ライフサイエンスコーパス: transplantation tolerance

1 Tregs may not have a central role in kidney transplantation tolerance.

2 autoimmune disorders as well as induction of transplantation tolerance.

3 ctions, autoimmune disease, and induction of transplantation tolerance.

4 n models and implicated strategies to induce transplantation tolerance.

5 ount for the antigen specificity of dominant transplantation tolerance.

6 he response to allogeneic tissues to promote transplantation tolerance.

7 sed in this study resulted in development of transplantation tolerance.

8 zed thymokidney transplantation that induced transplantation tolerance.

9 d signaling uniformly induces donor-specific transplantation tolerance.

10 le that may be required for the induction of transplantation tolerance.

11 may play a critical role in the induction of transplantation tolerance.

12 ncipal regulators of both self-tolerance and transplantation tolerance.

13 vances in the use of immunotherapy to induce transplantation tolerance.

14 -LFA therapy uniquely resulted in "dominant" transplantation tolerance.

15 ents of strategies being developed to induce transplantation tolerance.

16 irculation to the thymus in the induction of transplantation tolerance.

17 iate both induction and adoptive transfer of transplantation tolerance.

18 ti-CD154 mAb induces a state of "functional" transplantation tolerance.

19 ion of T-cell division by rapamycin promotes transplantation tolerance.

20 regimen for induction of mixed chimerism and transplantation tolerance.

21 r the inhibition of these pathways to induce transplantation tolerance.

22 presentation may have an adjunctive role in transplantation tolerance.

23 ritical for the induction and maintenance of transplantation tolerance.

24 graft acceptance and, in certain situations, transplantation tolerance.

25 otic pathways were resistant to induction of transplantation tolerance.

26 gulator, BLyS, may be effective in promoting transplantation tolerance.

27 conditioning regimen leads to donor-specific transplantation tolerance.

28 in cancers and possibly for the induction of transplantation tolerance.

29 t rejection and in some circumstances induce transplantation tolerance.

30 dult rats is capable of mediating long-lived transplantation tolerance.

31 4Ig is a well-established strategy to induce transplantation tolerance.

32 iod interrupts sensitization and may produce transplantation tolerance.

33 n the development of strategies for specific transplantation tolerance.

34 e expression and facilitate the emergence of transplantation tolerance.

35 en is a suitable target for the induction of transplantation tolerance.

36 approach for the induction of donor-specific transplantation tolerance.

37 a clinically relevant strategy to facilitate transplantation tolerance.

38 it these populations may be key to achieving transplantation tolerance.

39 ly regulate alloimmune responses and promote transplantation tolerance.

40 y which TLI/ATS/CTX conditioning may augment transplantation tolerance.

41 nd offer therapeutic potential for achieving transplantation tolerance.

42 ental models in which to study resistance to transplantation tolerance.

43 e control of autoimmunity and maintenance of transplantation tolerance.

44 T17 alloreactivity constitutes a barrier to transplantation tolerance.

45 transplantation can prevent the induction of transplantation tolerance.

46 her IL-6 and TNF-alpha promote resistance to transplantation tolerance.

47 a novel means to promote graft survival and transplantation tolerance.

48 thways may have therapeutic value to promote transplantation tolerance.

49 present general conditions for Treg-mediated transplantation tolerance.

50 nd may provide a novel approach to promoting transplantation tolerance.

51 ms used by B lymphocytes in the induction of transplantation tolerance.

52 onor-reactive Treg cells during induction of transplantation tolerance.

53 ing CD40-CD40L costimulatory signals induces transplantation tolerance.

54 rce of hematopoietic cells that could induce transplantation tolerance.

55 ation of anti-LFA/anti-ICAM reliably induced transplantation tolerance.

56 oci were not beneficial for the induction of transplantation tolerance.

57 ection and that their activation can prevent transplantation tolerance.

58 reagents for the induction of donor-specific transplantation tolerance.

59 vate adaptive immune responses that abrogate transplantation tolerance.

60 Ags by the mother is a physiologic model of transplantation tolerance.

61 s the detrimental effects of TLR agonists on transplantation tolerance.

62 eral and a well established model of central transplantation tolerance.

63 innate immune signaling in the induction of transplantation tolerance.

64 , clinically relevant strategy to facilitate transplantation tolerance.

