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1 oupled receptors (GPCRs, also known as seven-transmembrane receptors).
2 ai signaling module by a cell surface, seven-transmembrane receptor.
3 NA injection by T5 phage upon binding to its transmembrane receptor.
4 i) signaling module by a cell surface, seven-transmembrane receptor.
5 y similar defects as the knockout of the Dcc transmembrane receptor.
6 l guanosine 5'-triphosphatase (GTPase) and a transmembrane receptor.
7 the neuropeptide sensitivity of the neuronal transmembrane receptor.
8 tein that connects the actin cytoskeleton to transmembrane receptors.
9 connections by anchoring actin filaments to transmembrane receptors.
10 ptor tyrosine kinase, and the Frizzled seven-transmembrane receptors.
11 lowing their recruitment to signal-activated transmembrane receptors.
12 c lipids may modulate ectodomain shedding of transmembrane receptors.
13 nly at the carboxyl tails of GPCRs and other transmembrane receptors.
14 degradation, a pathway usually reserved for transmembrane receptors.
15 mains in extracytoplasmic regions in several transmembrane receptors.
16 mily (LRPs) are complex, multimodular type I transmembrane receptors.
17 function are G proteins controlled by seven transmembrane receptors.
18 receptors (GPCRs) are the largest family of transmembrane receptors.
19 (Galpha), most notably by G protein-coupled transmembrane receptors.
20 g pathways initiated by specific nuclear and transmembrane receptors.
21 stributed in the cytoplasmic domains of many transmembrane receptors.
23 stin1, which regulates many aspects of seven transmembrane receptor (7TMR) biology, has also been sho
25 or (beta 2AR) and other members of the seven-transmembrane receptor (7TMR) superfamily activate G pro
27 ransmitters, and receptors, as well as seven-transmembrane receptor (7TMR)-type putative gustatory re
31 estin-mediated signaling downstream of seven transmembrane receptors (7TMRs) is a relatively new para
34 upled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), both by inhibiting clas
39 ated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR intern
41 e first to reveal, we believe, for any seven-transmembrane receptor, a functional role of ubiquitinat
42 s, and our findings suggest that single pass transmembrane receptors act as GPCRs in plants, challeng
43 , for spatiotemporal control over endogenous transmembrane receptor activation, enabled through the o
44 talin are key steps to initiate the integrin transmembrane receptors' activation, which mediates many
45 med "energy taxis." In Escherichia coli, the transmembrane receptor Aer is the primary energy sensor
46 olic proteins that form complexes with seven-transmembrane receptors after agonist stimulation and ph
49 that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP).
50 ing cellular cytoprotective functions by a 7-transmembrane receptor and define the biochemical pathwa
51 bilical cord vascular endothelial cells as a transmembrane receptor and may recognize certain bacteri
53 otein expression and activation of NOTCH2, a transmembrane receptor and transcriptional regulator kno
54 structural and signaling scaffold that binds transmembrane receptors and a wide variety of intracellu
55 nctions through binding to ligand-stimulated transmembrane receptors and activating their kinase doma
56 located within the cytoplasmic tails of many transmembrane receptors and associated adaptor proteins
57 mains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins
63 s when extracellular signals are detected by transmembrane receptors and relayed to flagellar motors,
64 Rs) represent one of the largest families of transmembrane receptors and the most common drug target.
65 manner that required selective activation of transmembrane receptors and was distinct from VEGF-A-ind
66 ure accurate trafficking and distribution of transmembrane receptors and/or proteins and their ligand
67 terial MutS), ion transport (cystic fibrosis transmembrane receptor), and mRNA trafficking (yeast Elf
69 e last 20 years support the notion that some transmembrane receptors are activated not only by their
73 oupled receptors (GPCRs, also known as seven-transmembrane receptors) are typically found at the cell
74 TLRs), widely expressed and highly conserved transmembrane receptors, are at the intersection of diet
78 ance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C5a and C5adesArg, remain
80 ntrast to knownGPCRs, however, Arr4 is not a transmembrane receptor,but rather a soluble intracellula
82 esicles maintain the structural integrity of transmembrane receptors by keeping them in their physiol
83 ation of heterodimeric (alpha/beta) integrin transmembrane receptors by the 270 kDa cytoskeletal prot
84 echanism by which an anti-inflammatory seven-transmembrane receptor can negatively regulate JAK/STAT
85 e recent discoveries reveal the existence of transmembrane receptors capable of responding to steroid
86 rotein is necessary for transit of selective transmembrane receptor cargo by the COPII coat for anter
88 l. published in Nature demonstrates that the transmembrane receptor CD38 plays a critical role in reg
89 d for several genes, including those for the transmembrane receptor CD44 (CD44 [rs507230]; P = 3.98 x
90 ar carbohydrate-binding domain of the Type I transmembrane receptor CD44 is known to undergo affinity
91 nce suggests that interactions involving the transmembrane receptor CD44 may play an important role i
93 way as a result of defective cystic fibrosis transmembrane receptor (CFTR) expression and function.
