ライフサイエンスコーパス: transmigration

1 otypic transformation during cerebrovascular transmigration).

2 bose polymerase in ECs of mice prevented PMN transmigration.

3 tion was required for GM-CSF priming-induced transmigration.

4 ) mice displayed a 40% decrease in leukocyte transmigration.

5 ophages, which leads to decreased neutrophil transmigration.

6 generation, reduction in R(T), and bacterial transmigration.

7 delta decreased IL-1beta-mediated neutrophil transmigration.

8 ascular endothelium and unchecked neutrophil transmigration.

9 confirm a role for CD13 in impaired MO-MDSC transmigration.

10 uent crawling on the endothelium to sites of transmigration.

11 mportant for several steps in the process of transmigration.

12 ong the vascular wall to permissive sites of transmigration.

13 ccelerated as a result of increased cellular transmigration.

14 thelial barriers as well as their subsequent transmigration.

15 VE-cadherin, thereby facilitating efficient transmigration.

16 to support leukocyte rolling, adhesion, and transmigration.

17 expression and were required for lymphocyte transmigration.

18 endothelial adhesion molecules and leukocyte transmigration.

19 th docking structure formation and leukocyte transmigration.

20 dherin expression and promoting T lymphocyte transmigration.

21 endothelial RhoG and SGEF control leukocyte transmigration.

22 with wild-type PMNs and failed to induce PMN transmigration.

23 ation in regulating lymphocyte migration and transmigration.

24 ement of VLDLR in fibrin-dependent leukocyte transmigration.

25 of ICAM-1 in mediating PECAM-1-dependent PMN transmigration.

26 he vascular basement membrane (BM) for their transmigration.

27 dicating their positive role in cryptococcal transmigration.

28 cts of shear flow and cytokines on leukocyte transmigration.

29 icipate in signaling that enables lymphocyte transmigration.

30 plored the effects of substrate stiffness on transmigration.

31 -catenin signaling in response to neutrophil transmigration.

32 NPs does not alter neutrophil activation and transmigration.

33 a detergent-resistant membrane (DRM) during transmigration.

34 d expression patterns of ICAM-1 in leukocyte transmigration.

35 d induction of downstream signals that drive transmigration.

36 lling endothelial permeability and leukocyte transmigration.

37 's role as a negative regulator of leukocyte transmigration.

38 ediated neutrophil crawling and paracellular transmigration.

39 o endothelial cells but inhibited neutrophil transmigration.

40 n was a critical prerequisite for successful transmigration.

41 required for this crucial step in neutrophil transmigration.

42 g of gaps before the initiation of leukocyte transmigration.

43 sses, including cell adhesion, polarity, and transmigration.

44 thelial adhesion, intravascular crawling and transmigration.

45 r bounds of constriction size for successful transmigration.

46 odulators of nuclear deformation during cell transmigration.

47 on the contribution of endothelial cells to transmigration.

48 and myelin-reactive T-cells prevented T-cell transmigration.

49 , but TspanC8s remain unstudied in leukocyte transmigration.

50 adhesion (66.1 vs. 23.7% of input cells) and transmigration (35.1 vs. 7.20% of input cells) than did

51 C/PC bilayers support intermediate levels of transmigration (37.7%).

52 l binding (54.6% vs. 7.1%, respectively) and transmigration (63.7 vs. 8.8%, respectively) despite com

53 his induction is instrumental for neutrophil transmigration across an activated endothelium and for i

54 Finally, ART facilitated PBMC transmigration across an in vitro blood-brain barrier mo

55 eading to CAR phosphorylation and subsequent transmigration across cell junctions.

56 ted paracellular permeability and tumor cell transmigration across EC barriers.

57 gulated MMP-9 and stimulated MMP-9-dependent transmigration across endothelial cell monolayers by 2.6

58 mote myeloid and plasmacytoid dendritic cell transmigration across endothelial cell monolayers throug

59 o disrupted adhesion of myeloid cells to and transmigration across endothelial monolayers in vitro an

60 Neutrophil transmigration across HEVs is faster than across convent

61 l peptide cryptdin-4 but decreases bacterial transmigration across intestinal epithelial cells, colon

62 s further validated for studying cancer cell transmigration across lymphatic endothelium.

