ライフサイエンスコーパス: transmembrane

1 ase domain-containing protein 3 rs738409 nor transmembrane 6 superfamily member 2 rs58542926 polymorp

2 PCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiq

3 s in pharmacology, an understanding of seven transmembrane (7TMR) function has been gained from the c

4 Msp1 is a transmembrane AAA-ATPase, but its role in TA protein cle

5 h TA and LAP1 contributed to the assembly of transmembrane actin-associated nuclear (TAN) lines, whic

6 The B-cell receptor transmembrane activator and calcium modulator ligand int

7 a natural high-affinity ligand for BCMA and transmembrane activator and calcium-modulator and cyclop

8 e receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI).

9 of this system, B cell maturation Ag (BCMA), transmembrane activator and CAML interactor, and BAFF re

10 Linker for activation of T cells (LAT) is a transmembrane adaptor signaling molecule that is part of

11 paired to one or more of the nine different transmembrane adenylyl cyclase isoforms that generate th

12 sium channels exhibits classic signatures of transmembrane allostery.

13 muscarinic acetylcholine receptor formed by transmembrane alpha-helices.

14 ity, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TARPs),

15 mmation.SIGNIFICANCE STATEMENT In the brain, transmembrane AMPAR regulatory proteins (TARPs) critical

16 In the brain, transmembrane AMPAR regulatory proteins (TARPs) critical

17 These results indicate that a transmembrane anchor increases the efficiency of full fu

18 Adding a transmembrane anchor to the N-terminus of Sec17 bypasses

19 lls expressing either GPI-anchored PrP(C) or transmembrane-anchored PrP(C), which partitions it to a

20 Fusion required a transmembrane-anchored R-SNARE on one membrane and an an

21 The helix of FtsB is interrupted between the transmembrane and coiled coil regions by a flexible Gly-

22 ization of the bent conformation by integrin transmembrane and cytoplasmic domains must be overcome b

23 , revealing essential roles for the receptor transmembrane and cytoplasmic domains, as well as for th

24 as an engineered chimeric form in which its transmembrane and cytoplasmic tail (TMCT) domains were r

25 ligand-induced conformational changes in the transmembrane and intracellular regions of ACKR3 that el

26 g domain of the receptor while retaining the transmembrane and tyrosine kinase domains.

27 pore domains to produce a non-domain-swapped transmembrane architecture, which appears to be a hallma

28 Focal adhesions (FAs) are integrin-based transmembrane assemblies that connect a cell to its extr

29 The fabrication of monodisperse transmembrane barrels formed from short synthetic peptid

30 DeltaGsc(o) for all 20 amino acids using the transmembrane beta-barrel E. coli PagP as a scaffold pro

31 er-to-bilayer hydrophobicity scale using the transmembrane beta-barrel Escherichia coli OmpLA as a sc

32 the periplasmic binding protein NspS and the transmembrane bis-(3'-5') cyclic diguanosine monophospha

33 After endocytosis, transmembrane cargo reaches endosomes, where it encounte

34 Biosynthetic sorting of newly synthesized transmembrane cargos to endosomes and lysosomes is thoug

35 assays, we show that the surface hydrophilic transmembrane cavity exposed to the lipid bilayer on the

36 flipping of a M3 residue within a conserved transmembrane cavity impacts both gating and permeation

37 lic ring that extensively interacts with the transmembrane channel layer.

38 Here, we find that transmembrane channel-like 2b (Tmc2b) is differentially

39 showed that these compounds target TarG, the transmembrane component of the two-component ATP-binding

40 s to the gating mutations of cystic fibrosis transmembrane conductance regulator (CFTR or ABCC7; i.e.

41 ates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and

42 esults from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride chan

43 ppropriate activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride chan

44 ability, and function of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel

45 Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect C

46 rosis homozygous for F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in placebo-co

47 PTEN and the CF transmembrane conductance regulator (CFTR) interacted di

48 The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion c

49 The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-bin

50 ABSTRACT: Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gat

51 modulator compounds for the cystic fibrosis transmembrane conductance regulator (CFTR) is key for th

52 e carrying the most frequent cystic fibrosis transmembrane conductance regulator (CFTR) mutation in h

53 ons in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromi

54 ftor is a potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that reduces

55 s caused by mutations of the cystic fibrosis transmembrane conductance regulator (Cftr).

