ライフサイエンスコーパス: transplantable

1 resemble human uterine adenosarcoma and are transplantable.

2 -like features and subsequently AML that was transplantable.

3 Tumors express T-cell markers and are transplantable.

4 onocytic leukemia (CMML), which was serially transplantable.

5 em/progenitor compartments, and are serially transplantable.

6 sing multiple murine tumor models, including transplantable adenocarcinoma, melanoma, sarcoma, and th

7 to develop the use of isolated human GPCs as transplantable agents both for mediating enzymatic resto

8 ressing wild-type N-Myc developed clonal and transplantable AML after approximately 1 month; those tr

9 iquid culture, generated fully penetrant and transplantable AML in BM transplant recipients, and disp

10 ed in 90% of patients with AML and induces a transplantable AML in murine models provides an alternat

11 In 45% of animals, a transplantable AML of relatively short latency and frequ

12 imals, which died of a highly aggressive and transplantable AML within 3 to 5 months.

13 Moreover, the disease was easily transplantable and allowed different therapeutic options

14 pha-null cells for months that were serially transplantable and contributed to all lineages in second

15 Two tumors were transplantable and established as stable cell lines.

16 icent mice, HSCs from these animals were not transplantable and even selected against.

17 MML providing the first examples of serially transplantable and genetically accurate models of CMML.

18 MZLs were transplantable and homed to the spleen.

19 significantly suppressed the growth of both transplantable and inducible melanoma.

20 The disease was transplantable and maintained expression of mutant IDH1.

21 Lymphomas were transplantable and of clonal origin and were characteriz

22 The disease was not transplantable and prolonged observation showed normaliz

23 clude that NKG2C(+) memory-like NK cells are transplantable and require active or latent (subclinical

24 Moreover, Smo/Smo medulloblastomas were transplantable and serially passaged in vivo, demonstrat

25 y, these cells are altered at these sites in transplantable and spontaneous mouse models of cancer-in

26 therapeutic settings by taking advantage of transplantable and spontaneous mouse tumor models.

27 on, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion.

28 were obtained in a transgenic mouse model of transplantable APL, and in the RA response of leukemic c

29 body blockade of DC-HIL delays the growth of transplantable B16 melanoma in syngeneic mice, which is

30 We have used the preclinical transplantable B16 melanoma model to profile chemokines

31 its potential to prevent melanoma using both transplantable B16 tumor and autochthonous melanoma mode

32 Using a transplantable BA mouse mammary carcinoma, we show that

33 We also demonstrate in a transplantable BALB/c mouse tumor model that treatment w

34 -cell mass is limited by the availability of transplantable beta-cells and the need for chronic immun

35 , notochord and neural tube, and is serially transplantable between embryos.

36 ponents of cell-laden artificial tissues and transplantable biosensors.

37 ncing of normal, chronic phase, and serially transplantable blast crisis chronic myeloid leukemia (CM

38 Transplantable bone marrow-derived endothelial progenito

39 s significantly reduced tumor growth in both transplantable breast and lung cancer models.

40 of these observations, we used two different transplantable breast cancer models, yielding results th

41 ice carrying well-established, vascularized, transplantable breast tumors (MX-1).

42 ouse models of breast cancer and against 4T1 transplantable breast tumors in BALB/c mice.

43 The potential supply of transplantable cadaver kidneys is often expressed as don

44 limited tumor growth in several human, solid transplantable cancers.

45 system that facilitates ex vivo expansion of transplantable CD34(+) thy-1(+) cells using long-term he

46 Neoplasia manifested as transplantable CD8+ lymphoma or leukemia, indicating tha

47 ant melanoma is the lack of mouse models and transplantable cell lines.

48 Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a pu

49 stage for more applied pursuits to generate transplantable cells for treating blood disorders.

50 stem cells (hESCs) are a potential source of transplantable cells for treating diabetes and are curre

51 antagonist, AGN 193109, on the generation of transplantable cells, including pre-CFU-S, short-term re

52 led recipients to resist growth of malignant transplantable cells.

