ライフサイエンスコーパス: transmembrane domain

1 b, and only Ser5-001 has an extra C-terminal transmembrane domain.

2 ransmembrane domain or in the 4(th) putative transmembrane domain.

3 ies and a zinc binding site within the seven transmembrane domain.

4 esterol through direct interactions with the transmembrane domain.

5 activation of NaV1.5 by targeting the fourth transmembrane domain.

6 ice vaccinated with VSVm-ZENV containing the transmembrane domain.

7 to investigate deletions of its hydrophobic transmembrane domain.

8 and can cleave the receptors near the first transmembrane domain.

9 nd at a gamma-like site in the middle of the transmembrane domain.

10 n which EC2 separates substantially from the transmembrane domain.

11 mislocalization and/or loss of an essential transmembrane domain.

12 o Golgi apparatus through a novel N-terminal transmembrane domain.

13 ed in the cytoplasmic regions and one on the transmembrane domain.

14 member-ligand-binding domain, but lacks the transmembrane domain.

15 n to block ATPase activity by binding to the transmembrane domain.

16 alk of the nucleotide-binding domain and the transmembrane domain.

17 uctures, several lipids are bound within the transmembrane domain.

18 as metazoan Mitofusins contain only a single transmembrane domain.

19 domain and six alpha-helical segments in the transmembrane domain.

20 mino-acid protein with a putative C-terminal transmembrane domain.

21 the previously solved structure of the GCGR transmembrane domain.

22 ion in trans is abolished by mutation of the transmembrane domain.

23 e precursor envelope protein upstream of the transmembrane domain.

24 vely low hydrophobicity of the Tat-dependent transmembrane domain.

25 acellular domains in tandem with single-span transmembrane domains.

26 egion, potentially adjacent to the protein's transmembrane domains.

27 onserved and characterized extracellular and transmembrane domains.

28 cessary for the covalent dimerization of DR5 transmembrane domains.

29 ains (NBDs) to conformational changes in the transmembrane domains.

30 ied motifs, and most have numerous predicted transmembrane domains.

31 membrane topologies, characterized by three transmembrane domains.

32 d interactions between its extracellular and transmembrane domains.

33 129 kD D-type cellulose synthase with eight transmembrane domains.

34 amino-acid mutations, and the orientation of transmembrane domains.

35 he gating functions of the extracellular and transmembrane domains.

36 -like kinases lacking both extracellular and transmembrane domains.

37 embrane proteins with moderately hydrophobic transmembrane domains.

38 mplex by virtue of the proteins' luminal and transmembrane domains.

39 n the junction between the extracellular and transmembrane domains.

40 in a cluster of hydrophobic residues within transmembrane domain 1 affect barttin-CLC-K interaction

41 ument proteins, such as substitutions within transmembrane domains 1 and 3 of LMP1, FoP_duplication,

42 ur data indicate that the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 pr

43 mote a progressive outward shift of the A3AR transmembrane domain 2, which may contribute to the subs

44 Furthermore, we identified isoleucine-182 in transmembrane domain 3 of zDHHC3 as a key determinant in

45 This is caused by transmembrane domains 3 and 4, which are more efficaciou

46 fied herein and a backbone carbonyl group in transmembrane domain 4.

47 with a LeuT-type structural fold assign core transmembrane domain 6 (TM6') a central role in substrat

48 runcated splice variants containing only six transmembrane domains (6TM) through which selected opioi

49 n to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (

50 self-cleavage proximal to the start of the 7-transmembrane domain (7TM).

51 t-binding interaction derived from substrate transmembrane domain, a mechanism in stark contrast to r

52 Here, we identified a probable CLAG3 transmembrane domain adjacent to a variant extracellular

53 canonical Ggamma subunits, with a predicted transmembrane domain and a large cysteine-rich extracell

54 targeting to the NE requires its C-terminal transmembrane domain and a nuclear localization signal.

55 sion via controlling the conformation of the transmembrane domain and altering natural response modes

56 ectin-like extracellular recognition domain, transmembrane domain and cytoplasmic kinase domain.

57 e immunosuppressive moieties of CD147 to its transmembrane domain and Ig-like domain II.

58 Crumbs proteins contain a single transmembrane domain and localize to cell junction area

59 f ABC transporters, including helices in the transmembrane domain and nucleotide-binding domains.

