ライフサイエンスコーパス: translational repressor

1 argets tested thus far, GLD-1 functions as a translational repressor.

2 and the other as an mRNA-specific autogenous translational repressor.

3 er proteins, such as CYFIP1, which acts as a translational repressor.

4 s a sequence-specific RNA-binding autogenous translational repressor.

5 FMRP controls its function as an RNA-binding translational repressor.

6 tardation protein (FMRP), which functions as translational repressor.

7 1-mediated inhibition of the cellular 4E-BP1 translational repressor.

8 wheat germ extracts confirmed that DCP5 is a translational repressor.

9 a specific inhibitor of mTORC1, is a potent translational repressor.

10 SRC-3(-/-) macrophages implicate SRC-3 as a translational repressor.

11 translation rates, and also by mRNA-specific translational repressors.

12 hat also function as mRNA-binding autogenous translational repressors.

13 by preventing interaction of nanos RNA with translational repressors.

14 naling and the Pumilio (Pum) and Nanos (Nos) translational repressors.

15 translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) fo

16 ryotic initiation factor 4E (elF-4E) and the translational repressor 4E-binding protein 1 (4E-BP1) in

17 nslation by activating mTORC1 to inhibit the translational repressor 4E-binding protein 1 (4E-BP1).

18 ctor rpS6, as well as phosphorylation of the translational repressor 4E-binding protein 1.

19 show that the regulation of the TOR effector translational repressor 4E-BP is finely tuned to the nut

20 The translational repressor 4E-BP, the eukaryotic translatio

21 ream phosphorylation and deactivation of the translational repressor 4E-BP1 (eIF4E-binding protein 1)

22 n rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of th

23 Curiously, inactivating the host translational repressor 4E-BP1 in HCMV-infected cells st

24 orm of RSK1 is present in a complex with the translational repressor 4E-BP1 in IFNlambda-sensitive ce

25 While the translational repressor 4E-BP1 regulates binding of eIF4

26 mechanism that couples the abundance of the translational repressor 4E-BP1 with its target eIF4E via

27 cap binding protein eIF4E, together with the translational repressor 4E-BP1, are both phosphorylated

28 ression of the negative downstream effector, translational repressor 4E-BP1, partially reverses the e

29 tion of the mTORC1 substrate p70 S6K and the translational repressor 4E-BP1.

30 ducing hypophosphorylation/activation of the translational repressor 4E-BP1.

31 tiation factor eIF4F is regulated in part by translational repressors (4E-BPs) that prevent incorpora

32 complex and increases the association of the translational repressor 4EBP1 to the 7-methylguanosine c

33 ered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis.

34 ines of evidence demonstrate that GLD-1 is a translational repressor acting through the TGEs to repre

35 elevated brain protein levels due to loss of translational repressor activity.

36 FMRP is believed to be a translational repressor and may regulate the translation

37 ssary for its in vivo function as a neuronal translational repressor and regulator of synaptic archit

38 le protein complexes and functions both as a translational repressor and splicing regulator for anter

39 activators Dhh1p and Pat1p as functioning as translational repressors and facilitators of P body form

40 arate but overlapping recognition motifs for translational repressors and localization factors provid

41 ates of nontranslating mRNAs associated with translational repressors and the mRNA decapping machiner

42 NAT1 is likely to be a fundamental translational repressor, and its aberrant editing could

43 PUF family translational repressors are conserved developmental reg

44 Remarkably, loss of just the 4E-BP family of translational repressors, arguably the best characterize

45 MOV10--which is the homologue of Drosophila translational repressor Armitage--and proteins of the 60

46 elanogaster, has identified Pumilio (Pum), a translational repressor, as an essential component of on

47 Colocalization with translational repressor BC1 RNA in hippocampal dendrites

48 In Drosophila, the translational repressor Bgcn is required for spermatogon

49 Our analysis shows that translational repressor binding results in self-associat

50 t the MEF2A 3' UTR functions as a cis-acting translational repressor both in vitro and in vivo and su

51 Here, we demonstrate that the translational repressor Bruno binds the 3' UTR and inhib

52 in, has been implicated in this process as a translational repressor, but the underlying mechanism is

53 lation initiation factors and functions as a translational repressor by targeting assembly of 48S ini

54 ins to a translational activator, GLD2, or a translational repressor, CAF1.

