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1 insight into our knowledge of mRNA-specific translational activation and the function of the PABP-eI
4 ws that, rather than sterically blocking 40S translational active sites, the associated assembly fact
8 sed systematic literature reviews, published translational and clinical studies, clinical practice gu
10 rs interested in stress responses as well as translational and posttranslational regulation in plants
11 ass stems from the distinct behaviour of the translational and rotational degrees of freedom under in
14 America and Europe with expertise in basic, translational, and clinical sciences in the field of ant
18 biology and critical insights into the many translational applications for these small regulatory RN
19 ling and the exploration of Wnt agonists for translational applications in regenerative medicine.
20 reover, to move beyond proof-of-concept into translational applications, we discuss future prospects
23 uces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the sheddases, ADAM10
24 sequencing (WES) is widely utilized both in translational cancer genomics studies and in the setting
25 those of annotated isoforms and explore the translational capacity and quality of novel isoforms.
26 ral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at
32 on for GCN2 phosphorylation of eIF2alpha and translational control in the formation of an intact huma
33 est that mitochondrial GCN5L1 modulates post-translational control of FoxO1, regulates gluconeogenesi
34 tion changes are part of a coordinated early translational control response shared across environment
39 ainst M. abscessus infections with promising translational development possibilities for the treatmen
40 try, we found that as the conformational and translational dynamics of FN increased, the rate of bind
43 cularly in the early stages, should increase translational efficiency and streamline resource utiliza
44 m by which mTORC2 activity stimulates Rictor translational efficiency via an AKT/HSF1/HuR signaling c
45 data support the use of gamma-band ASSR as a translational end point in pro-cognitive drug discovery
46 the eIF4E-binding Panicum mosaic virus-like translational enhancer (PTE) and ribosome-binding 3' T-s
49 steine biosynthesis) to prevent challenge of translational fidelity, and may reflect the mechanism th
50 and N6-methyladenosine (m6A) did not perturb translational fidelity, O6-methylguanosine (m6G) at the
54 tion of RGGT, an enzyme responsible for post-translational geranylgeranylation of Rab GTPases represe
56 d the temporal ordering and kinetics of post-translational histone and RNA polymerase II modification
57 cells in cancer immunotherapy and provide a translational humanized mouse model to test the lifespan
59 dentifying infant-directed timbre has direct translational implications for speech recognition techno
60 y and beta cell health, which may have broad translational implications for therapeutics aimed at imp
62 beta, mir200, ZEB1, OVOL2, p63 and p300) and translational implications of the Grainyhead proteins in
64 These principles have important clinical and translational implications, and they show striking paral
70 direct simulation of trajectories for the co-translational insertion of arbitrary polypeptide sequenc
71 e being tested, which hopefully will provide translational insights to stop the growing incidence of
72 imulation for the mechanistic analysis of co-translational integration and for the engineering of mem
73 or tunes this signaling in vivo by producing translational isoforms differing only in the length of t
74 ith two different functional groups for post-translational labeling at the specific amino acid positi
76 utic neovascularization via rAAV.Tbeta4 in a translational large animal model of hibernating myocardi
77 his helicase regulates p21 expression at the translational level independent of the transcriptional a
80 otein synthesis rates are determined, at the translational level, by properties of the transcript's s
82 ot altered neither at transcriptional nor at translational levels, but its function was impacted sinc
86 n initiation resulting from mutations in the translational machinery or inappropriate activation of t
87 that the egg cell is primed to activate the translational machinery, and that hormones likely play a
89 sitivity, yet little is known as to the post-translational mechanism behind its somatosensitization.
90 rden of unfolded ER proteins suggests a post-translational mechanism for adjusting BiP's activity to
92 riptional program works in concert with post-translational mechanisms to regulate heme metabolism dur
93 RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these important tumour
94 spite the importance of such experiments for translational medicine, there have been relatively few e
95 ages a recently demonstrated link between co-translational membrane integration efficiency and protei
96 man health, and we suggest steps for scaling translational microbiome research to high-throughput tar