63 junction breakdown and facilitated bacterial transmigration across polarized airway epithelial cells,

64 om the tight junction complex, and bacterial transmigration across polarized cells.

65 tor, CLEC12A, in facilitating DC binding and transmigration across the BBB in response to CCL2 chemot

66 models, however, some mechanistic aspects of transmigration across the BBB still remain largely unkno

67 othelial cells (HBMEC) is a prerequisite for transmigration across the blood-brain barrier.

68 99 (expressed on all 3 cell types) inhibited transmigration across the composites (14.5% of control)

69 f control), and venular shear stress reduced transmigration across the ECs (17.3% of static) more tha

70 whereas TNF-alpha-activated PC-CM decreased transmigration across the ECs, and culturing on PC-deriv

71 PC-derived BM decreased both adhesion to and transmigration across the ECs.

72 CD95L promoted T helper 17 (Th17) lymphocyte transmigration across the endothelial barrier at the exp

73 that CX3CR1 is critical for Ly6Clo monocyte transmigration across the endothelium in murine CRC tumo

74 previously shown to be involved in leukocyte transmigration across the endothelium.

75 d become extremely elongated before complete transmigration across the endothelium.

76 ule (ALCAM) has been implicated in leukocyte transmigration across the endothelium.

77 ir activations are required for cryptococcal transmigration across the HBMEC monolayer.

78 d produce this cytokine as a result of their transmigration across the inflamed blood-spinal cord bar

79 tivated EC-conditioned medium (CM) increased transmigration across the PCs, whereas TNF-alpha-activat

80 t role in polymorphonuclear neutrophil (PMN) transmigration across tissue cells and extracellular mat

81 ared with WT, showed defects in adhesion and transmigration across tumor necrosis factor-alpha (TNF-a

82 MMP-9 activity, which facilitates leukocyte transmigration across vascular barriers in hepatic IRI.

83 MP-9) synthesis, which facilitates leukocyte transmigration across vascular barriers in liver IRI, wa

84 Leukocyte transmigration across vessel walls is a critical step in

85 ial gene expression revealed that neutrophil transmigration activated beta-catenin signaling, and thi

86 ession and contribute to monocyte/macrophage transmigration and adhesion, we isolated Exos from monoc

87 Neutrophil transmigration and airway infiltration were all but lost

88 trating CID peptide that prevented Th17 cell transmigration and alleviated clinical symptoms in lupus

89 and caused dysregulation of PMN chemotactic transmigration and cell surface protein interactions.

90 lphai2 controls arrest and Galphai3 controls transmigration and chemotaxis in response to chemokine s

91 e effects of substrate stiffness by reducing transmigration and eliminating hole formation in HUVECs

92 ul means of directly inactivating neutrophil transmigration and hence mitigating vascular inflammatio

93 n the current study, the role of CD47 in PMN transmigration and infiltration into tissues was further

94 ct on 2D migration but significantly reduced transmigration and macrophage-stimulated collagen invasi

95 cellular level in order to predict leukocyte transmigration and plaque evolution.

96 ing host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are

97 rin that promotes fibrin-dependent leukocyte transmigration and thereby inflammation.

98 eavage, loss of cell adherence, paracellular transmigration, and basolateral invasion.

99 esion in vivo; however, neutrophil crawling, transmigration, and chemotaxis were reduced in these mic

100 iple steps of the cascade, including arrest, transmigration, and chemotaxis.

101 lular domain of endoglin, enhanced leukocyte transmigration, and this increased motility was inhibite

102 Leukocyte adhesion, crawling, and transmigration are regulated by clustering of the endoth

103 ansmitted variants also did not have greater transmigration as compared to chronic-infection strains.

104 n strengthening, intravascular crawling, and transmigration, as each step necessitates the proper fun

105 emistry, and in the authors' novel leukocyte transmigration assay.

106 Transmigration assays were performed over 18 hours in tr

107 were investigated by using flow chamber and transmigration assays.

108 ALCAM was confirmed using cell adhesion and transmigration assays.

109 hemotaxis assays and flow-based adhesion and transmigration assays.

