ライフサイエンスコーパス: translocase

1 slpA, cwp66 (adhesin), and secA2 (secretory translocase).

2 taining precursor and Hcf106 (i.e. the cpTat translocase).

3 a 3' to 5' translocase, and RecD, a 5' to 3' translocase).

4 d with EcRep and EcUvrD (both 3' to 5' ssDNA translocases).

5 t these events reflect active pushing by the translocase.

6 ly through the membrane-embedded SecA-SecYEG translocase.

7 gets ribosome-associated proteins to the Sec translocase.

8 ition particle (SRP), an SRP receptor, and a translocase.

9 ated Tha4 entry into the chamber to form the translocase.

10 terminus (FtsKC) is a well characterized DNA translocase.

11 l morphology nor the assembly of the protein translocase.

12 nits a and b and the TatC subunit of the Tat translocase.

13 nerated at least in part by the SMARCAL1 DNA translocase.

14 tions for the mechanism of the bacterial Tat translocase.

15 catalyzes substrate transfer to the membrane translocase.

16 al sequence might be accommodated in the Tat translocase.

17 fur domain, required the activity of the Tat translocase.

18 annel to the import motor of the presequence translocase.

19 dria and are translocated by the presequence translocase.

20 gnal peptide-independent assembly of the Tat translocase.

21 -coupled repair (TCR) is mediated by the Mfd translocase.

22 ing and in triggering assembly of the active translocase.

23 ion with the very C-terminus of the FtsK DNA translocase.

24 l process catalyzed predominantly by the Sec translocase.

25 f substepping events in a hexameric helicase/translocase.

26 chloroplast envelope membrane by undescribed translocases.

27 that TatE-GFP associates with functional Tat translocases.

28 rs ABCA1 and ABCG1, which are membrane lipid translocases.

29 d into mitochondria with the help of protein translocases.

30 the SWI2/SNF2 family of ATPase-dependent DNA translocases.

31 rane and lumen by the SEC1, TAT, or SRP/ALB3 translocases.

32 Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane p

33 with and dephosphorylate adenine nucleotide translocase 1 (ANT1), a central molecule controlling mit

34 y acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane pr

35 of new glaucoma related candidates, ADP/ATP translocase 3 (ANT3), PC4 and SRFS1-interacting protein

36 as much more particular, requiring an intact translocase, a functional signal peptide, and a correctl

37 Here we report that the ZRANB3 translocase, a SNF2 family member related to the SIOD di

38 e PaoABC, that is co-translocated by the Tat translocase according to a ternary "hitchhiker" mechanis

39 To better understand how translocases act in crowded environments, we used single

40 ATP-independent manner, distinct from a DNA translocase actively threading the downstream DNA in the

41 und that ABCA1's PIP2 and phosphatidylserine translocase activities are independent from each other.

42 ain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a

43 dicates that RecBCD helicase possesses ssDNA translocase activities in both polarities.

44 to RNAP, Mfd exhibits robust ATPase and DNA translocase activities, but when released from its subst

45 inding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively.

46 lag in initiating its ATPase as well as the translocase activities.

47 r protein that has ATPase, endonuclease, and translocase activities.

48 Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiqui

49 that the recently identified RecBC secondary translocase activity functions within RecBCD and that th

50 s a previously unrecognized role of the Dna2 translocase activity in DNA break end resection and in t

51 Thus, Dda transduces all of its translocase activity into DNA unwinding activity so that

52 Here we probed the single-stranded DNA translocase activity of Escherichia coli UvrD by single

53 and provides strong structural support for a translocase activity of XPB.

54 We also found that FANCM translocase activity protects cells from accumulating 53

55 fication tag (TAPN-Drs2), retains ATPase and translocase activity, but Drs2p purified using a C-termi

56 scription elongation and, using its helicase/translocase activity, forces RNA polymerase to slide bac

57 though FANCM contains a helicase domain with translocase activity, this is not required for its role

58 ay limits R-loop accumulation requires FANCM translocase activity.

59 ntains an Ssl2-dependent double-stranded DNA translocase activity.

