ライフサイエンスコーパス: translational control

1 paralog specificity defines a novel means of translational control.

2 ulation of eIF2alpha phosphorylation and the translational control.

3 tylation as an important facet of eukaryotic translational control.

4 he rpoS mRNA to enable sRNA base pairing and translational control.

5 edominately in cytoplasm, where it regulates translational control.

6 ing the ribosome, suggesting a novel form of translational control.

7 eading to activation of this eIF2 kinase and translational control.

8 rapid developmental switch in the nature of translational control.

9 diated accumulation of hnRNP K resulted from translational control.

10 eotide biology including transcriptional and translational control.

11 echanism linking the cell cycle machinery to translational control.

12 anslation or removal of elements involved in translational control.

13 non-coding RNA (ncRNA) involved in neuronal translational control.

14 encoded mitochondrial genes are under strong translational control.

15 tle is known about the mechanisms underlying translational control.

16 mRNA decay that has also been implicated in translational control.

17 he study of 5'-UTR RNA G-quadruplex-mediated translational control.

18 le germline stem cell lineage is mediated by translational control.

19 entire cell complement of L13a and defective translational control.

20 NA regulatory processes such as splicing and translational control.

21 f the ribosome to confer transcript-specific translational control.

22 ory BC RNAs employ a two-pronged approach in translational control.

23 degradation, and in degradation-independent translational control.

24 d in relation to host-virus interactions and translational control.

25 rmediate may present an effective avenue for translational control.

26 s the existence of an alternative pathway of translational control.

27 ally redundant with regard to this aspect of translational control.

28 cell birth, to identify mRNAs under periodic translational control.

29 witch that rescues mRNA binding and restores translational control.

30 such as RNA localization, RNA stability, and translational control.

31 s triggered, representing a new form of post-translational control.

32 entiation, little is known about the role of translational control.

33 vestigated whether Unr has a general role in translational control.

34 ting posttranscriptional gene expression and translational control.

35 nk of a SZ risk gene to neurodevelopment and translational control.

36 ponse to diverse signals is a major point of translational control.

37 on rate would transform our understanding of translational control.

38 st protein may provide a novel means of post-translational control.

39 ion pathway, one that is critical for normal translational controls.

40 repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated

41 OLA1 thus represents a novel mechanism of translational control affecting de novo TC formation, di

42 We are just beginning to understand how translational control affects tumour initiation and mali

43 ombination of transcriptional regulation and translational control allows the eIF2 kinase pathway to

44 ressible 2 (GCN2) protein kinase facilitated translational control and differentiation-specific prote

45 yotic initiation factor-2 (eIF2) function in translational control and drive differentiation.

46 provide evidence of a mechanism that couples translational control and energy metabolism, two process

47 We investigated a role for PknK in translational control and established that PknK directs

48 a multifaceted signaling system coordinating translational control and gene transcription to promote

49 work provides more appropriate estimates of translational control and implies that TRmIND is under d

50 ignaling pathway has multiple layers of post-translational control and is a determinant of chronic in

51 Translational control and messenger RNA (mRNA) decay rep

52 e-associated proteins implicated in neuronal translational control and microRNA function.

53 Translation initiation is a focal point of translational control and requires the binding of eIF4E

54 ed expression in ET platelets, putatively by translational control (and not by mRNA target degradatio

55 ADD34 uORF affect the status of eIF2alpha-P, translational control, and cell adaptation to stress.

56 rrectly elucidated many important aspects of translational control, and I thought readers would be in

57 bly and disassembly is a structural basis of translational control, and its disorder is implicated in

58 Thus translational control appears as an important component

59 Because such UTRs can be involved in translational control as well as in mRNA stability, we c

60 ead role of short upstream reading frames in translational control as well as slower elongation at th

61 senger RNA have begun to uncover genome-wide translational control at codon resolution.

62 RNA metabolism, particularly translational control at or near the synapse, is one pro

63 y, here shown for messenger ribonucleic acid translational control at the CYB561 step of transmitter

64 Translational control at the initiation step has been re

65 on of gene expression occurs in part through translational control at the synapse.