94 d for inferring the functional properties of transmembrane receptor clusters from their structure.
95 ndothelial growth factor receptor, Flt1 is a transmembrane receptor co-expressed with an alternate tr
99 and detect their concentration via the AgrC transmembrane receptor, coordinating local bacterial pop
100 biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis-ret
106 norhabditis elegans through the leucine-rich transmembrane receptor DMA-1/LRR-TM expressed on PVD neu
107 peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular casc
112 eptors (MORs) are members of the large seven-transmembrane receptor family which transduce the effect
113 nergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been sho
117 ved signaling node comprising a prototypical transmembrane receptor for c-di-GMP, LapD, and a cognate
120 ranslocation disrupts ROBO2, which encodes a transmembrane receptor for SLIT ligand, and produces dom
122 or-like tyrosine kinase (RYK) functions as a transmembrane receptor for the Wnt family of secreted pr
123 The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth factor-be
126 Mammalian plexins constitute a family of transmembrane receptors for semaphorins and represent cr
131 results provide atomic insight into a type I transmembrane receptor heterocomplex and the mechanism o
132 ggest entry into neuronal stem cells through transmembrane receptors, hijacking cellular signaling to
133 s to reveal the arrangement of the component transmembrane receptors, histidine kinases (CheA) and Ch
134 The repeating ternary units are composed of transmembrane receptors, histidine-kinase CheA, and coup
135 Classic IL-6 signaling is conditioned by the transmembrane receptor (IL-6R) and homodimerization of g
136 ycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of disease
138 ch encodes an emerging positive regulator of transmembrane receptors in plants, suppressed the effect
139 show that somatodendritic sorting of various transmembrane receptors in rat hippocampal neurons is me
140 eriments, we investigated the roles of three transmembrane receptors in regulating dorsolateral pathf
141 Members of the plexin family are unique transmembrane receptors in that they interact directly w
142 t spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and in
144 le photocontrol of the clustering of diverse transmembrane receptors including fibroblast growth fact
145 onse to the triggering of a diverse array of transmembrane receptors, including antigen receptors.
146 l lamina is linked to the sarcolemma through transmembrane receptors, including integrins and dystrog
150 ase (ILK) plays a pivotal role in connecting transmembrane receptor integrin to the actin cytoskeleto
153 which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptiv
155 c embryogenesis receptor kinases (SERKs) are transmembrane receptors involved in plant immunity.
157 ession requires the RNase activity of the ER transmembrane receptor IRE-1, we developed a potent IRE-
159 In nonneuronal cells, CME of the majority of transmembrane receptors is either directly or indirectly
162 n AvrPto does so by directly targeting plant transmembrane receptor kinases involved in bacterial per
163 erceived by a protein complex containing two transmembrane receptor kinases, BRASSINOSTEROID INSENSIT
166 plasmic levels of cyclic-di-GMP activate the transmembrane receptor LapD that in turn recruits the pe
172 Mutations in the gene encoding the single transmembrane receptor multiple epidermal growth factor-
173 to heightened inflammatory responses from CF transmembrane receptor mutant cells and highlight autoph
179 microvessels to show that activation of the transmembrane receptor NOTCH1 directly regulates vascula
181 Deleted in colorectal cancer (DCC), a large transmembrane receptor of netrin-1, is critical for medi
184 The vibrio autoinducer molecules bind to transmembrane receptors of the two-component histidine s
187 (mRNA) expression of Indian Hh, a ligand of transmembrane receptor patched 1, was 184x higher in BE
188 d in a non-redundant fashion with the Draper transmembrane receptor pathway: loss of either pathway f
191 , renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligan
192 orin 3E (Sema3E), acts through a single-pass transmembrane receptor, plexin D1, to provide a repulsiv
195 learning rate, of the collagen formation and transmembrane receptor protein tyrosine kinase activity
196 proliferation, regulation of transcription, transmembrane receptor protein tyrosine kinase signaling
197 positional cloning and report it to encode a transmembrane receptor protein with two hypervariable ex
200 erial chemotaxis signaling cluster, in which transmembrane receptors regulate CheA autokinase activit
201 homodimerization and heterodimerization of 7-transmembrane receptors regulate processes including spe
