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1 arbitrary polypeptide sequences into the Sec translocon.
2 molecular chaperone, and a component of the translocon.
3 ypeptide through the membrane via the SecYEG translocon.
4 ic reticulum (ER) membrane by the ER protein translocon.
5 ignal sequence affinity and targeting to the translocon.
6 in the release of membrane proteins from the translocon.
7 ctions between import motor subunits and the translocon.
8 nd transient subunit of the bacterial SecYEG translocon.
9 p destabilized interaction of Tim44 with the translocon.
10 of targeted LacZ fusions that do not jam the translocon.
11 ion of the mutations that identified the Sec translocon.
12 ization of the interaction of Pam17 with the translocon.
13 rt motor, which is associated with the TIM23 translocon.
14 y from the cytosol using the newly assembled translocon.
15 the SRP-SR in the 'activated' state and the translocon.
16 talyzed by a protein-conducting channel, the translocon.
17 , suggesting functional asymmetry within the translocon.
18 se, allowing the assembly of the peroxisomal translocon.
19 of assembly and the pore properties of this translocon.
20 he arrival of another nascent chain TMS at a translocon.
21 associate with and potentially obstruct the translocon.
22 import of substrates that require the TIM23 translocon.
23 important for association of Pam16 with the translocon.
24 ents of the type III secretion system (T3SS) translocon.
25 C terminus of Tim17, a core component of the translocon.
26 ne via a protein-conducting channel, the Sec translocon.
27 ynamic interactions between the ribosome and translocon.
28 nding groove of the SRP M domain towards the translocon.
29 signal sequence transfer from the SRP to the translocon.
30 increase the transport capacity of the Sec61 translocon.
31 ed the proposal of a model of the functional translocon.
32 at SecYEG dimers are functional units of the translocon.
33 ere the signal peptide is transferred to the translocon.
34 d mutant forms of ZMPSTE24 fail to clear the translocon.
35 ation of the nascent chain through the Sec61 translocon.
36 ions between ribosomes and membrane-embedded translocons.
37 be the control of membrane stress at active translocons.
38 mported into organelles through multisubunit translocons.
39 onent of this highly conserved system is the translocon, a pore formed in the host membrane that is e
40 ribosome-nascent chain complex to the Sec61 translocon, a universally conserved protein-conducting c
41 of endomembrane organelle proteins, whereas translocon accessory proteins, such as ribophorin I, wer
42 it co-purifies with both PpiD and the SecYEG translocon after immunoprecipitation and blue native/SDS
43 tethering the Pam16:Pam18 heterodimer to the translocon and (2) positioning the import motor for effi
44 cific regions in SRalpha reprogramme the Sec translocon and facilitate recruitment of ribosome-nascen
46 A) and UV-photo-cross-linking in E.coli, the translocon and LPS intermediates were obtained at the N-
47 artitioning process between the water-filled translocon and membrane lipid bilayer, suggesting that p
49 small-molecule cotransin CT8 binds the Sec61 translocon and prevents the signal peptide of the nascen
50 ovel protein components of the putative tRNA translocon and provide additional evidence that mitochon
52 part of a secretion platform composed of the translocon and several secretion substrates and that it
54 MBBs are secreted through the inner membrane translocon and, thus, have a signal sequence, and (iv) t
55 taining membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors
57 brane proteins is a complex process in which translocons and proteases function in a concerted way.
