ライフサイエンスコーパス: transmembrane helix

1 embrane curvature even in the absence of the transmembrane helix.

2 which were predicted to contain at least one transmembrane helix.

3 41A1, resulting in an in-frame deletion of a transmembrane helix.

4 TatA assembly is mediated entirely by the transmembrane helix.

5 e normal and forms an extension of the first transmembrane helix.

6 rtially destabilized insertion of the eighth transmembrane helix.

7 main, resulting in the exposure of a nascent transmembrane helix.

8 e-forming activity resides in the C-terminal transmembrane helix.

9 ochondrial targeting signal and a downstream transmembrane helix.

10 ced at the beginning, middle, and end of the transmembrane helix.

11 segment between the C-terminus and the inner transmembrane helix.

12 htly acidic conditions (pH 6-6.5), forming a transmembrane helix.

13 slower (100 sec) insertion pathway to give a transmembrane helix.

14 distal to the cytoplasmic end of the second transmembrane helix.

15 HD1 and HD2), immediately follows the second transmembrane helix.

16 APP (Abeta(1-55)) is observed to have a long transmembrane helix.

17 share a positively charged domain flanking a transmembrane helix.

18 ersal that packs Phe-992-Phe-993 against the transmembrane helix.

19 disposed 16-residue motif follows the final transmembrane helix.

20 main being uncoupled from the motions of the transmembrane helix.

21 transmembrane helix and a buckling of the M2 transmembrane helix.

22 in a truncation within the carboxyl-terminal transmembrane helix.

23 ne dynamics of the amyloid precursor protein transmembrane helix.

24 have shown that the acidic residues E106 in transmembrane helix 1 (TM1) and E190 in TM3 contribute t

25 One clue may lie in two openings between transmembrane helix 1 (TM1) and TM7 and between TM5 and

26 functional contribution of highly conserved transmembrane helix 1 (TM1) on the hASBT transport cycle

27 sodium-binding sites, the unwound portion of transmembrane helix 1 and the substrate-binding site tha

28 s) between at least three lysine residues in transmembrane helix 1 are essential for both COPI comple

29 and a second essential aspartyl residue from transmembrane helix 1 into close proximity for catalysis

30 A conserved peptide motif, T1, within the DT transmembrane helix 1 mediates these interactions.

31 ntracellular loop or the Phe(223) residue in transmembrane helix 1 of alpha6 with the corresponding a

32 Further, we have shown that transmembrane helix 1 plays an essential, but as yet und

33 w that sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required

34 us, irrespective of sequence, the ability of transmembrane helix 1 to bind to COPI complex appears to

35 The transmembrane helix 1 unwinds when the K(+) channel ente

36 id membrane revealed water penetration along transmembrane helix 1 with the cooperation of a polar re

37 nstrate that substitution of the lysine-rich transmembrane helix 1 with the COPI binding portion of t

38 on connecting the outer transmembrane helix (transmembrane helix 1) and the pore helix behind the sel

39 GLUT1 trypsinization released full-length transmembrane helix 1, cytoplasmic loop 6-7, and the lon

40 h as TPP(+) and the essential residue E14 in transmembrane helix 1.

41 ions 359 and 448 of extracellular loop 4 and transmembrane helix 10, respectively.

42 e multiple distinctions, including a kink in transmembrane helix 12 halfway across the membrane bilay

43 revealing an unexpectedly large movement of transmembrane helix 1a (TM1a).

44 Zhou et al. suggest transmembrane helix 2 'tugs' on HAMP to destabilize x-da

45 ional changes include a distinct movement of transmembrane helix 2 (M2), from its position in the pre

46 ken together, we demonstrate that the top of transmembrane helix 2 (TM2) and the top of transmembrane

47 Transmembrane helix 2 (TM2) of the Tar chemoreceptor und

48 influenced by residues at the C-terminus of transmembrane helix 2 (TM2).

49 onserved tyrosine residue (Tyr81) located in transmembrane helix 2 adjacent to the aromatic arginine

50 nce presented here that interactions between transmembrane helix 2 and the nucleotide-binding domain,

51 hemoreceptor, they convert axial movement of transmembrane helix 2 into changes in packing of the cyt

52 -AR:CXCR4 heteromeric complexes by targeting transmembrane helix 2 of CXCR4 and depletion of the hete

53 Cys for residues on the cytoplasmic side of transmembrane helix 2 of subunit c and probed the access

54 s in the middle of the membrane at Asp-61 on transmembrane helix 2 of subunit c.

