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1 a direct interaction of Gbetagamma with the transporter.
2 etion of Slc6a2 or inhibition of the encoded transporter.
3 ts an intracellular regulatory module of the transporter.
4 se are also accomplished by the deprotonated transporter.
5 One possibility invokes misexpression of a transporter.
6 This effect is mediated by the Glut4 glucose transporter.
7 using major structural rearrangements in the transporter.
8 nt of the initiation of apoptosis by the ion transporter.
9 B/CusC to form the CusCBA periplasm membrane transporter.
10 erol/CHS in Drosophila melanogaster dopamine transporter.
11 d the carbohydrate specificities of each PTS transporter.
12 on its function as a plasma membrane folate transporter.
13 thology due to loss of the Golgi GDP mannose transporter.
14 onstrated that SLC25A3 functions as a copper transporter.
15 r and might be overcome by inhibition of the transporter.
16 opment, as well as the transport of some ion transporters.
17 part mediated by ATP-binding cassette (ABC) transporters.
18 dynamically regulated by Cl(-) channels and transporters.
19 ithout modifying the expression of the other transporters.
20 1;7 and 1;8 to function as high affinity Pi transporters.
21 paradigm for this class of secondary active transporters.
22 n Vibrio cholerae, there are 13 distinct PTS transporters.
23 lular compartmentalization, specifically for transporters.
25 ile increasing the function of the glutamate transporter 1 (GLT-1) and system xC- (Sxc) in the nucleu
26 al nerve (TN), and using Vesicular GLUtamate Transporter 1 (VGLUT1) and the 65 kDa isoform of glutami
27 e by gamma-aminobutyric acid (GABA) membrane transporter 1 immunoreactivity is lower, whereas the den
28 orter levels were higher and glial glutamate transporter 1 levels were lower in the DH of female, but
29 ructural studies suggest that GLUT1 (glucose transporter 1)-mediated sugar transport is mediated by a
30 sion upregulates ferritin and divalent-metal-transporter-1 (DMT-1), indicating PrP(C)-mediated iron u
34 RP projections coexpress vesicular glutamate transporter 2 (VGLUT2), providing evidence that excitato
35 TH1-S31E associated with vesicular monoamine transporter 2 (VMAT2) and alpha-synuclein in neuroblasto
37 novel, highly selective vesicular monoamine transporter 2 inhibitor that demonstrated favorable effi
40 mal tubules express transmembrane fatty acid transporter-2 (FATP2), encoded by Slc27a2, but not the o
41 rt-term treatment with the sodium-glucose co-transporter-2 (SGLT2) inhibitor empagliflozin reduced al
42 icking of the neuronal excitatory amino acid transporter 3 (EAAT3) blocks potentiation, suggesting th
43 oid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cause severe psychomotor retardatio
44 en proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of
46 with cis-expression of a reverse cholesterol transporter (ABCG1; P=7.2E-28) and incident cardiovascul
47 at alterations in the electrogenicity of the transporters accompanied changes in substrate specificit
49 ortant switch loop of the trimeric multidrug transporter AcrB separates the access and deep drug bind
50 Our results suggest that the phospholipid transporter activity of ALA1/ALA2 may be necessary for t
57 ance, lower brain glucose uptake and glucose transporters, alterations in glycolytic and acetate meta
58 the rhizosphere, the high-affinity ammonium transporters (AMTs) in Arabidopsis thaliana are efficien
60 se caused by mutation of glucose-6-phosphate transporter and characterized by altered glycogen/glucos
61 pression of the miR-183 cluster reduced zinc transporter and intracellular zinc levels in benign pros
62 complex (uniplex), an inner membrane Ca(2+) transporter and major pathway of mitochondrial Ca(2+) en
63 t systems, apical sodium-dependent bile acid transporter and Na(+) -taurocholate cotransporting polyp
65 evisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) a
66 were studied with tracers for the serotonin transporter and vesicular monoamine transporter 2 (VMAT2
67 restricted oxygen availability and specific transporters and catabolic pathways activated with incre
68 consistent with the known mechanisms of TRAP transporters and consider how the role of sugar oxidatio
69 expression of major hepatocellular bile salt transporters and cytochrome P450 7a1, the key regulator
70 cells resist, as they are well equipped with transporters and enzymes to regulate intracellular pH ho
71 by analyzing experimental structures of urea transporters and proteins crystallized in the presence o
74 different databases; genes encoding membrane transporters and their regulators were enriched, highlig
75 athway, leading to reduced expression of MDR transporters and thereby an increased accumulation of so
76 g pathway, as well as transcription factors, transporters, antioxidant enzymes, and enzymes associate
78 hanisms is puzzling because CLC channels and transporters are expected to share the same architecture
80 C were substrate-type releasers at monoamine transporters as determined in vitro, but only methylone
81 dels have been developed using bacterial ABC transporters as templates but these have low sequence si
82 cuses on some of these lysosomal enzymes and transporters, as well as current therapies that have eme
83 metabolites was then compared using in vitro transporter assays and in vivo microdialysis in rat nucl
84 proteasome and transported to the ER by the transporter associated with antigen processing (TAP).