53 to both ascites and solid cancers induced by transplantable cells.

54 lly reduce the mass of viable and functional transplantable cells.

55 tocytes could provide an unlimited supply of transplantable cells.

56 expressed in different in vivo passages of a transplantable ChC each contained immunoreactive phospho

57 ne-activating mutation in c-neu expressed in transplantable ChC.

58 higher in primary tumors than in a derived, transplantable cholangiocarcinoma serially-propagated in

59 -2 double KO mutants spontaneously developed transplantable CML-like myeloproliferative disease due t

60 Using a transplantable colon carcinoma model, we found that CD8(

61 e developed a model system in rats bearing a transplantable colon carcinoma sensitive to FUra therapy

62 dly prolonged and enhanced the production of transplantable colony-forming unit-spleen (CFU-S) during

63 tocol for the generation of a functional and transplantable corneal epithelium derived from human ind

64 ischemic injury could be discriminated from 'transplantable' DCD livers.

65 c system in Saccharomyces cerevisiae using a transplantable degron, CL1 (1).

66 AKT-initiated tumors were serially transplantable, demonstrating permanent genetic changes

67 There is a huge need for the availability of transplantable donor corneas worldwide to reduce the bur

68 responsible led to the discovery of serially transplantable, donor-derived, macroscopic, multilineage

69 hly efficient and reproducible production of transplantable dopamine progenitors from hESCs.

70 on of the dorso-ventral axis and activates a transplantable dorsal-determining activity in dorsal bla

71 library of shRNAs into individual mice using transplantable Emu-myc lymphoma cells.

72 is protein interaction domain functions as a transplantable endocytic sorting signal that is sufficie

73 essive, highly aneuploid, heterogeneous, and transplantable epithelial cancers in mice.

74 a et al. (2013) report a potential source of transplantable epithelial cells from fetal gut that can

75 se in transplanted mice, but caused a fatal, transplantable erythroleukemia instead.

76 CALR(del/+) mice develop a transplantable ET-like disease with marked thrombocytosi

77 The creation of a transplantable graft to permanently replace kidney funct

78 In initially transplantable HCC-cirr patients, ITT survival was bette

79 has moved the field closer to creation of a transplantable heart.

80 choice and preferable to (68)Ga-DOTA-JR11 in transplantable HEK293-hsst(2) tumors in mice.

81 emonstrated that expression of the G-CSFR on transplantable hematopoietic cells but not stromal cells

82 in telomere elongation and the formation of transplantable hematopoietic malignancies.

83 genomic instability, and the development of transplantable hematopoietic neoplasms with myeloprolife

84 uniparental ES cells can differentiate into transplantable hematopoietic progenitors in vitro that c

85 For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been

86 ilitate ex vivo maintenance and expansion of transplantable hematopoietic stem cells (HSCs) is vital

87 y marrow of adult zebrafish harbors about 10 transplantable hematopoietic stem cells; this tissue als

88 hat CD41-KO-associated defects are long-term transplantable, HSC-derived and, in part, mediated throu

89 hematopoiesis in adult axolotls and contain transplantable HSCs capable of long-term multilineage bl

90 The cells mature into transplantable HSCs in culture.

91 epresent an important step toward generating transplantable HSCs in vitro that are needed for autolog

92 utility of the human placenta as a source of transplantable HSCs.

93 e the value of ESCs as a potential source of transplantable HSCs.

94 n in air, resulting in increased recovery of transplantable HSCs.

95 tation in the ER from a tamoxifen-stimulated transplantable human breast tumor line.

96 orting the self-renewal and proliferation of transplantable human cord blood hematopoietic stem cells

97 Transplantable human haemopoietic cells could serve as a

98 human (SCID-hu) mice as an in vivo assay for transplantable human hematopoietic stem cells (HSCs).

99 al can be exploited to increase expansion of transplantable human HSCs and points to broader implicat

100 system that facilitates ex vivo expansion of transplantable human HSCs.