55 lencing by providing an environment in which translational repressors can encounter their mRNA target

56 screen identified components of the Pumilio translational repressor complex (Pumilio, Nanos, and Bra

57 The Nanos-Pumilio translational repressor complex and the miRNA pathway al

58 tions in the expression of the Pumilio (PUM) translational repressor complex enhanced phenotypes due

59 relationship between the Nanos (Nos)-Pumilio translational repressor complex, which promotes GSC self

60 lls lacking the mRNA decapping activator and translational repressor Dhh1.

61 re present from yeast to mammals, and act as translational repressors during embryo development and c

62 of normal, primary human cells destroys the translational repressor eIF4E binding protein (4E-BP) an

63 ed with inhibition of phosphorylation of the translational repressor eIF4E-binding protein 1 (4E-BP1)

64 mTORC1 directly phosphorylates the translational repressors eIF4E binding proteins (4E-BP)

65 n the signaling that converges onto the RsmA translational repressor either via RetS/LadS or via HptB

66 h the consequence of removing the downstream translational repressor element.

67 he binding affinity between eIF4B and BC RNA translational repressors, enabling the factor to engage

68 mTOR-mediated phosphorylation of both the translational repressor eukaryotic initiation factor 4E

69 essing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-

70 everse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-

71 by 58% and increased phosphorylation of the translational repressor, eukaryotic initiation factor (e

72 ative regulatory module, consisting of NOS-3 translational repressor, FEM-CUL-2 (E3 ubiquitin ligase)

73 In fragile X, the loss of the mRNA translational repressor FMRP leads to exaggerated protei

74 ptional silencing of FMR1, which encodes the translational repressor fragile X mental retardation pro

75 large intron of the previously characterized translational repressor gene pumilio (pum).

76 -3 in the adult germline is regulated by the translational repressor GLD-1: MES-3 is absent from the

77 ls: (1) translation regulation by a specific translational repressor, GLD-1; and (2) uORF elicited re

78 meiotic cell cycle: GLD-1 is a STAR/Quaking translational repressor, GLD-2 is a cytoplasmic poly(A)

79 (eIF4E) binding proteins (4E-BPs), which are translational repressors, have a multifaceted effect on

80 ve eIF4F complexes in relation to the 4E-BP1 translational repressor, illustrating a new strategy thr

81 ly, these results point to Puf3p acting as a translational repressor in a manner exceeding the global

82 ) RNA binding proteins function as important translational repressors in multiple biological contexts

83 witch, converting OMA proteins from specific translational repressors in oocytes to global transcript

84 ns from coliphages and yeast can function as translational repressors in plants.

85 We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for m

86 Translational repressors, increasing evidence suggests,

87 e show that Pumilio-2 (PUM2), an RNA binding translational repressor, is highly localized at the neur

88 The mRNA encoding the translational repressor Nanos (Nos) forms ribonucleoprot

89 A requirement for the translational repressor Nanos (Nos) in the Drosophila la

90 Here, we show that removing the translational repressor Nanos from either GSCs or their

91 The translational repressor Nanos is expressed in the germli

92 ipts in the fly ovary, including mRNA of the translational repressor Nanos.

93 The translational repressors Nanos (Nos) and Pumilio (Pum) a

94 The translational repressors Nanos and Pumilio act in GSCs t

95 press components of the Dpp cassette and the translational repressors Nanos and Pumilio, whereas cyst

96 this study suggest that TDP-43 represents a translational repressor not only for specific mRNAs but

97 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flowe

98 By contrast, TIA-1 functioned as a translational repressor of cytochrome c, with interventi

99 We propose that dFXR acts as a translational repressor of Futsch to regulate microtubul

100 bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid tra

101 otein, Bruno (Bru), has been implicated as a translational repressor of osk mRNA.

