ライフサイエンスコーパス: transmissibility

1 that may represent key initiators of clonal transmissibility.

2 ntly of great interest for determining virus transmissibility.

3 entified mutations associated with increased transmissibility.

4 nt can generate novel viruses with increased transmissibility.

5 ough this mechanism, have a potent effect on transmissibility.

6 are likely to be major determinants of virus transmissibility.

7 ns are subject to enhanced susceptibility or transmissibility.

8 by zoonotic viruses that acquired efficient transmissibility.

9 romoting influenza A virus pathogenicity and transmissibility.

10 in the flea foregut, which greatly increased transmissibility.

11 identify certain viral factors that enhance transmissibility.

12 asmid combinations that optimize fitness and transmissibility.

13 ighlighting its potential for human-to-human transmissibility.

14 f the influenza M segment to influence virus transmissibility.

15 us (MRSA) epidemiology is complicated by its transmissibility.

16 igs, acquired greatly enhanced virulence and transmissibility.

17 members reporting swine contact to estimate transmissibility.

18 t a role of HSV-2 infection in enhancing HIV transmissibility.

19 ner that is favorable to its survival and/or transmissibility.

20 nhancing their persistence and surprisingly, transmissibility.

21 jor determinant of infectivity and therefore transmissibility.

22 ersion of the traA mutation restored plasmid transmissibility.

23 (a 7:1 reassortant) is sufficient to enhance transmissibility.

24 al burden, which can contribute to increased transmissibility.

25 s in tissues, and mechanisms of toxicity and transmissibility.

26 its clinical presentation, epidemiology, and transmissibility.

27 cond wave, while accounting for its relative transmissibility.

28 mans and maintains the potential for greater transmissibility.

29 compatibility and in vivo pathogenicity and transmissibility.

30 thogenicity and equivalent viral fitness and transmissibility.

31 NA inhibitors without a change in fitness or transmissibility.

32 rs that determine viral pathogenicity and/or transmissibility.

33 d their relation to barriers of interspecies transmissibility.

34 uitable for transmission and the duration of transmissibility.

35 ngth P3/P5 as well as the loss of mechanical transmissibility.

36 ve, there was little geographic variation in transmissibility.

37 ese viruses acquire efficient human-to-human transmissibility.

38 SIV 1145-N66S displayed poor infectivity and transmissibility.

39 s prevent definitive classification of human transmissibility.

40 the virus mutates to increase human-to-human transmissibility.

41 cs in real time only provides a glimpse into transmissibility.

42 iotic resistance, colonization potential, or transmissibility.

43 rom somatic mutations that must drive clonal transmissibility.

44 We measured relative virus transmissibility across intact mucosae in macaques using

45 model with two possible values for intrinsic transmissibility across three epochs.

46 irus deposition, infectivity, virulence, and transmissibility among animals inoculated intranasally o

47 of shigellosis infection, including seasonal transmissibilities and basic reproductive number (R0).

48 ourse of an epidemic) with various levels of transmissibility and 5-fold fractional-dose vaccine effi

49 ynamics, especially if the disease shows low transmissibility and a long infectious period, and when

50 y sensitive to model parameters defining the transmissibility and clinical severity of the pandemic s

51 nd mucus may be an important factor in viral transmissibility and could be a barrier for interspecies

52 nd mucus may be an important factor in viral transmissibility and could be a species barrier between

53 l framework to deal with such path-dependent transmissibility and demonstrate the nontrivial interpla

54 eling the mechanisms causing increased viral transmissibility and disease severity requires experimen

55 SOIV also showed a sustained human-to-human transmissibility and higher reproduction ratio than comm

56 out how the disease spreads, such as uniform transmissibility and homogeneous mixing within a populat

57 es, with particular focus on influenza virus transmissibility and host-range specificity.

58 s therefore the primary determinant of viral transmissibility and immunogenicity.