55 ch to delineate the role of highly conserved transmembrane helix 2 on the expression and function of

56 We examined the functional role of transmembrane helix 3 (TM3) in NKCC1 using cysteine- and

57 e transport domain, including the peripheral transmembrane helix 3 (TM3), moves relative to the trime

58 lvent-accessible profile of highly conserved transmembrane helix 3 (TM3), spanning residues V127-T149

59 Our primary interest was focused on transmembrane helix 3 (TM3), which is identified as bein

60 To further probe GCR1, we have aligned transmembrane helix 3 of GCR1 to each of the six GPCR cl

61 te that the GLP-1R forms homodimers and that transmembrane helix 4 (TM4) provides the primary dimeriz

62 ubstitution of four lipid-facing residues in transmembrane helix 4 (TM4) that is known to be importan

63 Here, we show that the predicted transmembrane helix 4 of Escherichia coli FtsW (this pro

64 a heterodimer between S. Typhi MgtR and the transmembrane helix 4 of Mtb MgtC.

65 interface by introducing point mutations in transmembrane helix 4 of PAR1 or PAR4 that prevented het

66 e dimer interface to hydrophobic residues in transmembrane helix 4.

67 tion motifs but identified a requirement for transmembrane helix 4.

68 bonds with two conserved serine residues in transmembrane helix 5 (Ser(5.42) and Ser(5.46)), but par

69 ize a near-native state with a highly mobile transmembrane helix 5 (TM5) that is significantly popula

70 terface than ARC, especially in the receptor transmembrane helix 5 (TM5), TM6, and TM7 intracellular

71 predicted to lie near the cytoplasmic end of transmembrane helix 5 (TM5).

72 a substrate-induced disulphide crosslink in transmembrane helix 5 of TatC.

73 the cooperation of a polar residue (Y147 in transmembrane helix 5) in the adjacent protomer.

74 nsmembrane helix 8 or a threonine residue in transmembrane helix 5.

75 ntified the conserved aspartate in the upper transmembrane helix 6 (Asp(6.59)) of the receptor as the

76 s incorporated on the cytosolic interface of transmembrane helix 6 (Cys-265), (19)F NMR spectra of th

77 tward movements of the intracellular side of transmembrane helix 6 (TM6) and movements of TM5 toward

78 ion of rhodopsin is a rigid-body movement of transmembrane helix 6 (TM6) at the cytoplasmic surface o

79 of the chromophore, (ii) displacement of the transmembrane helix 6 (TM6) away from the binding pocket

80 Specifically, transmembrane helix 6 (TM6) movements associated with G-

81 he retinal leaving the protein and return of transmembrane helix 6 (TM6) to the inactive conformation

82 protein coupling entail outward movements of transmembrane helix 6 (TM6).

83 ns reveal that peptide binding to the ECS on transmembrane helix 6 (TMH6) and TMH7 at the base of ext

84 gests that the mutated residue at the top of transmembrane helix 6 mimics Arg(19) by interacting with

85 ed state, except that the cytoplasmic end of transmembrane helix 6 partially occludes the G-protein-b

86 results indicated that two substitutions in transmembrane helix 6 reverse stereoselectivity of Sp-AB

87 tation of the nucleotide binding domains and transmembrane helix 6 which is of particular relevance t

88 main result in a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular ha

89 ular loop three and the extracellular tip of transmembrane helix 6.

90 fferent amplitude of the outward movement of transmembrane helix 6.

91 The six-transmembrane helix (6 TM) tetrameric cation channels fo

92 It contains two homologous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence

93 l rearrangements such as the displacement of transmembrane helix-6.

94 racellular loop 2 (ECL2) and the apex of the transmembrane helix 7 (TM7) was exclusively broken.

95 uses distinct structural elements, including transmembrane helix 7 and helix 8, to recruit arrestin.

