ライフサイエンスコーパス: translational repression

1 olecules that act by mRNA degradation or via translational repression.

2 n both by destabilization of the mRNA and by translational repression.

3 e and non-cleavage-based mRNA degradation or translational repression.

4 is a cause or consequence of miRNA-mediated translational repression.

5 toplasmic stress granules is a mechanism for translational repression.

6 RNA is an authentic target of Nanos1/Pumilio translational repression.

7 slicer-independent turnover mechanisms, and translational repression.

8 anscripts is maintained during mRNA-specific translational repression.

9 ith P-bodies and stress granules, leading to translational repression.

10 highlighting the importance of TCE-mediated translational repression.

11 ient to move an mRNA from an active state to translational repression.

12 ted by the let-7 family of miRNAs leading to translational repression.

13 lear accumulation, or transcriptional and/or translational repression.

14 genin-, tiRNA-, and oxidative stress-induced translational repression.

15 RNA-binding protein involved in splicing and translational repression.

16 of mRNA, which leads to mRNA degradation and translational repression.

17 laces SPN-2 from the zif-1 3' UTR, releasing translational repression.

18 m with itself or with cofactors required for translational repression.

19 slated region by miR-98 or let-7 resulted in translational repression.

20 t at the posterior and plays a role in Nv-hb translational repression.

21 3'-UTR, suggesting that Nos is regulated by translational repression.

22 odium pump subunit abundance is modulated by translational repression.

23 et genes by cleavage of the targeted mRNA or translational repression.

24 a deadenylase to specific mRNAs, leading to translational repression.

25 3'-untranslated region by miR-513 results in translational repression.

26 identified as a potential target of miR-155 translational repression.

27 eins needed to respond to hypoxia evade this translational repression.

28 independent mechanism that leads to profound translational repression.

29 nvironmental stressors by acting as sites of translational repression.

30 lation, and a reduction of microRNA-mediated translational repression.

31 er significantly in their capacity to direct translational repression.

32 target accumulation through mRNA cleavage or translational repression.

33 association with the GluR1 mRNA and relieves translational repression.

34 et repertoire and/or enhance mRNA decay over translational repression.

35 nstead as an antagonist of PUMILIO-dependent translational repression.

36 dendrites, where it inhibits miRNA-mediated translational repression.

37 mRNA-bound L13a elicits transcript-specific translational repression.

38 le mRNA dictate their degradation or mediate translational repression.

39 specific mRNAs and triggering mRNA decay or translational repression.

40 heterochromatin assembly, mRNA cleavage and translational repression.

41 t regulate gene expression primarily through translational repression.

42 hermaphrodite spermatogenesis requires fem-3 translational repression.

43 ping and P body formation and are blocked in translational repression.

44 y of the VTE to bind ElrB and also abolished translational repression.

45 that these proteins are not involved in the translational repression.

46 TR) of this mRNA that is responsible for the translational repression.

47 e pathway by targeting mRNAs for cleavage or translational repression.

48 ing the messages of protein-coding genes for translational repression.

49 nd plants by targeting mRNAs for cleavage or translational repression.

50 accumulation of the protein is prevented by translational repression.

51 rity, facilitating site-specific cleavage or translational repression.

52 t are thought to regulate gene expression by translational repression.

53 Thus Xp54 oligomerization is a hallmark of translational repression.

54 on asd mRNA, and both are required for full translational repression.

55 ecapping factors, and promote mRNA decay and translational repression.

56 mRNA, thereby mediating mRNA degradation or translational repression.

57 regulates mRNA processing events, including translational repression.

58 eting complementary mRNAs for destruction or translational repression.

59 to SGs but is dispensable for tiRNA-mediated translational repression.

60 cing by facilitating posttranscriptional and translational repression.

61 ncluding blocking XBP1u splicing and causing translational repression.

62 motif in the 3'UTR of TRF1, resulting in its translational repression.

63 necessary and sufficient to mediate a strong translational repression.

64 md4) is an RNA binding protein that mediates translational repression.

65 dons within the uORF is sufficient to reduce translational repression.

66 on increases Nrf2 levels by overcoming basal translational repression.

67 ed region of the HIST1H2AC locus that confer translational repression.

68 icity of XTUT7 and abolished XTUT7-dependent translational repression.

69 in Rim4 protein levels, thereby alleviating translational repression.

70 target mRNAs by endonucleolytic cleavage or translational repression.

71 TR of the XIAP messenger RNA (mRNA) to exert translational repression.

72 terminant of the magnitude of miRNA-mediated translational repression.

73 y mislocalized Oskar that results from leaky translational repression.