59 protein aggregation and thus may enhance the transmissibility and pathogenesis of prion diseases rela

60 viral drug susceptibility, vaccine efficacy, transmissibility and pathogenicity studies.

61 ave been shown to regulate influenza A virus transmissibility and pathogenicity, but little is known

62 o-animal adaptation for establishing mucosal transmissibility and pathogenicity.

63 vered in several countries since 2004; their transmissibility and phenotypes in humans are unknown.

64 also found a significant association between transmissibility and population density, illiteracy, and

65 ick-borne equine pathogens, emphasizing tick transmissibility and potential control strategies to pre

66 ch outbreaks are driven by inherent pathogen transmissibility and pre-existing population immunity, a

67 The molecular mechanisms determining the transmissibility and prevalence of drug-resistant tuberc

68 t and limited, infrequent success of disease transmissibility and PrP(Sc) detection have been reporte

69 The high transmissibility and rapid evolutionary rate of noroviru

70 demic in Morocco during 2009-2010, including transmissibility and risk factors associated with fatal

71 ic diversity, we make an early assessment of transmissibility and severity.

72 genuine prion disease characterized by both transmissibility and strain variation.

73 s heritable variation in hosts in both their transmissibility and susceptibility along with costs to

74 ly by an individuals' susceptibility or when transmissibility and susceptibility are simply positivel

75 mechanisms may lead to relationships between transmissibility and susceptibility that generate divers

76 t identifying adaptations required for virus transmissibility and systems-level analyses of influenza

77 ion to clinical disease, together with viral transmissibility and the duration of naturally-acquired

78 al genetic markers associated with increased transmissibility and to examine whether these markers le

79 which indicates the potential for changes in transmissibility and virulence and could render current

80 onal programs mechanistically links parasite transmissibility and virulence.

81 ased host susceptibility or increased strain transmissibility and virulence.

82 but may impact in vivo infectivity, mucosal transmissibility, and early infection events.

83 with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential.

84 viral drug susceptibility, vaccine efficacy, transmissibility, and pathogenesis.

85 Here, we analyzed the virulence, transmissibility, and receptor-binding preference of fou

86 tory of the infectious disease, its inherent transmissibility, and the intervention feasibility in th

87 of molecular determinants of pathogenicity, transmissibility, and tropism.

88 notype may be related to enhanced virulence, transmissibility, and/or specific adaptation to a Euro-L

89 offs between toxicity, relative fitness, and transmissibility are critical for understanding the mult

90 wever, viral properties that determine HIV-1 transmissibility are not fully elucidated.

91 osocomial transmission, and changes in viral transmissibility, as well as diagnostic laboratory artif

92 e basic reproduction number, as a measure of transmissibility associated to each influenza strain, cr

93 18, for the first time quantifying influenza transmissibility at the person-to-person level during th

94 nship between prion strains and interspecies transmissibility barriers.

95 Method 4 assesses transmissibility before public health interventions, by

96 local beta2-alpha2 loop structure for prion transmissibility between different species.

97 rrets is considered a surrogate indicator of transmissibility between humans, these studies raised co

98 luenza viruses is a key determinant of their transmissibility, both from avian and animal species to

99 High virion production enhances transmissibility but also provokes an immune response le

100 Here we present the first study of SIV transmissibility by breast-feeding in an African NHP hos

101 eriod into intervals to allow for changes in transmissibility by infection stage.

102 ve contact animals, and demonstrated limited transmissibility by respiratory droplets.

103 poorly understood phenomenon of AIV airborne transmissibility by revealing a role for NS1 and charact

104 rtant (HA1-H17Y/HA2-R106K) regained airborne transmissibility by stabilizing HA to an activation pH o

105 es probably contribute to the acquisition of transmissibility by this mutant virus.