85 al steps in the transport cycle by recording transporter-associated currents: the recovery rate of ca
87 LptB2FG is unique among ATP-binding cassette transporters because it extracts lipopolysaccharide from
90 icant group differences in striatal dopamine transporter binding (all age ranges in caudate and putam
91 2 binding, (18)F-FDOPA uptake, and serotonin transporter binding in multiple brain regions were compa
92 Parkinson's disease show increased serotonin transporter binding in the striatum, brainstem, and hypo
94 ression of regulation of Ca(2+) channels and transporters can cause acquired arrhythmias, and how the
95 rst experimental evidence that synthetic ion transporters can disrupt both autophagy and induce apopt
96 port-elicited ubiquitylation of the arginine transporter Can1 is promoted by transition to an inward-
98 0, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metabolism diso
99 ed increased translocation of the fatty acid transporter CD36 from its endosomal storage compartment
102 e basal forebrain increased cortical choline transporter (CHT)-mediated choline transport in GTs, par
103 ction due to loss of the endolysosomal Cl(-) transporter ClC-b/CLCN7 delayed degradation of internali
105 d in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexp
107 s of astaxanthin biosynthesis, including ABC transporters, cytochrome P450 enzymes, and an acyltransf
109 uman alpha-synuclein A53T mutant or dopamine transporter (DAT) blockers also differentially affects t
110 To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic rapid e
111 We report here an atypical dopamine (DA) transporter (DAT) inhibitor, CTDP-32476, that may have t
113 tolerance to cocaine effects at the dopamine transporter (DAT) with aberrant cocaine-taking behaviors
114 duction of potassium channels and amino acid transporters, derepression of genes marked with histone
117 system that utilizes both activity-dependent transporter downregulation and regulation of transporter
118 ism of dietary salt excretion relies on urea transporter-driven urea recycling by the kidneys and on
119 MalE, and maltose on the conformation of the transporter during the transport cycle, we have reconsti
120 n the contribution of the neuronal glutamate transporter EAAC1 to the onset of compulsive behaviors.
