ライフサイエンスコーパス: transmembrane segment

1 at are permissive for cleavage of one type 2 transmembrane segment.

2 ion 202, located in the upper side of the S4 transmembrane segment.

3 ut a central residue in the carboxy-terminal transmembrane segment.

4 quence was uncleaved, creating an N-terminal transmembrane segment.

5 n span the OM despite the lack of an obvious transmembrane segment.

6 ng segments and the N-terminal end of the M4 transmembrane segment.

7 ialidases) has a single predicted N-terminal transmembrane segment.

8 Stp1 cleaves Sre1 within its predicted first transmembrane segment.

9 teine would be predicted to be in the fourth transmembrane segment.

10 a histidine in the A' helix following the S6 transmembrane segment.

11 ution is not required for studying the beta3 transmembrane segment.

12 nsing and signaling are captured in a single transmembrane segment.

13 n both the absence and presence of the PDGFR transmembrane segment.

14 n with a chloroplast transit peptide and one transmembrane segment.

15 mprising two turns of helix along the fourth transmembrane segment.

16 4A/R5A in the N terminus and F656I in the S6 transmembrane segment.

17 ic subdomains but has not yet been shown for transmembrane segments.

18 d negatively charged residues in neighboring transmembrane segments.

19 coding a membrane protein with four putative transmembrane segments.

20 e extracellular loops and outer parts of the transmembrane segments.

21 karyotic GluR subunits (e.g. GluR0) have two transmembrane segments.

22 trands, rigid connectors to their respective transmembrane segments.

23 ted (125)I, and 17 kDa, containing the M1-M3 transmembrane segments.

24 acetylcholine and GABA(A) receptor M3 and M4 transmembrane segments.

25 otein of 190 amino acids that contains three transmembrane segments.

26 tical importance to identify the location of transmembrane segments.

27 ligand binding domain in the presence of the transmembrane segments.

28 insically unstructured segments are close to transmembrane segments.

29 olesterol may be limited to insertion of the transmembrane segments.

30 second and His-244 and Asp-248 in the fifth transmembrane segments.

31 does not form pores, even though it contains transmembrane segments.

32 the cytoplasmic edge of the second and third transmembrane segments.

33 istidine, and an arginine are located in the transmembrane segments.

34 NBCe1-A transmembrane segment 1 (TM1) is involved in forming par

35 In this study the structural requirement of transmembrane segment 1 (TM1) residues in mediating NBCe

36 an unexpected role for the highly conserved transmembrane segment 1 residue Asn-101 in coupling Cl(-

37 His51Ala (in putative transmembrane segment 1, TM1) was the only mutation that

38 ss-linker in the matrix exposed loop between transmembrane segments 1 and 2 (loop 1) cross-linked to

39 formed primarily by the cytoplasmic ends of transmembrane segments 1, 2, 6 and 7 as well as intracel

40 and cocaine analogs is deeply buried between transmembrane segments 1, 3, 6 and 8, and overlaps with

41 ted mutagenesis at highly conserved sites of transmembrane segments 1, 3, 8, 9, and 10, which have be

42 cluster at two interfacial regions flanking transmembrane segments 1-4 and lie outside of the canoni

43 A domain (consisting of transmembrane segments 1-4) that moves during activation

44 id residue at or near a conserved glycine in transmembrane segment 10.

45 mbrane domains and a helical hairpin between transmembrane segment 2 (TM2) and TM3 on the cytoplasmic

46 erentially induces conformational changes in transmembrane segment 2 and extracellular loop 1 (EL1),

47 An asparagine residue (Asn-106) in transmembrane segment 2 of AHA2 is conserved in all P-ty

48 ed a number of positions in the loop between transmembrane segments 2 (M2) and 3 (M3) of a proton-gat

49 s study, we mutated multiple residues within transmembrane segments 2 and 7 of NCX1.1 (cardiac isofor

50 ion shows that the conserved residues within transmembrane segments 2 and 7, coordinating Na(+) and C

51 , located at the predicted interface between transmembrane segment 3 (TMS3) and extracellular loop 2

52 Cldn3/Cldn5 residues in transmembrane segment 3, TM3 (Ala-127/Cys-128, Ser-136/C

53 Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1

54 e highly conserved first arginine residue in transmembrane segment 4 (domain 1), the voltage sensor,

55 cytoplasmic domain of FlhA, located between transmembrane segments 4 and 5.