74 etworks, which are based primarily on mutual translational repression, act via interlocked feedback l

75 ular switch between target mRNA cleavage and translational repression activities of Ago2.

76 Analysis of IRE binding affinity and translational repression activity of the resulting IRP1

77 Translational repression afforded by the intron fulfils

78 ssages are downregulated by a combination of translational repression and accelerated decay caused by

79 atrial fibrillation caused dystrophin (DYS) translational repression and accelerated mRNA degradatio

80 d siRNAs is a complex process involving both translational repression and accelerated mRNA turnover,

81 homodimer by RPL26 may be the switch between translational repression and activation after stress.

82 MicroRNAs (miRNAs) predominantly induce translational repression and are emerging as a major reg

83 s, granule formation does not correlate with translational repression and can also take place in the

84 X6-4E-T interaction mediates miRNA-dependent translational repression and de novo P-body assembly, im

85 et mRNAs and silence gene expression through translational repression and deadenylation but not cleav

86 g bodies (P bodies), which are sites of mRNA translational repression and decay.

87 miRNAs) control gene expression through both translational repression and degradation of target messe

88 ces in messenger RNA transcripts, leading to translational repression and destabilization of the targ

89 n and de novo P-body assembly, implying that translational repression and formation of new P-bodies a

90 ng ribosome profiling, we find both a global translational repression and identified ~200 mRNAs that

91 ess, a condition when both microRNA-mediated translational repression and microRNA-directed mRNA clea

92 However, the magnitude of both translational repression and mRNA decay induced by miRNA

93 Translational repression and mRNA degradation are critic

94 MicroRNAs are well known to mediate translational repression and mRNA degradation in the cyt

95 3' untranslated regions (3'UTRs) and mediate translational repression and mRNA degradation.

96 We also determine the relative dynamics of translational repression and mRNA destabilization for en

97 For targets with less complementarity, both translational repression and mRNA destabilization mechan

98 gulate target mRNAs through a combination of translational repression and mRNA destabilization, with

99 Here we describe the importance of mRNA translational repression and mRNA subcellular location f

100 e specialized cytoplasmic compartments where translational repression and mRNA turnover may occur.

101 crease in cyclin D3 protein levels is due to translational repression and not due to attenuated trans

102 Our results showed that DCP5 is required for translational repression and P-body formation and plays

103 onjunction with Dhh1p, as it is required for translational repression and P-body formation in pat1Del

104 While stress-induced translational repression and recruitment of key SG prote

105 stomeres by a process that is independent of translational repression and requires the CCCH finger pr

106 r31, Ser34, and Ser35 of Puf6p increases its translational repression and results in ASH1 mRNA deloca

107 o examine the role of YB-1 in tiRNA-mediated translational repression and SG assembly.

108 tardation protein, proteins that function in translational repression and stress granule regulation.

109 TR interaction regions are critical for both translational repression and stress induction of p53 by

110 nd reveals a previously unknown link between translational repression and transcription of inflammato

111 As (miRNAs) regulate gene expression through translational repression and/or messenger RNA (mRNA) dea

112 mentary binding to target mRNAs and inducing translational repression and/or mRNA degradation.

113 by a posttranscriptional mechanism involving translational repression and/or promoting messenger RNA

114 n is linked to enhanced p-eIF2 alpha levels, translational repression, and a decrease in Ki67, pH 3,

115 rt their influence by guiding mRNA cleavage, translational repression, and chromatin modification.

116 d for both NCL dimerization and NCL-mediated translational repression, and is the domain of NCL that

117 2 (Alas2) results from loss of IRP-dependent translational repression, and markedly increased levels

118 Stress granule formation coincides with translational repression, and stress granules actively s

119 ctional: both clusters of BREs contribute to translational repression, and the 3' cluster has an addi

120 onal termination and RNA structure-dependent translational repression, and the level of holin functio

121 and development, including mRNA degradation, translational repression, and transcriptional gene silen

122 including messenger RNA (mRNA) degradation, translational repression, and transcriptional gene silen

123 sensitivity to NMD occurs when transport and translational repression are simultaneously impaired.

124 g cold shock proteins escape cooling-induced translational repression are unknown.

125 hile their roles in mRNA destabilization and translational repression are well appreciated, their inv

126 These results identify gene-specific translational repression as a means of controlling the m

127 rgets of FXR1 in striated muscle and support translational repression as a novel mechanism for regula

128 he 5'-UTR identified linkers supporting full-translational repression as well as a range of partial r

129 ranslation in mammalian cells, a bicistronic translational repression assay was developed to permit d

130 iRNAs predominantly mediated highly specific translational repression at 5' coding regions with limit

131 he Fst ribosome binding site is required for translational repression but a helix sequestering the 5'

132 equired for binding to the m(7)G cap and for translational repression but do not affect the assembly

133 by microRNA-98 (miR-98) or let-7 resulted in translational repression, but not CIS mRNA degradation.

