ライフサイエンスコーパス: transphosphorylation

1 omains pivot on conserved hinges to modulate transphosphorylation.

2 on but require a type II receptor capable of transphosphorylation.

3 th ADP and UDP were effective substrates for transphosphorylation.

4 utophosphorylation nor phospholipase C-gamma transphosphorylation.

5 er complex and likely activate each other by transphosphorylation.

6 multimers that carry out effective receptor transphosphorylation.

7 -rotation allows them to orient properly for transphosphorylation.

8 and in fact, UVB did not alter PKC-mediated transphosphorylation.

9 with the inhibition of both FGFR1 and FGFR2 transphosphorylation.

10 e active sites for efficient activation loop transphosphorylation.

11 ces signaling output through reciprocal BRI1 transphosphorylation.

12 3-3 mediated heterooligomerization and C-RAF transphosphorylation.

13 e difluoromethyluridine residue via internal transphosphorylation.

14 tors and activating their kinase domains via transphosphorylation.

15 on activates their kinase activities through transphosphorylation.

16 ires PKC but not PKD activity, indicative of transphosphorylation.

17 cal face was critical for mediating receptor transphosphorylation.

18 a, and subsequent autophosphorylation and/or transphosphorylation.

19 nce their appended PTKs, antigens induce PTK transphosphorylation, activating them to phosphorylate t

20 ining the balance between the hydrolysis and transphosphorylation activities and plays an important r

21 Galpha13 stimulates autophosphorylation and transphosphorylation activities of Tec.

22 domain decrease both autophosphorylation and transphosphorylation activities.

23 ted auto-activation of PKR and inhibited PKR transphosphorylation activities.

24 that tyrosine 360 of Bcr is critical for the transphosphorylation activity of Bcr and that in Ph-posi

25 The transphosphorylation activity of the K328C enzyme was se

26 pendent RcCDPK1 autophosphorylation and BTPC transphosphorylation activity, it is not critical for in

27 activity and sugar phosphate-dependent sugar transphosphorylation activity.

28 surface G protein-coupled receptors leads to transphosphorylation and activation of a number of recep

29 homology 2 (SH2) domain is critical for the transphosphorylation and activation of Emt/Itk catalytic

30 nding to the type II receptor results in the transphosphorylation and activation of the type I recept

31 ecruited a second Lyn molecule, allowing for transphosphorylation and amplification of Lyn activation

32 correlated with increased phosphotyrosine on transphosphorylation and autophosphorylation sites.

33 trating that CheA[1-149] fragments have both transphosphorylation and phosphotransfer capability in v

34 We first assessed in vitro PKC-PKD transphosphorylation and PKD activation.

35 he clustering of the Eph receptor, fostering transphosphorylation and signal transduction into the ce

36 tor BAK1 is then activated by BRI1-dependent transphosphorylation and subsequently enhances signaling

37 nduced dimerization, which promotes receptor transphosphorylation and thereby increases the receptor'

38 the SQ/TQ-cluster domain (SCD) abolished Mnk transphosphorylations and autophosphorylations, indicati

39 -elimination, Seyferth-Gilbert homologation, transphosphorylation, and a 1,3-dipolar cycloaddition re

40 ATM, followed by Chk2 oligomerization, auto-/transphosphorylation, and activation.

41 tor phosphorylation experiments, NDF-induced transphosphorylation appears to be correlated with syner

42 the hairpin ribozyme to enhance the rate of transphosphorylation are presented, and the roles of A38

43 such that high-affinity binding and receptor transphosphorylation are reduced.

44 Using an in vitro peptide transphosphorylation assay, sorbitol treatment activates

45 This occurs by transphosphorylation at Y551 in the Btk catalytic domain

46 Interestingly, transphosphorylation between HER1 and HER4 can be stimul

47 Heterologous transphosphorylation between TrkB and TrkC kinase domain

48 otetramer is capable of a low-level receptor transphosphorylation, but C-terminal phosphorylation and

49 can occur by phosphorylation of HDAC4 or by transphosphorylation by CaMKII bound to HDAC4.

50 this may reflect PIP(3) effects on PDK-1 or transphosphorylation by endogenous full-length PKC-zeta.

