ライフサイエンスコーパス: transversion

1 utator effect) is observed for the G.C-->T.A transversion.

2 ly 16%, and both included a dominant G --> T transversion.

3 to repair this lesion results in G:C to T:A transversion.

4 approximately fourfold that of each type of transversion.

5 -oxoG/dAMP base pair results in a G-C to T-A transversion.

6 osite template 8-oxoG can result in a G to T transversion.

7 e wild-type protein sequence through a codon transversion.

8 fold more mutagenic inducing primarily G-->T transversions.

9 pposite template adenine to yield A-T to C-G transversions.

10 ments include inversions, transpositions and transversions.

11 ood patterns and so do A <--> C and G <--> T transversions.

12 s pattern, with most mutations being GC-->TA transversions.

13 gistically to minimize the levels of G --> T transversions.

14 high mutation rates, all due to G:C --> T:A transversions.

15 n spectrum from predominantly T-->A to T-->G transversions.

16 ns and very unusual kinds (spectrum), mainly transversions.

17 tations, with 78% of these being A:T --> T:A transversions.

18 genic inducing primarily targeted Fapy.G-->T transversions.

19 t, where both lesions induced targeted A-->C transversions.

20 n generating C --> T transitions and C --> G transversions.

21 deoxyguanosine (OxodG) gives rise to G --> T transversions.

22 ighly mutagenic, causing G --> T and G --> C transversions.

23 ypes by having a higher frequency of G:C>T:A transversions.

24 cy and in a significant increase in AT-to-TA transversions.

25 l systems, transitions were more common than transversions.

26 e the lesion, primarily resulting in G --> T transversions.

27 f generating C --> T transitions and C --> G transversions.

28 ates are generally extended more easily than transversions.

29 that almost all of the mutations are GC-->TA transversions.

30 mutagenic, causing almost exclusive G --> C transversions.

31 ns, all somatic APC mutations were G:C-->T:A transversions.

32 and caused a mixture of G --> T and G --> C transversions.

33 ations in the RpoB gene, 20% were Gua to Thy transversions.

34 relatively frequent, and a large decrease in transversions.

35 DNA repair enzymes, could lead to G:C to C:G transversions.

36 n sites for N-OH-AABP, especially for G to T transversions.

37 onal uncorrected mispairs and to A:T --> T:A transversions.

38 tions, including deletions, transitions, and transversions.

39 h dG-AAF and dG-AF primarily induced G --> T transversions.

40 uld account for the commonly detected G to T transversions.

41 especially large relative excess of G:C>T:A transversions.

42 7 Endonuclease I preferentially corrects A/T transversions.

43 dual coding potential that leads to G --> T transversions.

44 which results in G.C --> T.A or G.C --> C.G transversions.

45 n defects associated with most, but not all, transversions.

46 ecies, and this lesion results in G:C to T:A transversions.

47 nce of the human enzyme for T-->A over A-->T transversions.

48 which leads to AL-II-dA-->T and AL-II-dG-->T transversions.

49 ication, resulting specifically in GC --> TA transversions.

50 bited a similar context effect: 4-fold G-->T transversions (24% versus 6%) occurred in the 5'-TGT seq

51 with predominant G --> C followed by G --> T transversions, 9% deletions of 1-3 nucleotides, and 6% i

52 sitions (G to A) and an adenosine-to-uridine transversion (A to U).

53 n of A.8-oxoG mispairs results in C:G to A:T transversions, a form of genomic instability.

54 er oxidative stress condition are G:C to T:A transversions, a signature of 8-oxoguanine (8-oxoG).

55 C and that 15 of these mutations are G:C-->A transversions--a significantly greater proportion than i

56 Transversions accounted for 64% of sequence differences

57 oxR V. cholerae overexpressing TcpP, several transversions affecting nucleotides within two direct re

58 h adenine (8-oxoG:A), leading to a G:C-->T:A transversion after replication.