56 o the L1 loop and the periplasmic portion of transmembrane segments 4-6.

57 bule closed and the intracellular portion of transmembrane segment 5 (TM5i) in either an unwound or a

58 on network leading to a discrete rotation of transmembrane segment 5 and the adjacent intracellular l

59 We have previously identified Ser293 in transmembrane segment 5 as a determinant for selective K

60 sed water exposure of the cytoplasmic end of transmembrane segment 5.

61 results show that conformational changes in transmembrane segments 5 and 6 (TM5 and TM6), which are

62 through a four-helix bundle motif formed by transmembrane segments 5 and 6.

63 ated in the large intracellular loop between transmembrane segments 5 and 6.

64 ansmembrane segment 6, and rearrangements of transmembrane segments 5 and 7 that are remarkably simil

65 metry around a central ion pathway formed by transmembrane segments 5-6 (S5-S6) and the intervening p

66 ive exons 8a and 8 encode alternate forms of transmembrane segment 6 (IS6) in channel domain 1.

67 A outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an alpha-helical exten

68 erved residues, including two histidines, of transmembrane segment 6 (TMS-6).

69 A outward movement of the cytoplasmic end of transmembrane segment 6, and rearrangements of transmemb

70 The role of transmembrane segment 6, predicted to be an outer helix

71 BK channels, members of the six-transmembrane-segment (6TM) ion channel family, were rec

72 ituting each successive residue in predicted transmembrane segment 9 with a cysteine residue.

73 RibU contains six transmembrane segments, adopts a previously unreported t

74 with two bound phospholipids located between transmembrane segments alphaTM8-10 and TMFXYD (site A) a

75 companion article, we showed that the single transmembrane segment ancillary (beta) subunits KCNE1 an

76 -harvesting complex-binding motif within the transmembrane segment and a large surface-exposed head d

77 SpoIIIAH consists of a transmembrane segment and an extracellular domain with s

78 olytic fragments of 8 kDa, containing the M4 transmembrane segment and approximately 60% of incorpora

79 surrounding the extracellular end of the M2 transmembrane segment and around the loop connecting the

80 first domain present downstream of the sixth transmembrane segment and connects the CNBD to the trans

81 rane domain, which include bending of the S6 transmembrane segment and consequent pore dilation, disp

82 ructure determinations of the beta3 integrin transmembrane segment and flanking sequences were carrie

83 in a hydrophobic pocket at the end of the S6 transmembrane segment and is involved in inter-subunit i

84 omains via concerted movements of the second transmembrane segment and major coupling helix.

85 ng domain (VSD) of Kv1.3 through W172 in the transmembrane segment and modifies the gating operation.

86 latelet-directed growth factor receptor beta transmembrane segment and the bilayer thickness.

87 e location of substrate-binding sites in the transmembrane segment and the translocation pathway acro

88 ontain a transmembrane domain (TMD) with six transmembrane segments and a nucleotide-binding domain (

89 llular space and are initially linked by two transmembrane segments and a single cytoplasmic domain.

90 ated near the intracellular end of S5 and S6 transmembrane segments and activates hERG1 channels by a

91 rough a control cable connection between the transmembrane segments and AS1 helices.

92 scriminating transmembrane segments from non-transmembrane segments and for discriminating intrinsica

93 They share four predicted core transmembrane segments and possess similar yet distinct

94 vised topology confirms the presence of four transmembrane segments and reveals a newly identified pe

95 s truncation mutant comprising the last five transmembrane segments and the intracellular C-terminus

96 itioned at three-residue intervals in the S4 transmembrane segment, and this movement is coupled to o

97 ity method was used to show that Acr3 has 10 transmembrane segments, and the conserved cysteine would

98 The movement of the M1M2 transmembrane segments, and the displacement of residues

99 arged voltage-sensing residues in the fourth transmembrane segment are energetically stabilized, beca

100 ted domain and the hydrophobicity within the transmembrane segment are important determinants of the

101 translation terminates before emergence of a transmembrane segment are translated in the stroma and t

102 These transmembrane segments are driven outward by the force o

103 inker of Eag1 is a five-residue loop and the transmembrane segments are not domain swapped, which sug

104 ptor residue Tyr(145), adjacent to the first transmembrane segment, as the site of labeling by the po

105 receptor function through interactions with transmembrane segments, as well as through peripheral in

106 g causes changes in the relative position of transmembrane segments both within a single subunit and

107 ion of sdp of a truncated KinD retaining the transmembrane segments but lacking the kinase domain.