60 sion incision activities, which requires its translocase activity.

61 We show that the FtsK DNA translocase acts differentially at the recombination sit

62 coli this threat is kept at bay by RecG DNA translocase and by single-strand DNA exonucleases.

63 pTatC is the core component of the thylakoid translocase and coordinates transport through interactio

64 rotated ribosomes favor binding of the eEF2 translocase and disfavor that of the elongation ternary

65 was strongly reduced by inactivation of the translocase and DNA binding activities of the FANCM/MHF

66 iated with the expression of CD36/fatty acid translocase and elevated free fatty acid (FFA) levels.

67 he RAD51 nucleoprotein filament, but not its translocase and helicase activities.

68 Hsp104 is a dynamic ring translocase and hexameric AAA+ protein found in yeast, w

69 onsumption independent of adenine nucleotide translocase and uncoupling proteins, decreased mitochond

70 induces transient increase of mitochondrial translocases and a dramatic accumulation of the mitochon

71 gy and conformation in actively transporting translocases and compared that with Tha4 in nontransport

72 Several translocases and insertases have been found in prokaryot

73 that RecBCD is able to switch between ssDNA translocases and rethread the other strand of ssDNA.

74 ses two superfamily-1 motors, RecB (3' to 5' translocase) and RecD (5' to 3' translocase), that opera

75 ooperates with cochaperones, the presequence translocase, and other chaperone systems.

76 ecBCD possesses two motors (RecB, a 3' to 5' translocase, and RecD, a 5' to 3' translocase).

77 hr-(1-856) is an autonomous ATPase, 3'-to-5' translocase, and RNA:DNA helicase.

78 Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochon

79 Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the

80 in the cell, where insertion is assisted by translocase apparatus.

81 Hsp100 polypeptide translocases are conserved members of the AAA+ family (a

82 e substrate receptor complex, and active Tat translocases are formed by the substrate-induced associa

83 Here, using a novel real-time translocase assay, we unexpectedly discovered that Mfd t

84 ucture of the pore complex inform models for translocase assembly and translocation.

85 ration: It binds the signal peptide, directs translocase assembly, and may facilitate translocation.

86 The SRP-independent pathway requires the Sec translocase-associated ER membrane protein Sec62 and can

87 rtner protein complexes like the presequence translocase-associated import motor and the respiratory

88 We observed the arrival of the FtsK translocase at individual preformed synaptic complexes a

89 ree, indicating the existence of alternative translocases at the inner envelope membrane.

90 mechanism for reorganization is for an ssDNA translocase (ATP-dependent motor) to push the SSB along

91 The results indicate that translocase-based mechanisms enable DNA synthesis to con

92 Furthermore, the stromal domain of the Alb3 translocase binds with high affinity to and regulates GT

93 d and processive single-stranded DNA (ssDNA) translocase but is unable to unwind DNA processively in

94 of the mitochondrial outer membrane protein translocase but not the two receptor subunits, one of wh

95 that is involved in their binding to the Tat translocase, but some facets of this interaction remain

96 nly two nucleotide transporters, the ATP/ADP translocase C. trachomatis Npt1 (Npt1(Ct)) and the nucle

97 We determined that carnitine acyl-carnitine translocase (CACT; Slc25a20) is a direct target of these

98 mplexes further suggests that a discrete Tat translocase can translocate a variety of substrates, pre

99 , which may explain why only a subset of DNA translocases can carry out fork reversal.

100 MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an essential membra

101 heterodimer with P4 ATPases to enhance their translocase catalytic activity.

102 tively associated with changes in fatty acid translocase CD36 (R(2) = 0.30), fatty acid transport pro

103 are induced by repression of the fatty acid translocase CD36, which is seen in desmoplastic and dise

104 old, p < 0.001), and, to a lesser degree, FA translocase (CD36) (3.1-fold, p < 0.001) relative to A1A

105 Here we show that the PA translocase channel has a transport function in which it

106 thrax toxin is composed of three proteins, a translocase channel-forming subunit, called protective a

107 ge, the injectisome, with a cytoplasm-facing translocase channel.