96 at either a conserved asparagine residue in transmembrane helix 8 or a threonine residue in transmem

97 Transmembrane helix 8 release did not abrogate cytochala

98 se binding capacity and released full-length transmembrane helix 8 upon cytochalasin B (but not D-glu

99 transporters is the helix-loop transition in transmembrane helix 8, which likely forms the structural

100 3 domains and vice versa, we show that GLUT1 transmembrane helix 9 (TM9) is necessary for optimal ass

101 the fifth cytoplasmic loop (CL5) connecting transmembrane helix 9 (TM9) to TM10 are critical for sta

102 Transmembrane helix 9 of the Glut1 glucose transporter w

103 20 in the pH gate in the hinges of the inner transmembrane helix (98-103), and in the selectivity fil

104 ive site of the enzyme, possibly mediated by transmembrane helix alpha7, which contains both Y241(Vc)

105 ns of the lipid-facing residues of the outer transmembrane helix also had no effect.

106 a tilting and straightening of the M4 inner transmembrane helix and a buckling of the M2 transmembra

107 realistic model of CYP3A4, complete with its transmembrane helix and a membrane, has been constructed

108 hipathic alpha-helix that precedes the first transmembrane helix and a subtle rigid-body repositionin

109 related proteins that comprise an N-terminal transmembrane helix and an adjacent amphipathic helix.

110 e needed to show how interaction between the transmembrane helix and catalytic domain might influence

111 Each repeat includes a discontinuous transmembrane helix and forms half of a channel across t

112 s between residues in a C-terminally located transmembrane helix and in more N-terminally located hel

113 multiple mutations were introduced into the transmembrane helix and its surroundings.

114 mutations are located in the putative sixth transmembrane helix and the adjacent extracellular loop

115 mutations are located in the putative sixth transmembrane helix and the adjacent extracellular loop

116 rising the membrane interactive domains, the transmembrane helix and the cytoplasmic helix, displayed

117 Although the transmembrane helix and the intracellular module togethe

118 sting that the membrane-proximal region, the transmembrane helix and the kinase domain of PDGFRbeta a

119 of Cys-35 at the C-terminus of the predicted transmembrane helix and thereby close to the surface of

120 ntains a small cytosolic region, a predicted transmembrane helix, and an extracellular domain with a

121 Comparison of the transmembrane helix architecture with other G-protein-co

122 Threonine mutations within this transmembrane helix are known to alter the cleavage patt

123 s, whereas only resonances from the immobile transmembrane helix are observed in the solid-state (1)H

124 helix and the hinge that connects it to the transmembrane helix are significantly more dynamic than

125 ignment of the helices identifies the second transmembrane helix as the key element lining the pore,

126 terface can exert a significant influence on transmembrane helix association affinity.

127 A transmembrane helix association mechanism and its implic

128 ogen bonding and helix-lipid interactions in transmembrane helix association, we have calculated the

129 highly packed residues that facilitate tight transmembrane helix association.

130 structured but folds across the bilayer as a transmembrane helix at pH approximately 6.

131 9) to Lys in the cytosolic portion of the M1 transmembrane helix at the other end of the molecule bro

132 ed (TA) proteins, defined as having a single transmembrane helix at their C terminus, are post-transl

133 omain (LBD), (2) the resulting separation of transmembrane helix attachment points across subunit dim

134 first cytoplasmic loop and the beginning of transmembrane helix B with the fluorescent dye fluoresce

135 rked differences in the histidine-containing transmembrane helix behavior between acidic and neutral

136 ne classifier to predict the likelihood of a transmembrane helix being involved in pore formation.

137 evolution has been able to liberally exploit transmembrane helix bending for the optimization of memb

138 M3 loop (deltaIle-288) and the delta subunit transmembrane helix bundle (deltaPhe-232 and deltaCys-23

139 The catalytic core of VKOR is a four transmembrane helix bundle that surrounds a quinone, con

140 trast, I260A appears to be buried within the transmembrane helix bundle, F342A may form a distant par

141 binds at the extracellular end of the seven-transmembrane-helix bundle and forms extensive contacts

142 This movement of the transmembrane helix bundles can cause a corresponding la

143 symmetrically arranged N- and C-terminal six-transmembrane helix bundles surrounding a deep internal

144 lecular hinge points about which the two six transmembrane-helix bundles flex and straighten to open

145 omplex are as follows: (i) substitution of a transmembrane helix by a lipid and chlorin ring, (ii) li

146 the membrane-embedded Fo subcomplex, as its transmembrane helix can be removed.

147 generated in silico structural models of the transmembrane helix complex that informed mutagenesis st

148 structure of the DAP12-NKG2C immunoreceptor transmembrane helix complex, five functionally required

149 intracellular "gates" and by an unfavorable transmembrane helix configuration when both gates are cl

150 function, using variations of a shared seven-transmembrane helix design and similar photochemical rea

151 e and not part of the structurally important transmembrane helix dimer crossing region.