110 solution not easily achieved in conventional transmigration assays.

111 diated by reverse migration from tissues and transmigration back into the vasculature.

112 ng vascular leakage or transendothelial cell transmigration being altered in denervated limbs.

113 se in T lymphocyte adhesion and consequently transmigration both in static and under flow conditions.

114 e endothelin-1 and a reduction in neutrophil transmigration, both known to be microtubule dependent.

115 alphai3-deficient neutrophils showed reduced transmigration but normal arrest in mice.

116 ted endothelial polymorphonuclear neutrophil transmigration, but not chemotaxis, is enhanced versus r

117 ICAM-1 was not required for local neutrophil transmigration, but supported optimal intravascular and

118 endothelial cell (EC) is known to facilitate transmigration, but the cellular and molecular mechanism

119 -phosphate (S1P), which promoted endothelial transmigration by activating the S1P receptor 3.

120 y regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interacti

121 ular scissor that is implicated in leukocyte transmigration by proteolytically cleaving its endotheli

122 riod of 4 days was required before bacterial transmigration commenced.

123 functions, including decreasing Ly6G(+) cell transmigration, delaying migration, and relieving suppre

124 Inflammation is driven by excessive transmigration (diapedesis) of leukocytes from the blood

125 o wild-type mice, fibrin-dependent leukocyte transmigration does not occur in such mice.

126 hat are thought to mediate basement membrane transmigration during development and tumor disseminatio

127 To begin transmigration, ECs deploy actin-based membrane protrusi

128 ing live-cell imaging, we find that prior to transmigration, endothelial docking structures form arou

129 ethasone and bevacizumab inhibited leukocyte transmigration from angiogenic vessels; however, dexamet

130 o technique for visualization of immune cell transmigration from corneal vessels toward implanted cyt

131 l adhesion under shear stress conditions and transmigration in a ChemR23-dependent manner.

132 nd CXCR2-dependent neutrophil but not T cell transmigration in a parallel-plate flow chamber system.

133 present a case report of a mandibular canine transmigration in a patient aged 12.

134 rved irreversible nuclear deformations after transmigration in lamin-A/C-deficient cells, whereas the

135 METHODS AND We observed defective PMN transmigration in response to lipopolysaccharide challen

136 ZAP-70 gene-deficient mice exhibited ablated transmigration in response to MIF or CXCL12.

137 CL12/CXCR4 and CCL19/CCR7 enhanced fibrocyte transmigration in the Asthma AE group and in patients wi

138 efficient extravasation of TRCs in vivo and transmigration in vitro are determined by TRC deformabil

139 PMN basolateral-to-apical transmigration in vitro significantly increased apical-t

140 ly unknown roles for pericytes in neutrophil transmigration in vivo and add additional steps to the l

141 nd led to a functional increase in leukocyte transmigration in vivo and CXCR2-dependent neutrophil bu

142 oncomitant increase in monocyte adhesion and transmigration in vivo, which was ameliorated by pretrea

143 microscopy, we show how pericytes facilitate transmigration in vivo.

144 Interestingly, neutrophil transmigration increased with increasing substrate stiff

145 However, the regulatory mechanisms of transmigration into infected tissue are not yet complete

146 R1/2 antagonist SCH527123 inhibits leukocyte transmigration into lung and subsequently reverses the p

147 al, whereas, in contrast, integrin-dependent transmigration into the alveolar space was impaired.

148 ation of alveolar macrophage precursors: (1) transmigration into the alveoli, and (2) engraftment in

149 buprenorphine limits CCL2-mediated monocyte transmigration into the CNS, thereby reducing neuroinfla

150 as a mediator of increased monocyte adhesion/transmigration into the CNS.

151 hil recruitment was impaired in fMLP-induced transmigration into the cremaster muscle, thioglycollate

152 esion molecule-1, which facilitate leukocyte transmigration into the lymphatic vessels.

153 Transmigration is a phenomenon of movement of an unerupt

154 Endothelial transmigration is accomplished by matrix metalloproteina

155 The next step in transmigration is creation of a migratory pore, and we f

156 Transmigration is more prevalent in females than in male

157 these underlying mechanisms of T lymphocyte transmigration is of great value to develop new strategi

158 t integrates the various known mechanisms of transmigration is proposed.