108 outward movement of gating charges in the S4 transmembrane segments catalyzed by sequential formation

109 difficult-to-overexpress members of the six-transmembrane segment channel family.

110 tures characteristic of porins, including 12 transmembrane segments comprised of amphipathic and anti

111 While the beta3 transmembrane segment consists of a linear 29-residue al

112 second and His-153 and Asp-157 in the fifth transmembrane segments coordinate zinc and are required

113 ied by azobenzene-containing reagents at the transmembrane segments could be reversibly turned on and

114 cause insertion of an artificial polyleucine transmembrane segment does not rescue surface expression

115 ar dynamics simulations of different nascent transmembrane segments embedded in a ribosome-bound bact

116 Here, using model transmembrane segments engineered into m-AAA protease-de

117 Members of the six-transmembrane segment family of ion channels share a com

118 Each Hrd1 molecule has eight transmembrane segments, five of which form an aqueous ca

119 pectroscopic measurements indicate its first transmembrane segment folds into an alpha-helix, in agre

120 alf contains a transmembrane domain with six transmembrane segments followed by a nucleotide-binding

121 pneumophila Cu(+)-ATPase shows that a kinked transmembrane segment forms a "platform" exposed to the

122 rs can, and have to, dissociate to leave the transmembrane segments free to deploy and lead to pore f

123 is domain-swapped with the first and second transmembrane segments from an adjacent subunit.

124 r cavity, which is formed jointly by four S6 transmembrane segments from domains D1 to D4.

125 he most useful properties for discriminating transmembrane segments from non-transmembrane segments a

126 sis to construct classifiers to discriminate transmembrane segments from non-transmembrane segments u

127 f detergents surrounding LeuT protecting its transmembrane segments from unfavorable hydrophobic/hydr

128 sults indicate that amino acids from several transmembrane segments functionally cooperate to form a

129 These results indicate that the first transmembrane segment generally comprises the signal tha

130 vation to channel gating, the pore-lining S6 transmembrane segment has not been systematically studie

131 dues in the Orai1 intracellular loop linking transmembrane segment II to III.

132 y disease proteins and it precedes the first transmembrane segment in both families.

133 We determined the structure of the transmembrane segment in dodecylphosphocholine micelles

134 Deletion of a transmembrane segment in the beta-subunit results in mis

135 hed ribosomes occurs shortly after the first transmembrane segment in the nascent peptide has emerged

136 , which is consistent with the presence of a transmembrane segment in their C-terminal regions.

137 utward movement of the positively charged S4 transmembrane segment in their voltage sensors.

138 The results further define the borders of transmembrane segments in subunit a.

139 llular unstructured region linking the S5-S6 transmembrane segments in the DII domain of the human Na

140 of conserved acidic side chains on the S1-S3 transmembrane segments in the hydrated interior of the V

141 hreshold hydrophobicity for the retention of transmembrane segments in the inner membrane is differen

142 annel (VGIC) superfamily members contain six-transmembrane segments in which the first four form a vo

143 nents, especially the loops that connect the transmembrane segments, in the assembly and function of

144 of an SRP-RNC complex exposing a hydrophobic transmembrane segment induces a rearrangement of the Sec

145 hly conserved asparagine (N220) in the first transmembrane segment is a key enforcer of glycerophosph

146 The lipid/aqueous interface of the last transmembrane segment is at Asp(960).

147 n that connects ankyrin repeats to the first transmembrane segment is crucial for temperature sensing

148 l/functional significance of this additional transmembrane segment is poorly defined.

149 asmic domain or if the hydrophobicity of the transmembrane segment is reduced by substituting polar r

150 uble domain and that the interaction between transmembrane segments is highly dynamic.

151 aptation, and its quantification at specific transmembrane segments is shown to predict favorable con

152 FtsW (this protein consists of 10 predicted transmembrane segments) is required for the transport ac

153 This motif, lying close to the S1 transmembrane segment, is situated near the T1 tetrameri

154 blasts showed that although MG53 contains no transmembrane segment it is tightly associated with intr

155 008 possible ectodomains and two alternative transmembrane segments, it may carry endodomains contain

156 examined the role of amino acid residues of transmembrane segment IV (TM IV) ((126)FPQINFLGSLLIAGCIT

157 sensor histidine kinase BovK contains eight transmembrane segments lacking any extensive surface-exp

158 X appeared collapsed against the hydrophobic transmembrane segments, leading to an aberrant topology

159 lipid head group in a groove outlined by the transmembrane segments M1, M2, M4, and M6, with the hydr

160 robed the conformation of pore-lining second transmembrane segment (M2) under conditions that favor t

161 ear the intracellular end of the pore-lining transmembrane segments (M2) that are also required to ac

162 lar domain (ICD) present in metazoa (between transmembrane segments M3 and M4).