60 g at synapses the receptor is cleaved in its transmembrane domain and releases a protein fragment tha

61 ns, are located in the interface between the transmembrane domain and the C-terminal nucleotide bindi

62 ealed between the intracellular loops on the transmembrane domain and the NADPH-oxidizing dehydrogena

63 to lie in the cytoplasmic side of the single transmembrane domain and the other which is just upstrea

64 n assay to demonstrate that Hhat contains 10 transmembrane domains and 2 re-entrant loops.

65 membrane (IM) protein PbgA, containing five transmembrane domains and a globular domain in periplasm

66 emains unclear because it lacks conventional transmembrane domains and does not have homology to ion

67 rall structure through interactions with the transmembrane domains and each other, and integrate to f

68 mily of chaperones for cytosolically exposed transmembrane domains and explain how they use ubiquitin

69 the PfRH5-interacting protein (PfRipr) lack transmembrane domains and GPI anchors.

70 de evidence that TMEM18 has four, not three, transmembrane domains and that it physically interacts w

71 One of two transmembrane domains and the C-terminal cytoplasmic reg

72 tch, 2) in close proximity to the first Mup1 transmembrane domain, and 3) close to the ubiquitinated

73 n aromatics with hydrophobic residues of the transmembrane domain, and contains the absolutely conser

74 tify specific domains (amino terminus, first transmembrane domain, and extracellular domain) and site

75 binding extracellular domain, ion-conducting transmembrane domain, and gating interface that control

76 agenesis scan on the S4-S5 linker and the S5 transmembrane domain, and studied functional properties

77 izes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transientl

78 get of broadly neutralizing antibodies), the transmembrane domain, and the cytoplasmic tail.

79 determined that the agonist binding domain, transmembrane domain, and the linker regions between the

80 the interface between the extracellular and transmembrane domains, and further to the pore-lining TM

81 syndrome protein COX20), a protein with two transmembrane domains, and maturation of its copper cent

82 ons, including the extracellular N-terminus, transmembrane domains, and transmembrane 3-transmembrane

83 ADIPOR1 crystal structure exhibiting a seven-transmembrane-domain architecture that is clearly distin

84 R1 and ADIPOR2, show a similar overall seven-transmembrane-domain architecture with large unoccupied

85 from the NBDs via the coupling helix to the transmembrane domains are composed of highly conserved r

86 The transmembrane domains are coupled to the nucleotide-bind

87 lysis suggests that the NRP1 cytoplasmic and transmembrane domains are necessary and sufficient to re

88 racellular region preceding the second LRRC8 transmembrane domain as a major determinant of ICl,vol i

89 the gating conformational changes in CFTR's transmembrane domains as even when NBDs are kept at a di

90 adapter function for VE-cadherin mediated by transmembrane domain association with VEGFRs.

91 t an intersubunit-binding site in the GABAAR transmembrane domain binds negative and positive alloste

92 ally activated in a manner that requires its transmembrane domain but not its cytoplasmic domain.

93 arges, results in abortive insertion of this transmembrane domain by the Sec pathway and its subseque

94 In the K(+) channel-like transmembrane domain, Ca(2+) selectivity is determined b

95 whether a SNARE such as STX11, which lacks a transmembrane domain, can support membrane fusion in viv

96 tilts/rotations ( approximately 13 trillion transmembrane-domain conformations) and selects the conf

97 8A, B, and C clades, members of M48D have no transmembrane domains, consistent with their unique subc

98 By contrast, a near-immobile transmembrane domain-containing Cdc42 allele supports vi

99 elements upstream and downstream of the RodZ transmembrane domain dictate nascent polypeptide selecti

100 XT2 lacking its cytosolic amino-terminal and transmembrane domain displays high catalytic activity.

101 these mutations in the sensory and adjacent transmembrane domains emulate the structural changes cau

102 Removal of a predicted transmembrane domain from SGRL reduced its activity in t

103 ion domains were replaced with a single-pass transmembrane domain, fully complemented the pollen tube

104 angiotensin II type 1 receptor (AT1) is a 7-transmembrane domain GPCR that when activated by its lig

105 f the extracellular CAR-D1, cytoplasmic, and transmembrane domains have been analyzed extensively, no

106 display significant movements of individual transmembrane domain helices, which correlated with the

107 assuming a quaternary structure in which two transmembrane domain I-II-helix VIII dimers interact to

108 ontributions of residues from within each of transmembrane domains I, II, IV, V, VI, and VII as well

109 icated important contributions of regions of transmembrane domains I, IV, V, VI, and VII as well as i

110 d, with the ers1-4 mutation being located in transmembrane domain III at a point nearly equivalent to

111 is mediated at least in part through sAnk1's transmembrane domain in a manner similar to that of sarc

112 containing both the extracellular domain and transmembrane domain in an inactive conformation.