51 omain, CheA[1-149], was a poor substrate for transphosphorylation by full-length CheA molecules, impl

52 These lesions reduced the rate of P1 transphosphorylation by P4.

53 rabidopsis PDK1 interacts with PID, and that transphosphorylation by PDK1 increases PID autophosphory

54 Catalysis of RNA 2'-O-transphosphorylation by ribonuclease A is proposed to in

55 Transphosphorylation by Src family kinases is required f

56 membrane localization, Btk kinase activity, transphosphorylation by Src family kinases, and an intac

57 nly modified through autophosphorylation and transphosphorylation by TRPM6.

58 omplex that is necessary for stable receptor transphosphorylation differs from the signaling complex

59 PIKfyve autophosphorylation or transphosphorylation engaged Ser but not Thr or Tyr resi

60 ously that Itk is regulated by an activating transphosphorylation event in which Tyr-511 in the kinas

61 nsitions would render Y416 available for the transphosphorylation event that ultimately locks down th

62 ies indicated that the rate of extracellular transphosphorylation exceeds that of nucleotide hydrolys

63 Transphosphorylation is mediated by specific asymmetric

64 P occurs from most cell types indicates that transphosphorylation is physiologically important in the

65 structural arrangement of the enzyme and its transphosphorylation mechanism.

66 ogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism.

67 ion is controlled by autophosphorylation and transphosphorylation mechanisms, which includes phosphor

68 istent with the recently proposed sequential transphosphorylation model for BRI1/BAK1 interaction and

69 We propose a sequential transphosphorylation model in which BRI1 controls signal

70 KSR acts via transphosphorylation, not by increasing c-Raf-1 autophos

71 Trk receptor transphosphorylation occurs in the two non-neuronal cell

72 nonphosphorylatable CheA(S) protein mediates transphosphorylation of a CheA(L) variant defective in b

73 s RTK to a less potent enzyme by disfavoring transphosphorylation of activation loop tyrosines.

74 fluorometric assay based upon the enzymatic transphosphorylation of adenosine diphosphate to adenosi

75 1 with Akt3 and as a consequence facilitated transphosphorylation of Akt molecules, which may contrib

76 DK1 and is not due to autophosphorylation or transphosphorylation of Akt.

77 phorylation activity of ArcB and enhance the transphosphorylation of ArcA, but have no effect on the

78 uced both autophosphorylation of Tyr-811 and transphosphorylation of Bcr, a recently identified Fes s

79 ion pathway in which autophosphorylation and transphosphorylation of BRI1 and BAK1, as well as phosph

80 dependent homo-oligomer, as evidenced by the transphosphorylation of BRI1 kinase in vitro, the domina

81 nd in vitro experiments where it blocked the transphosphorylation of Cps2D even in the presence of th

82 DNA-PKcs protein, we show that ATM-mediated transphosphorylation of DNA-PKcs regulates end-processin

83 are active in autophosphorylation as well as transphosphorylation of each other and specific peptide

84 riants defective for either G1 or G2 mediate transphosphorylation of each other poorly, if at all.

85 Transphosphorylation of EMS1 by SERK1 enhances EMS1 kina

86 mutant and Epo-R was associated with reduced transphosphorylation of Epo-R and expression of c-Myc.

87 he molecular basis underlying the control of transphosphorylation of FGF receptors and other receptor

88 tivated FGFR1 kinase domains is required for transphosphorylation of FGFR1 in FGF-stimulated cells.

89 t differentially with G(s) proteins and that transphosphorylation of GDP to GTP is not involved in th

90 ly than to ArcA; and that D1 accelerates the transphosphorylation of H2.

91 of the kinase impaired HER-3 as reflected in transphosphorylation of HER-3 and heteromers between HER

92 ssess the efficacy of HER TKIs should be the transphosphorylation of HER3 rather than autophosphoryla

93 ferent extracellular regions, intermolecular transphosphorylation of homologous cytoplasmic domains o

94 tion between ITK and SLP-76, recruitment and transphosphorylation of ITK, actin polarization at the T

95 This association is required for the transphosphorylation of Itk.

96 thought to involve receptor dimerization and transphosphorylation of juxtaposed catalytic domains.

97 t a requisite for signaling, indicating that transphosphorylation of K721M by ErbB2 was not an essent

98 bited by RNAi showed a dramatic reduction in transphosphorylation of myelin basic protein substrate.

99 s nuclear Erk1/2 signaling: It emanates from transphosphorylation of p21-activated kinases in their e

100 Sole transphosphorylation of p21-activated kinases is not suf

101 mains of TAFII250 are required for efficient transphosphorylation of RAP74 on serine residues.

