ライフサイエンスコーパス: transverse aortic constriction

1 subjected them to mechanical stress in vivo (transverse aortic constriction).

2 athological cardiac hypertrophy and HF after transverse aortic constriction.

3 ) loading compared with wild-type mice after transverse aortic constriction.

4 sis, and systolic dysfunction in response to transverse aortic constriction.

5 th global deletion of GRK5 were subjected to transverse aortic constriction.

6 oped sustained ventricular tachycardia after transverse aortic constriction.

7 vivo rescues mice from early mortality after transverse aortic constriction.

8 type (WT) and IL10 knockout (IL10KO) mice by transverse aortic constriction.

9 hibited cardiac myocyte apoptosis induced by transverse aortic constriction.

10 this association is disrupted in response to transverse aortic constriction.

11 was significantly upregulated in response to transverse aortic constriction.

12 loped cardiac insufficiency at 2 weeks after transverse aortic constriction.

13 n utero and that have subsequently undergone transverse aortic constriction.

14 ly and after inducing cardiac hypertrophy by transverse aortic constriction.

15 worsened hypertrophy/fibrosis from sustained transverse aortic constriction.

16 nal response to pressure overload induced by transverse aortic constriction.

17 d form of cardiac hypertrophy in response to transverse aortic constriction.

18 mice were subjected to pressure overload by transverse aortic constriction.

19 osed to chronic pressure overload induced by transverse aortic constriction.

20 d hypertrophic gene induction in response to transverse aortic constriction.

21 odel of chronic pressure overload induced by transverse aortic constriction.

22 MAO (0.12%) starting 3 weeks before surgical transverse aortic constriction.

23 n the mouse was achieved following 7 days of transverse aortic constriction.

24 milar findings were seen in HFpEF induced by transverse aortic constriction.

25 ckouts had delayed dilation after 28 days of transverse aortic constriction.

26 Mice were studied for 12 weeks after transverse aortic constriction.

27 recovery of failing hearts after reversible transverse aortic constriction.

28 fibrosis, and contractile dysfunction after transverse aortic constriction.

29 in a maladaptive cardiac phenotype following transverse aortic constriction.

30 bit less NFAT transcriptional activity after transverse aortic constriction.

31 roblasts were derived from bone marrow after transverse aortic constriction.

32 arly progression to heart failure seen after transverse aortic constriction.

33 ntained cardiac structure and function after transverse aortic constriction.

34 myocardial and circulating H2S levels after transverse aortic constriction.

35 versing established cardiac remodeling after transverse aortic constriction.

36 t alter the progression of hypertrophy after transverse aortic constriction.

37 s in Ins(1,4,5)P3 and IP3-R(2) are caused by transverse aortic constriction.

38 ac-specific Nox4 knockout mice 2 weeks after transverse aortic constriction.

39 ncreased mortality from cardiac stress after transverse aortic constriction, 5) abnormal mitochondria

40 ofibroblasts; however, after 7 to 28 days of transverse aortic constriction, a subset of cardiomyocyt

41 Transverse aortic constriction activated FYN in the left

42 fibrosis and pathology in mice subjected to transverse aortic constriction after the consumption of

43 in amino acids were observed after 1 week of transverse aortic constriction and 5 days after MI.

44 altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylati

45 Transverse aortic constriction and angiotensin-II (Ang-I

46 ted cardiac hypertrophy in mice subjected to transverse aortic constriction and improved cardiac func

47 Longer duration of transverse aortic constriction and MI led to a decrease

48 Both transverse aortic constriction and MI were associated wi

49 nd after hypertrophic stimulation, including transverse aortic constriction and phenylephrine treatme

50 Mice underwent transverse aortic constriction and serially followed up

51 ostcontrast T1 measurements, was elevated by transverse aortic constriction and showed direct linear

52 dothelium were both activated in response to transverse aortic constriction and the kinetics of LV T-

53 ersibly repressed gene in mouse hearts after transverse aortic constriction and was normalized after

54 on and dysfunction than wild-type mice after transverse aortic constriction, and cardiac-specific CSE

55 expression was induced in aortic SMCs after transverse aortic constriction, and Foxe3 deficiency inc

56 ultured cardiomyocytes, pressure overload by transverse aortic constriction, and myocardial infarctio

57 Mice underwent transverse aortic constriction, and the characteristics

58 is unchanged in CycD2(-/-) myocardium after transverse aortic constriction, and there is no dissocia

59 with angiotensin II or pressure overload by transverse aortic constriction as measured by echocardio