59 creased the individual rates of an A.T-->T.A transversion, an A.T-->G.C transition and the pooled rat

60 ent viruses through a nucleotide A200-to-T/C transversion and a vpr null mutation, but these isolates

61 ns in a lacZ reversion system, the G.C-->C.G transversion and A.T-->G.C transition are strongly enhan

62 at demethylation associated with C:G --> G:C transversion and C:G --> T:A transition mutations was ob

63 (specific increases in relative frequency of transversion and insertion/deletion [indel] mutations).

64 Analyses revealed both transversion and transition types of mutations at an ove

65 t DinB(Pa) has a propensity to promote C-->A transversions and -1 frameshift mutations within poly(dG

66 ual specificity: preferential enhancement of transversions and -1 frameshifts.

67 -dA is a miscoding lesion generating A --> T transversions and A --> G transitions.

68 AT-to-CG transversions and deletions at microhomologies were enha

69 potentially contributing to A-->T and A-->C transversions and frameshift mutations observed in cells

70 eplication, specifically in the avoidance of transversions and frameshift mutations.

71 pes similar to dnaX36: strong enhancement of transversions and frameshifts and only weak enhancement

72 tions induced by the POLD1-R689W are GC-->TA transversions and GC-->AT transitions, with transversion

73 the Sod1-null mice indicated mainly GC-to-TA transversions and GC-to-AT transitions, signature mutati

74 DNA 8-oxoguanine (8-oxoG) causes transversions and is also implicated in frameshifts.

75 ere is a significant mutational bias against transversions and significant variation in rates of chan

76 A wide spectrum of transitions, transversions and single base deletions are observed.

77 tatistically significant increases in G-to-T transversions and small tandem base deletions (P = 0.007

78 framework regions, most were R mutations and transversions and transitions equally contributed.

79 ransversions involve the C at CpG sites (CpG transversions) and that their rate is comparable to the

80 Transitions were more common than transversions, and the probability of a transversion inc

81 G.C-->A.T mutations and a hotspot T.A-->G.C transversion are known to increase with the frequency of

82 nce comparisons; however, several individual transversions are more frequent than the least common tr

83 Though the spontaneous G:C to C:G transversions are rare events, the pathways leading to t

84 s and the percentage of chemotherapy-related transversions are similar in t-AML and de novo AML, indi

85 enotoxic in human cells, and that G.C to T.A transversions are the most prevalent mutations induced b

86 describe the discovery of novel C > A/G > T transversion artifacts found at low allelic fractions in

87 istent with the occurrence of A x T to T x A transversions as common mutations in animal cells treate

88 transgene of such tumors were predominantly transversions as well.

89 utA in mutational specificity (predominantly transversions), as well as SOS independence, but in a pu

90 don frequency, bias-favoring transition over transversion, as well as explicit phylogenetic informati

91 here that BiSeqS can be applied to evaluate transversions, as well as small insertions or deletions,

92 inucleotide (deletion T followed by a T to A transversion) associated with SLE in subjects of Europea

93 This G.C to T.A transversion at codon 249, however, has been thought to

94 In contrast, a G-to-C transversion at G+4 is lethal; RNAs carrying this mutati

95 >G transversion at nt 8993 in mitochondrial DNA of MTATP6 (

96 levated Hb F levels and found a novel T-to-G transversion at nucleotide (nt) -567 of the HBG2 promote

97 Molecular analysis identified a C to G transversion at nucleotide -206 from the transcription s

98 >C transversion at nucleotide 109 predicts an amino acid ch

99 of the common BRAF missense mutation (T-->A transversion at nucleotide 1796) using restriction enzym

100 A virus with an A-->C transversion at position -3 replicates as well as wild-t

101 chromosome 17, and then ascribed to a C-->A transversion at position 3480 of the Tnf gene, correspon

102 ignature defined by a high prevalence of A>C transversions at AA dinucleotides.

103 tional signature characterized by C:G to A:T transversions at CCR sequence contexts that may have ari

104 ed by an increase in C:G-->A:T and A:T-->T:A transversions at certain mutagenic hot spots.