163 ted the importance of amino acid residues in transmembrane segment M4 of mammalian P4-ATPase ATP8A2 b

164 ontrast, eukaryotic GluRs have an additional transmembrane segment (M4), located C-terminal to the io

165 Hence, Lys(873), located in transmembrane segment M5 at a "hot spot" for cation bind

166 is located in the intracellular loop between transmembrane segments M8 and M9.

167 idues in cytoplasmic loops connecting distal transmembrane segments mediate calcium stimulation.

168 gy analysis revealed that FtsX has only four transmembrane segments, none of which contains a charged

169 f the cytoplasmic domain, which leads to the transmembrane segment not present in the crystal structu

170 ane proteolysis (RIP) involves cleavage of a transmembrane segment of a protein, releasing the active

171 ane proteolysis (RIP) involves cleavage of a transmembrane segment of a protein.

172 of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel for

173 ted at a conserved distance before the first transmembrane segment of both Sre1 and Sre2 and cleavage

174 of p85, between the GPS domain and the first transmembrane segment of CIRL.

175 light the importance of both calcium and the transmembrane segment of L-selectin in the interaction b

176 within the sequence from the second to third transmembrane segment of Orai3.

177 hand, when E5 was co-reconstituted with the transmembrane segment of PDGFR, it was able to tolerate

178 is incompatibility is localized to the first transmembrane segment of SSP (TM1).

179 in the N terminus and the other in the first transmembrane segment of the beta1 and beta4 subunits.

180 allization of a peptide corresponding to the transmembrane segment of the influenza M2 protein.

181 erved active-site Lys residue in the seventh transmembrane segment of the protein.

182 ophobic amino acid residues within the first transmembrane segment of the S units for S unit/T unit i

183 e, Golgi-localized protease that cleaves the transmembrane segment of the TatA rhomboid model substra

184 es showed that the mutation H22A, within the transmembrane segment of TolA, abolishes immunity protei

185 dentified a point mutation (N855S) in the S4 transmembrane segment of TRPA1, a key sensor for environ

186 Finally, we identified mutations in the transmembrane segment of YneA that abolish the ability o

187 serine binding site has been located between transmembrane segments of alphaTM8-10 and the FXYD prote

188 o(707) (HM-loop) that connects the first two transmembrane segments of ATP7A is important for copper

189 The transmembrane segments of CD81 pack as two largely separ

190 ross the plasma membrane via the single-pass transmembrane segments of each alpha and beta subunit.

191 All 12 of the predicted transmembrane segments of Glut1 encompassing 252 amino a

192 tify residues in the extracellular loops and transmembrane segments of hERG1 that might interact with

193 er ERAD components, requires the presence of transmembrane segments of Hrd1p, and depends on both the

194 conserved hydrophobic amino acids in the S3b transmembrane segments of Kv4.3 and the closely related

195 monstrates that YidC interacts with multiple transmembrane segments of LacY during membrane biogenesi

196 After threading into the SecYEG translocon, transmembrane segments of nascent proteins are thought t

197 tracellular" facing regions of the S2 and S3 transmembrane segments of Nav1.3 and Nav1.7 seem to be m

198 nd that increasing the hydrophobicity of the transmembrane segments of PClep can decrease the translo

199 cellular loops between the sixth and seventh transmembrane segments of PKD1 and PKD1L3, respectively.

200 The transmembrane segments of RHD3 are essential for targeti

201 nker) between the third (S3) and fourth (S4) transmembrane segments of the VSD alters the equilibrium

202 ind that the extracellular ends of the first transmembrane segments of the VSDs form the intersubunit

203 cation mutant of CFTR missing the first four transmembrane segments of TMD1, Delta264 CFTR, binds to

204 acellular loops between the first and second transmembrane segments of TRPP2 and TRPP3 associate with

205 conserved positively charged residue within transmembrane segment one (at position 72) is located in

206 g identified receptor residue Leu(141) above transmembrane segment one as its site of labeling for th

207 eaving membrane-associated proteins within a transmembrane segment or at a site near the membrane sur

208 se processes by cleaving substrates within a transmembrane segment or near the membrane surface.