121 machinery, including the vesicular glutamate transporter eat-4/VGLUT, induction of neuropeptide expre
122 bstituent of 4-MA reduces potency to inhibit transporters, eliminates substrate activity at DAT and N
123 ished models and that acquisition of a third transporter enhances the ability of the bacterium to cau
126 P6 also interacts with ZIP10 and the two ZIP transporters exhibit interdependency during their expres
127 ne triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hep
131 ton binding to the extracellular side of the transporter facilitates a reorientation from an inward-
133 The multidrug and toxin extrusion (MATE) transporter family comprises 70 members in the Medicago
135 Lotus japonicus nitrate transporter1/peptide transporter family, LjNPF8.6 The phenotypic characteriza
136 ochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal
138 Although mammalian Ctr1 functions as a Cu(+) transporter for Cu acquisition and is essential for embr
140 accharomyces cerevisiae and C. albicans have transporters for farnesylated peptides, like the a-facto
147 why NasA, NarK1 and NarK2, as well as other transporters from this protein family, have such differe
148 n of proteins between synapses, and chloride transporter function at excitatory and inhibitory synaps
150 ires adjustment of ion channel, receptor, or transporter function in response to changes in membrane
152 re- recombinase expression is under dopamine transporter gene (DAT) promoter control to ablate Cnr2 g
153 Analysis of shikimic acid accumulation, ABC-transporter gene expression, and cell death were used to
158 of cell cycle, meiosis-related and nutrient transporter genes, suggesting a fine control of nutrient
159 nregulation of the glial glutamate-aspartate transporter (GLAST), which causes an enhancement of the
161 ion, reduces sulfenylation of SIRT6, glucose transporter Glut1 expression, glucose uptake, and glycol
164 firing, nerve terminals rely on the glucose transporter GLUT4 as a glycolytic regulatory system to m
165 aracterisation of high affinity and specific transporters has implications for the marine phosphorus
168 but have a two-protein system comprised of a transporter (i.e., CblT) and a kinase (i.e., CblS) that
169 dly elevated expression of the GLUT1 glucose transporter in lung SqCC, which augments glucose uptake
174 and supports the centrality of these "drug" transporters in independently and synergistically regula
176 role in regulating the function of dopamine transporters in the striatum.SIGNIFICANCE STATEMENT Deli
177 le for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression an
178 dynamics trajectories of the human dopamine transporter, in which multiple spontaneous Na(+) release
179 by the protein siderocalin-a mammalian metal transporter-in contrast to the negatively charged specie
182 n, a rho-kinase inhibitor and norepinephrine transporter inhibitor, in patients with open-angle glauc
184 lular defense protein P-glycoprotein, termed transporter interfering compounds (TICs), ranged from 0.
185 conditions stimulates the ferroportin (FPN) transporter internalization, impairing the iron absorpti
186 tes affect the function of a monocarboxylate transporter involved in nutrient flux and hepatic lipid
187 change the expression of the following liver transporters involved in drug clearance: SLC10A1, SLC22A
191 ana auxin efflux transporter pin1 and influx transporter lax2 mutants showed reduced vein numbers.
193 sion imaging studies show increased dopamine transporter levels, but changes in other aspects of dopa
194 otein (P-gp) is a polyspecific ATP-dependent transporter linked to multidrug resistance in cancer; it
195 domain protein as a regulator of plant metal transporter localization, providing evidence that PH dom
196 her, or both, the glial and neuronal glycine transporters markedly decreased PV+ IN excitability, as
197 hagosomal transport systems and the pathogen transporter may serve as therapeutic targets for infecti
199 The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conduc
200 handle iron, highlighting how iron and heme transporters mediate the exchange and distribution of bo
206 gy modeling supported the alternating access transporter model for sugar transport by confirming at l
207 gradient copolymer, resulting in two protein transporter molecules more efficacious than currently co
208 vating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cause s
209 transport activity of two other major efflux transporters, multidrug resistance protein 2 and breast
213 C4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regulates intracellular pH (pHi)
215 two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, originally NKT)
216 ned that low expression of the ergothioneine transporter OCTN1 (SLC22A4; ETT) strongly predicts poor
217 tions, we suggest that CENP-F might act as a transporter of mitochondria and other cellular cargoes b
218 have characterized a nodule-specific citrate transporter of the multidrug and toxic compound extrusio
219 pressed in the CNS and the major anterograde transporters of cargos, such as mitochondria, synaptic v
220 vering that their association with magnesium transporters of the cyclin M (CNNM) family causes a rise
221 eal unique and opposing functions for copper transporters of the host and pathogen during infection.
222 enine, creatinine, urate) include two "drug" transporters of the organic anion transporter (OAT) fami
223 dicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl
224 T10-1 and TbAAT2-4 as the parasite ornithine transporters, one of which can be modulated by histidine
225 es the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by ABCB1 in hu
228 Arabidopsis (Arabidopsis thaliana) phosphate transporter PHO1;H3 comprising MYB15, MYB84, bHLH35, and
229 ally, both Arabidopsis thaliana auxin efflux transporter pin1 and influx transporter lax2 mutants sho
230 f the cell, suggesting that the two types of transporters play different roles in glucose sensing.