152 re, the stability of the human glycophorin A transmembrane helix dimer has been analyzed in lyso-phos

153 Here, we find that the transmembrane helix dimer, glycophorin A (GpATM), is act

154 a complex involving the alpha/beta integrin transmembrane helix dimer, the head domain of talin (a c

155 x relationships among DR5 network formation, transmembrane helix dimerization, membrane cholesterol,

156 mate in the extracellular part of the fourth transmembrane helix, distant to site III.

157 izes and induces structural changes in the 7-transmembrane helix domain, triggering G protein activat

158 FEX proteins consist of two homologous four-transmembrane helix domains folded into an antiparallel

159 w that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an

160 dynamics not only reveals the importance of transmembrane helix dynamics in interpretation of SSNMR

161 The structures reveal a monomeric eight-transmembrane helix fold that supports a periplasmic car

162 The structure has a seven-transmembrane-helix fold that features two triple-helix

163 ular dichroism analysis revealed a very long transmembrane helix for E5 of approximately 26 amino aci

164 MCU is a homo-oligomer in which the second transmembrane helix forms a hydrophilic pore across the

165 c helix oriented nearly perpendicular to the transmembrane helix forms an inward-facing base.

166 g at Na(+) site II, possibly via movement of transmembrane helix four.

167 upled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wi

168 The third transmembrane helix from each subunit is domain-swapped

169 H-1 serves as a scaffold, anchoring the lone transmembrane helix from nicastrin and supporting the fl

170 This prevented the inner transmembrane helix from undergoing conformational chang

171 thod to the well-characterized glycophorin A transmembrane helix (GpATM) reveals a dimer that is dram

172 In addition, mutations that disrupted transmembrane helix H-bonding (K61M-Kir1.1b) or stabiliz

173 Introducing a competing R-opsin transmembrane helix H1 or helix H8 peptide, but not heli

174 53) at the cytoplasmic terminus of the third transmembrane helix (H3C), a region within class A G pro

175 ization event drives the outward rotation of transmembrane helix H6, a hallmark of activated G protei

176 lycosylated region followed by a hydrophobic transmembrane helix, has been notoriously resistant to a

177 a large ligand-binding pocket and the first transmembrane helix having a 'stalk' region that extends

178 The GXGD motif and a short transmembrane helix, helix 4, are positioned at the cent

179 These dimers are stabilized by specific transmembrane helix-helix interactions, including a disu

180 DGFR) beta in a ligand-independent manner by transmembrane helix-helix interactions.

181 AMT1;1 carrying the mutation Q57H in transmembrane helix I (TMH I) showed increased ammonium

182 served disulfide bridge (7TM bridge) linking transmembrane helix III (TMIII) and ECL-2 is crucial for

183 This relatively long transmembrane helix implies a pronounced helix tilt with

184 The length of the alphaIIb transmembrane helix implies the absence of a significant

185 y site close to the kinked part of the first transmembrane helix, in a region loaded with negatively

186 affected only the intracellular part of the transmembrane helix, indicating that an asymmetric lipid

187 ng channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent m

188 oarse-grained estimates of the energetics of transmembrane helix insertion.

189 e itself plays an active role in driving DR5 transmembrane helix interactions or in the formation of

190 Several of these structures have the five transmembrane-helix inverted-topology repeat, LeuT-like

191 The mechanism through which a single transmembrane helix is able to recognize and interact wi

192 odel identifies that the presumed C-terminal transmembrane helix is buried within the core of the PLS

193 at the position of the motif relative to the transmembrane helix is critical.

194 n which a bulge conformation at Ser-382 in a transmembrane helix is eliminated to open the water chan

195 exibility at this point in the cavity-lining transmembrane helix is necessary for normal RyR function

196 Most notably, we also show that the transmembrane helix is tilted ~13 degrees from the lipid

197 The protein's N terminus, a predicted transmembrane helix, is not represented in the crystal s

198 (40), residing at the C-terminal side of the transmembrane helix, is observed to cause local membrane

199 We show that cholesterol binds to transmembrane helix IV, and cholesterol occupancy at thi

200 helices I and II, but a reduced presence of transmembrane helix IV, is observed at the dimer interfa

201 ii) stabilization of the iron-sulfur protein transmembrane helix, (iv) n-side charge and polarity com

202 n at the conserved 9'-leucines on the second transmembrane helix (M2-9') decreased successively durin

203 hem to the extracellular C-type gate through transmembrane helix M4 and pore helix 1.