106 Tick transmissibility can be lost with attenuation, but when

107 Transmissibility can be measured by the reproduction num

108 ansmitted viruses, suggesting that mammalian transmissibility can evolve through multiple genetic pat

109 phenotypes, phenotypes associated with viral transmissibility, cell or tissue tropism phenotypes, and

110 The transmissibility characteristics were similar to those o

111 further studies to examine their growth and transmissibility characteristics.

112 Estimates of viral transmissibility, clearance of initial infection and wan

113 Joint estimates of severity and transmissibility clustered within a relatively small reg

114 double mutant had virus shedding titers and transmissibility comparable to those of the wild type, i

115 This high transmissibility could be due to both high infectiousnes

116 The quantification of transmissibility during epidemics is essential to design

117 the bacterium, finding significantly higher transmissibility during the cooler and drier months.

118 indications of increased HIV-1 virulence and transmissibility during the course of the epidemic and a

119 We illustrate this by deriving transmissibility estimates for the H3N2v-M virus, an imp

120 reservoir, quantification of uncertainty in transmissibility estimates, and provision of the first e

121 ems where heterogeneity between serotypes in transmissibility facilitates competitive exclusion, here

122 An increasing temporal trend in transmissibility ([Formula: see text], p-value: 0.013) d

123 ined source was within 5 years, and assessed transmissibility from forward transmissions resulting in

124 estigation data, we sought to estimate H3N2v transmissibility from swine to humans.

125 effect of multiple exposures to fly bites on transmissibility has not been addressed.

126 -escape in acute-infection viruses with high transmissibility have been interpreted mainly through im

127 pts an alternative conformation and acquires transmissibility; hence, it becomes a prion.

128 of disease due to recent transmission and in transmissibility (highest for lineage-2 and lowest for l

129 r in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug re

130 circulating strains have low human-to-human transmissibility; however, widespread concerns exist tha

131 s in human airway cells and pathogenesis and transmissibility in animal models were also assessed.

132 f replicative ability in vivo, virulence and transmissibility in animal studies (mouse, ferret, and g

133 V627 genotype with uncompromised fitness and transmissibility in both avian and mammalian species.

134 their zoonotic infection characteristics and transmissibility in chickens.

135 nerated reassorted viruses conferred aerosol transmissibility in ferrets (a property shared by human

136 plicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess

137 1 influenza virus pathogenicity and airborne transmissibility in ferrets and is associated with pande

138 The H7N8 LPAI virus displayed limited transmissibility in ferrets placed in direct contact wit

139 us did not prevent influenza replication and transmissibility in ferrets, but did attenuate influenza

140 a viruses that exhibit diverse virulence and transmissibility in ferrets.

141 tested for viral fitness, pathogenicity, and transmissibility in ferrets.

142 NEP T48N) were identified as determinants of transmissibility in guinea pigs.

143 n opportunity to understand the evolution of transmissibility in guinea pigs.

144 man respiratory cells, virulence in mice and transmissibility in guinea pigs.

145 ylococcus aureus (MRSA) clones vary in their transmissibility in hospital settings, attempts to quant

146 ndemic H1N1 influenza virus is its efficient transmissibility in humans compared to that of precursor

147 led to genomic changes that increased viral transmissibility in humans.

148 tal finding that a mutant avian virus gained transmissibility in mammals despite the mutations confer

149 tability to H5N1 influenza virus fitness and transmissibility in mammals in the background of a non-l

150 in particular its relative pathogenicity and transmissibility in mammals, are not known.

151 e segments may also critically contribute to transmissibility in mammals.

152 H5N1 viruses with the potential for aerosol transmissibility in mammals.

153 eceptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolat

154 ssortant viruses with enhanced virulence and transmissibility in mice and guinea pig models.

155 tants demonstrated increased replication and transmissibility in pig, but were still inefficient when

156 and enhanced replication, pathogenicity, and transmissibility in pigs, guinea pigs, and ferrets in vi

157 N9) shows modest replication, virulence, and transmissibility in pigs, suggesting that it is not well

158 dm09 genes is responsible for less efficient transmissibility in pigs.