60 Following chronic transverse aortic constriction, both SUR1-tg and Kir6.2

61 attenuated cardiac hypertrophic responses to transverse aortic constriction but unchanged cardiac fun

62 Four weeks after transverse aortic constriction, Carabin-deficient (Carab

63 d preserved LV ejection fraction (61+/-2% in transverse aortic constriction cardiac Nix KO versus 36+

64 remodeling in Akt-nuc transgenic mice after transverse aortic constriction coincident with higher AN

65 ntly increased in mouse hearts after chronic transverse aortic constriction, coincident with the onse

66 tively, in perivascular fibrotic areas after transverse aortic constriction compared with sham-treate

67 latively protected from HF development after transverse aortic constriction compared with wild-type l

68 to pressure overload at 5 and 9 weeks after transverse aortic constriction compared with wild-type-t

69 t of heart failure associated with long-term transverse aortic constriction, conferring a survival be

70 left ventricular vasculature in response to transverse aortic constriction, corresponding to decreas

71 ecific (Nkx2.5-Cre) Nix KO mice subjected to transverse aortic constriction developed significantly l

72 Likewise, transverse aortic constriction-elicited increases in hyp

73 n II infusion (2.5 microg/kg for 14 days) or transverse aortic constriction for 28 days to provoke ca

74 C57/Bl6 mice underwent transverse aortic constriction for 4 weeks, increasing c

75 In a mouse model of transverse aortic constriction, galectin-3 expression wa

76 ng and systolic and diastolic dysfunction in transverse aortic constriction groups as expected.

77 The Cav-3 OE mice subjected to transverse aortic constriction had increased survival, r

78 ctivity remained preserved even in untreated transverse aortic constriction hearts.

79 occurred prior to any functional decline in transverse aortic constriction hearts.

80 left anterior descending artery ligation and transverse aortic constriction HF mouse models after 4 a

81 ment (10 mg/kg/day), initiated 4 weeks after transverse aortic constriction, improved survival and ca

82 velopment in nonischemic forms of HF such as transverse aortic constriction in mice.

83 verload was imposed on the left ventricle by transverse aortic constriction in the wild-type and in m

84 mic metabolism in male C57BL/6 mice model of transverse aortic constriction in which left ventricular

85 and Kir6.2 KO mice had decreased FOXO1 after transverse aortic constriction, in agreement with the re

86 In mice with myocardial hypertrophy after transverse aortic constriction, in pigs with chronic myo

87 In heart tissue, transverse aortic constriction increased active transfor

88 Although transverse aortic constriction induced a similar increas

89 In addition, transverse aortic constriction induced puma expression i

90 In control mice, 4 weeks of transverse aortic constriction induced significant cardi

91 ed in an attenuated hypertrophic response to transverse aortic constriction-induced (TAC-induced) pre

92 d IL10KO mice (IL10KO chimeric mice) reduced transverse aortic constriction-induced BM-FPC mobilizati

93 tary supplementation with fish oil prevented transverse aortic constriction-induced cardiac dysfuncti

94 row transplantation in IL10KO mice inhibited transverse aortic constriction-induced cardiac fibrosis

95 ated viral vector encoding Carabin prevented transverse aortic constriction-induced cardiac hypertrop

96 Transverse aortic constriction-induced HF results in inc

97 dioprotective response of IL-10 was found in transverse aortic constriction-induced hypertrophy and h

98 unction and survival in the chronic phase of transverse aortic constriction-induced hypertrophy.

99 lly, we show altered S427 phosphorylation in transverse aortic constriction-induced hypertrophy.

100 Whereas control mice manifested robust transverse aortic constriction-induced increases in card

101 ox2KO), and wild-type mice were subjected to transverse aortic constriction-induced pressure overload

102 pha gene deficiency also exacerbated chronic transverse aortic constriction-induced ventricular hyper

103 in response to myocardial stresses including transverse aortic constriction, ischemia/reperfusion inj

104 We further stressed transverse aortic constriction mice by feeding a high fr

105 nferior right ventricular insertion point of transverse aortic constriction mice concordant with the

106 Transverse aortic constriction mice displayed compensate

107 Moreover, CMs isolated from transverse aortic constriction mice treated with MR-409

108 Compared with transverse aortic constriction mice, transverse aortic c

109 aortic constriction compared with wild-type-transverse aortic constriction mice.

110 +/-1.6% versus 27.6+/-1.4% in wild type plus transverse aortic constriction mice; P<0.0001).

111 .9+/-1.2% versus 25.9+/-2.6% in control plus transverse aortic constriction mice; P<0.0001).

112 ression of cardiac remodeling in a long-term transverse aortic constriction mouse model.