58 y structural rearrangements in the ribosome, translocon, and associated proteins that occurred soon a
59 ing with the substrates or components of the translocon, and does not alter the energy potentials dri
60 e been implicated as constituents of the TIC translocon, and it remains to be determined how they int
61 teins insert into the membrane via the TIM23 translocon, and some are then further acted upon by the
65 is relatively constant regardless of whether translocons are actively engaged with protein substrate
66 ted role for Mgr2 of the mitochondrial TIM23 translocon as a gatekeeper in the release of membrane pr
67 the insertion into the membrane, invokes the translocon as an intermediary between the fully hydrated
68 t to be a novel ancillary subunit of the Sec translocon as it co-purifies with both PpiD and the SecY
69 approaches: an experimental microsomal Sec61 translocon assay, a biophysical (spectroscopic) characte
72 e elucidation of the molecular nature of the translocon-assisted protein insertion is a challenging p
73 RAP) complex is an integral component of the translocon, assisting the Sec61 protein-conducting chann
74 timulation of Hsp70's ATPase activity by the translocon-associated J-protein Pam18 is critical for th
77 interferon genes), an endoplasmic reticulum translocon-associated transmembrane protein, acts to det
78 teraction with a PAM18 mutation that affects translocon association of the Pam16:Pam18 heterodimer, s
79 ns we previously identified as important for translocon association resulted in cross-linking to Tim2
80 n of genetic interactions and enhanced Pam17 translocon association was observed in the absence of th
81 termini are important for the heterodimer's translocon association, with Pam18's and Pam16's N termi
83 brane form stable supercomplexes with a 1-MD translocon at the inner chloroplast envelope membrane of
84 ed that phyllobilin hydroxylation depends on TRANSLOCON AT THE INNER CHLOROPLAST ENVELOPE55 (TIC55).
85 ue component of the recently identified 1-MD translocon at the inner envelope membrane of chloroplast
86 d translocation-independent formation of the translocon at the outer envelope membrane of chloroplast
88 s the membrane channel of the protein import translocon at the outer envelope of chloroplasts (TOC).
90 cin colicin E9 (ColE9) assembles a cytotoxic translocon at the surface of Escherichia coli that incor
92 of hundreds of different proteins depends on translocons at the outer and inner chloroplast membrane
93 is guided by the interaction between SRP and translocon-bound FtsY in a quaternary targeting complex.
94 targeting of the nascent chain to the Sec61 translocon but with its subsequent productive translocat
95 C, and Hsp93, are present in the chloroplast translocon, but none has been shown to directly bind pre
97 e fifth cytosolic loop of SecY in the SecYEG translocon, but the functional role of the interaction i
98 nctions as an LPS transfer protein in the OM translocon by disaggregating LPS during transport to all
101 ted proteins are exported through the SecYEG translocon by the SecA ATPase motor via the general secr
103 when Deg1-Sec62 aberrantly engaged the Sec61 translocon channel and underwent topological rearrangeme
108 plasmic reticulum (ER) by the ribosome Sec61-translocon complex (RTC) through iterative cycles of tra
109 did not successfully translocate through the translocon complex are subjected to a preemptive quality
110 pendent and due to the operation of a unique translocon complex dubbed PTC (Pchlide-dependent translo
111 To examine the state of water in a SecY translocon complex embedded in a lipid bilayer, we carri
116 the interaction of native proteins with the translocon complex of the endoplasmic reticulum membrane
117 re, we provided evidence indicating that the translocon complex Sec61 mediates the release of beta-DG
118 GFP11, revealing that endoplasmic reticulum translocon complex Sec61B has reduced abundance in certa
119 1u mRNA, is recruited to the Ire1alpha-Sec61 translocon complex through its nascent chain, which cont
120 ractions among TTSS components of the needle-translocon complex using a chemical cross-linking-based
122 er, including the endoplasmic reticulum (ER) translocon complex, which mediates protein translation i
127 revealed molecular architecture of a central translocon component advances our understanding of membr
128 rmined how the nascent polypeptide modulates translocon component associations during defined cotrans
129 ation of the major type III secretion system translocon component in both membrane-bound and chaperon
130 pathway and reducing cellular levels of the translocon component Sec62 by RNA interference, we found
133 nstrate the evolutionary conservation of the translocon component Tic22 between cyanobacteria and chl
135 ide further knowledge on the function of the translocon components and the molecular basis for their
136 c and ER-bound polysome fractions identified translocon components as selective polysome-interacting
137 lts are discussed in light of how individual translocon components sequentially interact with the pre
138 any functions, such as stabilizing other Sec translocon components within the membrane, maintaining t
139 lar ERAD-associated isomerases, lectins, and translocon components, including ERAD E3 ubiquitin ligas
143 ial component of a translocation complex or "translocon" containing RIG-I, 14-3-3epsilon, and the TRI
148 g membrane proteins are targeted to membrane translocons early in translation, by the ubiquitous sign
149 age the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secr
150 and NEMF, core RQC components, are bound to translocon-engaged 60S subunits on native ER membranes.