134 Here, we address further the mechanism of translational repression by 4E-T by first identifying an

135 3'UTR of a miRNA-targeted reporter modulates translational repression by affecting the translation ef

136 ternal Caudal protein is established through translational repression by Bicoid of homogeneous caudal

137 Translational repression by Drosophila Pumilio (Pum) pro

138 n anabolic transcription program to overcome translational repression by eIF2alpha phosphorylation.

139 result from decreased translation; nor does translational repression by miRNAs require a poly(A) tai

140 (evident after 24 hr), suggesting an early, translational repression by perfectly targeted siRNAs.

141 teraction is RNA-dependent and essential for translational repression by Puf6p.

142 Reversal of beta(2)-adrenergic receptor translational repression by retroviral expression of 3'-

143 direct correlation between ElrB binding and translational repression by the Vg1 3'-UTR.

144 This constitutes a novel mechanism for translational repression by this family of regulators.

145 Here we present evidence that translational repression can also make a substantial con

146 We demonstrate that this translational repression can be overcome by blocking the

147 principle is straightforward, the extent of translational repression can be tuned and the regulator

148 zed cytoplasmic foci where mRNA turnover and translational repression can take place.

149 Thus, transcriptional induction and translational repression combine to form a negative feed

150 her mRNP assembly into a PB is important for translational repression, decapping, or decay has remain

151 ng attenuation protein (TRAP), showed potent translational repression, dependent on the level of TRAP

152 RNA sensors, demonstrated that miRNAs induce translational repression depending on their complementar

153 miRNA (argonaute), NMD (Upf1p), and general translational repression (Dhh1p/Me31B) pathways.

154 Translational repression during mRNA transport is essent

155 A translational repression element is contained within the

156 , we demonstrate two separable mechanisms of translational repression employed by Puf5p: a Pab1p-depe

157 e mRNA level and emphasize the importance of translational repression for the maintenance of proteome

158 g protein Pab1p is required for PUF-mediated translational repression for two distantly related PUF p

159 orylated, suggesting rapid inhibition of its translational repression function.

160 Bicc1 is an RNA-binding protein with robust translational repression function.

161 RNA cleavage, but examples of miRNA-mediated translational repression have also been reported.

162 to the translation apparatus to (i) maintain translational repression, (ii) mount various transcripti

163 f claudin-14 mRNA; induce its mRNA decay and translational repression in a synergistic manner.

164 h bind the 3' UTR of target mRNAs to mediate translational repression in animals.

165 These findings emphasize the importance of translational repression in balancing stem cell self-ren

166 We report that TCS elements exert translational repression in both the Wee1 mRNA 3' UTR an

167 ecessary and sufficient to mediate selective translational repression in cells.

168 r hitch) in FMRP-driven, argonaute-dependent translational repression in developing eye imaginal disc

169 erleukins, suggesting that HIV-1 may produce translational repression in host cells.

170 tigate the mechanism by which miRNAs mediate translational repression in human cells.

171 ment in the RINGO/Spy 3'UTR is necessary for translational repression in immature (G2-arrested) oocyt

172 n (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and

173 ng protein expression indicating large scale translational repression in P. falciparum female gametoc

174 destruction, most likely as a consequence of translational repression in the context of robust mRNA d

175 ct assessment of RNA-protein interaction and translational repression in transiently transfected livi

176 s by their uORFs, the range of uORF-mediated translational repression in vertebrate genomes is largel

177 ry neurons; and (3) in bantam miRNA-mediated translational repression in wing imaginal discs.

178 Particularly, microRNA (miRNA)-mediated translational repression involving PIWI/Argonaute family

179 pathway in Arabidopsis and demonstrate that translational repression is a functionally important asp

180 There is growing evidence that translational repression is a key transition that preced

181 Translational repression is mediated by BREs, regulatory

182 epresses the male fate as NOS-3 functions in translational repression leading to inactivation of the

183 In this paper, we report that translational repression may also play a role in MEI-1 d

184 on of the AccA and AccD subunits is due to a translational repression mechanism exerted by the protei

185 se operon is consistent with an RNA-mediated translational repression mechanism for this target.