159 ults provide strong evidence that neutrophil transmigration is regulated by myosin light chain kinase

160 Furthermore, CEC transmigration is significantly higher in Rap1-knockdown

161 ix proteins, although its role in neutrophil transmigration is unknown.

162 r antigenic inflammation, basophils initiate transmigration like other granulocytes but, upon activat

163 d in lung epithelial cells during neutrophil transmigration, likely via elastase-mediated cleavage of

164 timulus-dependent; PKCdelta was required for transmigration mediated by IL-1beta and fMLP (integrin-d

165 CAM-1-activated signaling contributes to PMN transmigration mediated by PECAM-1.

166 junction disassembly, and blood endothelial transmigration, MMP16 supported nodular-type growth of a

167 ng neutrophil migration, we used an in vitro transmigration model with human pulmonary microvascular

168 in the CNS, where inflammation and leukocyte transmigration must be tightly regulated.

169 thelial cell PECAM-1 at cell junctions where transmigration occurs, we considered that NB1-PR3 intera

170 Although transmigration of activated encephalitogenic T cells acr

171 mRNA expression of these markers, suggesting transmigration of activated neutrophils into the brain.

172 for the treatment of cancer, suppresses the transmigration of activated T cells through an inflamed

173 The adhesion and transmigration of antigen-nonspecific (bystander) effect

174 Increased transmigration of Arhgap25-deficient leukocytes is demon

175 ferentially migrate during wound healing and transmigration of cancer cells.

176 with human CCL17 significantly increased the transmigration of CCR4+ huTreg under physiological shear

177 in and bryostatin-1 also affect adhesion and transmigration of CD4(+) and CD8(+) T cells as well as m

178 MCAM blockade restricts the transmigration of CD8(+) T lymphocytes across human bloo

179 at RPE monolayers lacking Rap1 allow greater transmigration of CECs suggests a possible role for pote

180 Transmigration of cell-free and cell-associated HIV acro

181 st a role for pericytes in promoting reverse transmigration of cells across blood vessel endothelium.

182 n a more efficient manner chemerin-dependent transmigration of dendritic cells.

183 ollectively, our data suggest that immediate transmigration of donor T cells via primary vascularizat

184 abilization of the BBB, thus suppressing the transmigration of encephalitogenic T cells.

185 MK hyperpolarization triggers GPIb-dependent transmigration of entire MKs into BM sinusoids.

186 ckdown on primary HUVECs was found to impair transmigration of freshly isolated human peripheral bloo

187 a definitive role for endothelial ADAM10 in transmigration of freshly isolated primary leukocytes un

188 initial chemotactic gradient that guides the transmigration of hematogenous immune cells into the inj

189 a role for Notch signaling in GM-CSF-primed transmigration of human blood eosinophils in vitro and i

190 Transmigration of human dendritic cells across retinal e

191 reduce the leakage of dyes and to block the transmigration of immune cells towards chemoattractants.

192 isease is influenced by the infiltration and transmigration of inflammatory cells across the endothel

193 D88-mediated signalling is essential for the transmigration of inflammatory monocytes from the blood

194 This results in inadequate transmigration of Itk(-/-) CD4(+) T cells into the CNS a

195 romoting barrier function by suppressing the transmigration of leukocytes into the pulmonary vessel w

196 n WT and Myh9(-/-) mice, indicates increased transmigration of MKs from the BM.

197 urface has been implicated in enhancement of transmigration of monocytes across the brain blood barri

198 This results in greater adhesion and transmigration of monocytes across the endothelium.

199 ship between MMP-9 and SDF-1 in facilitating transmigration of monocytes into the injured spinal cord

200 e tethering, mechanical factors important in transmigration of monocytes through the BBB.

201 e, the initial mechanical step governing the transmigration of monocytes.

202 cose-treated proximal tubule cells to induce transmigration of mononuclear cells.