56 e the feasibility of using a cystic fibrosis transmembrane conductance regulator potentiator, ivacaft

57 lasped between the N-terminal domain and the transmembrane core of the receptor, and further stabiliz

58 extracellular face of excised membranes, and transmembrane currents were monitored using patch clamp.

59 llenges and thereby activated TRPV4-mediated transmembrane currents.

60 concomitant with a several-fold increase of transmembrane currents.

61 cochemical parameters, e.g. the rate of drug transmembrane diffusion and the antibiotic-target comple

62 hannels reveal a critical role for the fifth transmembrane domain (S5) in sensing anesthetics.

63 A stable homotrimeric structure for the transmembrane domain (TM) also was modeled and supported

64 Recent studies showed that its transmembrane domain (TMD) forms a trimer in lipid bilay

65 We identified lipid-exposed residues in the transmembrane domain (TMD) of the GluA2 subunit of AMPAR

66 This transmembrane protein binds to the transmembrane domain (TMD) of the platelet-derived growt

67 However, beyond the need for a transmembrane domain (TMD), little is known about the fe

68 Peptides corresponding to transmembrane domain (TMD)1, 2, 3, and 4, but not TMD5,

69 each anchored to a Kir6.2 by its N-terminal transmembrane domain (TMD0).

70 Furthermore, we identified isoleucine-182 in transmembrane domain 3 of zDHHC3 as a key determinant in

71 g at synapses the receptor is cleaved in its transmembrane domain and releases a protein fragment tha

72 ns, are located in the interface between the transmembrane domain and the C-terminal nucleotide bindi

73 Thus, EMC is a transmembrane domain insertase, a function that may expl

74 ry for maximal FERONIA activity, whereas the transmembrane domain is inhibitory.

75 The MacB transmembrane domain lacks a central cavity through whic

76 creases in membrane thinning/disorder by the transmembrane domain of BamA is greatest in thicker bila

77 cytoplasmic tail and inducing a kink in the transmembrane domain of beta3-integrin.

78 However, replacement of TM2 by the transmembrane domain of CD4, the asialoglycoprotein rece

79 Replacement of the transmembrane domain of CD74 or the asialoglycoprotein r

80 wo putative cholesterol-binding sites in the transmembrane domain of GIRK2.

81 ly incorporated into two residues within the transmembrane domain of KCNE1: F56 and F57.

82 hannel motion of both full-length M2 and the transmembrane domain of M2.

83 oteolytic activation of NOTCH1 to expose the transmembrane domain of NOTCH1.

84 Mutational analyses indicated that the transmembrane domain of sigma1R likely mediated this int

85 ary subunits require a shared surface on the transmembrane domain of the AMPAR for their function, bu

86 panins (TSPANs) comprise a large family of 4-transmembrane domain proteins.

87 CCRL2 is a 7-transmembrane domain receptor that shares structural and

88 Conformational changes in the transmembrane domain result in a sharp kink in the middl

89 oforms and mutants that do not have the 10th transmembrane domain show very poor activity.

90 oreactivities toward ZnT8 were mapped to its transmembrane domain that is accessible to extracellular

91 n aromatics with hydrophobic residues of the transmembrane domain, and contains the absolutely conser

92 izes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transientl

93 whether a SNARE such as STX11, which lacks a transmembrane domain, can support membrane fusion in viv

94 juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or redu

95 ested a potential activation site within the transmembrane domain, near the A-967079 cavity.

96 by their motif organization; each contains a transmembrane domain, serine rich region and a conserved

97 n to block ATPase activity by binding to the transmembrane domain.

98 uctures, several lipids are bound within the transmembrane domain.

99 as metazoan Mitofusins contain only a single transmembrane domain.

100 domain and six alpha-helical segments in the transmembrane domain.

101 mino-acid protein with a putative C-terminal transmembrane domain.

102 the previously solved structure of the GCGR transmembrane domain.

