ライフサイエンスコーパス: transverse tubule

1 ional SR surface facing the surface membrane/transverse tubule.

2 lin is highly enriched in the sarcolemma and transverse tubules.

3 communication with the voltage sensor in the transverse tubules.

4 )1.6 plus beta1 and/or beta3 subunits in the transverse tubules.

5 Na(v)1.3, and Na(v)1.6 are localized in the transverse tubules.

6 cose transporters to the plasma membrane and transverse tubules.

7 ivation of multiple Ca2+ release sites along transverse-tubules.

8 s are organized within the dyad, linking the transverse tubule and sarcoplasmic reticulum and ensurin

9 ) coupling in cat atrial myocytes which lack transverse tubules and contain both subsarcolemmal junct

10 Cat atrial myocytes lack transverse tubules and contain sarcoplasmic reticulum (S

11 A vacuolar myopathy with dilated transverse tubules and disruption of the triad junctions

12 colocalizes with L-type calcium channels in transverse tubules and is associated with L-type calcium

13 sorcin localizes to the dyadic junctions of transverse tubules and sarcoplasmic reticulum and coimmu

14 number of gold particles associated with the transverse tubules and the sarcolemma by three-fold.

15 two novel systems of internal membranes, the transverse tubules and the sarcoplasmic reticulum (SR).

16 The surface membrane/transverse tubules and the SR form functional units (cal

17 lut4 was highly enriched in membranes of the transverse tubules and the terminal cisternae of the tri

18 The transverse tubules and vacuoles displayed distinct Ca(2+

19 pose that these membranes, consisting of the transverse-tubules and sarcoplasmic reticulum, are dynam

20 ies of junctional sarcoplasmic reticulum and transverse tubules, and (4) attenuated mitochondrial abn

21 The transverse tubules are a system of membrane invagination

22 otoxin (TTX)-sensitive brain isoforms in the transverse tubules are small and are detectable only aft

23 D hearts displayed a marked reduction in the transverse tubule area (59% of sham) and the surface are

24 duces the targeting of these proteins to the transverse tubules as well as reducing overall protein l

25 nsport is mediated by Glut4 localized in the transverse tubules; (c) insulin increases the apparent s

26 teract with the carboxy-terminal tail of the transverse tubule dihydropyridine receptor (DHPR).

27 Additional studies revealed that transverse-tubule disruption precedes the development of

28 loss of SPEG phosphorylation of JPH2 led to transverse-tubule disruption, a precursor of HF developm

29 g in an increase of the channel activity and transverse-tubule expression.

30 re mature electrophysiology, and evidence of transverse-tubule formation.

31 and glycerol exposure promotes detachment of transverse tubules from the sarcoplasmic reticulum.

32 ial independence of electrical events in the transverse tubules from those responsible for the rapid

33 he importance of dysferlin and myoferlin for transverse tubule function and in the genesis of muscula

34 Atrial myocytes generally lack transverse tubules; however, during ECC Ca2+ release is

35 calized with beta1 and beta3 subunits in the transverse tubules, identified by immunostaining of alph

36 Calcium (Ca(2+)) and transverse-tubule imaging of ventricular myocytes from M

37 ole for brain sodium channel isoforms in the transverse tubules in coupling electrical excitation to

38 plasmic reticulum and ectopic and misaligned transverse tubules in FER skeletal muscle.

39 sulin increases the apparent surface area of transverse tubules in skeletal muscle; and (d) insulin c

40 colocalized with the L-type Ca2+ channel in transverse tubules in wild-type skeletal muscle and reta

41 partmentalized translocation of GLUT4 to the transverse-tubules in skeletal muscle.

42 The subcellular targeting of alpha2 to the transverse tubules is important for this role.

43 ed AKAP100 localization at the region of the transverse tubule/junctional sarcoplasmic reticulum.

44 ect sparks on an inhomogeneous background of transverse tubule-labeled rat ventricular cells.

45 ardiac atrial cells lack a regular system of transverse tubules like that in cardiac ventricular cell

46 The deeper regular transverse tubules located at each A-I boundary of the s

47 use hearts causes JPH2 dephosphorylation and transverse-tubule loss associated with downstream Ca(2+)

48 sensing dihydropyridine receptors (DHPRs) in transverse tubule membrane and Ca(2+) release channel ry

49 l muscle dihydropyridine receptor transduces transverse tubule membrane depolarization into release o

50 d by Ca(2+) influx across the sarcolemmal or transverse tubule membrane neighboring the cluster, the

51 e that interacts in vivo with the sarcolemma/transverse tubule membrane system, whereas CaM binds wit

52 rom ventricle because atrial myocytes lack a transverse tubule membrane system: Ca(2+) release starts

53 uscle fiber restores a small fraction of the transverse tubule membrane voltage sensors from the inac

54 18c to block GLUT4-EGFP translocation to the transverse-tubule membrane but not the sarcolemma membra

55 Munc18c inhibited GLUT4 translocation to the transverse-tubule membrane without affecting translocati

56 antially reduced levels of syntaxin 4 in the transverse-tubule membrane.