66 We show that in addition to translational control, ATF4 expression is subject to tra

67 In addition to translational control, ATF5 mRNA levels are significantl

68 Post-translational control based on an environmentally sensit

69 Select 5' untranslated regions exert robust translational control between cell lines, while 3' untra

70 mechanism for this change was independent of translational control but dependent on inflammatory DCs,

71 lpha~P/ATF4 pathway is required not only for translational control, but also for activation of ATF6 a

72 karyotic initiation factor 2 (eIF2)-mediated translational control, but its physiological functions r

73 uced SGs and protein kinase R (PKR)-mediated translational control, but the mechanism of PKR interpla

74 Thus, translational control by 4E-BP1 downstream of mTOR effec

75 en the 4E-BPs revealing mRNA specificity for translational control by each 4E-BP.

76 Previously, we identified that translational control by eIF2alpha phosphorylation (p-eI

77 he dimeric form of murine CTD led to loss of translational control by GCN2, suggesting that dimerizat

78 To address this issue and in particular translational control by microRNAs (miRNAs), we knocked

79 t may help in understanding the mechanism of translational control by miRNAs.

80 Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synapti

81 We reveal that translational control by phosphorylation of the translat

82 unctionally mimics other mechanisms, such as translational control by PKR-like ER kinase (PERK) and r

83 The usurping of translational control by sustained activation of transla

84 UnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation init

85 Thus, translational control by the heterotrimeric GAIT complex

86 ey introduced us to a novel mechanism of p53 translational control, by which a 5'-3' cap-independent,

87 BP protein family--operate as guardians of a translational control checkpoint in lung tumor defense.

88 Our study provides in vivo proof for a translational control checkpoint in lung tumor defense.

89 ults illustrate how eIF2 approximately P and translational control combined with transcription factor

90 fect synaptic function and how altered local translational control contributes to a form of human men

91 In every known example of CsrA-mediated translational control, CsrA binds to the 5' untranslated

92 This translational control culminates in reprogramming of the

93 Translational control during cell division determines wh

94 The degree and dynamics of translational control during mammalian development remai

95 important role in maintaining mTOR-dependent translational control during the biological responses of

96 A translational control element (TCE) within the KLF4 3'-u

97 sertions before this secondary structure, or translational control element (TCE), that provide the 15

98 somes and suggest the presence of unexplored translational controls embedded in the polysome structur

99 The results suggest that translational control exerted by IL-1 and IL-17 plays an

100 This new mechanism of translational control explains how expression of CHOP an

101 y has the potential to make investigation of translational control feasible with limited quantities o

102 Initiation is the primary target of translational control for all organisms.

103 Thus, with respect to mTOR's role in translational control, HCMV depends on it early in infec

104 We also examine mechanisms of translational control highlighting the mRNA cap-binding

105 dynamic range of transcript-isoform-specific translational control, identify isoform-specific sequenc

106 ce has now demonstrated a role for localized translational control in axon guidance decisions in vivo

107 quences being translated and found extensive translational control in both determining absolute prote

108 in human keratinocytes and the importance of translational control in cell survival.

109 Recent studies highlight the importance of translational control in determining protein abundance,

110 ation of eIF2 [eIF2(alphaP)] is critical for translational control in diverse settings including nutr

111 cap-dependent initiation, a primary point of translational control in eukaryotic cells.

112 However, the role of specific nodes of translational control in extinction is unknown.

113 Understanding translational control in gene expression relies on preci

114 This work reveals pervasive translational control in meiosis and helps to illuminate

115 C/EBPbeta protein expression is under eIF4E-translational control in MM.

116 in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells.

117 ay pivotal roles in mRNA transport and local translational control in neuronal processes.

118 ever, the fundamentals of stimulus-modulated translational control in neurons remain poorly understoo

119 These findings highlight the importance of translational control in regulating AdipoR1 protein expr

120 Although eIF2 approximately P elicits translational control in response to many different stre

121 Although eIF2-P elicits translational control in response to many different stre

122 cuss the key regulatory pathways that govern translational control in response to synaptic activity a

123 dings thus reveal critical roles for dynamic translational control in supporting specialized mammalia

124 thms, revealing a new and important role for translational control in the Drosophila circadian clock.

125 on for GCN2 phosphorylation of eIF2alpha and translational control in the formation of an intact huma

126 ion are critical for directing gene-specific translational control in the integrated stress response.