103 Transmembrane domains (TMDs) engage in protein-protein i

104 ns of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains

105 using coarse-grained molecular dynamics, the transmembrane domains (TMDs) of t-SNARE complexes are sh

106 of nucleotide binding domains (NBDs) to the transmembrane domains (TMDs), which switch between inwar

107 ument proteins, such as substitutions within transmembrane domains 1 and 3 of LMP1, FoP_duplication,

108 de evidence that TMEM18 has four, not three, transmembrane domains and that it physically interacts w

109 lysis suggests that the NRP1 cytoplasmic and transmembrane domains are necessary and sufficient to re

110 Mutations within transmembrane domains IV, V, VI, and VII had no effect o

111 Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-ex

112 we present de novo atomic structures of the transmembrane domains of mouse TMEM16A in nanodiscs and

113 CRAC) and CARC-like sequences within the two transmembrane domains of p33.

114 by a single cleavage between the EGF and the transmembrane domains of pro-EGF.

115 Bcl-2 protein transmembrane domains specifically homooligomerize and h

116 (the Pgp engines) lead to changes across Pgp transmembrane domains that result in substrate transloca

117 llographic studies have focused on conserved transmembrane domains, where multiple substrate binding

118 t fungal Fzo1 proteins exhibit two predicted transmembrane domains, whereas metazoan Mitofusins conta

119 embrane proteins with moderately hydrophobic transmembrane domains.

120 amino-acid mutations, and the orientation of transmembrane domains.

121 ts and in a patient with a variant in the S2 transmembrane element rather than the S4 to S6 region.

122 We conclude that a transmembrane embedded lysine residue is essential for e

123 nalysis, we identified a ferrireductase: six-transmembrane epithelial antigen of prostate 4 (STEAP4)

124 evealed that kidney proximal tubules express transmembrane fatty acid transporter-2 (FATP2), encoded

125 seen in the Col13a1-/- mice, pointing to the transmembrane form as the major conductor of collagen XI

126 as exaggerated in the Col13a1tm/tm mice, the transmembrane form's presence sufficed to prevent defect

127 IL-6 signals are transmitted via the transmembrane glycoprotein 130 by two distinct mechanism

128 Mutations affecting the function of the transmembrane glycoprotein dystroglycan cause a form of

129 The transmembrane glycoprotein dystroglycan functions as a r

130 ostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is highly expressed on p

131 Both proteins are large transmembrane glycoproteins expressed by the podocyte, a

132 gp120 exterior glycoproteins, and three gp41 transmembrane glycoproteins.

133 nformations, and consist of a series of four-transmembrane helical bundles that we term Piezo repeats

134 discs by monitoring the spatial positions of transmembrane helices 6 and 7 at the cytoplasmic surface

135 utward movement of the extracellular ends of transmembrane helices 6 and 7.

136 e beta1AR define ligand-binding sites in the transmembrane helices and effector docking sites at the

137 osed, indicating that local movements of the transmembrane helices can control ion access to the pore

138 There, the conformation of transmembrane helices constituting a membrane-spanning f

139 es located in a periplasmic loop between two transmembrane helices contain conserved charged residues

140 rangement of three distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD)

141 transmembrane region containing at least 26 transmembrane helices per protomer.

142 -terminal pore-forming domain comprising six transmembrane helices, a pore helix, and a selectivity f

143 te homotrimers, with each subunit having two transmembrane helices, TM1 and TM2.

144 id membrane revealed water penetration along transmembrane helix 1 with the cooperation of a polar re

145 ional changes include a distinct movement of transmembrane helix 2 (M2), from its position in the pre

146 ubstitution of four lipid-facing residues in transmembrane helix 4 (TM4) that is known to be importan

147 the cooperation of a polar residue (Y147 in transmembrane helix 5) in the adjacent protomer.

148 main result in a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular ha

149 transporters is the helix-loop transition in transmembrane helix 8, which likely forms the structural

150 upled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wi

151 ng channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent m

152 of a critical cysteine (Cys195) in the third transmembrane helix of Orai1.