203 ng domain of PECAM-1 significantly inhibited transmigration of NB1-positive neutrophils through IL-1b

204 we determined that PR3 activity facilitated transmigration of NB1-positive neutrophils under both st

205 tively inhibits chemokine-induced arrest and transmigration of neutrophils by inhibition of protein k

206 /TTC haplotype cells significantly increased transmigration of neutrophils confirming the functional

207 scular adherence and subsequent paracellular transmigration of neutrophils elicited by the chemokine

208 s was paralleled by diminishing the adhesion/transmigration of neutrophils in kidneys and liver after

209 ar adenosine levels in vitro, diminished the transmigration of neutrophils, and improved the epitheli

210 and interfering with LBRC trafficking blocks transmigration of neutrophils, monocytes, and lymphocyte

211 antly reduces intravascular accumulation and transmigration of neutrophils.

212 he regulation of intravascular adherence and transmigration of neutrophils.

213 ted intravascular adherence and paracellular transmigration of neutrophils.

214 mmatory response and, as such, modulates the transmigration of neutrophils.

215 nd to PB-MNCs and increased the adhesion and transmigration of PB-MNCs.

216 Thus, endotoxin-induced transmigration of PMNs was secondary to TRPM2-activated

217 nduction of SEMA7A translates into increased transmigration of polymorphonuclear neutrophil granulocy

218 l, we used a trans-well assay to measure the transmigration of primary neutrophils incubated with sup

219 es, and although it is beneficial to prevent transmigration of proinflammatory lymphocytes into the C

220 Transmigration of purified lymphocytes was dependent on

221 Transmigration of T lymphocytes is highly dependent on a

222 ions CXCL12-induced crawling and endothelial transmigration of Th1 cells was desensitized by CXCL9.

223 evented their retraction, facilitating their transmigration of the lymphatic endothelial barrier.

224 y, we showed that BBB disruption accelerates transmigration of the neurotropic fungus Cryptococcus ne

225 ients treated with natalizumab revealed that transmigration of this subset depends on the alpha4beta1

226 n of endothelial Galpha(i2) caused decreased transmigration of wild-type neutrophils.

227 es leukocytes to the stimuli responsible for transmigration offers a plausible explanation for this d

228 sion could not account for the dependence of transmigration on HUVEC substrate stiffness.

229 uidance for cell polarization and subsequent transmigration on inflamed endothelium.

230 yte cell adhesion molecule (ALCAM) inhibited transmigration (P </= 0.007), and CCL21 or CXCL10 increa

231 (P </= 0.007), and CCL21 or CXCL10 increased transmigration (P </= 0.031).

232 ation by abrogating endothelial adhesion and transmigration; paradoxically, it also promoted plaque i

233 all neutrophil functions including adhesion, transmigration, phagocytosis, degranulation, and neutrop

234 47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytok

235 cell activation, but impaired chemotaxis and transmigration; Pic-treated T cells underwent programmed

236 in renal carcinomas, in which, after nuclear transmigration, PKCalpha binds directly to pri-miRNA 15a

237 Paracellular transmigration predominates (>/=90% of events) in the cr

238 -mediated stimulation of in vitro tumor cell transmigration, proliferation, and migration and in vivo

239 This impairment was due to delayed transmigration rather than a complete block, and was ove

240 substrates several minutes after neutrophil transmigration reached a maximum.

241 incorporation of ECM exclusively within the transmigration regions.

242 ated adhesion to prevent excessive leukocyte transmigration remain unknown.

243 Subsequent lymphocyte arrest and transmigration require activation through binding of HEV

244 that cryptococcal association, invasion, and transmigration require host actin cytoskeleton rearrange

245 Neutrophil transmigration requires the localization of neutrophils

246 ls from Cxcr7(-/-) mice exhibited an ablated transmigration response to MIF, indicating that CXCR7 is

247 for the transcellular over the paracellular transmigration route.

248 bout the requirements for so-called "reverse transmigration" (RT).

