ライフサイエンスコーパス: translocator protein

1 a specific PET ligand for the assessment of translocator protein.

2 exoprotein and a cognate TpsB outer membrane translocator protein.

3 AhR-hsp90, AhR-XAP2, and/or AhR-AhR nuclear translocator protein.

4 acking the aryl hydrocarbon receptor nuclear translocator protein.

5 ween pRb and the AhR but not the AhR nuclear translocator protein.

6 de (DPA-714) is a radioligand for the 18-kDa translocator protein.

7 1 polymorphism in the gene encoding the 18Kd translocator protein.

8 ceptor and aryl hydrocarbon receptor nuclear translocator proteins.

9 Typhimurium chaperone and translocator proteins.

10 ation is associated with increased levels of translocator protein 18 kDa (TSPO) and binding sites for

11 (PET) imaging with radiotracers that target translocator protein 18 kDa (TSPO) has become a popular

12 ssion tomography (PET) studies targeting the translocator protein 18 kDa (TSPO) have been limited by

13 In AD, the translocator protein 18 kDa (TSPO) is overexpressed in t

14 d can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microgli

15 ET imaging of brown adipose tissue (BAT) and translocator protein 18 kDa (TSPO) via a combination of

16 Translocator protein 18 kDa (TSPO), a biomarker of neuro

17 To measure translocator protein 18 kDa (TSPO), a marker of activate

18 ro evaluated for their potential to bind the translocator protein 18 kDa (TSPO), a protein today reco

19 ssion tomography with (11)C-PBR28 to measure translocator protein 18 kDa (TSPO), a putative biomarker

20 BR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO).

21 The PET radioligand (11)C-PBR28 targets translocator protein (18 kDa) (TSPO) and is a potential

22 As a PET biomarker for inflammation, translocator protein (18 kDa) (TSPO) can be measured wit

23 some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the sy

24 Translocator protein (18 kDa), known as TSPO, is a recog

25 Translocator protein (18 kDa, TSPO), previously known as

26 The translocator protein (18 kDa; TSPO), previously known as

27 (PET) radiotracer [11C]PBR28, which binds to translocator protein, a molecular marker that is up-regu

28 at is consistent with the biodistribution of translocator protein and yields a dose burden that is co

29 cterial cells HrpJ controls the secretion of translocator proteins and inside plant cells it suppress

30 structure and topology of the outer membrane translocator proteins and the large exoproteins that the

31 iple systems indicates that the pore-forming translocator proteins are exported before effectors, but

32 T3SS translocator proteins are required for effector proteins

33 These translocator proteins are stabilized in the cytoplasm an

34 following the binding of the AhR/AhR nuclear translocator protein (ARNT) heterodimer to dioxin respon

35 (AHR) and aryl hydrocarbon receptor nuclear translocator protein (ARNT) were coexpressed in the yeas

36 ex prior to association with the AhR nuclear translocator protein (ARNT).

37 e form of a heterodimer with the AHR nuclear translocator protein (ARNT).

38 This is the first demonstration of a translocator protein being stably associated with the TT

39 the healthy volunteers, suggesting increased translocator protein binding (z > 4.72).

40 n patients, and could explain the overlap in translocator protein binding values between patients wit

41 We found higher translocator protein-binding in slow decliners than fast

42 here when PET imaging was performed with the translocator protein-binding radioligand (18)F-GE180.

43 Amyloidosis controls displayed higher translocator protein-binding than controls, especially i

44 f interest and voxel-wise comparison, 18-kDa translocator protein-binding was higher in high affinity

45 Translocator protein-binding was measured using a simple

46 Translocator protein-binding was positively correlated w

47 as to test for an association between 18 kDa translocator protein brain positron emission tomography

48 e secretion channel because the pore-forming translocator proteins can still be secreted while effect

49 on channel protein or the adenine nucleotide translocator protein could not be demonstrated by immuno

50 ovide new insights into interactions between translocator proteins critical for virulence.

51 Translocator protein density increases when microglia ar

52 Translocator protein density measured by distribution vo

53 ecretion system, or with mutants lacking the translocator proteins, do not develop clinical disease,

54 interaction between EspD and the hydrophilic translocator protein EspA.

55 EspA filaments are homo-polymers made of the translocator protein EspA.

56 the needle that is composed of the secreted translocator protein EspA.

57 hogenic E. coli is unique in that one of the translocator proteins, EspA, polymerizes to form an exte

58 intimin receptor (Tir) and EspF, and for the translocator proteins EspB and EspD.