153 We isolated substitutions, locating to the transmembrane helix of TatB that restored transport acti

154 erium-exchange analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD

155 It contains two homologous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence

156 Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2

157 ractions with a range of proteins, including transmembrane ion channels.

158 We propose cells generate large transmembrane ion gradients to form information circuits

159 ransporting protein function that diminishes transmembrane iron flux in distinct sites and directions

160 biochemical isolation and reveal VRK2A as a transmembrane kinase in the NE that regulates BAF.

161 Mechanistically, JAGGED-1, a transmembrane ligand for the NOTCH receptor, is downregu

162 , and through a RNAi screen, they identify a transmembrane LRR protein-Lapsyn-that plays a critical r

163 The MacA-MacB-TolC tripartite complex is a transmembrane machine that spans both plasma membrane an

164 pregulating Rab27-dependent recycling of the transmembrane matrix metalloprotease, MT1-MMP to promote

165 Zinc metallopeptidase STE24 (ZMPSTE24) is a transmembrane metalloprotease whose catalytic activity i

166 essed on myeloid cells 2 (TREM2) is a single transmembrane molecule uniquely expressed in microglia.

167 Although collagen XIII is a muscle-bound transmembrane molecule, it also undergoes ectodomain she

168 ls and likely function as a barrier to limit transmembrane movement of apoplastic solutes into the en

169 These findings show how upregulation of the transmembrane mucin MUC1 contributes to immune escape in

170 atively low levels of N-glycans are found on transmembrane mucins, and their structure and function r

171 ease in SMG epithelial cells is dependent on transmembrane Na(+) and/or K(+) flux and the activation

172 ein Patched1, chemiosmotically driven by the transmembrane Na(+) gradient common to metazoans, regula

173 Transmembrane O-methyltransferase (TOMT/LRTOMT) is respo

174 cassettes containing codon optimized HLA-G1 (transmembrane) or HLA-G5 (soluble) isoforms were validat

175 Although the extended transmembrane Orai N-terminal region (Orai1 amino acids

176 Cells expressing transmembrane P-selectinE88D or L-selectinE88D detached

177 Our findings suggest that the transmembrane pathway through unsuberized endodermal cel

178 dermal cells limits Ca transport through the transmembrane pathway, thereby causing reduced Ca delive

179 report on the development of new fluorogenic transmembrane peptide substrates, which are cleaved by s

180 cell membrane, with subsequent alteration of transmembrane potential that is a function of cell bioph

181 nd 5'-UTR of the androgen-regulated TMPRSS2 (transmembrane protease, serine 2) gene to the open readi

182 The prevalence of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with th

183 Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the

184 plex with proteins of the interferon-induced transmembrane protein (IFITM) family.

185 Transmembrane protein 16A (TMEM16A), also called anoctam

186 Transmembrane protein 175 (TMEM175), the lysosomal K(+)

187 The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of

188 Interferon-induced transmembrane protein 3 (IFITM3) is a cellular endosome-

189 re, coexpression of the viral reticulon-like transmembrane protein A17 and the capsid-like scaffold p

190 This transmembrane protein binds to the transmembrane domain

191 e presence of IgE autoantibodies against the transmembrane protein BP antigen 2 (BP180, type XVII col

192 R as the Vgamma9Vdelta2 T cell Ag-presenting transmembrane protein butyrophilin 3A1, providing inform

193 process in all photosynthetic organisms is a transmembrane protein called the reaction center.

194 The transmembrane protein Cx43 has key roles in fibrogenic p

195 or expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on microglia within the

196 NT*-transmembrane protein fusions yield up to eight times mo

197 The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to f

198 CD7 is a transmembrane protein highly expressed in acute T-cell l

199 e that ODZ1 (also known as TENM1), a type II transmembrane protein involved in fetal brain developmen

200 We show that LRP4, a conserved transmembrane protein known for its postsynaptic roles,

201 e-wide haploid genetic screen identified the transmembrane protein neuropilin 2 (NRP2) and tetraspani

202 Here we show that VCAM1, a transmembrane protein previously found in quiescent adul

203 ue to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog (Shh

204 ABCD1 encodes a peroxisomal transmembrane protein required for very long chain fatty

205 ceptor is an evolutionarily highly conserved transmembrane protein that is essential to a wide spectr