65 lymphoid compartments play critical roles in transplantation tolerance.

66 otective role against allograft rejection in transplantation tolerance.

67 trategies to induce durable and reproducible transplantation tolerance.

68 whether testicular immune privilege promotes transplantation tolerance.

69 T cells by Foxp3 gene transfer could induce transplantation tolerance.

70 question: is B cell tolerance essential for transplantation tolerance?

71 of allochimeric protein with FTY720 induces transplantation tolerance, a state that may be associate

72 ote allogeneic SC engraftment with resulting transplantation tolerance across complete MHC barriers w

73 logeneic chimerism can induce donor-specific transplantation tolerance across full MHC barriers.

74 llografts to support thymopoiesis and induce transplantation tolerance across fully MHC-mismatched ba

75 tional vascularized thymic grafts can induce transplantation tolerance across fully MHC-mismatched ba

76 reconstitution and results in donor-specific transplantation tolerance across MHC disparities, withou

77 ore transplantation, could induce allogeneic transplantation tolerance across two-haplotype fully maj

78 suggest that regulatory T cells maintaining transplantation tolerance after CD4 Ab blockade can be i

79 nipulate thymic function in adults to induce transplantation tolerance after the age of thymic involu

80 as been hypothesized that regimens to induce transplantation tolerance and long-term hematopoietic ch

81 ripts shared with Th2 cells, suggesting that transplantation tolerance and normal immunoregulation ma

82 of innate immunity prevents the induction of transplantation tolerance and shortens skin allograft su

83 l production is critical in the induction of transplantation tolerance and the maintenance of durable

84 mechanisms explains the difficulty to induce transplantation tolerance and to develop reliable biomar

85 velopment of new strategies for induction of transplantation tolerance and treatment of cancer, chron

86 y cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Tr

87 roliferation can present to the induction of transplantation tolerance, and have important implicatio

88 rgets to prevent allograft rejection, induce transplantation tolerance, and inhibit autoimmune diseas

89 tailor Treg cells for cell therapy to induce transplantation tolerance are highlighted.

90 It appears that skin and islet transplantation tolerance are mediated by different CD4

91 nnate immune system impairs the induction of transplantation tolerance, but the responsible inflammat

92 st that Idd loci can facilitate induction of transplantation tolerance by costimulation blockade and

93 for induction and maintenance of peripheral transplantation tolerance by its ability to alter the ba

94 These data suggest that transplantation tolerance can be achieved by reducing th

95 hat durable hemopoietic chimerism and robust transplantation tolerance can be achieved without cytoto

96 Transplantation tolerance can be induced in animals and

97 Transplantation tolerance can be induced in mice by graf

98 i-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion

99 at the genetic threshold for normalizing the transplantation tolerance defect is higher than that for

100 Transplantation tolerance, defined as acceptance of a gr

101 Transplantation tolerance, defined as allograft acceptan

102 Transplantation tolerance depends on the right balance b

103 tivated T cells is one critical mechanism of transplantation tolerance, drugs such as ciclosporin tha

104 ft-versus-host disease (GVHD) protection and transplantation tolerance following allogeneic bone marr

105 use) results in donor-specific cross-species transplantation tolerance for subsequent nonvascularized

106 allografts, whereas a 90-day therapy induced transplantation tolerance (>200 days).

107 ft rejection can occur long after a state of transplantation tolerance has been acquired.

108 role of CD4(+) T regulatory cells (Treg) in transplantation tolerance has been established, putative

109 and alloantibodies on the ability to induce transplantation tolerance has not been elucidated.

110 assuming that autoimmunity and resistance to transplantation tolerance have a common basis.

111 Recent investigations using animal models of transplantation tolerance have demonstrated that immunor

112 Prior experimental strategies to induce transplantation tolerance have focused largely on modify

113 Agents that interfere with peripheral transplantation tolerance impair establishment of chimer

114 n indirectly presented donor peptide induces transplantation tolerance in a transiently immunosuppres

115 rompted this study to achieve donor-specific transplantation tolerance in adult recipients using a no

116 t rejection in one mouse strain, and achieve transplantation tolerance in another.

117 oward understanding the mechanistic basis of transplantation tolerance in experimental models, which

118 ould be generated in vitro and could promote transplantation tolerance in immunocompetent recipient m

119 nale for a safe approach for inducing robust transplantation tolerance in large animals and humans.

