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1 expression by influencing mRNA stability and translational efficiency.
2 known about the effects of radiation on gene translational efficiency.
3 heses that invoke constraints on function or translational efficiency.
4 broblasts that also binds mRNA and regulates translational efficiency.
5 is important in messenger RNA stability and translational efficiency.
6 considerably weaker than the enhancement of translational efficiency.
7 stem-loop structure drastically reduced the translational efficiency.
8 m messages by influencing mRNA stability and translational efficiency.
9 binding to ribosomes, and their influence on translational efficiency.
10 in exponential phase and increased rpoS mRNA translational efficiency.
11 nd provide evidence that avoidance increases translational efficiency.
12 nduction by regulating message stability and translational efficiency.
13 binding to alpha-MHC mRNA and attenuate its translational efficiency.
14 ic extracts revealed striking differences in translational efficiency.
15 egulation of MMP-9 synthesis at the level of translational efficiency.
16 let-7 miRNA biogenesis or modulation of mRNA translational efficiency.
17 tory roles in modulating mRNA degradation or translational efficiency.
18 at the loss of activity was due to decreased translational efficiency.
19 suggesting that polyadenylation may enhance translational efficiency.
20 rodent genes with a selective advantage for translational efficiency.
21 nes have higher codon usage bias to maximize translational efficiency.
22 criptional control of mRNA stability or mRNA translational efficiency.
23 poly(A) tail to increase synergistically the translational efficiency.
24 ated in the regulation of mRNA stability and translational efficiency.
25 s likely due to factors other than increased translational efficiency.
26 region and exhibit a significantly enhanced translational efficiency.
27 a protein kinase involved in the control of translational efficiency.
28 dance, fatality rates, codon adaptation, and translational efficiency.
29 ermine GRN expression via mRNA stability and translational efficiency.
30 coding sequences have been shown to increase translational efficiency.
31 actors that control transcript longevity and translational efficiency.
32 bias of the kaiBC genes is not optimized for translational efficiency.
33 phenotypes and the idea that i6A37 promotes translational efficiency.
34 ly codon bias, has a key role in determining translational efficiency.
35 eved through control of both mRNA levels and translational efficiency.
36 nges in mRNA expression than with changes in translational efficiency.
37 region of the Rictor transcript and enhance translational efficiency.
38 ase reporter assays significantly alter mRNA translational efficiency.
39 atory signals determining mRNA stability and translational efficiency.
40 critical determinant of their stability and translational efficiency.
41 t RNA dimerization, also strongly influenced translational efficiency.
42 llular processes, regulate mRNA stability or translational efficiency.
43 tein (PABP) to achieve maximal IRES-mediated translational efficiency.
44 ream open reading frames, suggesting varying translational efficiencies.
45 that are responsible for modulation of mRNA translational efficiencies.
46 same cell can exhibit dramatically different translational efficiencies.
47 is was used to generate mutants with altered translational efficiencies.
48 f transcript-specific ribosome densities and translational efficiencies.
50 better understand this control, we profiled translational efficiencies and poly(A)-tail lengths thro
56 atural amino acid was incorporated with high translational efficiency and fidelity into the dimeric p
58 imilar to a poly(A) tail in that it enhances translational efficiency and is co-dependent on a cap in
59 es in these cell types are the regulation of translational efficiency and let-7 miRNA maturation.
66 ene and point to a strong connection between translational efficiency and RNA accumulation in mammali
67 and tissue-specific manner and regulate the translational efficiency and stability of partial or ful
68 o control gene expression by attenuating the translational efficiency and stability of transcripts.
69 cularly in the early stages, should increase translational efficiency and streamline resource utiliza
70 t the Fed-1 iLRE mediates a rapid decline in translational efficiency and that iLRE-containing mRNAs
72 ys an important role in determining both the translational efficiency and the stability of an mRNA.
73 at codon usage is the key factor determining translational efficiency and, surprisingly, also mRNA st
74 these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, b
75 her factors, natural selection for increased translational efficiency and/or fidelity may shape nucle
77 ar dsRNA structures within 3'-UTRs decreases translational efficiency, and although the structures un
78 Ps generally exhibit high protein stability, translational efficiency, and protein abundance but thei
79 o study the roles of translational accuracy, translational efficiency, and the Hill-Robertson effect
84 th translational machinery and modulates the translational efficiency as well as the mTOR pathway.