101 This need for transplantable human islets has stimulated efforts to ex

102 ll, differentiation, and near elimination of transplantable human LSCs in mice, while sparing normal

103 gate LHRH receptors in MRI-H255 and MRI-H187 transplantable human melanoma tumor lines.

104 This suggests that ex vivo expansion of transplantable human stem cells under this in vitro cult

105 igation of mesodermal development to produce transplantable human tissue progenitors and uncover deve

106 IBC phenotype by establishing a unique human transplantable IBC xenograft, MARY-X, which manifests fl

107 t, we report here that in a well-established transplantable (ID8 cell line) model of peritoneal/ovari

108 In addition, the tumors are serially transplantable in irradiated wild-type mice, underlying

109 lymphoproliferative disorder, which was not transplantable in late-stage disease into secondary reci

110 0%) developed AML resembling M2-AML that was transplantable in secondary recipients.

111 he abnormalities in leukocyte production are transplantable, indicating that the defect resides in th

112 multiple mice, the CML-like disease has been transplantable, inducing a similar myeloproliferative sy

113 his end, we have established the first human transplantable inflammatory breast carcinoma xenograft (

114 Generation of transplantable insulin-producing cells from human embryo

115 , but the myeloproliferative disease was not transplantable into secondary recipients.

116 Disease was transplantable into secondary recipients.

117 The tumors were transplantable into syngeneic immunocompetent mice.

118 eveloping mouse embryo the first definitive (transplantable-into-the-adult) haematopoietic stem cells

119 utic opportunity to improve the viability of transplantable islets.

120 A significant increase in transplantable kidneys could be achieved by extension of

121 d should compensation increase the number of transplantable kidneys, laws and regulations prohibiting

122 ten pumping less-than-ideal, yet potentially transplantable kidneys, may help reverse the trend.

123 ng seems a promising approach to produce new transplantable kidneys.

124 stnatal progenitor cell-based technology for transplantable large tissue-engineered constructs.

125 o myeloproliferative disease within days and transplantable leukaemias within weeks.

126 se that developed was shown to be a uniform, transplantable leukemia with both erythroid and megakary

127 p16/p19(-/-) bone marrow cells, we generated transplantable leukemia-initiating cells that rapidly in

128 disease progression culminating in serially transplantable leukemia.

129 liferative disorder (MPD) that progresses to transplantable leukemia.

130 Several transplantable lines were obtained from the RCCs, and on

131 In this study we show that the MinD MTS is a transplantable lipid-binding motif that can effectively

132 a proof of principle for the generation of a transplantable liver graft as a potential treatment for

133 we demonstrate a novel approach to generate transplantable liver grafts using decellularized liver m

134 the challenges of creating fully functional transplantable liver grafts with this whole liver engine

135 duct epithelial phenotypes in vitro, and (5) transplantable liver-repopulating cells.

136 in homing efficiency, 3.8-fold reduction in transplantable long-term hematopoietic stem cells (LT-HS

137 inst an inducible genetic melanoma model and transplantable lung and ovarian tumors, demonstrating po

138 ealthy syngeneic mice induces rapidly fatal, transplantable lymphoblastic leukemias that resist imati

139 When inoculated with a transplantable lymphoma cell line, EL4, the treated old

140 JAK3A572V induces an aggressive, fatal, and transplantable lymphoproliferative disorder characterize

141 -isoleucine signal acts in an autonomous and transplantable manner.

142 ssay in mice, we show here that gene-marked, transplantable marrow cells from the plastic-nonadherent

143 rom cultures of blood is mostly derived from transplantable marrow-derived cells.

144 binding sites for LHRH were detected in both transplantable melanoma tumor lines.