186 and probably in numerous other bacteria by a translational repression mechanism in which nucleotide-r

187 Importantly, the translational repression mediated by miR-155 can be regu

188 Translational repression mediated by RNA-binding protein

189 ss the expression of protein-coding genes by translational repression, messenger RNA degradation, or

190 miRNA regulates gene expression by translational repression, mRNA cleavage, and mRNA decay

191 challenge to establish whether miRNAs induce translational repression, mRNA decay, or both.

192 nto PBs is governed by the relative rates of translational repression, mRNP multimerization, and mRNA

193 Translational repression occurs before complete deadenyl

194 he message remains constant, suggesting that translational repression occurs by reducing the rate of

195 Although translational repression occurs rapidly, its effect is r

196 This mutation resulted in translational repression of a reporter gene in a Dicer-d

197 Lowering HuR or let-7 levels relieved the translational repression of c-Myc.

198 onally by guiding transcript cleavage and/or translational repression of complementary mRNA targets,

199 Rbp4 and Fest are required for translational repression of cycB in immature spermatocyt

200 ecent findings, is the maskin hypothesis for translational repression of cyclin B1 in Xenopus oocytes

201 rease in cyclin T1 mRNA levels, suggesting a translational repression of cyclin T1 in resting CD4(+)

202 iR-378a-5p upregulation were associated with translational repression of CYPs.

203 ciated effects of miR-34 require adult-onset translational repression of Eip74EF, an essential ETS do

204 We show that full APC activation requires translational repression of Emi1 in addition to its degr

205 which downregulates cleavage and upregulates translational repression of endogenous microRNA (miRNA)-

206 a has been implicated in transcriptional and translational repression of genes encoding contractile p

207 ism that involves (1) direct recruitment and translational repression of genes that promote spermatog

208 n during prion replication causes persistent translational repression of global protein synthesis by

209 hen binds to CsrA and relieves CsrA-mediated translational repression of hag for flagellin synthesis

210 ved function in embryonic patterning through translational repression of hb, the timing and mechanism

211 d, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.

212 inhibitory protein IkappaBA followed by the translational repression of IkappaBA.

213 n of ribosomal protein L13a is essential for translational repression of inflammatory genes by the in

214 ranscriptional activation of miR-302 and the translational repression of its targets, such as cyclin

215 was prepared, and tested for BS15-dependent translational repression of lacZ activity in Escherichia

216 s in BS15 were tested for their effects upon translational repression of lacZ activity.

217 interaction was shown to be responsible for translational repression of manX and to contribute to de

218 ol element (TCE) act independently to direct translational repression of maternal nanos mRNA in the o

219 d posttranscriptional gene silencing through translational repression of messenger RNA during sexual

220 Also, we observed widespread translational repression of microRNA target genes in bot

221 In addition, Sbp1p promotes translational repression of mRNA during glucose deprivat

222 nction is restricted to the posterior by the translational repression of mRNA that is not incorporate

223 yeast results in nonsense-mediated decay and translational repression of mRNA, and that these roadblo

224 e cell differentiation predominantly through translational repression of mRNAs encoding pro-different

225 t the posterior of the embryo, together with translational repression of nanos in the bulk cytoplasm,

226 Overexpression of FBP1 resulted in translational repression of NPM mRNAs, whereas depletion

227 yeast, the RNA-binding protein Rim4 mediates translational repression of numerous mRNAs, including th

228 One function of arrest is in translational repression of oskar mRNA; this biochemical

229 ger RNA, the Tribolium Otd gradient forms by translational repression of otd mRNA by a posteriorly lo

230 ponse through coordinate transcriptional and translational repression of p53 levels, which reduces p5

231 that the full-length protein is required for translational repression of para mRNA.

232 slation assay, we examined the mechanisms of translational repression of PUF proteins in the budding

233 n Rubisco deficiency and was correlated with translational repression of rbcL.

234 enous miRNAs to mediate RNA-like cleavage or translational repression of reporter mRNAs.

235 onal inhibition of the miR cluster by Runx2, translational repression of Runx2 and of SATB2 by the cl

236 tranded noncoding RNAs that function through translational repression of specific target mRNAs.

237 NA molecules that have been shown to mediate translational repression of target mRNAs involved in cel

238 ivo experiments to test CT tetramer-mediated translational repression of the accA and accD mRNAs.

239 frames initiated by ATG but not CTG mediated translational repression of the downstream main open rea

240 maphrodite spermatogenesis requires germline translational repression of the female-promoting gene tr

241 ogenesis in an otherwise female body through translational repression of the gene tra-2.