204 Replacement of the cysteine C932 in transmembrane helix M8 of Na(+),K(+)-ATPase with arginin

205 nner membrane protein will ultimately form a transmembrane helix may therefore depend on whether or n

206 In the 12-transmembrane-helix MFS transporters, four triple-helix

207 thin the interior of rhodopsin is coupled to transmembrane helix motion and receptor activation.

208 k of extracellular salt bridges and blocking transmembrane helix motions necessary for activation.

209 Our experimental analyses show that the transmembrane helix of ADCK3 oligomerizes, with an inter

210 A peptide derived from the second transmembrane helix of CXCR4 induced chemical shift chan

211 odified wild-type sequences of the conserved transmembrane helix of E is sufficient to lyse host cell

212 To locate the transmembrane helix of E1 (E1-TM) relative to the Q1 TM

213 In the TatBC receptor complex the transmembrane helix of each TatB molecule is sandwiched

214 introduced at selected positions within the transmembrane helix of Escherichia coli TatA and used to

215 CIQ modulation in the region near the first transmembrane helix of GluN2D, including in a putative p

216 howed that rs3749171 is located in the third transmembrane helix of GPR35 and could possibly alter ef

217 The mutated glycine is in the pore-lining transmembrane helix of Kir6.2; an equivalent glycine in

218 of a critical cysteine (Cys195) in the third transmembrane helix of Orai1.

219 he receptor dimer causes a shift in a single transmembrane helix of roughly 0.15 nm towards the cytop

220 e of residues in the cytosolic cavity-lining transmembrane helix of RyR (G(4864)LIIDA(4869) in RyR2)

221 dimer-specific subunits e and g or the first transmembrane helix of subunit 4 lack both dimers and la

222 We isolated substitutions, locating to the transmembrane helix of TatB that restored transport acti

223 ed by mutations affecting amino acids in the transmembrane helix of TatB.

224 g substitutions were identified in the fifth transmembrane helix of TatC.

225 y sequential proteolytic cleavage within the transmembrane helix of the 99 residue C-terminal fragmen

226 ino acid peptide corresponding to the second transmembrane helix of the CXCR4 forms self-assembled pa

227 ars to be independent of the presence of the transmembrane helix of the full-length enzyme, significa

228 between the macroglycopeptide region and the transmembrane helix of the GPIbalpha subunit.

229 The M1 transmembrane helix of the muscle endplate AChR is linke

230 Finally, substitutions within the first transmembrane helix of the TMR and deletions within the

231 nce of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the endo

232 secutive addition of individual helices to a transmembrane helix or helix bundle, in contrast to curr

233 vides a means to simultaneously extract both transmembrane helix orientation and dynamics information

234 f labeled alanines method for estimating the transmembrane helix orientation.

235 mismatch is the dominant factor guiding the transmembrane helix packing.

236 effects reaching from as far away as the M2 transmembrane helix perturb the function of the catalyti

237 pic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cel

238 el configuration to produce the 6- and 6 + 1-transmembrane-helix pores, respectively.

239 se permease of Escherichia coli (LacY), a 12-transmembrane helix protein LacY that catalyzes symport

240 G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extr

241 The rotation of the transmembrane helix (Q16-A46) around its long axis chang

242 constructs for rapid reconstitution of seven-transmembrane helix receptors into nanoscale apolipoprot

243 Proteus mirabilis revealed an inverted five-transmembrane-helix repeat similar to that in the amino

244 a(2)K274C in the extracellular end of the M2 transmembrane helix reported a small but significant F(T

245 er Kv channel was truncated after the fourth transmembrane helix S4 (Shaker-iVSD).

246 ectrophysiology, mainly regarding the fourth transmembrane helix (S4), which constitutes a moderate v

247 ied by opening of the L5 cap and movement of transmembrane helix S5 toward S6 in a direction differen

248 -to-pi-helical transition in the pore-lining transmembrane helix S6 at an alanine hinge just below th

249 ved residue within the C-terminal end of the transmembrane helix S6 region of the ion permeation path

250 utation, within the C terminus of domain III/transmembrane helix S6, shifts channel activation by -7.

251 x bundle formed by the intracellular ends of transmembrane helix six of each subunit.