159 he values of R and Rindex and an increase in transmissibility in recent years were noted with all met

160 ycans are key determinants of host range and transmissibility in several pathogens.

161 rican lineage H7 influenza viruses and their transmissibility in the ferret model.

162 ariants of the prion protein (PrP) determine transmissibility in the hosts, as has been shown for cla

163 viruses revealed genetic markers of airborne transmissibility in the Polymerase Basic 2 (PB2), PB1, P

164 sponses to influenza virus pathogenicity and transmissibility in this model by measuring the level of

165 , replicative efficiency, pathogenicity, and transmissibility in vitro and in vivo.

166 evolution of M. tuberculosis toward enhanced transmissibility in vivo that are associated with altere

167 determine the likelihood of interhuman viral transmissibility, in turn enabling general predictions o

168 us could mutate to have increased interhuman transmissibility, increasing its pandemic potential.

169 In addition to enhancing transmissibility, induction of the PhoP-PhoQ system in t

170 between parasite clearance following ACT and transmissibility is currently unknown.

171 model prediction for SCLs of varying oxygen transmissibility is in good agreement with available the

172 nsmit from person to person, and their human transmissibility is influenced by the environment in whi

173 ines influenza A virus fitness and therefore transmissibility is the interaction of the surface glyco

174 Transmissibility is therefore substantially higher than

175 ve implications for understanding how dengue transmissibility may depend on the immune status of infe

176 However, we find that transmissibility may increase substantially if vaccine c

177 the first quantitative evidence of enhanced transmissibility of a pandemic MRSA lineage, and highlig

178 The simulations suggest that at the expected transmissibility of a pandemic strain, timely implementa

179 novel infection depends on both the inherent transmissibility of a pathogen, and the level of suscept

180 ological characteristics, pathogenicity, and transmissibility of A/Anhui/1/2013 (H7N9) virus and vari

181 unity (which affects both infection risk and transmissibility of any resulting infection), age-mediat

182 We found that, as the relative transmissibility of asymptomatic infection increases, a

183 analyses underscore the need to quantify the transmissibility of asymptomatic infections, without whi

184 provided the opportunity to investigate the transmissibility of avian Bornavirus (ABV) and its linka

185 The restrictions to transmissibility of avian influenza viruses in mammals a

186 ue opportunity to study the pathogenesis and transmissibility of bacterial vaginosis (BV) because it

187 rsion, virulent sequences do not enhance the transmissibility of ChimeriVax viruses.

188 of mouse models for assessing the potential transmissibility of common neurodegenerative diseases.

189 We studied the transmissibility of community-associated methicillin-res

190 resent a method to quantify the time-varying transmissibility of different subtypes of common bacteri

191 tent with the emerging concept of prion-like transmissibility of disease-causing amyloidogenic protei

192 tanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimate

193 s the importance of studying the fitness and transmissibility of drug-resistant viruses.

194 ts, which raises concern about the potential transmissibility of germline damage to their offspring.

195 ar transmission properties, we estimated the transmissibility of H3N2v from swine to humans and the b

196 ains, we compared the relative virulence and transmissibility of H7N9 viruses isolated during the sec

197 ity and viral replication, pathogenicity and transmissibility of H7N9 viruses.

198 We also compared the transmissibility of H9N2:pH1N1 (P0), H9N2:pH1N1 (P7) and

199 lly acquired mutations known to increase the transmissibility of highly pathogenic H5N1 influenza vir

200 The variable infectivity and transmissibility of HIV/SHIV has been recently associate

201 ture residues are involved in increasing the transmissibility of infecting viruses; therefore, they a

202 define the optimal screening assays and the transmissibility of infection with allografts.

203 We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mo

204 ect pigs under experimental conditions, with transmissibility of influenza B/Victoria lineage virus a

205 Here, we discuss the pathogenesis and transmissibility of influenza viruses and we emphasize t

206 H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered inte

207 is a key determinant for the host range and transmissibility of influenza viruses.