108 Therefore, peptide-clamp sites in translocase channels can sense large steric features (li

109 These translocase channels interact with the substrate protein

110 Tom40 is the central subunit of the translocase complex and forms a pore in the mitochondria

111 A new study of the bacterial Sec translocase complex reports that ADP/ATP binding to SecA

112 potential or the structure of the preprotein translocase complexes.

113 n of both the incoming presequence and other translocase components at the translocation contact.

114 We show that a lipid membrane (devoid of translocase components) is sufficient for successful co-

115 The presequence translocase constituent Pam17 is specifically recruited

116 ring-shaped protein and nucleic acid protein translocases control essential biochemical processes thr

117 te a lipid-dependent dimer formation of MraY translocase correlating with the enzymatic activity.

118 licensed and fired, it is possible that DNA translocases could disrupt pre-replicative complexes (pr

119 post-translationally by the highly conserved translocase Cox18 and associated proteins.

120 We demonstrate that cells expressing translocase-defective FANCM show altered global replicat

121 number of SecYEG units involved in an active translocase depends on the precursor undergoing transfer

122 We also show that translocase depletion in tumor cell lines leads to the a

123 The protein translocases do not operate as separate entities but are

124 a catalytic subunit that bears an ATPase/DNA-translocase domain and flanking regions that bind nucleo

125 An ATP-dependent DNA translocase domain consisting of seven conserved motifs

126 that involves ATP hydrolysis by RIG-I's RNA translocase domain.

127 Bidentate interactions with the Alb3 translocase drive cpSRP43 to a partially inactive state,

128 Two protein translocases drive the import of beta-barrel precursor p

129 approaches to guide studies of the putative translocase EccC, a unique enzyme with three ATPase doma

130 ormed with the Taura syndrome virus IRES and translocase eEF2*GTP bound with sordarin.

131 conserved principles of interaction between translocase/effector and substrate/recipient.

132 the effect of force directionality, and the translocase efficacy.

133 RecG is a DNA translocase encoded by most species of bacteria.

134 ed substrates are chaperone-delivered to the translocase, EscV in enteropathogenic Escherichia coli,

135 ave tackled the question of how FtsK/SpoIIIE translocases establish and maintain directional DNA tran

136 ion stress response is the ATP-dependent DNA translocase FANCM, which we have shown to be hyperphosph

137 ion in a pathway parallel to that of the DNA translocase FANCM.

138 f multiple types of branched DNAs by the DNA translocase FANCM.

139 Genetic variants in the fatty acid (FA) translocase FAT/CD36 associate with abnormal postprandia

140 hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the s

141 Fatty acid translocase (FAT/CD36), whose expression is inducible in

142 Lipid translocases (flippases) have been implicated in vesicle

143 agonizing both the FANCM-family DNA helicase/translocase Fml1 and the RecQ-type DNA helicase Rqh1 to

144 the pore-forming component to assemble a new translocase for each substrate.

145 The active translocase for the precursor of periplasmic galactose-b

146 in, each require the concerted action of two translocases for their assembly.

147 e special cases, the divisome-associated DNA translocase FtsK is required.

148 upt RAD51 filaments on DNA through its ssDNA translocase function.

149 The FtsK dsDNA translocase functions in bacterial chromosome unlinking

150 , the known conductance bottleneck in the PA translocase, gates as either a more closed state or a mo

151 It remains unclear how these DNA translocases harness chemical energy (ATP turnover) to p

152 riers, but their association with preprotein translocases has been controversial.

153 The RAD54 family DNA translocases have several biochemical activities.

154 factor configuration, without the dedicated translocase/helicase encoding factor TFIIH.

155 responses in humans is the Rad5-related DNA translocase, HLTF.

156 essential, membrane-embedded subunit of the translocase; however, its function is only poorly unders

157 Translocase I (MraY/MurX) is an essential enzyme in grow

158 while not affecting the architecture of the translocase, impedes both protein and tRNA import.

159 TatE being a regular constituent of the Tat translocase in E. coli.

160 long-timescale investigations of the active translocase in near-native conditions and, more generall

161 he respective roles of UvrD helicase and Mfd translocase in repair of UV-induced damage.