206 Dysferlin is a large transmembrane protein that plays a key role in cell memb

207 as TMEM97, an endoplasmic reticulum-resident transmembrane protein that regulates the sterol transpor

208 ABCG4 is an ATP-binding cassette transmembrane protein which has been shown, in vitro, to

209 und that OIG-8, a previously uncharacterized transmembrane protein with a single immunoglobulin (Ig)

210 /H(+) exchanger type I (chNHE1), a multispan transmembrane protein, is a cellular receptor of the sub

211 Caveolin (Cav)1, a widely expressed transmembrane protein, is involved in the regulation of

212 The lysosomal transmembrane protein, SLC38A9, is required for mTORC1 a

213 ABSTRACT: Small transmembrane proteins are important for regulation of c

214 t determination of extracellular segments of transmembrane proteins based on the identification of su

215 inclusion, which is enriched with bacterial transmembrane proteins called Incs.

216 The influence of the membrane on transmembrane proteins is central to a number of biologi

217 Although similar transmembrane proteins mediate self/nonself recognition

218 MDR is typically associated with transmembrane proteins mediating efflux of administered

219 affic, including the poorly understood small transmembrane proteins neural-specific gene 1 and 2 (Nsg

220 4) domain of Sun proteins [5-7], a family of transmembrane proteins of the inner nuclear membrane (IN

221 Transmembrane proteins play crucial role in signaling, i

222 We found that the integral transmembrane proteins SUN1/UNC84A and SUN2/UNC84B are p

223 KEY POINTS: Ion channels are transmembrane proteins that are synthesized within the c

224 ture virions, were severely deficient in the transmembrane proteins that comprise the entry fusion co

225 A subset of eSTKs are single-pass transmembrane proteins that have extracellular penicilli

226 ected by mutations in the genes encoding the transmembrane proteins TMHS, TMIE, TMC1 and TMC2.

227 eases are involved in ectodomain cleavage of transmembrane proteins, and ADAM17 is known to cleave Ne

228 okines), extracellular matrix molecules, and transmembrane proteins.

229 preference for acetylating N termini of the transmembrane proteins.

230 e further research on alloherpesvirus virion transmembrane proteins.

231 gs were: (i) the FL strain encodes 16 virion transmembrane proteins; (ii) eight of these proteins are

232 In this study of the virion transmembrane proteome of CyHV-3, the major findings wer

233 viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifies the virion a

234 ased free energy to pump protons against the transmembrane proton gradient.

235 blastoma cells, likely due to segregation of transmembrane PrP(C) and GPI-anchored PrP(res) in distin

236 Thus, it remained unclear whether transmembrane PrP(C) might convert to PrP(res) if seeded

237 Previous studies showed that nonraft transmembrane PrP(C) variants resist conversion to PrP(r

238 Mice lacking the CD44 transmembrane receptor for the glycosaminoglycan hyaluro

239 Activation of transmembrane receptor integrin by talin is essential fo

240 microvessels to show that activation of the transmembrane receptor NOTCH1 directly regulates vascula

241 The transmembrane receptor protein neuropilin 1 (Nrp1) was r

242 Integrins are heterodimeric transmembrane receptors consisting of alpha and beta sub

243 Cell transmembrane receptors play a key role in the detection

244 ds, that establishes the organization of the transmembrane region and proximal coiled coil of the com

245 a three-bladed propeller shape with a curved transmembrane region containing at least 26 transmembran

246 a highly conserved glutamate residue in the transmembrane region of E. coli TatC, which when modifie

247 The transmembrane region of FtsLB is stabilized by hydrophob

248 tward-facing hydrophobic residues within the transmembrane region of the AT1R.