145 The helix also acts as an autonomous transplantable membrane binding domain capable of direct

146 al and spatial experimental designs and to a transplantable metastasis model derived from human cance

147 This study establishes a novel, transplantable model of murine histiocytic/myeloid sarco

148 xome sequencing of ID8, the most widely used transplantable model of ovarian cancer, covering 194,000

149 metastatic niche formation, we established a transplantable model of spontaneous melanoma brain metas

150 ively specific inducers of these tumors, but transplantable models and transgenic animals are also us

151 sion protein (Fc:TbetaRII) on transgenic and transplantable models of breast cancer metastases.

152 Using transplantable models of lung tumors in mice, we found t

153 e (restricted to BM and lymphoid tissues) to transplantable monoclonal T-cell leukemia/lymphoma scatt

154 (relative to the rapid growth rates of other transplantable mouse kidney tumors), propensity for lung

155 We tested this hypothesis using a transplantable mouse mammary tumor model.

156 In experiments using the B16 transplantable mouse melanoma, tumor-expressed chemerin

157 In a transplantable mouse model based on the EmuTCL1 transgen

158 A transplantable mouse MPNST-like melanoma cell line recap

159 s in all 10 mammary glands, and also using a transplantable mouse tumor model.

160 dings were further validated in mice bearing transplantable MT-RET-1 melanoma, in which L-NIL normali

161 ted rats, as well as in subsequently derived transplantable mucin-producing tumors.

162 late, respectively, to inhibit the growth of transplantable murine bladder cancer in vivo.

163 in a reduction of hematopoietic clusters and transplantable murine HSCs.

164 Using B16/BL6, a transplantable murine melanoma model, we show a dichotom

165 Transplantable murine models of ovarian high grade serou

166 There is a need for transplantable murine models of ovarian high-grade serou

167 fetal liver line, which supports culture of transplantable murine stem cells.

168 he basis for defective TIL lytic function in transplantable murine tumor models.

169 The most used models include transplantable murine tumors grown in syngeneic hosts an

170 , can be effective at inducing regression of transplantable murine tumors.

171 Transplantable, myelo-lymphoid hematopoietic stem/progen

172 125b alone in mice causes a very aggressive, transplantable myeloid leukemia.

173 Dnmt3a+/- mice also spontaneously developed transplantable myeloid malignancies after a long latent

174 lesterolemic mice, displayed leukocytosis, a transplantable myeloproliferative disorder, and a dramat

175 s the result of genetic knockdown, develop a transplantable myeloproliferative phenotype that closely

176 results depict human ES cells as a source of transplantable neural precursors for possible nervous sy

177 A possible source for transplantable neurons in Parkinson's disease are adult

178 population defined in these studies includes transplantable, non-self-renewing B lymphocyte progenito

179 ansformation, as they are polyclonal and not transplantable or immortal in cell culture.

180 gous thymic transplantation to produce a new transplantable organ (thymokidney) and to examine the fu

181 hanical properties promoted formation of 3D, transplantable organ buds from tissues including kidney,

182 at high risk of discard, though potentially transplantable organs are still being discarded.

183 It is important to identify new sources of transplantable organs because of the critical shortage o

184 The critical shortage of transplantable organs has resulted in the use of extende

185 urce utilization required for procurement of transplantable organs in an organ procurement organizati

186 As the need for transplantable organs increases, waiting lists of patien

187 The critical shortage of transplantable organs necessitates utilization of unconv

188 The shortage of transplantable organs provides an impetus to develop tis

189 There is an ever-growing demand for transplantable organs to replace acute and chronically d

190 and for development of a renewable source of transplantable organs via modified xenotransplantation.

191 nsplantation, given the critical shortage of transplantable organs, maximal benefit may be achieved b

192 T3/T4 therapy results in more transplantable organs, with no detriment to posttranspla

193 goal by increasing the number and quality of transplantable organs.

194 will save lives by increasing the number of transplantable organs.

195 thical framework to guide the procurement of transplantable organs.

196 tential solution to the critical shortage of transplantable organs.

197 f donor livers and improving the function of transplantable organs.

198 g viral infections are a potential source of transplantable organs.

199 th is seriously limited by acute shortage of transplantable organs.

200 an development, and to the creation of human transplantable organs.