162 ct evidence for the participation of the Tat translocase in structural proofreading of substrate prot

163 iver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane.

164 es evidence for a role of adenine nucleotide translocase in the mechanism underlying altered mitochon

165 endosome (EE) requires Drs2, a phospholipid translocase in the type IV P-type ATPase family.

166 uctural model for assembly of the active Tat translocase in which substrate binding triggers replacem

167 drives both the primary and secondary RecBC translocases in a tightly coupled reaction.

168 AT family as a widely used system of protein translocases in different membranes of endosymbiotic ori

169 d PE affect the function of distinct protein translocases in mitochondrial beta-barrel biogenesis.

170 Using purified proteins we show that DNA translocases, including RNA polymerase, can push budding

171 These FRET spikes result from translocase-induced directional (5' to 3') pushing of th

172 for understanding the integration of protein translocases into a large network that controls organell

173 case-like transcription factor (HLTF), a DNA translocase involved in the repair of damaged replicatio

174 ed with precursor proteins and Tha4, the Tat translocase is an approximately 2.2-megadalton complex t

175 Targeting to the translocase is mediated by signal peptides.

176 ulator of chromatin, subfamily A-like 1) DNA translocase is one of several related enzymes, including

177 MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme that catalyz

178 TatC, a subunit of the twin arginine translocase, is a 6-membrane-spanning protein exposing t

179 ana RECG1, an ortholog of the bacterial RecG translocase, is an organellar protein with multiple role

180 emonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-ds

181 s on the core subunits of the protein import translocase, it does not require the protein import rece

182 D54L and RAD54B, which are Swi2/Snf2-related translocases known to dissociate RAD51 filaments from ds

183 se of the antiassociation factor Tif6 by the translocase-like guanosine triphosphatase Efl1 is a crit

184 These data demonstrate that the SEC2 translocase likely integrates a subset of inner envelope

185 e imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane

186 results also suggest that XPB/Ssl2 uses this translocase mechanism during DNA repair rather than phys

187 the direction for the movement of the dsDNA translocase motor domain for fork reversal.

188 FtsK/SpoIIIE translocases move DNA in a highly processive, directiona

189 Phospho-MurNAc-pentapeptide translocase (MraY) catalyzes the synthesis of Lipid I, a

190 obules but lacks a uniquely folded structure-translocase mutants that rescued export of this protein

191 rane protein and core component of the TIM22 translocase of inner membrane, as a protein with cystein

192 H dehydrogenase 1alpha subcomplexes 2 and 3, translocase of inner mitochondrial membrane 50, and valy

193 consisting of the mitochondrial translocase, translocase of outer mitochondrial membrane 22 (Tom22),

194 hepatocyte nuclear factor 4, alpha), TOMM34 (translocase of outer mitochondrial membrane 34) and SRC

195 beta1 gene (two studies, 449 participants), translocase of outer mitochondrial membrane 40 gene (one

196 , we identify novel BMI associations in loci translocase of outer mitochondrial membrane 40 homolog (

197 metric data, the apolipoprotein E (APOE) and translocase of outer mitochondrial membrane 40 homolog (

198 and Erv1/ALR facilitates import of the small translocase of the inner membrane (Tim) proteins and cys

199 The presequence translocase of the inner membrane (TIM23 complex) mediat

200 esent in respiratory chain complex I and the Translocase of the Inner Membrane 17:23.

201 14.7 like (B14.7 [encoded by At2g42210]) and Translocase of the inner membrane subunit 23-2 (Tim23-2

202 There are three isoforms of the TRANSLOCASE OF THE INNER MEMBRANE17 (Tim17).

203 Previously, we characterized the essential translocase of the mitochondrial inner membrane (TIM) co

204 is required for the assembly of the archaic translocase of the outer membrane (ATOM), the functional

205 e domain of the translocase subunit, archaic translocase of the outer membrane (ATOM)14, on the other

206 s into the mitochondrial outer membrane: The translocase of the outer membrane (TOM complex) promotes