113 Twelve weeks post transverse aortic constriction, myocardial tissues were

114 Transverse aortic constriction-operated mice showed sign

115 expressing mice demonstrated protection from transverse aortic constriction or Ang-II-induced patholo

116 d in cardiac tissue from mice in response to transverse aortic constriction or expression of activate

117 he cluster miR-212/132 was upregulated after transverse aortic constriction or on activation of alpha

118 Male C57BL/6J mice were subjected to transverse aortic constriction or permanent coronary occ

119 n of the CryAB/HSPB2 genes were subjected to transverse aortic constriction or sham surgery.

120 Mice were subjected to transverse aortic constriction or sham surgery.

121 d 3.5-fold compared with sham controls after transverse aortic constriction (P<0.01).

122 In a mild model of cardiac hypertrophy after transverse aortic constriction, PDE3 effects were not af

123 In wild-type mice, angiotensin II and transverse aortic constriction perturbations caused left

124 ed with transverse aortic constriction mice, transverse aortic constriction plus deoxycorticosterone

125 nsistently, inhibition of Meg3 in vivo after transverse aortic constriction prevented cardiac MMP-2 i

126 re, T-cell depletion in wild-type mice after transverse aortic constriction prevented HF.

127 Most die within 1 h of transverse aortic constriction, probably due to arrhythm

128 Even at 12 weeks after transverse aortic constriction, Puma(-/-) mice displayed

129 Transverse aortic constriction rats progressively develo

130 HF patients or from mice with HF induced by transverse aortic constriction revealed enhanced adhesio

131 After transverse aortic constriction, S2814A mice did not exhi

132 TRPC6-deficient mouse hearts 1 week after transverse aortic constriction showed comparable increas

133 Hemodynamic loading imposed by 7 days of transverse aortic constriction showed that the beta1 int

134 scription were measured in sham-operated and transverse aortic constriction (studied 2 weeks later) m

135 on and aconitase activity was decreased with transverse aortic constriction, suggesting that G6PD def

136 57Bl/6 mice were subjected to either sham or transverse aortic constriction surgery to induce HF.

137 Eight weeks after transverse aortic constriction surgery, mice were divide

138 osition to sudden arrhythmogenic death after transverse aortic constriction surgery.

139 uced arrhythmias versus wild-type mice after transverse aortic constriction surgery.

140 In response to transverse aortic constriction, T cell-deficient mice (T

141 ld-type mouse as a control for in vivo PO by transverse aortic constriction (TAC) and for cultured ca

142 METHODS AND miR-133a is downregulated in transverse aortic constriction (TAC) and isoproterenol-i

143 ed hypertrophy and early heart failure after transverse aortic constriction (TAC) because of GRK5 nuc

144 C57BL/6 mice subjected to transverse aortic constriction (TAC) developed cardiac h

145 Male C57/Bl6 mice underwent transverse aortic constriction (TAC) for 1 week followed

146 Mice were subjected to transverse aortic constriction (TAC) for 1 week, after w

147 ic expression of betaARKct peptide underwent transverse aortic constriction (TAC) for 12 weeks.

148 Mice were subjected to transverse aortic constriction (TAC) for 3 weeks to esta

149 pe (WT) and SPARC-null mice underwent either transverse aortic constriction (TAC) for 4 weeks or serv

150 Similarly, pressure overload induced by transverse aortic constriction (TAC) for 6 weeks caused

151 We performed transverse aortic constriction (TAC) in dopamine beta-hy

152 ardiac hypertrophy was induced using 4 wk of transverse aortic constriction (TAC) in mice overexpress

153 In WT and KO mice, transverse aortic constriction (TAC) induced comparable

154 of T cells in the progression to HF using a transverse aortic constriction (TAC) model.

155 ins from heart tissues of wild type (WT) and transverse aortic constriction (TAC) mouse models were a

156 tion and pathological development induced by transverse aortic constriction (TAC) or isoproterenol in

157 underwent experimental pressure overload by transverse aortic constriction (TAC) or myocardial infar

158 ls and reduced cardiac hypertrophy following transverse aortic constriction (TAC) or phenylephrine/An

159 In wild-type mice, chronic transverse aortic constriction (TAC) resulted in myocard

160 e model of pressure-overload-induced HF with transverse aortic constriction (TAC) surgery and compare

161 Mice underwent transverse aortic constriction (TAC) surgery and deoxyco

162 es linked to inflammation and fibrosis after transverse aortic constriction (TAC) surgery, a pressure

163 d-induced heart muscle hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5'

164 )) and wild-type (WT) mice were subjected to transverse aortic constriction (TAC) to increase left ve