102 Thus, Cup is a translational repressor of oskar that is required to ass

103 The R17/MS2 coat protein serves as a translational repressor of replicase by binding to a 19

104 protein also acts as a transcript-selective translational repressor of selenoprotein synthesis durin

105 We demonstrate that Pr76gag acts as a translational repressor of these mRNAs in a dose-depende

106 E-binding) protein (4E-BP) family, which are translational repressors of 5' cap-dependent protein syn

107 made in identifying localization factors and translational repressors of oskar, none of the known com

108 MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in anim

109 fect of the binding of an RNA stem-loop (the translational repressor) on the association rates of the

110 Control of the translational repressor, PHAS-I, was investigated by exp

111 oupled by an interaction between Sqd and the translational repressor protein Bruno.

112 iometry of the complex formed between the T4 translational repressor protein regA and the 16 nt gene

113 control mechanism involving the release of a translational repressor protein that allows the immediat

114 ulatory factors, demonstrated binding of the translational repressor protein TIA-1 to COX-2 mRNA.

115 Thus, CPEB appears to act as a translational repressor protein to control myc translati

116 e RNA-binding studies of the phage RB69 RegA translational repressor protein, regA was configured to

117 each other and associate with Bruno, a known translational repressor protein.

118 These include translational repressor proteins (eukaryotic initiation

119 ith both the scaffold protein, eIF4G and the translational repressor proteins, the eIF4E-binding prot

120 Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of

121 contain putative recognition motifs for the translational repressor, Pumilio, which also exhibits th

122 increased expression of the transcriptional/translational repressor purine-rich element binding prot

123 The T4 translational repressor RegA protein folds into two stru

124 We report a translational repressor (Smt1p) of the ATP6/8 mRNA that,

125 protein (Orb); this regulation involves the translational repressor Squid (Sqd).

126 SRC-3 may cooperate with other translational repressors such as TIA-1 and TIAR to regul

127 bition of the proteasome causes a buildup of translational repressors, such as polyadenylate-binding

128 Recently, GLD-1 was found to be a translational repressor that acts through regulatory ele

129 Pumilio (Pum) is a translational repressor that binds selectively to target

130 The T4 protein, RegA, is a translational repressor that blocks ribosome binding to

131 es by signalling the degradation of GLD-1, a translational repressor that blocks V-ATPase synthesis.

132 activation of 4E-binding protein (4E-BP1), a translational repressor that inhibits the function of eu

133 om a single operon for which L10(L12) 4 is a translational repressor that recognizes a secondary stru

134 teins from the bacteriophage T4 and RB69 are translational repressors that control the expression of

135 pports a model in which BC1 RNA and FMRP are translational repressors that operate independently.

136 Enforced expression of the cap-dependent translational repressor, the eukaryotic translation init

137 Pat1 in yeast are mRNA decapping activators/translational repressors thought to play key roles in th

138 NF90 and decreased its association with the translational repressors TIAR and TIA-1.

139 idence that bcd also binds RNA and acts as a translational repressor to generate an opposing gradient

140 he rme-2 yolk receptor mRNA, GLD-1 acts as a translational repressor to spatially restrict RME-2 accu

141 3K) class IB and increased expression of the translational repressor translation initiation factor 4E

142 tion, a mutant 4E-BP (eIF4E-binding protein) translational repressor unresponsive to mTORC1 stimulate

143 The pumilio translational repressor was found from both approaches,

144 S6K) (p70) and phosphorylation of the 4E-BP1 translational repressor, we assessed these potential mol

145 levels, suggesting that miR398 can act as a translational repressor when target site complementarity

146 Thus, we establish PML and Z as translational repressors, with potential contributions t

147 , tiRNA(Ala), tiRNA(Cys)) cooperate with the translational repressor Y-box binding protein 1 (YB-1) t