59 ar within the EPEC LEE region: CesD, for the translocator proteins EspB and EspD; CesT, for the effec

60 N terminus of the type III secretion system translocator proteins EspB, EspD, and EspA mediate prote

61 carbon receptor and aryl hydrocarbon nuclear translocator protein expression are not responsible for

62 Translocator protein genotyping allowed the classificati

63 fying the increased expression of the 18-kDa translocator protein have been developed.

64 lter nuclear AhR levels or hAhR/hAhR nuclear translocator protein heterodimer DRE-binding activity as

65 The reduction of (11)C-PBR28 binding to translocator protein in the brain of patients with Parki

66 m Salmonella and is therefore likely to be a translocator protein in the type-III secretion system of

67 ion of the aryl hydrocarbon receptor nuclear translocator protein in vivo by adenovirus-mediated RNA

68 es pilus protein and no longer secretes four translocator proteins in culture, and it fails to inject

69 Translocator proteins include two hydrophobic proteins,

70 slocation to the nucleus, or AhR-AhR nuclear translocator protein interactions.

71 he recruitment and stable association of the translocator protein IpaB at the TTSA needle tip in the

72 tal sensor for triggering recruitment of the translocator protein IpaB to the needle tip.

73 trigger recruitment of the first hydrophobic translocator protein, IpaB, to the tip complex where it

74 The Shigella translocator proteins, IpaB and IpaC, form a pore comple

75 eruginosa, the chaperone of the pore-forming translocator proteins is PcrH.

76 ic members of the Yersinia genus require the translocator protein LcrV for proper function of the typ

77 ibition does not alter hAhR and hAhR nuclear translocator protein levels or TCDD-induced down-regulat

78 GE180 for imaging activated microglia (18-kD translocator protein ligand [TSPO]) and static 30- to 60

79 ement, were examined using a specific 18-kDa translocator protein ligand, (11)C-PBR28, and T1-weighte

80 Translocator protein of 18 kDa (TSPO) is a highly conser

81 Glial activation in white matter assessed by translocator protein PET significantly improves predicti

82 The translocator proteins PopB, PopD, and PcrV are secreted

83 Here we used the Pseudomonas aeruginosa translocator protein PopD as a model to identify its exp

84 progression using a second-generation 18-kDa translocator protein positron emission tomography radiot

85 whether microglial activity, measured using translocator-protein positron emission tomography (PET)

86 sitron emission tomography scanning with the translocator protein radioligand 11C-PBR28 was performed

87 ivation in patients with MS using the 18-kDa translocator protein radioligand [(18)F]PBR111.

88 YopD, a translocator protein, represses the expression of T3SS g

89 on particle and association with ER membrane translocator protein Sec61.

90 on receptor and the aryl hydrocarbon nuclear translocator protein, suggesting that aryl hydrocarbon r

91 We used translocator protein-targeted molecular imaging to obtai

92 Translocator protein-targeted PET is a reliable tool for

93 pe III secretion systems rely on hydrophobic translocator proteins that form a pore in the host cell

94 To accomplish this, bacteria secrete translocator proteins that form a pore in the host-cell

95 n factor that dimerizes with the AHR nuclear translocator protein to mediate gene regulation.

96 ata for the structure of the A139T mutant of translocator protein TSPO from Rhodobacter sphaeroides s

97 Translocator protein TSPO is an 18 kDa protein implicate

98 ectional design using (18)F-FDG (n = 43) and translocator protein (TSPO) ((18)F-GE180; n = 58) small-

99 e ((18)F-PBR06) for detecting alterations in translocator protein (TSPO) (18 kDa), a biomarker of mic

100 Translocator protein (TSPO) (18 kDa), a marker of inflam

101 Translocator protein (TSPO) (18 kDa), formerly called th

102 ivated, microglia increase the expression of translocator protein (TSPO) 18 kDa, thereby making the T

103 wth, inflammation, and invasion, such as the translocator protein (TSPO) and matrix metalloproteinase

104 In glioblastoma multiforme (GBM), translocator protein (TSPO) and murine double minute (MD

105 althy volunteers, genetically stratified for translocator protein (TSPO) binding status, underwent PE

106 es the first comprehensive quantification of translocator protein (TSPO) binding using SPECT and 6-ch

107 Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprot

108 11C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within macrophages

109 line class was exploited to search for a new translocator protein (TSPO) fluorescent probe endowed wi

110 et al. reported on a crystal structure for a translocator protein (TSPO) from Rhodobacter sphaeroides