86 ocalization of the mRNA or variations in the translational efficiency at different sites along the de
87 enomes to identify those that exhibit strong translational efficiency bias (389 out of 1,700 sequence
88 ruct resulted in a corresponding increase in translational efficiency, but the most pronounced effect
92 g on the context, this can strongly modulate translational efficiency by a variety of mechanisms.
95 t leaders lacking the 5'UTR intron increased translational efficiency compared to that of the unsplic
96 ol of cyclin D1 and c-myc mRNA stability and translational efficiency constitutes a coordinate respon
98 255 transcripts that manifest an increase in translational efficiency during eIF4E-mediated escape fr
99 ta suggest that PABP may exert its effect on translational efficiency either by increasing the format
100 inity and isoform preference correlates with translational efficiency, fluorescence spectroscopy was
101 determinant of ribosome binding strength and translational efficiency for mRNA with or without the 5'
102 ream in-frame ATG also resulted in increased translational efficiency from the downstream gp64-cat OR
103 In the absence of a functional minicistron, translational efficiency from the downstream gp64-cat re
104 5'-UUUU-3' results in a 15-fold reduction in translational efficiency; however, removing the leader a
105 ds attenuate mRNA translation at two levels: translational efficiency, i.e. translation initiation, a
107 As expected, tail lengths were coupled to translational efficiencies in early zebrafish and frog e
108 on, the different transcripts showed varying translational efficiencies in several cell lines, indica
110 criminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes
112 the pseudoknot structure and correlates with translational efficiency in both the PTV-1 and HCV IRES.
113 ciated with lymphoid replication and altered translational efficiency in cell culture, were found in
116 nterruptions have no detectable influence on translational efficiency in either a cell-free system or
117 >A and G(243)-->A mutations showed preserved translational efficiency in HuH7 cells but reduced effic
119 how that MMP-9 levels are also controlled by translational efficiency in murine prostate carcinoma ce
122 characteristics that are known to influence translational efficiency in their free-living relative.
123 te NRF-1 expression by interfering with mRNA translational efficiency in transfected cells and in an
124 these codons to more common codons increases translational efficiency in vitro and increases mRNA abu
130 ffect of the S209L mutation on mitochondrial translational efficiency is due to reduced activity of t
131 s in the case of hereditary thrombocythemia: translational efficiency is increased by mutations that
134 port that of these two parameters, increased translational efficiency is the predominant source of in
135 eased Fmr1 mRNA production but impaired FMRP translational efficiency, leading to a modest reduction
137 ndicating that processes determining overall translational efficiency may vary between these two cate
139 s carrying one of these constructs show that translational efficiency mirrors gene transcription; gen
140 hat the eIF4G or eIFiso4G subunits influence translational efficiency more than the cap-binding subun
141 ) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degrad
145 that eliminating eIF4B reduces the relative translational efficiencies of many more genes than does
149 that receptor-mediated cell death has on the translational efficiency of a large number of mRNAs, tra
156 initiation factor (elF) 4E (eIF4E) regulates translational efficiency of c-jun mRNA as measured by fl
160 o test this hypothesis, we have measured the translational efficiency of CGG-repeat mRNAs with 0-2 AG
161 and DEN 3' UTR were the main sources of the translational efficiency of DCLD RNA, and they acted syn
162 tein 1 (AUF1) regulates the stability and/or translational efficiency of diverse mRNA targets, includ
163 (A) tail act synergistically to increase the translational efficiency of eukaryotic mRNAs, which sugg
164 etaxolol is likely to reflect an increase in translational efficiency of existing mRNA and/or stabili
166 isoacceptor over-expression may increase the translational efficiency of genes relevant to cancer dev
168 erefore allows analysis of variations in the translational efficiency of individual mRNAs by accounti
170 hers; the addition of caffeine increased the translational efficiency of most SRSF2 transcripts.