209 either via an annular layer surrounding the transmembrane segments or by specific lipid-protein inte

210 demonstrates that HiGlpG, with a simple six-transmembrane-segment organization, is more robust than

211 els are membrane proteins that consist of 24 transmembrane segments organized into four homologous do

212 iar in that more gating charge is carried by transmembrane segments other than S4.

213 egion encoding the FtsK motor domain and one transmembrane segment partially alleviates the segregati

214 maritima CorA shows a homopentamer with two transmembrane segments per monomer connected by a short

215 an extended allosteric interface between the transmembrane segments performing the large scale confor

216 s unstable insertion of the eighth and final transmembrane segment, preventing proper position of the

217 c-epitopes we show that forces acting on the transmembrane segment produce loose clusters, while cyto

218 Fusion of a FLAG-tagged one-transmembrane segment protein Tac to the SERT N terminus

219 exposing 'masked' conformational dynamics of transmembrane segments rather than sequence-specific bin

220 first example of a naturally occurring seven-transmembrane segment receptor that is both obligately u

221 ylatoxin functions by interacting with two 7-transmembrane segment receptors, the C5aR and C5L2.

222 We report that the N terminus plus the first transmembrane segment (residues 1-153) is sufficient to

223 iments that establish that SppA has only one transmembrane segment (residues 29-45) with the C-termin

224 ract predominantly with sites located in the transmembrane segments, resulting in nativelike complexe

225 e alpha-helix, the structure of the alphaIIb transmembrane segment reveals a linear 24-residue alpha-

226 channels, we identify a region encompassing transmembrane segments S1, S2, and S3 in the second homo

227 gatively charged residues distributed in the transmembrane segments S1, S2, and S3 that bind to and f

228 ed mutations have been reported in the first transmembrane segment (S1) of Kv11.1 channels, but the r

229 nserved protein modules that consist of four transmembrane segments (S1-S4) and confer voltage sensit

230 tage-gated potassium channel subunit has six transmembrane segments (S1-S6) to form the voltage-sensi

231 VSDs consist of four transmembrane segments, S1-S4, forming an antiparallel h

232 We chose the second transmembrane segment, S2, of a voltage-gated potassium

233 In long-QT syndrome, transmembrane segments S3-S5+S6 and the DIII/DIV linker

234 at includes the C-terminal part of the third transmembrane segment (S3b) and the N-terminal part of t

235 re positively charged residues in the fourth transmembrane segment (S4) sense the potential.

236 d by the linkers between the fifth and sixth transmembrane segments (S5-S6).

237 9, which codes for the linker connecting the transmembrane segment S6 and the cytosolic RCK1 domain--

238 to the highly conserved homologous S3 and S4 transmembrane segments, suggesting a shared mechanism of

239 udy: intrinsically unstructured segments and transmembrane segments tend to have opposite properties;

240 ind that a protein with a highly hydrophobic transmembrane segment that inserts into the membrane by

241 om biochemical analysis reveals three common transmembrane segments that are similarly arranged aroun

242 oltage-sensor domains (VSDs) are specialized transmembrane segments that confer voltage sensitivity t

243 lar elements involved in GABA binding to the transmembrane segments that control the opening of the i

244 rokaryotic iGluR subunits have an additional transmembrane segment, the M4 segment, which positions t

245 ructures, however, are in the absence of the transmembrane segments, the primary functional component

246 closed state by acting as wedges between the transmembrane segments, thereby preventing gating rearra

247 obust than PsAarA, which has seven predicted transmembrane segments, thus rendering HiGlpG amenable t

248 s bridge, between residues E(90) [located in transmembrane segment (TM) 2] and K(121) (TM3), is assoc

249 f CCK1R exon 3, extending from the bottom of transmembrane segment (TM) 3 to the top of TM5, includin

250 agent, we tested the effects of mutations at transmembrane segment (TM) 6 and 12 helices in HEK293 ce

251 Site I is constituted by two Cys in transmembrane segment (TM) 6 and a Tyr in TM7.

252 ach located at the centre of a distinct four transmembrane segment (TM) bundle.