202 RIIa) has been identified as an ITAM-bearing transmembrane receptor responsible for mediating "outsid
206 ted neurorepellent Slit2, acting through its transmembrane receptor, Roundabout (Robo)-1, inhibits ch
207 discovery over 20 years ago, eukaryotic-like transmembrane receptor Ser/Thr protein kinases (STPKs) h
208 ondins (TSP or THBS) and the Notch family of transmembrane receptors share a role in multiple, overla
209 Members of the Frizzled family of sevenpass transmembrane receptors signal via the canonical Wnt pat
212 overed for their role in desensitizing seven-transmembrane receptor signaling via the heterotrimeric
213 how membrane nanoscale organization controls transmembrane receptors signaling activity remains a cha
214 ted that these glycoproteins would influence transmembrane receptor spatial organization and function
219 pattern recognition receptors-which include transmembrane receptors such as toll-like receptors (TLR
220 " Their receptors are part of a larger seven-transmembrane receptor superfamily, commonly referred to
221 nd colleagues have identified a novel 17-kDa transmembrane receptor, termed Plg-R(KT), that binds pla
222 are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR
224 ycation end products (RAGE) is a multiligand transmembrane receptor that can undergo proteolysis at t
230 (Spz) into the activating ligand for Toll, a transmembrane receptor that is distributed throughout th
232 ate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial c
234 ial cells, guanylyl cyclase 2C (GUCY2C) is a transmembrane receptor that makes cGMP in response to th
236 AIL-R1; also known as death receptor 4) is a transmembrane receptor that mediates TRAIL-induced apopt
237 ked peptidoglycan, suggesting that PrkC is a transmembrane receptor that monitors the integrity of th
240 eceptor 5 (DR5) is a death domain-containing transmembrane receptor that triggers apoptosis upon bind
241 eptor (LIMR)-type proteins are putative nine-transmembrane receptors that are evolutionarily conserve
250 TPsigma) and its subfamily member LAR act as transmembrane receptors that mediate growth inhibition o
252 Integrins are bidirectional, allosteric transmembrane receptors that play a central role in hemo
256 ryotic organisms, where it is often found in transmembrane receptors that regulate two-component sign
257 ycle and signal transduction properties of 7-transmembrane receptors that serve to integrate many bio
258 dulators is controlled by endocytosis of the transmembrane receptors that transduce their effects.
259 are made possible by integrins, a family of transmembrane receptors that, upon binding to the extrac
260 otective signaling stimulated by a typical 7-transmembrane receptor the angiotensin ATII 1A receptor,
261 (interactome) as modulated by a model seven-transmembrane receptor, the angiotensin II type 1a recep
262 l lattice formed from three core proteins: a transmembrane receptor, the His kinase CheA, and the ada
263 in is one of the most mechanistically direct transmembrane receptors-the intracellular domain contain
264 aling proteins, cytoskeletal components, and transmembrane receptors, thereby serving as a scaffold t
265 The primary initiator of coagulation, the transmembrane receptor tissue factor (TF), has gained co
267 nteractions that promoted the endocytosis of transmembrane receptors, TLR4 was selected as cargo for
270 is a highly conserved kinase cascade linking transmembrane receptors to downstream effector mechanism
271 s relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules
272 s of studies, namely the propensity of seven transmembrane receptors to form dimers and thus demonstr
273 chestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular
278 wth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been p
285 Epidermal growth factor receptor (EGFR) is a transmembrane receptor-tyrosine kinase that is associate
286 protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting in recepto
289 RDC3 and ARRDC4 upon activation of the seven transmembrane receptors vasopressin 2 and beta adrenergi
290 pression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells dur
291 kinase activation and migration evoked by 7-transmembrane receptors were greater than wild type in b
293 eceptor (TLR) gene family consists of type 1 transmembrane receptors, which play essential roles in b
295 gene encodes an approximately 50 kDa type I transmembrane receptor with an ectodomain containing thr
297 The Kdrb locus encodes a 1361-amino acid transmembrane receptor with strong homology to mammalian
298 f chemokine receptors CXCR4 and CXCR7, two 7-transmembrane receptors with central functions in normal
299 human cytomegalovirus (HCMV)-encoded type I transmembrane receptors with Fcgamma-binding properties
300 herefore hypothesized that preorganizing the transmembrane receptors would potentiate local TGF-beta
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