172 ction in Drosophila to increase the apparent translational efficiency of mRNAs by as much as 20-fold.
173 teins (ARE-BP) regulate the stability and/or translational efficiency of mRNAs containing cognate bin
174 Polysome profiles confirmed the decreased translational efficiency of mRNAs in tit1-Delta cells.
175 gies to alter the stability, solubility, and translational efficiency of nascent lacritin, and discov
181 in vitro transcribed mRNAs, we examined the translational efficiency of reporter genes that simulate
182 de non-coding RNA molecule, acts to increase translational efficiency of RpoS mRNA under some growth
185 overshadowed by differential effects on the translational efficiency of specific existing mRNA speci
187 hat the 5'-UTR functions as a determinant of translational efficiency of specific mRNAs, such as c-ju
188 molecules that regulate the stability or the translational efficiency of target messenger RNAs (mRNAs
190 RNAs) in bacteria modulate the stability and translational efficiency of target mRNAs through limited
191 upstream open reading frame, which restored translational efficiency of the 92-nt 5'-UTR AS mRNA.
194 nd ndhA are absent in ppr53 mutants, and the translational efficiency of the residual ndhA mRNAs is r
196 Elimination of these two uORFs raises the translational efficiency of the transcript by over 10-fo
197 These mutations dramatically enhance the translational efficiency of the v4 5'-UTR, leading to el
199 , which express endogenous let-7a miRNA, the translational efficiency of these IRES-containing report
200 on of cyclin E was associated with increased translational efficiency of this mRNA, suggesting that c
201 rnate codon usage significantly enhanced the translational efficiency of this tightly regulated gene
203 tone stem-loop did not function to influence translational efficiency or mRNA stability in plant prot
204 gest that mechanisms such as mRNA transport, translational efficiency or mRNA turnover may be implica
205 ion of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome
206 n (UTR) and regulates its expression through translational efficiency rather than RNA stability.
207 antitatively examined the effects of several translational-efficiency-related sequence features on mR
209 riptome-proteome datasets for estimating the translational efficiencies, resulting in an increased co
210 abnormally short poly(A) tail and a reduced translational efficiency, resulting in an approximately
211 mportant determinant of RNA quality control, translational efficiency, RNA-protein interactions and s
212 - 2 fold change; O: +1.9 +/- 1 fold change), translational efficiency (S6K1 phosphorylation, Y: +10 +
213 at the suppressors do not generally increase translational efficiency, since some alleles that strong
214 hich newly created 5'-UTR Alu exons modulate translational efficiency, such as the creation or elonga
215 quadruplex lead to a 15-fold enhancement of translational efficiency, suggesting that a possible bio
217 ects of mutations in Ded1 or eIF4A on global translational efficiencies (TEs) in budding yeast Saccha
218 gnificantly lower mRNA stability and greater translational efficiency than proximal isoforms on avera
219 A synthetases (UaaRS) are evaluated on their translational efficiency (the extent to which they allow
221 A cargo shifting and resultant regulation of translational efficiency upon the initiation of differen
223 m by which mTORC2 activity stimulates Rictor translational efficiency via an AKT/HSF1/HuR signaling c
224 RNAs and because tRNA competition determines translational efficiency vs. fidelity and production of
227 s was performed to identify genes whose mRNA translational efficiency was differentially affected fol
228 yribosomes by 2.3-fold, which indicates that translational efficiency was enhanced by mobilization.
231 onal capacity, in E-UN offspring (P < 0.05); translational efficiency was similar across dietary trea
232 that the mRNA level of the AS form with high translational efficiency was specifically reduced in mor
233 oncogenic Ras and Akt signaling pathways on translational efficiencies, we compared the gene express
234 ader sequences of transcripts with increased translational efficiency, we find a highly enriched mess
235 it was once thought that mRNA stability and translational efficiency were directly linked, the inter
236 ive changes in poly(A)-tail length, and thus translational efficiency, were largely retained in the a
237 erived variants showed altered IRES-mediated translational efficiency, which might favor CNS infectio
238 ed protein synthesis resulted from decreased translational efficiency with impaired initiation of tra
239 f recombinant protein through extremely high translational efficiency without the need for viral repl
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