249 chemokine and cytokine expression, monocyte transmigration, smooth-muscle cell apoptosis, and MC and

250 Moreover, in vitro transmigration studies reveal that IL-15 selectively att

251 t experimental data suggest that during cell transmigration the deformability of the nucleus could be

252 its barrier function, and promoting monocyte transmigration; these effects were reversed by T770A/T77

253 tal oral/intestinal epithelia, cell-free HIV transmigration through adult oral epithelia was ineffici

254 -dimensional migration through Matrigel, and transmigration through an endothelial cell monolayer of

255 etain important cellular functions including transmigration through an endothelial monolayer and diff

256 Leukocyte transmigration through cell monolayers of endoglin trans

257 oward monocyte chemoattractant protein-1 and transmigration through collagen.

258 arrest and significantly impaired neutrophil transmigration through endothelial cells by inhibition o

259 X11(+) MCL cells have higher cell migration, transmigration through endothelial cells, adhesion to st

260 latelet aggregation, leukocyte adhesion, and transmigration through endothelium and extracellular mat

261 ng important cellular processes such as cell transmigration through extracellular matrix and endothel

262 ssion of CD44 limited T-cell adhesion to and transmigration through murine endothelial monolayers in

263 il adhesion to (41.4%), it does not increase transmigration through PC monolayers.

264 to the underlying biophysical factors during transmigration through small constrictions is still lack

265 e and for nuclear plastic deformation during transmigration through small constrictions.

266 and E-cadherin, facilitating staphylococcal transmigration through the cell-cell junctions.

267 awling on the surface of the endothelium and transmigration through the endothelial layer.

268 h, in turn, is critical for their successful transmigration through the extracellular matrix.

269 ion disrupted T cell and DC localization and transmigration through tolerant LNs.

270 Neutrophil transmigration through venular walls that are composed o

271 ow production, release into the circulation, transmigration to and activation in peripheral tissues,

272 LAIV increased bacterial transmigration to and persistence within the middle ear.

273 us and bacteria, LAIV may increase bacterial transmigration to the middle ear and could thus increase

274 s, constitute barriers regulating leukocytes transmigration to the site of inflammation.

275 and they become activated during endothelial transmigration toward the inflammatory site.

276 al pneumonia, whether it may alter bacterial transmigration toward the middle ear, where it could hav

277 iment, but slightly enhanced response to and transmigration toward, the chemoattractant fMLF.

278 rved that IC-activated neutrophils underwent transmigration, triggered further IC formation, and tran

279 al ligands induced proliferation, migration, transmigration, tube formation of HIMEC, vessel sproutin

280 and NOD2, and cell proliferation, migration, transmigration, tube formation, and production of pro-an

281 tional increase in T cell but not neutrophil transmigration under laminar shear flow.

282 ediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that

283 thelial cell contraction-mediated neutrophil transmigration using an in vitro model of the vascular e

284 on with the extracellular matrix, it reduced transmigration velocity.

285 ly enhanced leukocyte rolling, adhesion, and transmigration via localized dissociation to mCRP in inf

286 Consequently, leukocyte transmigration was inhibited after 6-MP/6-T-GTP treatmen

287 Although PMN transmigration was not delayed in CD47(-/-) mice, fewer

288 To study the role of endothelial ASM in transmigration, we generated brain endothelial cells lac

289 slow rolling, chemokine-induced arrest, and transmigration were investigated by using flow chamber a

290 d that CXCL1-induced neutrophil adhesion and transmigration were reduced in the absence of CD37, cons

291 (-/-) mice, leukocyte rolling, adhesion, and transmigration were significantly reduced, with markedly

292 reased on NB1-positive neutrophils following transmigration, whereas neutrophils lacking NB1 demonstr

293 s in periodontitis is regulated by leukocyte transmigration, whereas the neutrophilic antimicrobial p

294 role for CtsB in leukocyte extravasation and transmigration, which advances our understanding of the

295 endothelial venules (HEVs) permit lymphocyte transmigration while maintaining vascular integrity is u

296 ived chemokines, and in vitro BBB models for transmigration, with a particular focus on new and recen

297 report that CD99 is critical for lymphocyte transmigration without affecting adhesion in a human blo

298 of Rac1 activity significantly inhibited CEC transmigration without affecting PI-3K activity.

299 sporter activity, plasma membrane, leukocyte transmigration, Wnt signaling pathways and angiogenesis.

300 ow S1P concentrations near exit sites before transmigration, yet S1PR1 signaling is rapidly terminate