102 Lysophosphatidic acid (LPA)-elicited transphosphorylation of receptor tyrosine kinases has be

103 Thus, auto-/transphosphorylation of S379 is required for Chk2 ubiqui

104 artic acid in the activation loop favors the transphosphorylation of the activation loop tyrosines, a

105 intrinsically inactive and dependent on the transphosphorylation of the activation loop.

106 Such dimers are capable of transphosphorylation of the cytoplasmic domain of the re

107 LPA-induced transphosphorylation of the EGFR, ErbB2, or PDGF recepto

108 I-mediated activation of MEK and Ras but not transphosphorylation of the epidermal growth factor (EGF

109 Also, PII significantly reduced the rate of transphosphorylation of the isolated central domain by t

110 dimerization induced by IP6, which promotes transphosphorylation of the kinase domains.

111 /Akt pathway is driven predominantly through transphosphorylation of the kinase-inactive HER3.

112 er of a CheA dimer form a unit that mediates transphosphorylation of the other protomer within that d

113 Transphosphorylation of the PKD activation loop at serin

114 Transphosphorylation of the receptor subunits is followe

115 o probe the mechanism of base-catalyzed 2'-O-transphosphorylation of the RNA dinucleotide 5'-UpG-3'.

116 meric (type I-type II) complex formation and transphosphorylation of the type I receptor by the type

117 e II receptor results in the recruitment and transphosphorylation of the type I receptor.

118 he T cell antigen receptor (TCR) induces the transphosphorylation of the zeta chain-associated protei

119 or transcripts, yet LPA caused no detectable transphosphorylation of these receptor tyrosine kinases.

120 activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C ter

121 lation or activation of ERK, but it inhibits transphosphorylation of Tyr845 and activation of signal

122 Btk* enhances the transphosphorylation of Y551 by endogenous Src family ty

123 esized to occur as a consequence of auto- or transphosphorylation on tyrosine residues associated wit

124 Trk receptor was explored by determining if transphosphorylation on tyrosine residues can occur betw

125 ves ligand-induced receptor dimerization and transphosphorylation on tyrosine residues.

126 breakpoint in the pH dependence of the 2'-O-transphosphorylation rate to a pH independent phase abov

127 of adenylate kinase (ADK) in the equilibrium transphosphorylation reaction (ATP + AMP <--> 2ADP).

128 cause the fructose-1-phosphate:[14C]fructose transphosphorylation reaction appeared normal, we conclu

129 The kinetics of the transphosphorylation reaction catalyzed by the two IIGlc

130 ecific hydrolysis of phosphomonoesters and a transphosphorylation reaction in which phosphate is tran

131 nly arise from the specific enzyme catalyzed transphosphorylation reaction.

132 phoenzyme intermediates, ComB can catalyze a transphosphorylation reaction.

133 The failure of TrkA to take part in transphosphorylation reactions with TrkB and TrkC was co

134 n-off assays monitor the forward and reverse transphosphorylation reactions, respectively.

135 or facilitate asymmetric dimer formation and transphosphorylation, respectively.

136 We propose a model whereby Mps1 transphosphorylation results in its release from kinetoc

137 ErbB4 receptors and were able to modulate a transphosphorylation signal from ErbB3 to ErbB2 in MCF7

138 enzymes and an intact Btk PH domain and Src transphosphorylation site.

139 225 and Glu314) within 2.8 A of the proposed transphosphorylation site.

140 hich individual Btk molecules undergo serial transphosphorylation (site 1) then autophosphorylation (

141 Among 12 in vitro autophosphorylation and transphosphorylation sites identified by tandem mass spe

142 se domains of chimeric receptors or act as a transphosphorylation substrate for these two receptors.

143 Transphosphorylation targeted Ser(744), whereas autophos

144 Transphosphorylation thio effects in solution are studie

145 The ratio of the transphosphorylation to the hydrolysis activities increa

146 in a chemically detailed description of 2'-O-transphosphorylation transition states provides an oppor

147 IIA as well as IIBC (the PEP reaction), and transphosphorylation using a sugar phosphate (glucose-6-

148 Both the autophosphorylation and transphosphorylation were demonstrated with PIKfyve immu

149 As RLK activation requires transphosphorylation with a second associated RLK, it re

150 OsSERK2 undergoes bidirectional transphosphorylation with XA21 in vitro and forms a cons

151 he activity of Btk is partially regulated by transphosphorylation within its kinase domain by Src fam

152 naling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor com

153 c variant of the protein underwent efficient transphosphorylation, yet failed to activate appreciably