201 trics as a means of increasing the supply of transplantable organs.

202 bowel donation was lower than for the other transplantable organs.

203 claim warm ischemic livers that would not be transplantable otherwise.

204 from aggressive mammary tumors derived from transplantable p53 null mouse mammary outgrowth lines re

205 bA1c levels between 3.5 and 6.2 in otherwise transplantable pancreata are not associated with differe

206 ous injection of either 250,000 cells of the transplantable pancreatic adenocarcinoma cell line Pan02

207 and wild type (WT) mice were injected with a transplantable pancreatic adenocarcinoma cell line.

208 We established a bank of transplantable patient-derived prostate cancer xenograft

209 ces regeneration of high-risk MM in serially transplantable patient-derived xenografts.

210 allowed obtaining an increase of potentially transplantable patients (+8.9% in training set and 24.6%

211 rcinoma (HCC) as the first-line treatment in transplantable patients followed by "salvage transplanta

212 8 months of age, over half developed readily transplantable PCT in lymph nodes, Peyer's patches, and

213 MSCV-Myc-induced AML was polyclonal, readily transplantable, possessed an intact Arf-p53 pathway, and

214 eminated lymphoma characterized by a clonal, transplantable pre-B-cell population of neoplastic lymph

215 Arf in mice triggers a highly aggressive and transplantable precursor B-ALL.

216 indings demonstrate that MDS originates in a transplantable, premalignant, long-term repopulating, MD

217 Using a two-compartment transplantable prostate tumor model in which survival of

218 s, Flt3-L treatment of mice with preexisting transplantable prostate tumors results in tumor regressi

219 ill also lead to improved disease models and transplantable prototypes with adult-like physiological

220 y was conceived for initially resectable and transplantable (R&T) hepatocellular carcinoma (HCC) pati

221 is a hallmark of epithelial cells from model transplantable rat prostate tumors that progress to mali

222 We identify a transplantable recycling sequence that is both necessary

223 s, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung

224 ed the first immortal cell line (SPARKY) and transplantable scid mouse xenograft (Sparky-X) from a ma

225 These observations define a transplantable signal mediating rapid recycling of a het

226 effective expansion of HCEC monolayers to a transplantable size with a normal HCEC density, through

227 id hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bon

228 iation-induced SJL acute myeloid leukemia, a transplantable spontaneous SJL lymphoma, and the C57BL/6

229 abeta T cells, we examined the growth of the transplantable squamous cell carcinoma (SCC) line, PDV,

230 In addition, maintenance of input levels of transplantable stem cell activity is accompanied by expa

231 at qualitatively and quantitatively supports transplantable stem cell activity present in highly puri

232 hese findings are relevant for generation of transplantable stem cell-derived beta-cells.

233 ells of both parental origins can form adult-transplantable stem cells and can repopulate an adult or

234 We also observe that transplantable stem cells are largely quiescent during o

235 gramming may be a strategy for derivation of transplantable stem cells for clinical application.

236 act on ex vivo manipulation and expansion of transplantable stem cells in clinical applications such

237 ividing tumors; however, neither ascitic nor transplantable subcutaneous tumors are predictive of act

238 rved in PLCgamma2(-/-) and Lyn(-/-) mice was transplantable, suggesting the involvement of an immune

239 ntileukemia activity induced by CpG ODN in a transplantable syngeneic pre-B ALL model.

240 To develop a syngeneic transplantable system to study immunotherapeutic approac

241 essing JAK3 mutants developed a long-latency transplantable T-ALL-like disease, characterized by an a

242 A-binding mutant developed an aggressive and transplantable T-cell lymphoma 4 to 10 months after tran

243 Different strategies to generate transplantable tissue grafts in vitro and harness host r

244 sue engineering involves the construction of transplantable tissues in which bone marrow aspirates ma

245 and reliable screening of donated blood and transplantable tissues.

246 This leukemia was transplantable to conditioned wild-type recipients.

247 The sarcomas are transplantable to immunologically compromised hosts, sho

248 the bone marrow (BM) stroma since it is not transplantable to irradiated wild-type recipients.