208 The bites of uninfected sand flies favor the transmissibility of L. donovani by infected hosts, owing

209 ates were most sensitive to estimates of the transmissibility of MDR strains, the probability of acqu

210 se introductions rather than a change in the transmissibility of measles.

211 plications for our understanding of the high transmissibility of measles.

212 This study hence demonstrates epigenetic transmissibility of metabolic and inflammatory traits re

213 l variations in mRNA editing and the genetic transmissibility of mRNA editing are equivocal.

214 Transmissibility of neoplasia was preventable by prior n

215 s, lessen unwarranted apprehension about the transmissibility of noninfectious proteopathies, and pro

216 racterizing the amplitude and variability in transmissibility of novel human influenza strains as the

217 provide insights into the pathogenicity and transmissibility of novel reassortant H3N2 viruses in pi

218 ging in mammals owing to the relative tissue transmissibility of orange-red light, but their dependen

219 ent failures after ACT and the viability and transmissibility of persisting ring stage parasites rema

220 of infection mimics the prolonged cough and transmissibility of pertussis, and we hypothesized that

221 c virus makes it an ideal virus to study the transmissibility of potentially pandemic influenza strai

222 ular prion protein (PrP) function(s) and the transmissibility of prion protein neurodegenerative dise

223 cosylation and GPI anchoring, can affect the transmissibility of prions as well as the biochemical pr

224 etic approaches to estimate the variation in transmissibility of rapidly-evolving viral epidemics.

225 that are only slightly asymmetric, increased transmissibility of secondary infections through immune

226 that directly test the in vivo cross-species transmissibility of SIVcpz strains to humans.

227 We apply it to assess the transmissibility of swine-origin influenza A H3N2v-M vir

228 Transmissibility of TB is high; therefore, transplant te

229 The transmissibility of the 2009 H1N1 influenza virus in hou

230 However, transmissibility of the Congo Basin clade was slightly g

231 on in endemic states, where small changes in transmissibility of the diseases can lead to explosive o

232 re bred with wild-type SD mates and germline transmissibility of the ES cell line was confirmed by id

233 model for examining the genetics underlying transmissibility of the Eurasian avian-like swine lineag

234 We find that substantially increased transmissibility of the H1N1pdm09 virus is required to r

235 es, then were added to target cells, and the transmissibility of the HK2 Bogota reporter was tracked

236 ion decisions will be determined by both the transmissibility of the novel strain (measured by the ba

237 in animal models, and the pathogenicity and transmissibility of the other seven genotype viruses rem

238 on and tumorigenesis, as demonstrated by the transmissibility of the phenotype and protection conferr

239 The transmissibility of the strain of influenza virus which

240 ecies-including humans-at present, efficient transmissibility of the swine-adapted H5N2 virus could f

241 ability to control an Ebola outbreak include transmissibility of the virus and the proportion of tran

242 es elucidating the exceptional virulence and transmissibility of the virus are providing exciting new

243 as raised great concerns about the potential transmissibility of the virus in humans.

244 the morphology of the influenza A virion and transmissibility of the virus in the guinea pig model.

245 Transmissibility of the virus was comparable to observat

246 cts of ferrets; however, contact and aerosol transmissibility of the virus was unaffected.

247 t position 228 in the HA is critical for the transmissibility of these reassortant H3N2 viruses.

248 The transmissibility of these viruses further highlights the

249 d to better understand the pathogenicity and transmissibility of these viruses in mammals.

250 er, most amyloids appear to lack the natural transmissibility of TSE prions.

251 tudy was undertaken to quantify variation in transmissibility of TSWV isolates by T. tabaci, in the a

252 fection, we determined the pathogenicity and transmissibility of two Asian-origin H5Nx viruses in mam

253 Here, we evaluated the pathogenicity and transmissibility of two TRS viruses associated with dise

254 Our results suggest that an increase in the transmissibility of typhoid due to the emergence of drug

255 st range, tissue tropism, pathogenicity, and transmissibility of viruses.