113 eport crystal structures of the human GLP-1R transmembrane domain in complex with two different negat

114 reveal a trimeric architecture with a single transmembrane domain in each protomer.

115 We solve the NMR structure of its transmembrane domain in micelles and collect structural

116 ractions and identify a critical role of the transmembrane domain in receptor dimerization.

117 tate, triggering selective release of LHCP's transmembrane domains in a productive unloading complex

118 urrent study investigates the involvement of transmembrane domains in AT1R homomer assembly with the

119 We show that Ubiquilin family proteins bind transmembrane domains in the cytosol to prevent aggregat

120 g to sites on the M3 helix of the AMPA-GluA2 transmembrane domain; independent from the binding site

121 juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or redu

122 Thus, EMC is a transmembrane domain insertase, a function that may expl

123 ce microscopy (smAFM) was employed to unfold transmembrane domain interactions of a unique vacuolar H

124 C-terminal Bax transmembrane domain interactions were implicated recent

125 GluN2D p.Val667Ile exchange occurs in the M3 transmembrane domain involved in channel gating.

126 A cavity in the transmembrane domain is accessible laterally from the cy

127 retion of CpaA and CpaB, indicating that the transmembrane domain is dispensable for CpaA secretion a

128 ry for maximal FERONIA activity, whereas the transmembrane domain is inhibitory.

129 trifugation, and DEER EPR, indicate that the transmembrane domain is monomeric.

130 It was found that the 10th transmembrane domain is required for Ser5 stable express

131 We further demonstrate that the extra transmembrane domain is required for Ser5 stable express

132 meric constructs show that the NMDA receptor transmembrane domain is sufficient to account for most p

133 er, because GRP78 does not contain classical transmembrane domains, its mechanism of transport and it

134 ance between reference alpha carbon atoms of transmembrane domains IV and V and I and II, both of whi

135 Mutations within transmembrane domains IV, V, VI, and VII had no effect o

136 x against a CCR5/CCR2b chimera consisting of transmembrane domains IV-VI of CCR5 with an IC50 of 55 n

137 o acids in the extracellular loop connecting transmembrane domains IVS3 and IVS4.

138 The MacB transmembrane domain lacks a central cavity through whic

139 he results of mutagenesis suggested that the transmembrane domains M1, M3 and M4, which contribute to

140 "unzipping" the extracellular domain and the transmembrane domain, mediated by a unique segment withi

141 th MAVS from spontaneous aggregation through transmembrane domain-mediated homotypic interaction.

142 transmembrane protein that harbors a second transmembrane domain near its amino terminus.

143 ) proteins, whose sole defining feature is a transmembrane domain near their C-terminus.

144 ested a potential activation site within the transmembrane domain, near the A-967079 cavity.

145 However, neither the presence of the transmembrane domain nor the membrane topology have been

146 Their simultaneous presence within the same transmembrane domain obeys a "mirror code" controlling p

147 h the extracellular domain of ADAM10 and the transmembrane domain of ADAM17 with or without the cytop

148 teraction in sites of cell-cell contact, the transmembrane domain of an engineered receptor is cleave

149 creases in membrane thinning/disorder by the transmembrane domain of BamA is greatest in thicker bila

150 cytoplasmic tail and inducing a kink in the transmembrane domain of beta3-integrin.

151 However, replacement of TM2 by the transmembrane domain of CD4, the asialoglycoprotein rece

152 is insensitive to replacement of TM2 by the transmembrane domain of CD74 or by 21 alanines.

153 Replacement of the transmembrane domain of CD74 or the asialoglycoprotein r

154 Interestingly, deletion of the N-terminal transmembrane domain of CpaB results in robust secretion

155 we identify conserved residues in the second transmembrane domain of Erv14 that mediate interaction w

156 wo putative cholesterol-binding sites in the transmembrane domain of GIRK2.