249 The MPN phenotype is transplantable to secondary recipient mice.

250 The leukemic cells were readily transplantable to secondary recipients and could be esta

251 The leukemia is transplantable to secondary recipients and is ATRA respo

252 developed acute myeloid leukemias that were transplantable to wild-type recipients.

253 diseases in humans because they solely used transplantable tumor lines, and instead of true tumor an

254 ults suggest the possibility of developing a transplantable tumor model in this large-animal system.

255 With a transplantable tumor model, we compared the efficacy of

256 Using the A20 B cell lymphoma as a transplantable tumor model, we demonstrate that this tum

257 ad statistically reduced tumor onset in both transplantable tumor models (FVB/n and BALB/c) and signi

258 ng cells in the tumor microenvironment using transplantable tumor models in mice.

259 restriction reduces prostate tumor growth in transplantable tumor models in rodents, which suggests t

260 In transplantable tumor models such as P1.HTR, tumors grow

261 etastatic effect than does wtIL-2 in several transplantable tumor models: the experimental metastasis

262 3 oncoprotein from its signaling function, a transplantable tumor system was developed.

263 ouse 4T1 mammary carcinoma, a BALB/c-derived transplantable tumor that shares many characteristics wi

264 A transplantable tumor was established after the transfer

265 tion in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postin

266 both T cells participated in resistance to a transplantable tumor.

267 od preparations of tumor cells and eradicate transplantable tumor.

268 origenic cells isolated from a furan-induced transplantable tumor.

269 Transplantable tumors are an accepted gold standard in c

270 t tumor growth and metastasis in the form of transplantable tumors derived directly from individuals

271 Transplantable tumors derived from human colon cancer ce

272 Furthermore, transplantable tumors derived from NAG-1 transfected HCT

273 First, transplantable tumors developing in a mouse expressing g

274 Second, transplantable tumors developing in chimeric mice recons

275 plete regression of primary, metastatic, and transplantable tumors following the ablation of c-Myc, s

276 The lack of transplantable tumors has limited assessment of graft-ve

277 e requirement of cathelicidin in controlling transplantable tumors in mice.

278 developing methods to screen chemicals using transplantable tumors in rodents.

279 Overall, this panel of transplantable tumors provides a resource for detailed e

280 The spectrum of transplantable tumors that were initially induced and ma

281 d to either enhance or inhibit the growth of transplantable tumors, depending on the system.

282 d against the transplant antigens present on transplantable tumors, not against the tumor-specific an

283 )Stro-1(+) cells efficiently formed serially transplantable tumors, whereas CD117(-)Stro-1(-) cells r

284 CD4(+) and CD8(+) T cells in three distinct transplantable tumors.

285 ased survival from and clearance of multiple transplantable tumors.

286 n stem-like cells that can initiate serially transplantable tumors.

287 the growth of primary carcinogen-induced and transplantable tumors.

288 ity of DC, and their impact on the growth of transplantable tumors.

289 dered mice more susceptible to the growth of transplantable tumors.

290 We present a transplantable tumour line, maintained in immune-comprom

291 approach using CRISPR-Cas9 genome editing in transplantable tumours in mice treated with immunotherap

292 o bioengineered mini-organs in vitro yielded transplantable units that also suppressed hyperglycemia

293 In this study, transplantable urinary bladder neo-organs were reproduci

294 Transgenerational effects were transplantable using diet-associated bacteria communitie

295 Transplantable vascularized bioengineered intestine coul

296 Overall, 32 stably transplantable xenograft lines were established, represe

297 Transgenic spontaneously occurring and transplantable xenograft models of adenocarcinoma of the

298 Both models yielded stably transplantable xenografts at comparably high rates ( app

299 xpressed MCSC-specific markers and generated transplantable xenografts in nude mice.

300 TN aggressive human breast tumors as well as transplantable xenografts obtained from SKBR3 expressed