120 rived suppressor cells, for the induction of transplantation tolerance in light of new clinical trial

121 s has been shown to prevent the induction of transplantation tolerance in mice via the generation of

122 lass II molecules are effective in promoting transplantation tolerance in mice, which suggests that s

123 mune activation via TLRs is known to prevent transplantation tolerance in multiple animal models.

124 The inability to induce transplantation tolerance in NOD (H2g7) mice was associa

125 pothesis that autoimmunity and resistance to transplantation tolerance in NOD mice are distinct pheno

126 that mechanisms controlling autoimmunity and transplantation tolerance in NOD mice are not completely

127 f autoimmune diabetes and induction of islet transplantation tolerance in nonobese diabetic (NOD) mic

128 persistent gene expression and long-lasting transplantation tolerance in recipients of genetically m

129 lonal antibody therapy can be used to induce transplantation tolerance in rodent models.

130 is a powerful and effective means to achieve transplantation tolerance in rodent models.

131 gand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates.

132 of costimulatory signal 2 may induce a true transplantation tolerance in sensitized rats, as documen

133 Antigen-specific transplantation tolerance in the absence of immunosuppre

134 portant for the induction and maintenance of transplantation tolerance in the CTLA4-Ig plus bone marr

135 mit clinical SC engraftment and induction of transplantation tolerance in the future.

136 cyclosporine (CsA) has been shown to induce transplantation tolerance in the nonfunctional rat heter

137 to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, w

138 on the recipient RT1.Aa background to induce transplantation tolerance in the rat cardiac transplant

139 Transplantation tolerance in this model developed within

140 e immunomodulatory effect of DST in inducing transplantation tolerance in vivo.

141 identify a role for LIF in the regulation of transplantation tolerance in vivo.

142 eraction with LFA-1 form a central aspect of transplantation tolerance induced by anti-CD45RB therapy

143 n self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation block

144 ency do not correct resistance to peripheral transplantation tolerance induced by costimulation block

145 e diabetic mice and prevented acquisition of transplantation tolerance induced by costimulation block

146 lls exported from the thymus are critical to transplantation tolerance induced by intrathymic Ag inoc

147 or role in both the early and late phases of transplantation tolerance induced by the ALS, sirolimus,

148 of activated T cells (NFAT) pathway impairs transplantation tolerance induced with anti-CD154 antibo

149 Our results support the notion that transplantation tolerance, induced by class II gene tran

150 mportant implications for the development of transplantation tolerance-inducing strategies in primate

151 eic hematopoietic stem cells (HSCs) on organ transplantation tolerance induction and immune reconstit

152 Specifically, islet transplantation tolerance induction holds out the promis

153 We conclude that transplantation tolerance induction in mice treated with

154 The data suggest that transplantation tolerance induction protocols that incor

155 ic murine skin transplant model that resists transplantation tolerance induction when innate immunity

156 new generation of immunomodulating agents in transplantation tolerance induction.

157 d exhibit genetically dominant resistance to transplantation tolerance induction.

158 the H2g7 MHC, and precludes the induction of transplantation tolerance irrespective of MHC haplotype.

159 Transplantation tolerance is facilitated by activation-i

160 correlated with Th1 differentiation, whereas transplantation tolerance is frequently associated with

161 A major obstacle to transplantation tolerance is humoral immunity.

162 Transplantation tolerance is induced by perioperative ad

163 Transplantation tolerance is induced reliably in experim

164 A reliable, nontoxic method of inducing transplantation tolerance is needed to overcome the prob

165 The induction of transplantation tolerance is one of the primary goals fo

166 The state of transplantation tolerance is these hosts was documented

167 ulating alloimmune responses but its role in transplantation tolerance is unknown.

168 In experimental organ transplantation, tolerance is induced by administration

169 In studies of transplantation tolerance it appears that regulatory T c

170 Such signals may also provide a barrier to transplantation tolerance mediated by Tregs.

171 e investigated the role of chimerism in this transplantation tolerance model.