242 istinct regions of FsrA are required for the translational repression of the GltAB and SDH enzyme com

243 In Caenorhabditis elegans, translational repression of the key sex-determination ge

244 In the current study, we report that translational repression of the manY and manZ genes by S

245 asome-mediated degradation of C/EBPalpha and translational repression of the p53 protein by the CUGBP

246 as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4.

247 that Bic-C functions in spatially regulated translational repression of the xCR1 mRNA during Xenopus

248 anslational activation of tumor suppressors, translational repression of transcripts enriched with mi

249 Not4 is involved in translational repression of transcripts that cause trans

250 predict a model in which Cup and Sqd mediate translational repression of unlocalized grk mRNA, and PA

251 estricted Nanos synthesis is accomplished by translational repression of unlocalized nanos mRNA toget

252 pole of the oocyte and early embryo through translational repression of unlocalized nos mRNA coupled

253 uing for a role for the ELAV proteins in the translational repression of Vg1 mRNA during early oogene

254 Here, we show that vegetal cell-specific translational repression of xCR1 mRNA contributes to thi

255 tantly, this interaction is required for the translational repression of Zfp36's target mRNAs in reso

256 ority of these regulatory mechanisms involve translational repression, one example of translational a

257 ts strongly support the model that S(MK) box translational repression operates through occlusion of t

258 the regulation of gene expression by either translational repression or degradation of target mRNAs.

259 ract with multiple mRNAs resulting in either translational repression or degradation.

260 Ago) protein complex that usually results in translational repression or destabilization of the targe

261 tary sequences of target mRNAs, resulting in translational repression or target degradation and thus

262 ovide insight into how arrest contributes to translational repression or that may be targets for arre

263 with small RNAs that guide mRNA degradation, translational repression, or a combination of both.

264 rence (RNAi) pathways to guide RNA cleavage, translational repression, or methylation of DNA or chrom

265 sequence-specific messenger RNA degradation, translational repression, or transcriptional inhibition.

266 gly, overexpression of Dhh1p or Pat1p causes translational repression, P body formation, and arrests

267 rom mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylat

268 is present in cytoplasmic granules with the translational repression proteins Dcp1 and 4E-T.

269 Yet, synaptic mechanisms regulated by 4E-BP2 translational repression remain unknown.

270 represents a novel target of Bruno-mediated translational repression required for cystoblast differe

271 A combination of translational repression, RNA degradation, and activatio

272 Transfected NSCLC cells with enhanced translational repression showed pronounced cell death fo

273 particular, Clb3 is regulated by a striking translational repression specific to meoisis I.

274 rticle that has been linked to pathogenesis, translational repression, starvation responses, and ribo

275 zation has been correlated with release from translational repression, suggesting an important regula

276 hus, Smaug2 and Nanos1 function as a bimodal translational repression switch to control neurogenesis,

277 sults identify a broadly acting mechanism of translational repression that targets mRNAs for decappin

278 Although this led to a 5.4-fold general translational repression, the protein coding open readin

279 a consequence of a defect in miRNA-mediated translational repression; the effect of suo on vegetativ

280 ost & Microbe, Zhang et al. (2017) show that translational repression through eIF2alpha phosphorylati

281 tion was required directly or indirectly for translational repression through elements of the glp-1 3

282 Finally, a one-hybrid screen based on translational repression through the 5'-UTR identified l

283 tor 2alpha (eIF2alpha), which caused general translational repression to inhibit HIF-1alpha expressio

284 ow that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state

285 iated deadenylation concurrently shifts from translational repression to mRNA destabilization.

286 for eIF2alpha phosphorylation and subsequent translational repression to occur.

287 An important regulatory mechanism of translational repression under hypoxic conditions involv

288 The absence of Not4 affected global translational repression upon nutrient withdrawal, enhan

289 Reversal of eIF2alpha-mediated translational repression using ISRIB potently suppressed

290 for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, f

291 biologically relevant molecular mechanism of translational repression via modulating the cytoplasmic

292 In actively dividing cells, translational repression was followed by mRNA decay; how

293 Translational repression was relieved during oocyte matu

294 known to function in microRNA (miRNA)-based translational repression, we lack a comprehensive unders

295 To understand the mechanism of translational repression, we used rabbit reticulocyte ly

296 oRNA-directed target transcript cleavage and translational repression were impaired in the AGO3 mutan

297 (ALAS2) levels attributable to IRP-mediated translational repression were observed in erythroid cell

298 ly equivalent with bulged miRNA duplexes for translational repression, whereas Ago1 and Ago2 appear t

299 This allele is thought to primarily affect translational repression, which has been linked with the

300 by stress are predominantly associated with translational repression, while more actively initiating