111 adiolabeled ligands selective for the 18 kDa translocator protein (TSPO) has become the most widely u

112 The mitochondrial translocator protein (TSPO) has been implicated in CNS d

113 Elevated expression of translocator protein (TSPO) has been shown to predict di

114 ssion tomography (PET) imaging of the 18 kDa translocator protein (TSPO) has been used to investigate

115 PET radioligands targeting the 18-kDa translocator protein (TSPO) have been used as in vivo ma

116 ective of this study was to evaluate whether translocator protein (TSPO) imaging could be used to vis

117 Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4'

118 PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients wi

119 The translocator protein (TSPO) is a commonly used imaging t

120 Increased expression of translocator protein (TSPO) is a feature of microglial a

121 Translocator protein (TSPO) is a key member of the mitoc

122 Translocator protein (TSPO) is an 18-kDa cholesterol-bin

123 Translocator protein (TSPO) is expressed at a low level

124 Translocator protein (TSPO) is upregulated in activated

125 The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade

126 in-3-yl)-N,N-die thylacetamide (6b), a novel translocator protein (TSPO) ligand exhibiting a 36-fold

127 4-phenylquinazoline-2-carboxamide series of translocator protein (TSPO) ligands have been explored f

128 It remains unclear how different translocator protein (TSPO) ligands reflect the spatial

129 ol-3-ylglyoxylamides as potent and selective translocator protein (TSPO) ligands, two subsets of nove

130 5 PET, which aims to image expression of the translocator protein (TSPO) on activated microglia in th

131 nificant role in Alzheimer disease (AD), and translocator protein (TSPO) PET imaging allows us to qua

132 -L-DOPA, 6-[(18)F]fluoro-m-tyrosine, and the translocator protein (TSPO) PET ligand [(18)F]DAA1106.

133 On the one hand, the translocator protein (TSPO) radioligand N,N-diethyl-2-(2

134 a-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthe

135 se of SPECT/PET imaging agents targeting the translocator protein (TSPO) that is upregulated on activ

136 (11)C-PBR28 is a second-generation translocator protein (TSPO) tracer with characteristics

137 we investigated the involvement and role of translocator protein (TSPO), a biomarker of microglial a

138 For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflamm

139 Ligands of the 18 kDa translocator protein (TSPO), a marker for activated micr

140 on tomography (PET) and radioligands for the translocator protein (TSPO), a marker for glial activati

141 re the binding of [(11)C]PBR28 to the 18 kDa translocator protein (TSPO), a marker for microglial act

142 PBR28, we quantified expression of the 18kDa translocator protein (TSPO), a marker of activated micro

143 PBR28, we show increased brain levels of the translocator protein (TSPO), a marker of glial activatio

144 Brain levels of 18-kDa translocator protein (TSPO), a marker of microglial acti

145 eration tracer for PET imaging of the 18-kDa translocator protein (TSPO), a marker of neuroinflammati

146 Translocator protein (TSPO), also referred to as periphe

147 l with high affinity and selectivity for the translocator protein (TSPO), expressed on activated glia

148 composed of the outer mitochondrial membrane translocator protein (TSPO), previously known as periphe

149 Translocator protein (TSPO), previously known as the per

150 The 18-kilodalton translocator protein (TSPO), proposed to be a key player

151 Translocator protein (TSPO), which is upregulated in act

152 ivation can be detected in vivo using 18-kDa translocator protein (TSPO)-binding radioligands and PET

153 vated expression of the 18 kDa mitochondrial translocator protein (TSPO).

154 r developed for SPECT and targets the 18-kDa translocator protein (TSPO).

155 anied by a rapid up-regulation of the 18-kDa translocator protein (TSPO).

156 mography (PET) radioligands that bind to the translocator protein (TSPO).

157 oidogenic acute regulatory protein (StAR) or translocator protein (TSPO).

158 tive inflammatory processes by targeting the translocator protein (TSPO).

159 Function of the mammalian translocator protein (TSPO; previously known as the peri

160 The 18 kDa translocator protein, TSPO, is a cholesterol-binding pro

161 Translocator proteins (TSPOs) bind steroids and porphyri

162 istribution volume of (11)C-PBR28 binding to translocator protein was significantly reduced compared

163 f (11)C-PBR28 to the microglia marker 18 kDa translocator protein, was examined using positron emissi

164 11)C](R)PK11195-PET measures upregulation of translocator protein, which is associated with microglia

165 The T3SS translocator proteins YopB and YopD form pores in host m

166 Both were able to associate with the translocator protein YopD, and Scc3 expression restored