256 131) are undefined, but may include enhanced transmissibility or ability to colonize the intestine co

257 -infection does not significantly affect the transmissibility or the mutation rate of Mtb within pati

258 r and peramivir without any loss in fitness, transmissibility, or pathogenicity.

259 our study was robust to the removal of high transmissibility outliers and to the removal of the smal

260 aracterized by the layer-wise path-dependent transmissibility over a contact, that is dynamically det

261 model assumptions about CD4 decline and HIV transmissibility over the course of infection explained

262 volve in such a way as to maximize their own transmissibility: over time, the languages in our experi

263 se clones may have determinants that enhance transmissibility, persistence, or invasiveness.

264 fecting begomoviruses, including lack of sap transmissibility, phloem limitation, a resistance phenot

265 of resistance, 10-year trend of resistance, transmissibility, preventability in the community settin

266 pt to the environment, yielding cell-to-cell transmissibility, prion infectivity and toxicity.

267 adaptation is required for a virus to attain transmissibility, providing an opportunity to understand

268 We infer the viral transmissibility, rate of waning natural immunity and ra

269 es are low; however information on virulence-transmissibility relationships is required to explain th

270 However, the mechanism of IsaB on host transmissibility remains unclear.

271 Assessment of transmissibility requires tools that can accurately iden

272 sults provide evidence that not only is tick transmissibility retained by the attenuated T2Bo strain,

273 waning immunity rates and oral polio vaccine transmissibility reveals that higher waning immunity rat

274 resistance without compromising fitness and transmissibility, showing that, in addition to weaknesse

275 A suggested increase in measles transmissibility since elimination warrants continued mo

276 ely identify critical determinants for viral transmissibility since they were transmitted under simil

277 to new infectious PrP(Sc) Interspecies prion transmissibility studies performed by experimental chall

278 et-adapted virus was able to account for the transmissibility, suggesting that currently circulating

279 e epidemic depends critically on the disease transmissibility, suggesting that for a sufficiently hig

280 ture influenza A(H5N1) mutants with airborne transmissibility, suggesting that human influenza pandem

281 A(H1N1)pdm09 genes displayed less efficient transmissibility than the endemic and reassortant H3N2 v

282 vert to neurovirulence and reacquire greater transmissibility that could potentially result in the re

283 ly, we test whether EVD strains have uniform transmissibility through a novel statistical test, and f

284 HA segments are required to provide optimal transmissibility to an influenza virus.

285 To probe the structural features that confer transmissibility to prion protein (PrP) fibrils, we have

286 Transmissibility to rabbits (>470 d) has been confirmed

287 segment of the Cal/09 virus promoted aerosol transmissibility to recombinant viruses with PR8 and sw/

288 tand which segment of Cal/09 virus conferred transmissibility to the poorly transmissible PR8 virus.

289 elded a virus with indistinguishable contact transmissibility to the wild-type pandemic strain.

290 ective regarding the mechanism of Leishmania transmissibility to vector sand flies.

291 different species vary considerably in their transmissibility to xenogeneic hosts.

292 We sought to assess the risk of its human transmissibility using two complementary approaches.

293 ity, suggesting that for a sufficiently high transmissibility, vaccine delivery after the onset of ep

294 Measles transmissibility was assessed by estimation of the repro

295 No change in fitness or transmissibility was observed.

296 had been shown to enhance experimental prion transmissibility, we hypothesized that prion transmissio

297 Fitness and transmissibility were assessed in ferrets and tissue cul

298 rides with alpha2,3 or alpha2,6 linkages) on transmissibility were assessed.

299 lity, ease of contact transmission, and seed transmissibility, which are typical tobamovirus characte

300 are permissive for infection and sustainable transmissibility with the 2014 initial wild bird-adapted