105 Transversions at GC base pairs in the supF gene were the

106 tably, we observed a high frequency of C-->G transversions at the cytosine residues targeted by both

107 AFB(1) frequently induces G:C to T:A transversions at the third base in codon 249 of TP53 and

108 This T to A transversion, at base 131 of the coding sequence, occurs

109 ), synonymous transitions (A(s)), synonymous transversions (B(s)), and nonsynonymous substitutions (K

110 or phenotype characterized by enhancement of transversion base substitutions and certain (-1) framesh

111 was extremely miscoding (>90%) with G --> T transversions being predominant.

112 Nine transversions between -96 to -83 reduced toxT promoter a

113 We also described the transversion bias, which is the preference for some tran

114 three different codon positions, transition/transversion biases, and codon usage.

115 s that also account for codon and transition:transversion biases.

116 nucleotide transitions are more common than transversions, by roughly a factor of two.

117 et extreme obesity due to a novel homozygous transversion (c.298G-->T) in LEP, leading to a change fr

118 onal-candidate genes detected a heterozygous transversion (c.386A-->T) in exon 3 of the gene for chro

119 ns approximately CpG transversions > non-CpG transversions, captures qualitative features of the muta

120 itution to a stop codon and one dinucleotide transversion compared to the donor genomic DNA.

121 iparallel Flop orientation, or with multiple transversions, conserving their base composition but cha

122 have an unexpected high frequency of A:T>T:A transversions, consistent with exposure to aristolochic

123 sitional cell cancers, and (iii) A:T --> T:A transversions dominate the p53 mutational spectrum in th

124 Transversions dominate the spectrum of spontaneous mutat

125 leomycin resistance gene and that G.C-to-T.A transversions dominated the spectrum in cells transcribi

126 otentially cause cancer by producing G --> T transversions during DNA replication.

127 cytosine, T = thymine), typically outnumber transversions (e.g., exchanges between a purine and a py

128 ater genetic variability, with more frequent transversion events, than did populations in control and

129 anged from 3.1% to 9.8%, whereas the G --> T transversion frequencies observed upon Fapy.dG bypass we

130 ions > non-CpG transitions approximately CpG transversions > non-CpG transversions, captures qualitat

131 The C>A transversion has been identified in the heterozygous sta

132 generation of abasic sites (which can induce transversions) has been inhibited.

133 onal reporter genes, is the target of G to T transversion hotspots in cells exposed to the model PAH

134 that there is a strong coincidence of G to T transversion hotspots in lung cancers and sites of prefe

135 The first mutation, a T-->G transversion in codon 64, is predicted to change a conse

136 mapping and the identification of a c.504G>C transversion in ELOVL4 resulting in the p.L168F substitu

137 o the different disease chromosomes: a G-->T transversion in exon 3, introducing a stop codon on the

138 ditional TA repeats in intron 2 and a G-to-T transversion in intron 3 that were sufficient to promote

139 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPARalpha gene and progr

140 A single G>C transversion in position -3 of the new Alu exon was insu

141 on detected in LG-CMS patients is a c.*22C>A transversion in the 3'-untranslated region (UTR).

142 The method revealed an A-->T transversion in the 5' splice site of intron 2 that is t

143 chromosome 18 and then ascribed to a T to A transversion in the acceptor splice site of intron 4 at

144 nist application showed that each amino acid transversion in the beta 3-v2 subunit (P11S, S15F, and G

145 7:H7 strain ATCC 43895, a guanine-to-thymine transversion in the csgD promoter created strain 43895OR

146 PI 518671]) as a reference, a G --> T(2,822) transversion in the genomic DNA sequence at a functional

147 A cytosine to adenine transversion in the mitochondrially encoded NADH dehydro

148 o-4-nitroimidazole may cause G-->T and G-->C transversions in calf thymus polymerase alpha and E. col

149 could explain the high levels of G:C --> T:A transversions in cells treated with bleomycin.