57 es and intramembrane charge movements in the transverse tubule membranes (T-system) of frog fast twit

58 lization of the AHNAKs in close proximity to transverse tubule membranes and Z-band regions of cardia

59 rlin is located at the intercalated disc and transverse tubule membranes.

60 d L-type channels from detergent-solubilized transverse tubule membranes.

61 ted translocation to both the sarcolemma and transverse-tubule membranes.

62 Disruption of transverse tubule morphology by in vitro glycerol shock

63 The average diameter of transverse tubules observed in longitudinal sections inc

64 ocalizes with CaV1.2 channels and PKA in the transverse tubules of isolated ventricular myocytes.

65 ized by immunofluorescence microscopy to the transverse tubules of murine cardiac myocytes.

66 ABSTRACT: Dysferlin concentrates in the transverse tubules of skeletal muscle and stabilizes Ca(

67 phy 2B and Miyoshi myopathy, concentrates in transverse tubules of skeletal muscle, where it stabiliz

68 re present and functionally important in the transverse tubules of ventricular myocytes.

69 plasma membrane forms tubular invaginations (transverse tubules or T-tubules) that function in depola

70 uction in adult animals results in disrupted transverse tubule organization and calcium handling.

71 n function, which may include maintenance of transverse tubule organization and intracellular Ca(2+)

72 cement with S157A/S161A telethonin disrupted transverse tubule organization and prolonged the time to

73 distributed on the cell surface membrane and transverse tubules, resulting in a striated pattern.

74 se function, ie, Ca(2+) spikes at individual transverse tubule-sarcoplasmic reticulum (T-SR) junction

75 n initial segments, specialized sites at the transverse tubule/sarcoplasmic reticulum in cardiomyocyt

76 scle dihydropyridine receptor complex to the transverse tubule/sarcoplasmic reticulum junction.

77 inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardio

78 Disrupted transverse tubule structure may contribute to the decrea

79 d take up Ca(2+) from the cytoplasm but only transverse tubules supported store-operated Ca(2+) entry

80 to study global and localized regions of the transverse tubule system (T-system).

81 In many species atrial myocytes lack a transverse tubule system, dividing the sarcoplasmic reti

82 natal skeletal muscle lacks a well developed transverse tubule system, the RyR3 reinforcement of CICR

83 taining SH3-BAR domains and regulates muscle transverse tubule (T-tubule) formation in flies.

84 Despite normal transverse tubule (T-tubule) formation, GLT myotubes lac

85 ldtype skeletal muscle EHD1 localizes to the transverse tubule (T-tubule), and loss of EHD1 results i

86 Transverse tubules (t-tubules) are uniquely-adapted memb

87 The transverse tubules (t-tubules) of mammalian cardiac vent

88 eases, especially in cells lacking organized transverse tubules (T-tubules) such as atrial myocytes (

89 -selective dye Di-8-ANEPPS demonstrated that transverse tubules (t-tubules) were absent in atrial cel

90 o lateral sarcolemma, intercalated discs and transverse tubules (t-tubules), while NHE1 is absent fro

91 Ca(2+) alternans in cardiac myocytes lacking transverse tubules (t-tubules).

92 opy revealed their colocalization in cardiac transverse tubules (T-tubules).

93 ovide evidence for ET-1 receptors in cardiac transverse tubules (T-tubules).

94 g integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tubule (t-tubule) membrane microfolds, which

95 aborate, unique surface topography including transverse-tubule (T-tubule) openings leading into a cel

96 The transverse-tubule (T-tubule) system of ventricular myocy

97 ranched from the SSTN, indicating individual transverse tubules that form triads are continuous with,

98 brane (comprising the surface sarcolemma and transverse-tubules), the intracellular calcium store (th

99 ailure, beta2ARs were redistributed from the transverse tubules to the cell crest, which led to diffu

100 rial myocyte (AM) is characterized by sparse transverse tubule (TT) invaginations and slow intracellu

101 sides of a flattened vesicle derived from a transverse tubule (TT).

102 ease and increased spatial dispersion of the transverse tubules (TTs).

103 between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs).

104 r-protein kinase D1-Rem1 signaling increases transverse-tubule VLCC expression that results in increa

105 ponsible for the flattened appearance of the transverse tubules when viewed in cross-section.

106 ack alpha2 protein and have no alpha2 in the transverse tubules, where its expression is normally enh

107 ignals are localized exclusively to the deep transverse tubules, whereas functional beta1ARs are dist

108 rain of as little as 5% affects the shape of transverse tubules, which has important implications for