165 AC6-KO and control (CON) mice underwent transverse aortic constriction (TAC) to induce pressure

166 In the reverse direction, we used transverse aortic constriction (TAC) to induce pressure

167 during hypertrophy, we subjected animals to transverse aortic constriction (TAC) to induce pressure

168 st this hypothesis, we used a mouse model of transverse aortic constriction (TAC) together with PET a

169 3) on the development of heart failure after transverse aortic constriction (TAC) using global and T-

170 Transverse aortic constriction (TAC) was applied to MAFb

171 Transverse aortic constriction (TAC) was performed in CD

172 After 4 weeks of aortic banding (transverse aortic constriction (TAC)), increases in left

173 After 8 weeks of pressure overload via transverse aortic constriction (TAC), ACC2H-/- mice exhi

174 e left ventricle of male C57BL/6J mice after transverse aortic constriction (TAC), and the fraction o

175 After transverse aortic constriction (TAC), G4D mice developed

176 ute cardiac remodeling events in response to transverse aortic constriction (TAC), including temporal

177 30 activation is observed transiently during transverse aortic constriction (TAC), its mechanism of i

178 At 2 weeks after transverse aortic constriction (TAC), KO mouse survival

179 Following pressure overload by transverse aortic constriction (TAC), ST2(-/-) mice had

180 lacebo or 17beta-estradiol (E2), followed by transverse aortic constriction (TAC), to induce pressure

181 hypertrophy compared with control mice after transverse aortic constriction (TAC), which was largely

182 ge CHF and normal donors and from mice after transverse aortic constriction (TAC)-induced CHF.

183 to evaluate the global proteomics changes in transverse aortic constriction (TAC)-induced heart failu

184 urine model of nonischemic hypertrophic CHF, transverse aortic constriction (TAC).

185 ial infarction (MI) or pressure overload via transverse aortic constriction (TAC).

186 and wildtype (WT) controls were subjected to transverse aortic constriction (TAC).

187 nd subjected to pressure overload induced by transverse aortic constriction (TAC).

188 in mice with increased pressure load due to transverse aortic constriction (TAC).

189 re subjected to pressure overload induced by transverse aortic constriction (TAC).

190 f pressure overload-induced LVH, produced by transverse aortic constriction (TAC).

191 cient in the molecule (Bmx knockout mice) to transverse aortic constriction (TAC).

192 3)R knockout [KO]) mice and A(1)R KO mice to transverse aortic constriction (TAC).

193 of cardiac stress, such as that generated by transverse aortic constriction (TAC).

194 romised the ability of the heart to adapt to transverse aortic constriction (TAC).

195 ng approximately 13 000 mRNAs in response to transverse aortic constriction (TAC).

196 r conditions of pressure overload induced by transverse aortic constriction (TAC).

197 by Ang II infusion (400 ng/kg/min, 28 d) or transverse aortic constriction (TAC).

198 ollowing acute hemodynamic stress imposed by transverse aortic constriction (TAC); 4) cardiac dysfunc

199 Chronic transverse aortic constriction (TAC; for 3 and 9 weeks)

200 hysiological (aging) and pathophysiological (transverse aortic constriction [TAC]) mouse model.

201 n in sham-operated (SHAM) and hypertrophied (transverse aortic constriction [TAC]) rat hearts.

202 used a well-established mouse model of LVH (transverse aortic constriction [TAC]).

203 s and a pressure overload hypertrophy model (transverse aortic constriction; TAC).

204 By 6 weeks transverse aortic constriction, the metabolic profile re

205 d insulin sensitivity in response to 2 weeks transverse aortic constriction versus sham, linked to en

206 SG-1002 resulted in cardioprotection during transverse aortic constriction via upregulation of the v

207 Hypertrophic growth in response to transverse aortic constriction was attenuated in CycD2-n

208 Transverse aortic constriction was performed in wild-typ

209 ) had been deleted (DCM-2TgxIP3-R(2)-/-) and transverse aortic constriction was performed on IP3-R(2)

210 roblasts in response to pressure overload by transverse aortic constriction were exaggerated in ANP-n

211 50% reduction of perivascular fibrosis after transverse aortic constriction, when compared with mock-

212 mice) resulted in aggravated fibrosis after transverse aortic constriction, when compared with wild-

213 In adult animals, hypertrophy induced by transverse aortic constriction, which causes translocati

214 signaling in early cardiac hypertrophy after transverse aortic constriction, which was in sharp contr

215 onstriction cardiac Nix KO versus 36+/-6% in transverse aortic constriction wild-type mice; P=0.003)