127 ighlight a critical role for light-regulated translational control in the physiology of the circadian

128 -UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form o

129 r findings underscore the importance of post-translational controls in epidermal cell differentiation

130 mine the role of another form of regulation, translational control, in the repeated evolution of self

131 We recently demonstrated that this translational control involves a stress-specific reprogr

132 Deregulation in different steps of translational control is an emerging mechanism for cance

133 Translational control is crucial in the regulation of ge

134 Translational control is emerging as an important factor

135 Translational control is frequently exerted at the stage

136 Our study provides an example of how translational control is integrated with transcriptional

137 The relationship of the poly(A) tail to translational control is intimately related to the funct

138 control in yeast, showing that this form of translational control is more widely employed than previ

139 e protein that binds to the TCS and mediates translational control is not known.

140 Message-specific translational control is required for gametogenesis.

141 Furthermore, we found that mTORC1-mediated translational control is required for memory reconsolida

142 Translational control is widely used to adjust gene expr

143 obility and is subject to autorepression and translational control, is also regulated posttranslation

144 be a crucial event in regulating fibroblast translational control machinery on collagen matrix.

145 insic signaling from the niche and intrinsic translational control machinery regulate the balance bet

146 f Retroviridae suggests conservation of this translational control mechanism among vertebrates, and c

147 rotein Arpc5 sets the stage for an elaborate translational control mechanism by facilitating the sequ

148 The translational control mechanism identified is interprete

149 but also uncovers a previously unappreciated translational control mechanism in heat shock response.

150 xpression levels and cellular physiology, no translational control mechanism is known that links codo

151 An important translational control mechanism is the Ca(2+)/calmodulin

152 Here we report the discovery of a step-wise translational control mechanism responsible for survival

153 mRNA levels was noted, we identified a novel translational control mechanism stimulated by oxidative

154 These observations imply the existence of a translational control mechanism that enhances the abilit

155 Here, we demonstrate a novel translational control mechanism that responds to the spe

156 Thus, we have identified a translational control mechanism that selectively underli

157 ception to the activation of a gene-specific translational control mechanism.

158 caused by dysregulation of a microRNA-based translational control mechanism.

159 activating transcription factor (ATF) 4 by a translational control mechanism.

160 gically relevant ER stress-mediated adaptive translational control mechanism.

161 Although translational control mechanisms are fundamental mediato

162 Understanding SSAT translational control mechanisms has the potential for t

163 endous insight they provide into fundamental translational control mechanisms in health and disease.

164 a combination of selective RNA retention and translational control mechanisms instills nanos accumula

165 characterized extensively, and more recently translational control mechanisms that may underlie its c

166 , and suggest that mRNA-specific and general translational control mechanisms work in tandem to regul

167 participate in transcription attenuation and translational control mechanisms, respectively.

168 protein expression as well as biomarkers of translational control mechanisms.

169 n be a previously unappreciated substrate of translational control mediated by RBPs.

170 Posttranscriptional and translational controls mediated by microRNAs (miRNA) reg

171 BC RNA translational control, mediated via eIF4B phosphorylatio

172 f S6K1 prevented elevated phosphorylation of translational control molecules, exaggerated protein syn

173 To address the role of RNA localization and translational control more systematically, we assembled

174 Translational control most commonly targets the initiati

175 rotein response (UPR), a transcriptional and translational control network designed to restore protei

176 Furthermore, loss of GCN2 thwarted translational control, normal epidermal differentiation,

177 translation are tightly coupled, with overt translational control occurring for less than 10% of the

178 Whether such translational control occurs in sensory neurons is not k

179 inhibitor of translation (GAIT) complex for translational control of a subset of inflammation-relate

180 ation factor 4a3 (eIF4a3) is involved in the translational control of a subset of selenoproteins.

181 examine the influence of cholesterol in post-translational control of ABCA1 and ABCG1 protein express

182 nce for a rapid, cholesterol-dependent, post-translational control of ABCA1 and ABCG1 protein levels,

183 stream open reading frame (uORF) confers the translational control of ACC1 and adjusts Acc1p protein

184 eIF6 acts by exerting translational control of adipogenic transcription factor

185 In Arabidopsis, the translational control of auxin response factors (ARFs) b

186 s review, we discuss the transcriptional and translational control of cathepsin expression, the regul

187 consequential reprogramming of ribosomes in translational control of cell survival.