249 rrected a previously identified error in the transmembrane region of the original cryo-electron micro

250 otetramer, with each monomer consisting of a transmembrane region, a stalk, and a globular head with

251 ium channels, we engineered chimeras wherein transmembrane regions of TRPV1 were transplanted into th

252 82X is the fifth most common cystic fibrosis transmembrane regulator (CFTR) mutation that causes cyst

253 sal jawless vertebrate, which suggests small transmembrane regulators of ion transport emerged early

254 e we report that the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human a

255 We identify the linker connecting transmembrane repeats II and III in two different CaV is

256 ecular dynamics experiments identified three transmembrane residues (Val-86, Lys-93, and Asn-258) tha

257 ed mutations have been reported in the first transmembrane segment (S1) of Kv11.1 channels, but the r

258 id residue at or near a conserved glycine in transmembrane segment 10.

259 e highly conserved first arginine residue in transmembrane segment 4 (domain 1), the voltage sensor,

260 omains via concerted movements of the second transmembrane segment and major coupling helix.

261 c-epitopes we show that forces acting on the transmembrane segment produce loose clusters, while cyto

262 cytoplasmic domain of FlhA, located between transmembrane segments 4 and 5.

263 llular space and are initially linked by two transmembrane segments and a single cytoplasmic domain.

264 tify residues in the extracellular loops and transmembrane segments of hERG1 that might interact with

265 The transmembrane segments of RHD3 are essential for targeti

266 e of DsbB, one located between the two first transmembrane segments where the quinone ring binds and

267 Each Hrd1 molecule has eight transmembrane segments, five of which form an aqueous ca

268 nteract via association of the C-terminal or transmembrane segments, with consequences for the assemb

269 type GPI anchor signal sequence or a nonraft transmembrane sequence containing a flexible linker were

270 Exchanging the GPI anchor for a nonraft transmembrane sequence redirects PrP(C) away from rafts.

271 TMPRSS13 is a member of the type II transmembrane serine protease (TTSP) family.

272 ave previously demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts a

273 al control signal by employing an artificial transmembrane signal transduction mechanism.

274 phorus-containing molecules, which initiates transmembrane signaling and activates butyrophilin-respo

275 ligand led to the identification of a second transmembrane site (TM2) that inhibits dissociation of a

276 2+) exchanger that uses energy stored in the transmembrane sodium gradient to facilitate the exchange

277 ectional calcium transport controlled by the transmembrane sodium gradient.

278 tly found at the dimerization interface of a transmembrane structural motif called GASright, which is

279 f a surface subunit (SU) and a fusion active transmembrane subunit (TM).

280 Apobec3 Pathogenic potential maps to the env transmembrane subunit segment encoding the N-heptad repe

281 nterface between the ATPase subunits and the transmembrane subunits of the LPS transporter.

282 he modeling of parallel homodimers formed by transmembrane (TM) alpha-helices.

283 an exo-membrane nitrilase domain fused to a transmembrane (TM) domain.

284 Mutations in F protein transmembrane (TM) domains implicated the TM domain in t

285 Although backbone hydrogen bonds in transmembrane (TM) helices have the potential to be very

286 ponents within the membrane, maintaining the transmembrane (TM) potential, and facilitating the ATP-i

287 y conformational dynamics of a seven-helical transmembrane (TM) protein, Anabaena Sensory Rhodopsin (

288 putational modeling of single-pass (bitopic) transmembrane (TM) proteins and their complexes by provi

289 that a triple mutation in the middle of the transmembrane (TM) segment of KCNE3 introduces KCNE1-lik

290 2, and CD3), but share the extracellular and transmembrane (TMD) domains, as well as an intracellular

291 ing enzyme (TACE) proteolytic release of the transmembrane TNF (tmTNF) ectodomain.

292 l/mole and at neutral pH, the peptide adopts transmembrane topologies.

293 protein-lipid interactions and revealed the transmembrane topology of cytochrome b5.

294 scopic identifiers to register the events of transmembrane transport denies their intracellular vs. e

295 tion studies with Caco-2 cells confirmed the transmembrane transport of the dye-integrated UAPs.

296 in cellular growth, cellular trafficking and transmembrane transport.

297 ABCC6, a transmembrane transporter primarily expressed in liver a

298 Importantly, novel transmembrane transporters probably mediating Cu(+) infl

299 intracellular cyclic nucleotides instead of transmembrane voltage.

300 The transmembrane VRK2A isoform is retained at the NE by ass