157 ingle amino acid substitution (F438I) in the transmembrane domain of glycoprotein is attenuated but g

158 ly incorporated into two residues within the transmembrane domain of KCNE1: F56 and F57.

159 r molecule at a canonical cation site in the transmembrane domain of KdpB.

160 cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH.

161 diffraction: potassium channel KcsA and the transmembrane domain of M2 protein of influenza A virus.

162 hannel motion of both full-length M2 and the transmembrane domain of M2.

163 2R indicated that only mutation of the third transmembrane domain of MC2R resulted in a decrease in D

164 The extracellular and transmembrane domain of Met was required to fully rescue

165 In contrast, the helicity of the transmembrane domain of monomeric C991-55 is relatively

166 The transmembrane domain of MRAP is also required in only th

167 f the endothelial barrier; expression of the transmembrane domain of NOTCH1 is sufficient to rescue d

168 oteolytic activation of NOTCH1 to expose the transmembrane domain of NOTCH1.

169 A human mutation affecting the transmembrane domain of otoferlin impaired its ER target

170 Mutational analyses indicated that the transmembrane domain of sigma1R likely mediated this int

171 hat the mechanism of ion coordination in the transmembrane domain of SLC30A10 may be substantially di

172 homologous intersubunit binding sites in the transmembrane domain of synaptic alpha1beta3gamma2 GABAA

173 ary subunits require a shared surface on the transmembrane domain of the AMPAR for their function, bu

174 n addition, our approach was extended to the transmembrane domain of the cell adhesion protein l-sele

175 he membrane-proximal external region and the transmembrane domain of the envelope glycoprotein subuni

176 Although an X-ray structure of the transmembrane domain of the GCGR has previously been sol

177 ntifying two anesthetic binding sites in the transmembrane domain of the Gloeobacter violaceus ligand

178 on (A653T) falls within the highly conserved transmembrane domain of the ion channel gate, immediatel

179 Although T->A mutations in the transmembrane domain of the Neu (c-ErbB-2) gene are the

180 r a series of inter-residue distances in the transmembrane domain of the P2X2 receptor during activat

181 We show that nearly the entire transmembrane domain of the substrate is important for e

182 nce of ceramide, the N terminus of the first transmembrane domain of TM4SF20 is exposed to cytosol.

183 Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion f

184 We now show that the transmembrane domain of VE-cadherin mediates an essentia

185 adapter function by binding directly to the transmembrane domain of VEGFR2, as well as VEGFR3, which

186 esults suggest that interactions between the transmembrane domains of Bax and antiapoptotic Bcl-2 pro

187 Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-ex

188 han was substituted for residues in all four transmembrane domains of connexin32.

189 we present de novo atomic structures of the transmembrane domains of mouse TMEM16A in nanodiscs and

190 The 4.2 A-resolution structure of the transmembrane domains of nucleotide-free MsbA reveals th

191 CRAC) and CARC-like sequences within the two transmembrane domains of p33.

192 we identified the conformational changes in transmembrane domains of presenilin 1 that affect the pr

193 by a single cleavage between the EGF and the transmembrane domains of pro-EGF.

194 onstrated that both the cytoplasmic and ecto-transmembrane domains of TfR2 interact with CD81.

195 Both variants completely lacked the transmembrane domains of the channel and produced cytopl

196 gained from recent crystal structures of the transmembrane domains of the glucagon and corticotropin

197 and complete structures of the pore-forming transmembrane domains of these receptors remain unclear.

198 Furthermore, we reveal that the transmembrane domains of TLR4 and TLR6 have an essential

199 Mutations to the F protein transmembrane domain or cytoplasmic tail that disrupted

200 an extracellular domain following the first transmembrane domain or in the 4(th) putative transmembr

201 bunit anesthetic-binding sites in the GABAAR transmembrane domain or to known convulsant sites in the

202 in at the boundaries between the ectodomain, transmembrane domains, or endodomain.

203 and the other which is just upstream of this transmembrane domain; our results suggest that these cys

204 Fbxw7) and Prolyl 4-hydroxylase possessing a transmembrane domain (P4HTM) respectively.

205 rtantly, insect OR models exhibit a distinct transmembrane domain packing arrangement to that of cano

206 published NMR structure of the hGlyR-alpha1 transmembrane domain (PDB ID: 2M6I ) and the critical ro

207 l isoform that restricts HIV-1, and the 10th transmembrane domain plays a critical role in this proce

208 panins (TSPANs) comprise a large family of 4-transmembrane domain proteins.

