dependent translation initiation gene, EIF4E, is one of the most M

215 Translation initiation generally occurs at AUG codons in

216 Although the canonical mechanism of translation initiation has been studied extensively, her

217 ic isoforms of LANA, resulting from internal translation initiation, have been reported, but their fu

218 psaA/B transcript accumulation and translation initiation, however, occurred in var1 and va

219 nformational rearrangements at every step of translation initiation; however, the underlying molecula

220 RES may have similar strategies for internal translation initiation.IMPORTANCE Cap-independent transl

221 erized example of regulation at the level of translation initiation in bacteria.

222 UG) are considered as the 'start codons' for translation initiation in Escherichia coli.

223 Translation initiation in eukaryotes requires the interp

224 the growing number of diverse mechanisms for translation initiation in eukaryotes.

225 nstrate the participation of CUG-codon-based translation initiation in pathogen immunosurveillance.

226 n contrast, host cell-promoted inhibition of translation initiation in response to the pathogen was i

227 tion score can be related to the strength of translation initiation in various biological scenarios,

228 m(6)A modification site in the 5'UTR enables translation initiation independent of the 5' end N(7)-me

229 TC and identify that phosphorylated eIF2-GTP translation initiation intermediate complexes can be inh

230 Eukaryotic translation initiation involves two conserved DEAD-box R

231 ies with synapse type.SIGNIFICANCE STATEMENT Translation initiation is a central regulator of long-te

232 Translation initiation is a focal point of translational

233 Eukaryotic translation initiation is a highly regulated process inv

234 Translation initiation is a key step in the regulation o

235 nit initiation complex (IC) during bacterial translation initiation is catalyzed by the initiation fa

236 Upregulation of translation initiation is common to and preserved in gen

237 As translation initiation is globally reprogrammed by envir

238 ic cells assemble stress granules (SGs) when translation initiation is inhibited.

239 RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic

240 les are mRNA-protein granules that form when translation initiation is limited, and they are related

241 Translation initiation is regulated by phosphorylation o

242 translation through an interaction with the translation initiation machinery.

243 Aberrant proteins generated by non-canonical translation initiation may be a factor in the neuron dea

244 ERK-dependent switching to an eIF3-dependent translation initiation mechanism, resulting in partial,

245 Here, we show that it is the translation initiation (not termination) factor, namely

246 Here, we quantified translation initiation of green fluorescent protein and

247 In prokaryotic systems, the translation initiation of many, though not all, mRNAs de

248 three proteins specifically required for the translation initiation of natural mRNAs, eIF4A, eIF4B, a

249 nd processing of mRNA, from transcription to translation initiation, often requires splicing of intra

250 absence of other stabilising factors, rapid translation initiation on mRNAs correlates with less sta

251 that the 5' UTR-intron interaction represses translation initiation on the unspliced HAC1 mRNA.

252 joining is a key checkpoint in the bacterial translation initiation pathway during which initiation f

253 al ribosome entry site (IRES)-dependent mRNA translation initiation pathway results in continued tran

254 abilization of this crucial component of the translation-initiation process.

255 It can act as an activator or inhibitor of translation initiation, promote mRNA turnover, or stabil

256 n the form of m(6)A promotes cap-independent translation initiation, providing a mechanism for select

257 s consistent with regulation at the level of translation initiation, providing the first biochemical

258 with the kl-TSS did not markedly affect the translation initiation rate but rather increased the num

259 ocused on how RNA folding energetics control translation initiation rate under equilibrium conditions

260 nts that encoded systematic perturbations of translation initiation rate, the number of stall sites,

261 some's binding rate collectively control its translation initiation rate.

262 2 kinase mutants were used to reduce in vivo translation initiation rates.

263 ribosome queues, which dissipated at reduced translation initiation rates.

264 bly are the two major rate-limiting steps in translation initiation regulated by eIF2alpha phosphoryl

265 Global reductions in translation initiation resulting from mutations in the t

266 regions of mRNA targets, causing changes in translation initiation, RNA stability, and/or transcript

267 scanning model of translation based on Kozak translation initiation sequences alone does not adequate

268 Here we present quantitative translation initiation sequencing (QTI-seq), with which

269 rovides an example of an RNA structure-based translation initiation signal capable of operating in tw

270 e Shine-Dalgarno sequence towards a stronger translation initiation signal.

271 resence of YscQC, the product of an internal translation initiation site in yscQ, for their cooperati

272 rst example of a developmental regulation in translation initiation site preference for a T. gondii p

273 However, the evidence for noncanonical translation initiation sites (TISs) is largely indirect

274 In addition to the annotated translation initiation sites (TISs), the translation pro

275 The presence of upstream translation initiation sites (uTISs) at the mRNA 5' untr

276 which residues of the major splice donor and translation initiation sites are sequestered by long-ran

277 ing regions and, particularly, in predicting translation initiation sites in modelled as well as in a

278 ding frames associated with these additional translation initiation sites were short, raising questio

279 red regions around canonical and alternative translation initiation sites, is dynamic in response to

280 y a mechanism suggested to involve increased translation initiation stringency during stress-induced

281 structure near the start codon that impacts translation initiation, structures located adjacent to U

282 universal initiation factor in cap-dependent translation initiation that functions beyond its role in

283 During translation initiation the eukaryotic initiation factor

284 During eukaryotic translation initiation, the 43S preinitiation complex (4

285 We show that a combination of the rate of translation initiation, the availability of secretory ap

286 In the scanning model of translation initiation, the decoding site and latch of t

287 the deletion of a negative regulator of mRNA translation initiation, the eukaryotic initiation factor

288 to regulate gene expression at the level of translation initiation through tRNA-dependent stabilizat

289 The development of the translation initiation (TI) sequencing (TI-seq) techniqu

290 E, allowing eIF4E to interact with eIF4G and translation initiation to resume.

291 hat requires the disassembly of eIF4F during translation initiation to yield free subunits (eIF4A, eI

292 reveal the importance of the aSD in plastid translation initiation, uncover chloroplast genes whose

293 ed or identified two forms of unconventional translation initiation: usage of AUG-like sites (near co

294 nitiation sites after drug-induced arrest of translation initiation, validating many of the novel cod

295 This dysregulation of translation initiation via alteration of the Tsc2-mTor-E

296 The WIG1-AGO2 complex attenuated translation initiation via an interaction with translati

297 protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha.

298 m-loop and a poly(G) motif, not only inhibit translation initiation when inserted into an mRNA 5 untr

299 y undocumented role for CK2 in regulation of translation initiation, whereby CK2 stimulates phosphory

300 Alternative translation initiation yields two protein forms: the lon