99 The mechanism and regulation of this post-translational mode of targeting by cpSRP remain unclear.
101 nt of atherogenesis, however, reliable human translational models aimed at characterizing these mecha
103 tion has recently emerged as a dominant post-translational modification (PTM) in Alzheimer's disease
104 try for simultaneous quantification and post-translational modification (PTM) profiling of targeted p
105 tyrylation (Khib) is a newly identified post-translational modification found in animal and yeast cel
107 iring in disulfide linkages is a common post-translational modification in proteins entering the secr
108 cNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage of be
109 rgets in Arabidopsis and show that this post-translational modification is central to the rewiring of
110 phagy protein, on Tyr-233 and that this post-translational modification limits Beclin1 association wi
111 gradation, and we hypothesize that this post-translational modification may act as a signal for the s
113 yrosine phosphorylation is a widespread post-translational modification mechanism underlying cell phy
114 rotein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl acyltra
115 latter function involves reversing the post-translational modification of cellular proteins conjugat
117 While chromatin remodeling mediated by post-translational modification of histone is extensively stu
118 riant histone sequences, in addition to post-translational modification of histones, serves to modula
119 t it is unclear how mutations affecting post-translational modification of molecular clock proteins i
121 lmethyltransferase (ICMT) catalyzes the post-translational modification of RAB GTPases that contain C
122 Rtr1, and Fcp1), which act through the post-translational modification of the C-terminal domain (CTD
123 atalyzing protein S-acylation, a common post-translational modification on proteins frequently affect
124 fier (SUMO) conjugation is a reversible post-translational modification process implicated in the reg
126 lation is a recently identified protein post-translational modification that is known to affect the a
127 on of histone proteins is a fundamental post-translational modification that regulates chromatin stru
128 RMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent
129 iptional RNA editing, splice variation, post-translational modification, and subunit composition.
130 tively, these data demonstrate that the post-translational modification, O-GlcNAcylation, is a novel
131 cover new aspects of regulation by this post-translational modification, we undertook an analysis of
138 tions in protein expression and histone post-translational modifications (PTMs) in bladder carcinoma
139 ciently translate upstream signals into post-translational modifications (PTMs) on histones and coreg
140 alternative splice variants (ASVs) and post-translational modifications (PTMs) reportedly tied to ce
141 sensors is sophisticatedly regulated by post-translational modifications (PTMs) resulting in a robust
142 es in epigenetic markers, i.e., histone post-translational modifications (PTMs), in the layers of the
144 their regulation is complex, involving post-translational modifications and allosteric regulation wi
145 sstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflammation
146 neuron activity is enhanced and drives post translational modifications at the dopamine transporter
148 nd biophysical tools to investigate how post-translational modifications impact the aggregated prion
149 ide novel insight into the role of Nt17 post-translational modifications in regulating the structure
150 ision, signal peptide removal, and some post-translational modifications including oxidation and acet
151 in ligation simplifies incorporation of post-translational modifications into the protein scaffold.
152 modify specific signaling pathways via post-translational modifications of Cys residues in key regul
155 re, we discuss recent insights into the post-translational modifications of junctional proteins and s
157 ukaryotic genes are marked by conserved post-translational modifications on the RNA pol II C-terminal
158 tailoring enzymes introduce additional post-translational modifications that are unique to each lant
159 ization in combination with rigidifying post-translational modifications to achieve high-potency bind
161 sequences of amino acids and localized post-translational modifications, are identified using precur
162 ic and protein interactions, and 38 559 post-translational modifications, as manually annotated from
163 ogen from healthy controls displayed no post-translational modifications, fibrinogen from patients on
164 of MCR (McrA) contains several unusual post-translational modifications, including a rare thioamidat
165 to the presence of antagonistic histone post-translational modifications, including acetylation and m
168 ination of tubulin isotypes and tubulin post-translational modifications-can generate microtubule div
175 multidomain enzymes may be modulated by post-translational modifications/mechanisms, allowing them to
176 ased on widely used protein domains and post-translational modifications; therefore, many membrane-as
178 e to monitor the conformational changes of a translational molecular machine during its operation.
179 cells.Distinguishing rotational motions from translational motions in the z-axis has been a long-stan
180 ge in distinguishing rotational motions from translational motions in the z-axis in differential inte
181 tasets confirmed PCSK9 hypomethylation and a translational mouse model of AUD showed that alcohol exp
182 ent hippocampal local field potential during translational movement, suggesting that theta encodes se
184 protein translocation channel to catalyze co-translational N-linked glycosylation of proteins in the
187 y agent by modifying transcriptional and non-translational neutrophil responses, which might permit a
188 sign, and implementation of N-of-1 trials in translational nutrition research that are meant to asses
192 odeled collagen with Eulerian rotational and translational parameters of adjacent rungs in the triple
197 r (DAT) inhibitor, CTDP-32476, that may have translational potential for treating cocaine addiction.