209 rmance in BnaDGAT1 is in the ninth predicted transmembrane domain (PTMD9).

210 l analysis indicated that the kinase and the transmembrane domains, rather than the extracellular dom

211 CCRL2 is a 7-transmembrane domain receptor that shares structural and

212 Chemokine receptors are seven transmembrane-domain receptors belonging to class A of G

213 -trimeric complex with ubiquitin-like 4A and transmembrane domain recognition complex 35 (TRC35).

214 is family is characterized by one or two LHC transmembrane domains (referred to as the LHC motif) to

215 The transmembrane domain restores barrier function by cataly

216 Conformational changes in the transmembrane domain result in a sharp kink in the middl

217 me encodes 13 NAC genes which have predicted transmembrane domain(s) (SlNACMTFs).

218 hannels reveal a critical role for the fifth transmembrane domain (S5) in sensing anesthetics.

219 by their motif organization; each contains a transmembrane domain, serine rich region and a conserved

220 oforms and mutants that do not have the 10th transmembrane domain show very poor activity.

221 nt analysis of the movements of the receptor transmembrane domains showed that the buprenorphine-boun

222 ed by cholesterol through their heptahelical transmembrane domains, SMO is activated by cholesterol t

223 Bcl-2 protein transmembrane domains specifically homooligomerize and h

224 e gain-of-function mutation within the STIM1 transmembrane domain (STIM1-TM), here we show that local

225 TMC1 is thought to have a six-transmembrane domain structure reminiscent of some other

226 opposite faces of a predicted alpha-helical transmembrane domain, suggesting that the domain lines a

227 The resulting kink in the inner transmembrane domain swings the aromatic rings from down

228 en the His(37) residues in the middle of the transmembrane domain take on a +2 or +3 charged state.

229 n which resides the Na(+)-binding site and a transmembrane domain that closely resembles voltage-gate

230 nd identified a region proximal to the first transmembrane domain that confers tachyphylaxis upon ASI

231 ratable histidine, His-27, in the tetrameric transmembrane domain that forms a reverse WXXXH motif wi

232 teap family proteins are defined by a shared transmembrane domain that in Steap3 has been shown to fu

233 oreactivities toward ZnT8 were mapped to its transmembrane domain that is accessible to extracellular

234 pecies and originates a change of one of the transmembrane domains that avoids the liberation of prot

235 s contain intracellular N and C termini, two transmembrane domains that constitute the pore, and a la

236 the secretion signal from the substrate, two transmembrane domains that form a translocation pathway,

237 (the Pgp engines) lead to changes across Pgp transmembrane domains that result in substrate transloca

238 e the proton conduction mechanism in the AM2 transmembrane domain; the four transmembrane helices fla

239 t external loop 4 (eL4) and the outer end of transmembrane domain (TM) 10' participate in the reversi

240 in (interfacial helix 2, hairpin 1, putative transmembrane domain (TM) 7, and TM8), as well as TM9 of

241 A stable homotrimeric structure for the transmembrane domain (TM) also was modeled and supported

242 undergoes proteolytic cleavage in the second transmembrane domain (TM2) and that a disulfide bond hol

243 tors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine

244 Recent studies showed that its transmembrane domain (TMD) forms a trimer in lipid bilay

245 idues near either the N or C terminus of the transmembrane domain (TMD) likely promotes a rotation of

246 t triggers the conformational changes in the transmembrane domain (TMD) necessary for intracellular G

247 ootprints of agonists and antagonists on the transmembrane domain (TMD) of CRF1R and identified numer

248 We identified lipid-exposed residues in the transmembrane domain (TMD) of the GluA2 subunit of AMPAR

249 This transmembrane protein binds to the transmembrane domain (TMD) of the platelet-derived growt

250 The C-terminal transmembrane domain (TMD) of viral fusion proteins such

251 41, are anchored by a single helical segment transmembrane domain (TMD) on the viral envelope membran

252 that is involved in synaptic targeting, the transmembrane domain (TMD) that forms the ion channel, t

253 gand-binding domain (LBD), a channel-forming transmembrane domain (TMD), and a carboxyl-terminal doma

254 However, beyond the need for a transmembrane domain (TMD), little is known about the fe

255 oteins anchored to each fusing membrane by a transmembrane domain (TMD), the role of TMDs remains unc

256 y uphill efflux of substrates by a dedicated transmembrane domain (TMD).