207 ority of precursor proteins, the role of the translocase of the outer membrane (TOM) and mechanisms o

208 mponents and Tim21, which interacts with the translocase of the outer membrane (TOM) and the respirat

209 res two preprotein translocases, the general translocase of the outer membrane (TOM) and the sorting

210 sport machineries of the outer membrane, the translocase of the outer membrane (TOM) and the sorting

211 Emc proteins interact with the mitochondrial translocase of the outer membrane (TOM) complex protein

212 enous PINK1 forms a 700 kDa complex with the translocase of the outer membrane (TOM) selectively on d

213 way, namely transferring substrates from the translocase of the outer membrane complex onto the small

214 must be transported into mitochondria by the translocase of the outer membrane complex.

215 ort and assembly of proteins, including TOM (translocase of the outer membrane) and SAM (sorting and

216 tional Tom40 and instead employs the archaic translocase of the outer mitochondrial membrane (ATOM),

217 and use instead a protein termed the archaic translocase of the outer mitochondrial membrane (ATOM).

218 The preprotein translocase of the outer mitochondrial membrane (TOM) fu

219 One SNP--rs2075650, located in TOMM40 (translocase of the outer mitochondrial membrane 40 homol

220 and enter the organelle via the TOM complex (translocase of the outer mitochondrial membrane).

221 Furthermore, Tim29 contacts the Translocase of the Outer Mitochondrial Membrane, TOM com

222 imported into mitochondria via multiprotein translocases of the mitochondrial outer and inner membra

223 both eukaryotic Tom40 and bacterial protein translocases of the Omp85 family.

224 gation utilizes highly conserved directional translocases of the SpoIIIE/FtsK family.

225 show that isolated NPH I acts as a 5' to 3' translocase on single-stranded DNA.

226 y of UvrD when it is functioning either as a translocase or a helicase on DNA in the absence of RecA.

227 istent with EF4 functioning either as a back-translocase or a ribosome sequester.

228 lesion, perhaps by Cockayne syndrome group B translocase, or during the synthesis of a repair patch.

229 p90, and translocated to its interior by the translocase outer membrane (TOM) complex.

230 the Tha4 conformation that is adopted in the translocase primed for translocation.

231 relocate the His-289 residue, such that the translocase reaction can proceed via a nucleophilic atta

232 e imaging to determine how the ATP-dependent translocase RecBCD travels along DNA occupied by tandem

233 e mechanisms by which SMARCAL1 and other DNA translocases repair replication forks are poorly underst

234 n is a member of the Swi2/Snf2 family of DNA translocases required for meiotic and mitotic recombinat

235 smembrane segments of PClep can decrease the translocase requirement for translocation of the peptide

236 Here, we find that the translocase requirements can be altered for PClep in a p

237 SpoIIIE is a homo-hexameric dsDNA translocase responsible for completing chromosome segreg

238 charomyces cerevisiae Pif1, a 5' to 3' ssDNA translocase, results in the appearance of isolated, irre

239 s forward less effectively or because 2) the translocase retains substrate less well when resetting b

240 pon the adenosine triphosphate-dependent RNA translocase Rho, which binds nascent RNA and dissociates

241 , upregulating the expression of the protein translocase SecA.

242 loading of the targeting complex at membrane translocase sites in the post-translational cpSRP pathwa

243 Each mutant translocase still efficiently exported folded substrate

244 vels of the mitochondrial adenine nucleotide translocase stress-sensitive B (SesB), increased adenosi

245 on of TFIIH preparations carrying mutant XPB translocase subunit further indicate that this relief of

246 nits, i.e., Ssl1, Tfb4, and Tfb2, in the DNA translocase subunit Ssl2, and in the kinase module subun

247 dent despite a requirement for the TFIIH DNA translocase subunit Ssl2.