253 idues located at the C terminus of the first transmembrane segment (TM-1) are important structural co

254 P(1B)-type ATPases have six or eight transmembrane segments (TM) with metal coordinating amin

255 inge, the conserved Gly-98 site in the first transmembrane segment (TM1) of Orai1.

256 hydrophobicity of key residues in the first transmembrane segment (TM1).

257 utations at two conserved sites in the first transmembrane segment (TM1): arginine 91 located near th

258 on of the extracellular ligand binding loop, transmembrane segments (TM1 and TM2), and intracellular

259 The enzyme contains ten transmembrane segments (TM1-10).

260 units in the membrane domain and bears three transmembrane segments (TM1-3).

261 SERCA2a and SERCA1a, SERCA2b houses an 11th transmembrane segment (TM11) and a short luminal extensi

262 he central glycine in the pore-lining second transmembrane segment (TM2) to proline in Kir6.2 causes

263 n to the symmetrical interface in the fourth transmembrane segment (TM4) we identified previously by

264 The sixth transmembrane segment (TM6) of the CFTR chloride channel

265 ins that occurred soon after a nascent chain transmembrane segment (TMS) entered the ribosomal tunnel

266 posure is switched after a newly synthesized transmembrane segment (TMS) enters the ribosomal tunnel.

267 Solute carrier 11 (Slc11) family, such as 12-transmembrane segment (TMS) topology (N- and C-termini c

268 NPC1 contains 13 transmembrane segments (TMs) and three distinct lumenal

269 g cassette (ABC) proteins, is composed of 12 transmembrane segments (TMS) and two large cytoplasmic n

270 gh these studies also identified a number of transmembrane segments (TMs) as pore-lining, the exact l

271 uring polytopic protein biogenesis, multiple transmembrane segments (TMs) must pass through the ribos

272 Whereas the core transmembrane segments (TMs) of SSSs share high structur

273 exchanger (NCX1) is modeled to contain nine transmembrane segments (TMS) with a pair of oppositely o

274 aped transmembrane domain, which contains 19 transmembrane segments (TMs), and a large extracellular

275 in of DsbD (DsbDbeta), which comprises eight transmembrane segments (TMs), contains two redox-active

276 TR) chloride channel have identified several transmembrane segments (TMs), including TM1, 3, 6, 9, an

277 Each protomer comprises six transmembrane segments (TMs), with TM3 and TM4 contribut

278 release-activated Ca(2+) channels, has four transmembrane segments (TMs).

279 transmembrane region of NBCe1-A contains 14 transmembrane segments (TMs).

280 ed within a major substrate binding site, in transmembrane segments TMS1, TMS3, TMS6 and TMS8.

281 e translocon, where nonpolar nascent protein transmembrane segments (TMSs) are widely believed to par

282 tagenesis of the primary sequences of the 12 transmembrane segments (TMSs) found in the TMDs.

283 The topological model is comprised of nine transmembrane segments (TMSs).

284 By attaching an extra transmembrane segment to the N terminus of SpoIVFB, expr

285 is composed of claudins that consist of four transmembrane segments, two extracellular segments (ECS1

286 change toward the ligand-binding domain and transmembrane segments, ultimately inhibiting the channe

287 discriminate transmembrane segments from non-transmembrane segments using four classification techniq

288 other proteins indicated that the N-terminal transmembrane segment was responsible for EFC interactio

289 48 in the first (Glu-25) or fourth (Asn-127) transmembrane segments were required.

290 med with the full-length protein or with the transmembrane segments were used along with in vivo homo

291 e of DsbB, one located between the two first transmembrane segments where the quinone ring binds and

292 by interactions between the second and third transmembrane segments, which affect the ion channel lum

293 Each subunit is composed of two transmembrane segments, which are linked by a large extr

294 or, but simply surrounding the chemoreceptor transmembrane segment with a lipid bilayer was not suffi

295 x switch involving interaction of its second transmembrane segment with one or more cytochromes under

296 s a quinone, connected through an additional transmembrane segment with the periplasmic thioredoxin-l

297 ed that the C terminus of NBCe1-A contains 5 transmembrane segments with greater average size compare

298 s numerous mutations are tolerated in the E5 transmembrane segment, with the exception of one hydroge

299 nteract via association of the C-terminal or transmembrane segments, with consequences for the assemb

300 The intracellular aspect of the sixth transmembrane segment within the ion-permeating pore is

301 no group of G444, capping the alpha-helix of transmembrane segment XII and thus stabilizing the struc