257 Peptides corresponding to transmembrane domain (TMD)1, 2, 3, and 4, but not TMD5,

258 each anchored to a Kir6.2 by its N-terminal transmembrane domain (TMD0).

259 e transporter structure, predicted that PCFT transmembrane domains (TMDs) 1, 2, 7, and 11 form an ext

260 ssibility method to analyze the structure of transmembrane domains (TMDs) 4 and 5 of human presenilin

261 f the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding doma

262 ], the cysteine-rich domains (CRDs), and the transmembrane domains (TMDs) at the TM56/TM56 interface.

263 Hypothesizing that protein transmembrane domains (TMDs) determine raft association,

264 Transmembrane domains (TMDs) engage in protein-protein i

265 Transmembrane domains (TMDs) from single-spanning membra

266 le roles of juxtamembrane regions (JMRs) and transmembrane domains (TMDs) in catalyzing lipid rearran

267 ns of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains

268 traints for solving structures of oligomeric transmembrane domains (TMDs) of cell surface receptors a

269 pposing membranes, but it is unknown whether transmembrane domains (TMDs) of SNARE proteins serve mec

270 using coarse-grained molecular dynamics, the transmembrane domains (TMDs) of t-SNARE complexes are sh

271 ried out via direct interactions between the transmembrane domains (TMDs) of Vpu and the target.

272 me require the correct interaction of the 19 transmembrane domains (TMDs) present in its four subunit

273 und that interactions between v- and t-SNARE transmembrane domains (TMDs) promote, but are not essent

274 r NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure.

275 ction scheme for isotope-labeled single-pass transmembrane domains (TMDs) with or without intrinsical

276 the gating conformational changes in CFTR's transmembrane domains (TMDs) without altering the functi

277 the fifth, seventh, eighth, ninth, and tenth transmembrane domains (TMDs), and in the regions between

278 of nucleotide binding domains (NBDs) to the transmembrane domains (TMDs), which switch between inwar

279 The EaDAcT model contains four transmembrane domains (TMDs), with both the N- and C-ter

280 n fusion is mediated by interactions between transmembrane domains (TMDs).

281 ly of Dispanins, whose members share the two-transmembrane domain topology with a large N terminus an

282 ist' interface, and leads to rotation of the transmembrane domain towards the pore axis, occluding th

283 ER by fusion with the Sec61beta ER-directing transmembrane domain triggers its clearance.

284 As these proteases contain multiple transmembrane domains typical of ion channels, we examin

285 ino acid sequence located at the junction of transmembrane domain V and second extracellular loop.

286 key positively charged arginine residues in transmembrane domains V and VII of FFA2, there are clear

287 mer via an interface involving residues from transmembrane domains VI and VII.

288 s the ligand-binding site, is coupled to the transmembrane domain via a cysteine-rich domain, and LBD

289 l changes in the NBDs cause reorientation of transmembrane domains via interactions with CL1 and resu

290 The structure of the transmembrane domain was refined using restrained molecu

291 The Sec22 transmembrane domain was required for efficient homodime

292 g motif and a long sequence motif within the transmembrane domains were found conserved at the NH2-te

293 llographic studies have focused on conserved transmembrane domains, where multiple substrate binding

294 t fungal Fzo1 proteins exhibit two predicted transmembrane domains, whereas metazoan Mitofusins conta

295 y spliced isoforms: Ser5-001 has 10 putative transmembrane domains, whereas Ser5-004, -005, -008a, an

296 assembly accompanied by local changes in the transmembrane domain, which include bending of the S6 tr

297 we overcome this limitation by replacing the transmembrane domain with a soluble hexameric coiled coi

298 beta3gamma2 GABAAR, S-mTFD-MPPB binds in the transmembrane domain with high affinity to the gamma(+)-

299 Each subunit consists of 16 transmembrane domains with both ends facing the lumen si

300 motes rearrangement of the extracellular and transmembrane domain 'wrist' interface, and leads to rot