153 d that Sal4 treatment impaired T3SS-mediated translocon formation and attenuated the delivery of tagg
156 etion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positi
158 lous water behavior affects the mechanism of translocon function and, more generally, the partitionin
161 wn translation, and release of arrest at the translocon has been proposed to occur by mechanical forc
163 -mannosyltransferases (PMTs) also act at the translocon, however, in recent years it turned out that
164 -YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membr
166 es the targeting of membrane proteins to the translocon in a multistep process controlled by GTP hydr
167 rough a transmembrane conduit called the Sec translocon in a process that is facilitated by ancillary
168 tor component, are found associated with the translocon in both PAM16 and TIM44 mutants that affect t
169 letion of SRP, the SRP receptor or the Sec61 translocon in cells leads to reduced Ire1alpha-mediated
170 y (CET) to study the structure of the native translocon in evolutionarily divergent organisms and dis
175 ular weight preproteins and imported via the translocons in the outer (TOC) and inner (TIC) envelope
176 erved, posttranslational mechanism involving translocons in the outer (TOC) and inner envelope (TOC).
177 cular features of protein insertion into the translocon, including signal-peptide docking at the tran
178 ce of cross-linkable LcrV-YscF interactions, translocon insertion is abolished, but Yersinia still re
181 ian cells requires Yersinia to both insert a translocon into the host cell membrane and sense contact
186 n the ribosome and its insertion through the translocon is analyzed, focusing on the recently discove
190 th previous data, this implies that the ColN translocon is distinct from those of other known colicin
191 nts during nascent-chain passage through the translocon is generally viewed as a simple partitioning
192 ults suggest that direct RNC transfer to the translocon is guided by the interaction between SRP and
193 is to movements of the precursor through the translocon is much less efficient than the coupling by t
194 s SA-I immediately, the interaction with the translocon is perturbed and topology of the protein in E
199 erein the first step, the insertion into the translocon, is energized by protein synthesis and, there
200 h the YopBD pore, and/or (iii) the YopB-YopD translocon itself or its membrane insertion is proinflam
202 SecY dimer can be captured associated with a translocon-jammed substrate, indicative of SecY dimer fu
204 ined path through the ribosome, the ribosome translocon junction, the Sec61-translocon pore, and into
205 con, including signal-peptide docking at the translocon lateral gate (LG), large lengthscale conforma
206 gthscale conformational rearrangement of the translocon LG helices, and partial membrane integration
209 ro transcription/translation system to study translocon-mediated folding of the WT pro-SP-C poly-Val
211 between integral membrane protein topology, translocon mutagenesis, and nascent-protein sequence.
212 testable predictions regarding the effect of translocon mutations on membrane protein topogenesis.
213 tric representations of the ribosome and Sec translocon, obtained directly from experimental structur
214 Moreover, Sec62/63 stabilization within the translocon occurred for native endogenous substrates, su
216 n of proteins in LS, including P. falciparum translocon of exported proteins 150 (PTEX150) and export
218 Although some PRAT proteins, such as the translocon of the mitochondrial inner membrane (TIM) pro
220 Tom22 (TgTom22), a central component of the translocon of the outer mitochondrial membrane (TOM) com
221 plasmic translation zone and enriched in the translocons of the outer and inner chloroplast envelope
222 of well-known transport machineries like the translocons of the outer/inner chloroplast membranes (To
224 coordinated processes that take place at the translocon-oligosaccharyltransferase (OST) complex.
225 on the outer chloroplast membrane) and TIC (translocon on the inner chloroplast membrane) machinerie
226 p70)-based import motor, associated with the translocon on the matrix side of the mitochondrial inner
228 , protein import is accomplished by the TOC (translocon on the outer chloroplast membrane) and TIC (t
230 rotein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membra
232 to cells entailed the development of protein translocons, partially by recycling bacterial proteins.