199 precludes their clinical use and limits the translational potential of MPIO-based contrast agents.
203 iting features of painful neuropathy and the translational potential of this marker of spinal inhibit
204 ied Runx1 as a novel therapeutic target with translational potential to counteract the effects of adv
208 e cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins
210 ectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiological ch
214 cluster of down regulated genes that encode translational proteins, especially those with ribosome b
215 RPE cells were subsequently treated with two translational readthrough inducing drugs (G418 & PTC124)
218 gies that seek to address the alterations in translational regulation and energy metabolism that char
219 demonstrates that nutrient availability and translational regulation controls protein and small pept
220 a critical process in protein synthesis, but translational regulation in antigen-specific T cells in
221 This identified unexpected and pervasive translational regulation of most of the core signalling
224 Together, these findings suggest that post-translational regulation of the Thr(567) in the MT1-MMP
227 , we investigated the axonal localization of translational regulators and associated mRNAs in five pa
229 s and establish a hitherto unidentified post-translational regulatory mechanism of carotenogenic enzy
230 to propose putative transcriptional and post-translational regulatory mechanisms of metabolic process
232 the expected phosphorylation of MAP kinases, translational regulatory proteins, and subunits of APC/C
233 tablished as a widely used animal model with translational relevance for neurodevelopmental psychiatr
237 for Gc action directly on the podocyte, with translational relevance to designing new selective synth
240 et mRNAs and silence gene expression through translational repression and deadenylation but not cleav
241 Here we describe the importance of mRNA translational repression and mRNA subcellular location f
242 tardation protein, proteins that function in translational repression and stress granule regulation.
244 3'UTR of a miRNA-targeted reporter modulates translational repression by affecting the translation ef
245 RNA sensors, demonstrated that miRNAs induce translational repression depending on their complementar
246 rticle that has been linked to pathogenesis, translational repression, starvation responses, and ribo
248 es by signalling the degradation of GLD-1, a translational repressor that blocks V-ATPase synthesis.
250 immune system represent a promising tool for translational research as they may allow modeling and th
251 we review the most current basic science and translational research findings on several of the most c
252 scuss gaps and opportunities in clinical and translational research in metastatic breast cancer.
253 ering strategies, increasing the options for translational research in the vector control field.
256 huge public health gains, while support for translational research is leading to the development of
257 echnique is now widely employed in basic and translational research, and increasingly is also used pr
258 nvened of world experts in immunology, human translational research, and positron emission tomographi
259 aming patient waveform data for clinical and translational research, and will advance the study and m
260 overy in developmental biology as well as in translational research, but whether organoids can truly
261 Part One includes the sections: Basic & Translational Research, Cardiac Failure, Cardiomyopathie
269 attention has been paid to the role of post-translational responses to pathogen-associated molecular
270 , thalamus, and hypothalamus) of BAC aldh1l1-translational ribosome affinity purification (TRAP) mice
272 ent that we assume the mantle of the leading translational science journal in the world and the flags
274 domains requiring the dual action of the co-translational Sec and post-translational Tat pathways fo
275 activation is through its ability to reverse translational shutoff and sustain the expression of othe
280 nonucleotide repeat that is placed between a translational start codon and a membrane-bound fluoresce
281 ogenesis is necessary for the development of translational strategies to harness this process for neu
282 T cells is mounting in animal models and in translational studies involving subjects with active HSV
283 pecies will facilitate the implementation of translational studies that better predict clinical outco
284 ector has greatly facilitated both basic and translational studies that require co-expression of mult
289 n, a G4 ligand, specifically potentiated the translational suppressing effect of P1-HNF4A-5' UTR.
291 nalogy of crystals in space, the breaking of translational symmetry in time and the emergence of a 't
292 onucleoprotein particle that mediates the co-translational targeting of newly synthesized proteins to
295 stem cells (MSCs) are regularly utilized for translational therapeutic strategies including cell ther
298 ntains plasticity-enhancing proteins of high translational value for targeting ageing- or disease-ass
300 s are discussed for extending the predictive translational value of mouse research, with an emphasis
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