172 In transplantation tolerance, numerous regulatory populatio

173 ve T cells may be partly responsible for the transplantation tolerance observed in mice with defectiv

174 rior review has focused on the immunology of transplantation tolerance or development of phase 3 auto

175 -2 pathway to treat autoimmunity, facilitate transplantation tolerance, or potentiate tumor immunothe

176 resistance to costimulation blockade-induced transplantation tolerance phenotypes in NOD mice can be

177 The ability to induce durable transplantation tolerance predictably and consistently i

178 yeloablative conditioning using a peripheral transplantation tolerance protocol.

179 Clinical application of transplantation tolerance protocols may require patient

180 ll depletion is a critical component of many transplantation tolerance protocols.

181 Research in transplantation tolerance relies on application of succe

182 ve macrophages that mediate the induction of transplantation tolerance remain elusive.

183 Achieving transplantation tolerance remains an unresolved clinical

184 ntation have any effect on the generation of transplantation tolerance remains to be established.

185 Thus, transplantation tolerance requires both costimulatory bl

186 cal application of mixed chimerism to induce transplantation tolerance requires novel approaches to s

187 D25(+) T cells do have a suppressive role in transplantation tolerance, so do CD4(+)CD25(-) T cells,

188 oid or lymphoid dendritic cells (DC) induces transplantation tolerance suggests that adoptive transfe

189 recipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant s

190 MT) induces mixed chimerism that establishes transplantation tolerance, the preconditioning regimens

191 potential of experimental protocols inducing transplantation tolerance through mixed chimerism.

192 Induction of transplantation tolerance to alloantigens without genera

193 ar immune privilege fosters the induction of transplantation tolerance to allografts in both immunolo

194 c chimerism carries with it the induction of transplantation tolerance to any other tissue or organ f

195 tional vascularized thymic grafts permitting transplantation tolerance to be induced in a large anima

196 s studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts

197 indings to the generation and maintenance of transplantation tolerance to extrathymic tissue allograf

198 d anti-CD40L) to produce mixed chimerism and transplantation tolerance to fully major histocompatibil

199 D8, and CD154 (CD40 ligand) induces dominant transplantation tolerance to fully mismatched skin allog

200 matopoietic chimerism induces donor-specific transplantation tolerance to lung allografts.

201 Although transplantation tolerance to organ allografts has been a

202 ame target Ag (OVA) achieves Foxp3-dependent transplantation tolerance to OVA-expressing skin grafts,

203 apies targeting CD154 and LFA-1 for inducing transplantation tolerance to pancreatic islet allografts

204 pproach both issues by establishing specific transplantation tolerance to pig organ grafts.

205 imeric administration induced donor-specific transplantation tolerance to rat cardiac allografts.

206 rized thymic lobe (VTL) allografts to induce transplantation tolerance to renal allografts across a f

207 or bone marrow (DBM) infusion induces robust transplantation tolerance to skin allografts in mice.

208 (DCs) that might facilitate the induction of transplantation tolerance to the replacement tissues.

209 ligands CD80 and CD86, can be used to induce transplantation tolerance to vascularized allografts.

210 f 10 microg of alpha1h u70-77-RT1.Aa induced transplantation tolerance toward WF grafts in four of si

211 e treated with a protocol designed to induce transplantation tolerance toward WF heart allografts: a

212 the translation of strategies for promoting transplantation tolerance towards a new clinical era.

213 Donor-specific transplantation tolerance was induced by administration

214 When transplantation tolerance was induced to grafts mismatch

215 ism in the establishment of CTLA4-Ig-induced transplantation tolerance was investigated using reverse

216 In the context of transplantation tolerance, we present a hypothesis that

217 on of regulatory cells to the development of transplantation tolerance, we suggest the possibility th

218 ly study the role of Fas in the induction of transplantation tolerance, we used Fas mutant B6.MRL-lpr

219 onor hematopoietic repopulation and specific transplantation tolerance were achieved in mice treated

220 ecipient-type sequences were shown to induce transplantation tolerance when administered at the time

221 applicable approach for induction of "true" transplantation tolerance where chronic rejection is con

222 Therefore, the achievement of transplantation tolerance will likely require induction

223 Induction of transplantation tolerance with certain therapeutic nonde

224 ods for inducing hematopoietic chimerism and transplantation tolerance, with a special emphasis on re

225 w chimerism reliably produces donor-specific transplantation tolerance without immunosuppressive drug

226 Induction of islet transplantation tolerance would be far preferable.