231 ETRATION 3 (PEN3) ATP binding cassette (ABC) transporter plays a role in defense against numerous pat
232 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from
234 synaptic termination, and the glutamatergic transporter profiles of DCN A and C fibers and their rel
239 ng glucose reabsorption by sodium glucose co-transporter proteins (SGLTs) in the kidneys is a relativ
241 ins necessary for PT function, including ion transporters, receptors, and membrane-trafficking machin
242 chiometries of electrogenic secondary active transporters reconstituted in proteoliposomes by measuri
243 enolic inhibitors of SGLT1 and GLUT2 glucose transporters, reduced the glucose transport of almost 10
244 confirmed that the plasma membrane-localized transporter (renamed CDR6/ROA1 for consistency with C. a
245 .4-fold, consistent with blood-to-hepatocyte transporter repression (Slco1a1, Slc10a1, Slco2b1, Slco1
246 bly expressing specific uptake and/or efflux transporters revealed that OATP1B1, OATP1B3, and OATP1A2
248 sized that biosynthesis of the selenium (Se) transporter selenoprotein P (SELENOP) is particularly se
250 number of PET studies imaging the serotonin transporter (SERT) have been used and provided evidence
251 FP-CIT has modest affinity for the serotonin transporter (SERT), predominantly represented in extrast
255 and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutro
256 tinal reabsorption due to induction of ileal transporters (Slc10a2, Slc51a) and increases in whole gu
257 d significantly increased levels of the urea transporter SLC14A1 in the OVT73 striatum, along with ot
258 based on structural data from related anion transporters (SLC26Dg and UraA), to have a 7 + 7 inverte
259 rnal polymorphism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal stress is rep
261 However, mutations made within the predicted transporter substrate channel differentially altered the
262 of the biosynthetic pathways, exemplify how transporter substrate specificities originate and evolve
265 gic layer, substrate affinities of expressed transporters suggest that, in addition to amino acids, p
266 the structure and mechanism of an entire ABC transporter superfamily and the many diverse functions i
267 ment of short-chain lipids in activating the transporter supports a model for regulation within the h
269 transporter downregulation and regulation of transporter synthesis by internal nutrient levels can cr
270 From differential expression of bacterial transporter systems, we hypothesize that nine diatom met
271 water column, with yet higher abundances of transporters targeting aromatic compounds in the bathype
272 entified nuclear export factor 3 (NXF3) as a transporter that alters the nucleocytoplasmic distributi
273 rotein MRP1 is an ATP-binding cassette (ABC) transporter that confers resistance to many anticancer d
274 racts with the conserved regions in the LAT1 transporter that have been shown to bind to cholesterol/
275 e nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal e
276 P14 (SLC39A14) is viewed primarily as a zinc transporter that is inducible via proinflammatory stimul
277 FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapoptosis and may be an a
278 ansport is mediated by an alternating access transporter that successively presents exofacial (e2) an
280 in large (MmpL) proteins are cell wall lipid transporters that are important for basic mycobacterial
281 purified P-gp and other ATP-binding cassette transporters that transport amphipathic or hydrophobic s
282 ds and organic cations may interact with the transporter through different functional groups some of
284 encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xenob
286 f the molybdate transporter family Molybdate Transporter type 1 (MOT1) were identified in the model l
288 T-type calcium channel variants and 1 ABCB1 transporter variant were associated with differential dr
290 u hybridization to label vesicular glutamate transporters (vglut1, vglut2.1, vglut3), glutamate decar
293 crystal structure of an NST, the GDP-mannose transporter Vrg4, in both the substrate-free and the bou
295 s cytoplasmic chaperones and plasma membrane transporters, whereas CopR/S responds to periplasmic Cu(
296 ma membranes occurs via the large amino acid transporter, which is overexpressed in malignant cells,
300 266634 in the SLC30A8 gene encoding the zinc transporter ZnT8, is associated with an increased risk f
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