150 mutations (one transition in exon 8 and two transversions in exons 5 and 8, respectively), one in-fr

151 cated proteins, dominant alleles all contain transversions in highly conserved amino acids of the ext

152 PAH-DNA adducts, induce predominantly G-to-T transversions in human cells.

153 Two transversions in intron 1 (T2951033A homozygote and hete

154 ozygote and heterozygote, C2951049A) and one transversions in intron 7 (G2924536C homozygote and hete

155 However, the rate of AT-->CG transversions in our mutT(+) progenitor strain is some t

156 sites in vitro, and binding was abrogated by transversions in the binding sites that conserved the in

157 re was no significant increase in G:C to T:A transversions in the ogg1(-/-) clones, which would be ex

158 tational pattern is consistent with dG to dT transversions in the repetitive guanine tracts.

159 have distinct TP53 mutations, such as G to T transversions in the second guanine of codon 249 (AGG to

160 than transversions, and the probability of a transversion increased with increasing A + T content at

161 Probability of a transversion increased with increasing A + T content of

162 n, which was restored to wild type by G to T transversion induced by oxidative stress.

163 ct responsible for the observed pattern of G transversions induced by exposure to elevated glucose or

164 s only Pol V was indispensable for the T-->A transversion introduced by these lesions.

165 ransversions, we find that the most frequent transversions involve the C at CpG sites (CpG transversi

166 The G --> T transversion is the dominant mutation induced by the cat

167 The prevalence of G to T transversions is 30% in smokers' lung cancer but only 12

168 UUC, dominated by otherwise rare A:T to T:A transversions, is identical to that observed in UUC asso

169 genic in Escherichia coli, producing G --> T transversions; it thermally stabilizes the DNA duplex.

170 It can be used to detect the transversion mutation between pyrimidines and purines.

171 omic DNA demonstrated a >6-fold elevation in transversion mutation frequency, resulting in a highly u

172 45G > A c.427G > A p.Ala143Thr) and an ITGB6 transversion mutation in Exon 6 (g.27415T > A c.825T > A

173 l candidate gene analyses revealed an A to T transversion mutation in exon 9 of the glucokinase gene,

174 es was found, with much more transition than transversion mutation in the D genome after its divergen

175 We report a G>T transversion mutation in the last nucleotide of exon 2,

176 In addition, as the ratio of transition and transversion mutation is often used as a discriminative

177 Transversion mutation of the HP1 loop produced a smaller

178 duce deletions, generating primarily G --> T transversions (mutational frequency, 7.6-8.4%).

179 The average ratios of transition to transversion mutations (Ts/Tv) in diverging LTRs were >1

180 cing analysis showed an enrichment in G-to-C transversion mutations and further supports the idea tha

181 rch out rare 8-oxoguanine lesions to prevent transversion mutations arising from oxidative stress.

182 UNGs are relatively ineffective in restoring transversion mutations at C:G pairs during hypermutation

183 fold increase in the incidence of G/C-to-T/A transversion mutations following AFB1 exposure.

184 To identify those nucleotides a set of 27 transversion mutations in H11 was constructed and their

185 of both genes was linked to smoking-related transversion mutations in lung tumors.

186 is highly mutagenic, resulting in G:C to T:A transversion mutations in the absence of repair.

187 rease in the frequency of transition but not transversion mutations in the presence of ribavirin.

188 the frequency of Ha-ras codon 61 A(182)-->T transversion mutations in this cell population compared

189 ions should occur at a frequency of 1/15000, transversion mutations should occur at a frequency of le

190 expression correlates with C-to-A and C-to-G transversion mutations within 5'-TC dinucleotide motifs

191 ations of the AC-GT ends of the ZRE, whereas transversion mutations within the central 5 bp of the ZR

192 eta and Rev1 together are required for G-->T transversion mutations, a major type of mutagenesis indu

193 nalysis showed enrichment of G-->A and C-->T transversion mutations, increased mutation frequency, an

194 mon oxidative lesions in DNA and can promote transversion mutations.