188 pathway, while exerting inhibitory effect on translational control of cytokines and chemokines.

189 gs establish an obligatory role for upstream translational control of downstream Snail1-mediated tran

190 Restoring translational control of eIF2alpha holds the promise to

191 Hypusine-dependent translational control of essential proteins (hubs) and p

192 ecutioner caspase 3' UTRs in many metazoans, translational control of executioner caspases by RBPs mi

193 est that mitochondrial GCN5L1 modulates post-translational control of FoxO1, regulates gluconeogenesi

194 This study addresses post-translational control of GCL activity, which increased r

195 d, a detailed molecular mechanism regulating translational control of gene expression by 4EBP-1 is no

196 Translational control of gene expression contributes to

197 Translational control of gene expression has recently be

198 age response, consistent with a role for the translational control of gene expression in cellular rad

199 The extent of translational control of gene expression in mammalian ti

200 yet we know little about the role played by translational control of gene expression in mediating th

201 More specifically, they suggest that the translational control of gene expression may provide a s

202 Translational control of gene expression plays a key rol

203 Antigen-specific T cells exerted dynamic translational control of gene expression that correlated

204 The extensive nature of this shift in translational control of gene expression was revealed us

205 response to radiation occurs at the level of translational control of gene expression.

206 gulatory capacity of neuronal BC RNAs in the translational control of gene expression.

207 on phase of protein synthesis is crucial for translational control of gene expression; however, in co

208 GLD4-mediated translational control of GLUT1 mRNA is dependent of an R

209 nitrosation, providing insight into the post-translational control of GSTP1-1 as well as the process

210 m whereby O-GlcNAcylation of 4E-BP1 mediates translational control of hepatic gene expression.

211 ranslation in vivo and provide evidence that translational control of HIF2alpha expression dominates

212 Thus, our findings identify the role of translational control of hnRNP K in morphine-induced ana

213 been associated with the transcript-specific translational control of inflammatory proteins and activ

214 tivity to meiosis II, through 5'UTR-mediated translational control of its transcript.

215 n of long-term memory is believed to require translational control of localized mRNAs.

216 major noncanonical function of EPRS, namely translational control of macrophage inflammatory gene ex

217 -initiation provides the molecular basis for translational control of mammalian ATF4 and yeast GCN4 m

218 ts suggest an important role for ERK2 in the translational control of MBP, a myelin protein that appe

219 des the first genetic evidence for selective translational control of meiotic exit in mammalian sperm

220 Translational control of mRNAs in dendrites is essential

221 her identified unappreciated coordination in translational control of mRNAs within molecular complexe

222 of interleukin-10 which was under the direct translational control of mTOR.

223 and COX-2 occurs via PI3K- and Akt-dependent translational control of mTORC1 and PI3K-dependent, Akt-

224 Here, we show that localization and translational control of nos mRNA are essential for da n

225 n, and provide a mechanistic explanation for translational control of Nrf2 by oxidative stress.

226 study, we elucidate the mechanism underlying translational control of Nrf2.

227 The translational control of oncoprotein expression is impli

228 tumor suppression, at least in part, through translational control of p27.

229 he potential role of this interaction in the translational control of p53 after stress.

230 Hardly anything is known about translational control of plant mitochondrial gene expres

231 Our results uncover pervasive translational control of protein synthesis, with widespr

232 plicated in the stabilization, transport and translational control of several target mRNAs.

233 to any organism, these results suggest that translational control of stress response involves a cont

234 h to create orthogonal ON-switches, enabling translational control of target gene expression in respo

235 R-dependent long-term synaptic depression or translational control of target mRNAs of fragile X menta

236 We propose that global translational control of the host by eIF4E phosphorylati

237 ucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded

238 ally characterize three methods for the post-translational control of the PB transposon in four cell

239 ential link between alternative splicing and translational control of the resultant mRNA isoforms.

240 e metabolism in Toxoplasma and that the post-translational control of this pathway is required for no

241 Translational control of transcription factor ATF4 throu

242 ocytes may be determined by the differential translational control of two Cyclins.