248 eriochlorophyll synthase (BchG), the protein translocase subunit YajC and the YidC membrane protein i

249 ion of the intermembrane space domain of the translocase subunit, archaic translocase of the outer me

250 l similarities with the motor domains of DNA translocases, such as the VirD4/TrwB conjugative couplin

251 Sam37 functions as a coupling factor of the translocase supercomplex of the mitochondrial outer memb

252 Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-d

253 The twin-arginine translocase (Tat) carries out the remarkable process of

254 The twin-arginine translocase (Tat) transports folded proteins across the

255 The twin-arginine translocase (Tat) transports folded proteins across tigh

256 The twin arginine translocase (Tat) transports folded proteins of widely v

257 In the translocase, Tha4 made an additional contact within the

258 bstrate proteins and reveals epitopes in the translocase that are important for this process.

259 PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs)

260 rsely with the need for Rho activity, an RNA translocase that can bind to emerging transcripts and di

261 flippase trigger expression of an alternate translocase that can resist inhibition.

262 scherichia coli UvrD is an SF1A DNA helicase/translocase that functions in chromosomal DNA repair and

263 D is an SF1A (superfamily 1 type A) helicase/translocase that functions in several DNA repair pathway

264 r is a highly processive single-stranded DNA translocase that is stopped by a double-stranded DNA, wh

265 SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to med

266 FtsK is a hexameric DNA translocase that participates in the final stages of bac

267 FtsK is a bacterial translocase that promotes chromosome dimer resolution an

268 hat depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replic

269 coli Rho factor is an exemplar hexameric RNA translocase that terminates transcription in bacteria.

270 ns, recombinases (RecA/Rad51), and helicases/translocases that operate as motor proteins and play cen

271 sugars across the plasma membrane relies on translocases that share resemblance with small multidrug

272 cB (3' to 5' translocase) and RecD (5' to 3' translocase), that operate on the complementary DNA stra

273 NA-packaging motor, beside the bacterial DNA translocases, that uses a revolving mechanism without ro

274 ences through the TIM23 complex (presequence translocase), the activity of the Hsp70-powered import m

275 nhibitors of Mtb phospho-MurNAc-pentapeptide translocase, the enzyme responsible for the synthesis of

276 beta-barrel proteins requires two preprotein translocases, the general translocase of the outer membr

277 some; the second was to have an impaired DNA translocase; the third was to use a strain in which the

278 r could interrupt degradation because 1) the translocase thrusts forward less effectively or because

279 The carrier translocase (TIM22 complex) inserts multispanning protei

280 The presequence translocase (TIM23 complex) sorts precursor proteins wit

281 gulatory modules adapt an ancient active DNA translocase to conduct particular tasks only on the appr

282 SecA2 works with SecY and the canonical Sec translocase to export proteins.

283 It causes the ATPase translocase to slip on its protein track, stalling unfol

284 The ability of translocases to chemo-mechanically push heterologous SSB

285 pe III secretion system (T3SS) effectors and translocases to inhibit bacterial invasion of epithelial

286 ay have emerged by adaptation of ancient DNA translocases to respond to specific features of chromati

287 We report that the mitochondrial translocase Tom22 is essential for metabolic conversion,

288 oteins with the outer mitochondrial membrane translocase, Tom22, to activate metabolic activity in th

289 of a complex consisting of the mitochondrial translocase, translocase of outer mitochondrial membrane

290 Two protein translocases transport precursor proteins into or across

291 striking structural similarity with the DNA translocase TrwB.

292 lar Cell, Wei et al. (2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquit

293 miniscent of findings reported for the TIM22 translocase, which is involved in the import of carrier

294 cO supercomplexes is independent of the Bcs1 translocase, which mediates Rip1 translocation during bc

295 uced dysregulation in the adenine nucleotide translocase, which results in a slower rate of ADP or AT

296 otic elongation factor 2 (eEF2), a ribosomal translocase whose phosphorylation inhibits protein synth

297 In physiological settings, DNA translocases will encounter DNA-bound proteins, which mu

298 nd to reveal molecular details about the Wzx translocase, Wzy polymerase and O-PS chain-length determ

299 F), and the SWI/SNF catalytic subunit (SNF2) translocase zinc finger ran-binding domain containing 3

300 vitro by multiple enzymes, including the DNA translocase ZRANB3, shown to bind polyubiquitinated PCNA