252 ion efflux domain, putatively disrupting its transmembrane helix structure.

253 cal pattern of accessibility changes along a transmembrane helix, suggesting a rigid-body helical re-

254 ctive mutations at the cytoplasmic face of a transmembrane helix suggests that they restore biogenesi

255 hat informed mutagenesis studies of the YycI transmembrane helix supporting the accuracy of the in si

256 ging motion at the center of the pore-lining transmembrane helix that underlies channel gating either

257 minal amphipathic helix preceding a putative transmembrane helix that would constrain the catalytic d

258 tion with the extracellular region of the S4 transmembrane helix, the primary voltage-sensing domain

259 ly transporters that occurs before the first transmembrane helix, the signal sequence recognized by t

260 In addition to the transmembrane helix, the SNARE motif consists of two wel

261 e helix implies the absence of a significant transmembrane helix tilt in contrast to its partnering b

262 Our previous study showed that transmembrane helix (TM) 11 of NaDC1 is important for so

263 In contrast, the mutation of residues within transmembrane helix (TM) 2 and the second extracellular

264 milar mode of binding in which they straddle transmembrane helix (TM) 3, wedge between TM3/TM8 and TM

265 roteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and

266 The results support an eight transmembrane helix (TM) model of subunit a in which the

267 helix, which propagates to the pore-forming transmembrane helix TM1.

268 terminal tail of SERCA2b consists of an 11th transmembrane helix (TM11) with an associated 11-amino a

269 er advocate that the elimination of the last transmembrane helix (TM14) of NuoM and the TM16 (at leas

270 conformation, which involve the movement of transmembrane helix TM1a away from the transmembrane hel

271 conformational changes transmitted through a transmembrane helix (TM2), a five-residue control cable

272 extracellular N-terminal domain and a second transmembrane helix (TM2), it is different from the foun

273 In the conductive state, rotation of a transmembrane helix (TM4) about a central hinge seals th

274 ix bundles, connected by an inversion linker transmembrane helix (TM4) to create the translocation pa

275 lly on key movements that occur in the sixth transmembrane helix (TM6) during GPCR activation.

276 T motif on the partially unwound part of the transmembrane helix TM7 and the residues Asp-390 and Asp

277 r in the middle of the membrane at Asp-61 on transmembrane helix (TMH) 2 of subunit c.

278 ent on human cannabinoid 1 (hCB(1)) receptor transmembrane helix (TMH) conformational dynamics was in

279 enhanced detection of peptides encompassing transmembrane helix (TMH) domain, as compared with stron

280 occur at Asp-61 in the middle of the second transmembrane helix (TMH) of F(0) subunit c.

281 occur at Asp-61 in the middle of the second transmembrane helix (TMH) of F(o) subunit c.

282 occur at Asp-61 in the middle of the second transmembrane helix (TMH) of F0 subunit c.

283 occur at Asp-61 in the middle of the second transmembrane helix (TMH) of Fo subunit c.

284 py identify a pivotal role of the oligomeric transmembrane helix (TMH) of Mga2 for intra-membrane sen

285 ddle of the membrane at Asp-61 on the second transmembrane helix (TMH) of subunit c, which folds in a

286 Of these residues, Gln(332) in transmembrane helix (TMH) VI was protected against MTS i

287 tonation of a conserved Asp/Glu at the outer transmembrane helix (TMH).

288 , if occluded by aromatic rings, may cause a transmembrane helix to exit the lipid bilayer.

289 mbrane surface and becomes parallel with the transmembrane helix to form one nearly continuous long h

290 s of deltaOR homodimers involving the fourth transmembrane helix to predict their association constan

291 re, protein fold, protein structural domain, transmembrane helix topology, metal binding sites, regio

292 The charged S4 transmembrane helix transduces changes in transmembrane

293 that the turret region connecting the outer transmembrane helix (transmembrane helix 1) and the pore

294 erium-exchange analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD

295 ned from engineered proteins, from which the transmembrane helix was absent.

296 nteraction between TatC helix 5 and the TatB transmembrane helix was confirmed by the formation of a

297 n of the receptor were localized to the last transmembrane helix, whereas those in the histidine kina

298 creases the probability of forming the 3(rd) transmembrane helix, which impairs the pore structure of

299 label rigidly coupled to the backbone of the transmembrane helix, while SERCA was reacted with a Cys-

300 her characterize the interaction site of the transmembrane helix with MraY demonstrating E forms a st