243 gement of Argonaute proteins in the specific translational control of viral transcripts is a key fact

244 The improved translational control offered by these designed MCSs is

245 nstrate that inclusion of uORFsTBF1-mediated translational control over the production of snc1-1 (an

246 elucidate a novel developmentally regulated translational control pathway that establishes the meiot

247 s advance our knowledge on dystonia, linking translational control pathways and calcium physiology to

248 Despite the emergence of translational control pathways as mediators of nocicepti

249 iruses have evolved to infiltrate and hijack translational control pathways as well as to integrate s

250 ered dysregulation of eiF2alpha and Akt/mTOR translational control pathways in the DYT1 brain, a find

251 l ER protein processing and dysregulation of translational control pathways.

252 Translational control permits cells to respond swiftly t

253 S6 kinase 1 (S6K1) signaling is critical for translational control, pharmacological manipulation in v

254 ng of gene expression; additionally, precise translational control plays a critical role in many cell

255 Translational control plays a pivotal role in the regula

256 Whereas it has been proposed that translational control plays a predominant role in germin

257 Translational control plays a vital role in regulating g

258 eprogramming, highlighting the key role that translational control plays in regulating this process.

259 ranslation initiation factor eIF2 is a major translational control point.

260 dentified two p53 IRES trans-acting factors, translational control protein 80 (TCP80), and RNA helica

261 otein synthesis, deficits in agonist-induced translational control, protein synthesis-independent LTD

262 that manipulation of common pathways such as translational control, rather than disease-specific appr

263 Inhibition of eIF2-P and translational control reduced viability following UVB th

264 our findings suggest that eIF2alpha-mediated translational control regulates the progression from tra

265 The magnitude of translational control relates directly to the affinity o

266 tion changes are part of a coordinated early translational control response shared across environment

267 nal transduction pathways indirectly through translational control responses.

268 lecular mechanism underlying ASDs is altered translational control resulting in exaggerated protein s

269 To explore the contribution of translational control, RNA-seq and ribosome profiling we

270 nding to different stress arrangements, this translational control scheme is referred to as the integ

271 The Translational Control Sequence (TCS) in the 3' untransla

272 t eIF2Bgamma mutations known to disrupt GCN4 translational control significantly impair GDF activity

273 bosomal proteins are themselves subjected to translational control, suggesting a means of reinforcing

274 y in FXS reduces sAPPalpha levels, restoring translational control, synaptic morphology, and behavior

275 pathways, microRNA networks and RNA-protein translational control systems.

276 an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis an

277 key features of uORFs that serve to optimize translational control that is essential for regulation o

278 Here we show that to quantitate translational control, the translation rate must be deco

279 Thus, translational control through 4E-BP2 represents a unique

280 Here we demonstrate that translational control through eIF2alpha phosphorylation

281 Translational control through programmed ribosomal frame

282 Translational control through the mammalian target of ra

283 We further show that Ime2 mediates translational control through the meiosis-specific RNA-b

284 Little is known about the contribution of translational control to circadian rhythms.

285 Altogether, this work reveals a new layer of translational control to major signalling components and

286 have focused largely on targets upstream of translational control to normalize FXS-related phenotype

287 This study reveals an alternate mechanism of translational control to regulate p53 levels.

288 rapeutic potential of targeting dysregulated translational control to treat cognitive disorders of sy

289 numerous aspects of posttranscriptional and translational control under both growth conditions.

290 cing as a previously uncharacterized mode of translational control under hypoxia and are supported by

291 These results show that translational control underlies ART-induced latency and

292 l translation during learning and that local translational control varies with synapse type.SIGNIFICA

293 protein translation by integrating synthetic translational control via a small-molecule-regulated RNA

294 We also discuss translational control via phosphorylation of eukaryotic

295 imate lineages, our data suggest that BC RNA translational control was necessitated and implemented d

296 inases have been implicated in cap-dependent translational control, we find that in the context of AK

297 ion than did cell origin, and differences in translational control were more prominent than alteratio

298 adult mice with reduced p-eIF2alpha-mediated translational control were more susceptible to cocaine-i

299 ulators, each subject to transcriptional and translational control, which can switch cell fate toward

300 r, selectively inhibiting eIF2alpha-mediated translational control with a small molecule ISRIB, or kn