ライフサイエンスコーパス: transmethylation

1 betaine is as an osmolyte and methyl donor (transmethylation).

2 nly metahydroxyl groups to be positioned for transmethylation.

3 roach to achieve transalkylation rather than transmethylation.

4 ilic substitution (SN2) transition state for transmethylation.

5 he intermediates of phosphatidylethanolamine transmethylation.

6 t this mutation affects the chemical step of transmethylation.

7 Despite the presence of motifs essential for transmethylation activity, catalytic activity of DNMT2 h

8 Transmethylation affects several cellular events, includ

9 their common S-adenosylmethionine-dependent transmethylation and has implications for human MTHFD1-a

10 e N-methyltransferase regulates flux through transmethylation and hence the S-adenosylmethionine/S-ad

11 We aimed to measure methionine flux, its transmethylation and its transsulfuration, and homocyste

12 We find that both transmethylation and propylamine transfer fluxes amount

13 centrations of metabolites in the methionine transmethylation and transsulfuration pathways in childr

14 thylation or methionine transsulfuration and transmethylation between the groups at clinical phase 1.

15 o catalyze S-adenosyl-L-methionine-dependent transmethylation by UPM1 in a multistep process involvin

16 It suffers two major metabolic fates: transmethylation catalyzed by methionine synthase or bet

17 Some of the transmethylation changes are inherited and some affect g

18 analyzing the transcripts and activities of transmethylation enzymes in the livers of the same micro

19 raised about labile methyl balance and total transmethylation fluxes, and further discussion has been

20 onstrating the necessity of pcMTase-mediated transmethylation for steroid induced Na(+) reabsorption.

21 MtvA catalyzes transmethylation from MtvC to tetrahydrofolate, forming

22 r, despite considerable effort in the 1980s, transmethylation has never been established as a compone

23 neutrophils and strongly suggest a role for transmethylation in chemotaxis of eukaryotic cells.

24 hionine and its rate of transsulfuration and transmethylation in healthy women with advancing gestati

25 definitive measurements of the rate of total transmethylation in humans of both sexes on various diet

26 pathways for S-adenosylmethionine-dependent transmethylation in mammals are the syntheses of creatin

27 nd assuming insignificant transamination and transmethylation in this tissue.

28 Here, we demonstrate that transmethylation inhibition by a novel reversible S-aden

29 Treatment with the transmethylation inhibitor averted, and even ameliorated

30 indicate that S-adenosylmethionine-dependent transmethylation is inhibited in mthfd1-1.

31 These results suggest that a critical transmethylation is necessary for aldosterone-induction

32 The data suggest that transmethylation is required for CD4 T cell activation,

33 The significant improvements observed in transmethylation metabolites and glutathione redox statu

34 ial diet for 18 weeks and then switched to a transmethylation micronutrient-supplemented (MS) or -res

35 DNA methylation depends on both dietary transmethylation micronutrients and ERK-regulated DNA me

36 zes the S-adenosylmethionine (SAM)-dependent transmethylation of 6-TPs and shares 45% similarity (33%

37 ent O-methyltransferases (OMTs) catalyze the transmethylation of a variety of phenolics in bacteria,

38 e in the methionine cycle that catalyzes the transmethylation of homocysteine to methionine in a coba

39 tion early in gestation and a higher rate of transmethylation of methionine in late gestation.

40 Transmethylation of methionine was significantly higher

41 Homocysteine, which is produced by the transmethylation of methionine, can be either remethylat

42 suring the catalytic properties of enzymatic transmethylation of phenolics.

43 However, the role the transmethylation of phosphatidylethanolamine plays in th

44 hilic nature of S-adenosyl-l-methionine, the transmethylation of the demethylated precursor of vitami

45 wer rates of methionine transsulfuration and transmethylation or homocysteine remethylation.

46 that methionine transamination, and not the transmethylation or transsulfuration pathways, contribut

47 men (P < 0.005) and a tendency toward higher transmethylation (P < 0.10).

48 xogenous adenosine reduces activation of the transmethylation pathway and attenuates the endothelial

49 lux of homocysteine through the MS-dependent transmethylation pathway in HepG2 and 293 cells, respect

50 ine in endothelial cells, and activating the transmethylation pathway through increasing the associat

51 of DNA via biochemical interference with the transmethylation pathway.

52 S-adenosyl-L-homocysteine (AdoHcy/SAH), the transmethylation product of AdoMet-dependent methyltrans

53 nd the protein catalyzed a methyl iodide:CoM transmethylation reaction at a rate of 2.3 micromol/min/

54 It catalyzes a transmethylation reaction in which a methyl group is tra

55 iron-sulfur protein that is involved in the transmethylation reaction.

56 enosylmethionine (AdoMet), a key molecule in transmethylation reactions and polyamine biosynthesis.

57 sylmethionine (AdoMet), a metabolite used in transmethylation reactions and polyamine synthesis.

58 onine and ATP, is the major methyl donor for transmethylation reactions and propylamino donor for the

59 These novel effects on transmethylation reactions may be implicated in the path

60 mpairment because of its requirement for two transmethylation reactions that can both be inhibited by

61 r SAH), a common product of AdoMet-dependent transmethylation reactions, is first hydrolyzed by recom

62 it is needed to metabolize the by-product of transmethylation reactions, S-adenosylhomocysteine (AdoH

63 As a methyl donor for biological transmethylation reactions, S-adenosylmethionine (SAMe)

64 e TGS by nonspecifically inhibiting cellular transmethylation reactions.

65 eptor molecule, is a potent inhibitor of all transmethylation reactions.

66 activities of hepatic enzymes that regulate transmethylation reactions.

67 olyamine metabolism and in the regulation of transmethylation reactions.

68 rs to be established, but several aspects of transmethylation remain uncertain: definitive measuremen

69 Here we provide the first evidence that the transmethylation step of the SDPM pathway occurs in the

70 studies provide the first evidence that the transmethylation step of the SDPM pathway of P. falcipar

71 While distal from the site of transmethylation, the propanoid tail substituent governs

72 PET) and indicated that the contribution of transmethylation to total hind limb methionine utilizati

73 centrations by altering its flux through the transmethylation, transsulfuration, and transamination m

74 acid, would improve plasma concentrations of transmethylation/transsulfuration metabolites and glutat

75 Metabolites in the transmethylation/transsulfuration pathway were measured

76 etabolism is homocysteine, which can undergo transmethylation via methionine synthase (MS) or transsu

77 ing the first trimester, whereas the rate of transmethylation was higher during the third trimester.