236 the ribosome translocon junction, the Sec61-translocon pore, and into the ER lumen coincident with c
241 ins from all the major mitochondrial protein translocons present in yeast, suggesting these arose ear
242 st acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-ret
243 GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing
246 eractions of VKORC1v2, vIL-6, and pCatD with translocon proteins (SEL1L and/or HRD1) and ERAD-associa
248 s indicate that lysosomal damage by Yersinia translocon proteins promotes inflammasome activation and
249 virulence by limiting hyperinjection of the translocon proteins YopD and YopB into cells, thereby li
251 ivation with the type three secretion system translocon providing the second signal for inflammasome
252 er stage, positively regulated by the SecYEG translocon, providing an attractive mechanism for ensuri
253 m44, interacting with the matrix face of the translocon, recruits other motor subunits and binds inco
254 c protrusion of SecYEG demonstrates that the translocon remains competent for binding after tens of m
257 en the nascent-protein N-terminus, cytosolic translocon residues, and phospholipid head groups are sh
258 TMS and flanking sequence interactions with translocons, ribosomes, and associated proteins, thereby
260 odopsin from Halobacterium salinarum and the translocon SecYEG from Escherichia coli, we demonstrate
261 established a reconstitution system for the translocon SecYEG in proteoliposomes in which 55% of the
262 engaged in protein transport, the bacterial translocon SecYEG must maintain the membrane barrier to
263 that a single protein component of the T3SA translocon-Shigella IpaC, Salmonella SipC, or Chromobact
264 uggested to work alongside SecY2 to form the translocon, similar to the associated SecY, SecE, and Se
265 cid-dependent secretion process in which the translocon SseB moves away from the bacterial cell surfa
266 the required features of the putative retro-translocon, suggesting alternative retro-translocation m
269 x protein import occurs through a remarkable translocon that can accommodate folded and even oligomer
270 those ERdj proteins associate with the Sec61 translocon that facilitates entry of nascent proteins in
271 s a hetero-oligomeric complex with the Sec61 translocon that is activated upon ER stress with little
272 This level corresponds to the fraction of translocons that are active in vitro when assessed in th
273 ryotes, relatively little is known about the translocons that transport proteins across the two membr
274 e insertion of RodZ requires only the SecYEG translocon, the SecA ATPase motor, and the TM proton mot
275 cognition particle (SRP), SRP receptors, the translocon, the signal peptidase complex, and over 100 o
277 ectly targets the alpha subunit of the Sec61 translocon to block the production of secreted and integ
279 These proteins then traffic via an export translocon to the host membrane, where they form a nutri
280 he effective transfer free energies from the translocon to the membrane have been determined for both
281 ing the trafficking of proteins from the Sec translocon to the periplasmic chaperone network that con
283 hat IRE1alpha forms a complex with the Sec61 translocon, to which its substrate XBP1u mRNA is recruit
284 coarse-grained simulations that combine the translocon (TR) insertion profile and the effective chem
286 nsit into the host cell via a membrane pore (translocon) typically formed by 3 bacterial proteins.
287 ely synthesized GPCRs in the vicinity of the translocon until the complete receptor is released into
288 responding to conformational changes in the translocon upon a translocating polypeptide entering the
289 could demonstrate that Ste24 approaches the translocon upon clogging, and it interacts with and gene
291 of nascent proteins are thought to exit the translocon via a lateral gate in SecY, where YidC facili
295 the bacterial SecY nor the eukaryotic Sec61 translocon was able to efficiently transport proteins en
296 otranslationally into the ER membrane at the translocon, where nonpolar nascent protein transmembrane
297 CTD serves primarily to anchor Tim44 to the translocon, whereas the NTD is a dynamic arm, interactin
298 modular and versatile composition of the Sec translocon, which is probably essential for its ability
299 ocation and membrane integration via the Sec translocon, while retaining sufficient chemical and stru
301 with components of PTEX, a putative protein translocon within the membrane of the parasitophorous va
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