195 which included a 8.7% G-->T and a 1.2% G-->C transversion mutations.

196 -2'-deoxyguanosine (OG), produces G:C to T:A transversion mutations.

197 ighly mutagenic, causing G --> C and G --> T transversion mutations.

198 tagenic, producing almost exclusively G to C transversion mutations.

199 can suppress the mutH-dependent increase in transversion mutations.

200 acco smoke carcinogens also can cause G to T transversion mutations.

201 verse transcription by enhancement of G-to-C transversion mutations.

202 error-free fashion, thus preventing GC-->AT transversion mutations.

203 mutation load as well as elevated levels of transversion mutations.

204 product, which can lead to downstream G to T transversion mutations.

205 pecific single-nucleotide polymorphism (SNP) transversion mutations.

206 A novel transversion mutator phenotype was reported recently in

207 dues in RGYW motifs along with a decrease in transversions normally related to UNG2 activity.

208 consistent with the large number of G --> T transversions observed at this nucleotide in smoking-ind

209 The presented data show that transitions and transversions occur during HRSV replication and that the

210 R) and alternative splicing, since the G-->C transversion occurs at the -1 position of the 5' splice

211 NPs, accounting for 69.8% in cattle; (2) the transversion occurs most frequently (38.56%) in cattle w

212 Remarkably, a cytosine-to-guanine (C-->G) transversion occurs specifically at target cytosines, al

213 , we found a heterozygous exon 5 + 128 T-->A transversion of SFTPC in a large familial pulmonary fibr

214 Although transversion of U8A abrogates signalling of yopQ(1-10),

215 om affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-ad

216 By generating transversions of every single nucleotide in yopQ(1-10),

217 m A* of adenine in DNA may result in AT-->CG transversions or AT-->GC transitions, which can eventual

218 OR, 3.37; 95% CI, 1.03-11.06), and G:C-->T:A transversions (OR, 10.53; 95% CI, 1.77-62.55) compared w

219 ikely than never smokers to harbor G:C-->T:A transversions (OR, 2.43; 95% CI, 0.37-15.73), although t

220 5% confidence interval (CI), 1.17-3.78], p53 transversions (OR, 3.37; 95% CI, 1.03-11.06), and G:C-->

221 In family B, a G-to-T transversion (ORF15+1176G>T) resulted in a nonsense muta

222 Both lesions promote G --> T transversions overall, with dG-N(2)-AAF being less mutag

223 significantly increased frequency of G --> T transversions (p < 0.0003; relative to the control), whi

224 001) and a signature mutation of G:C --> T:A transversions (p < 0.03), relative to the control.

225 y via a particular one of the six transition/transversion pathways.

226 ydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain o

227 had a G-->A transition and the other a G-->T transversion, possibly associated with error-prone misma

228 AT>CG transversions predominated for the T-glycosylase.

229 Whereas G to T transversions predominated in the induced cII mutations

230 Spontaneous G:C-->T:A transversions, previously not measured using reporter tr

231 s in all eight cases revealed an increase in transversions, probably due to DNA damage caused by cyto

232 rts only direct RNA substrates and the C-->G transversion provides an important criterion for target

233 Our DeltamutT allele elevates the AT-->CG transversion rate 27,000-fold, consistent with published

234 cleotide transition and an increased C --> A transversion rate.

235 hybrid progeny had decreased T-->G and T-->A transversion rates but an increased C-->T transition rat

236 We show that the transition and transversion rates in the 2 subgroups are similar, sugge

237 creasing number of plant studies revealing a transversion rather than transition bias, we chose to pe

238 d transitions over transversions (transition-transversion ratio = 1.29).

239 a highly unusual inversion of the transition/transversion ratio characteristic of normal epithelium;

240 erate nucleotide sites and the transition-to-transversion ratio is described.

241 vs 1.41, P < .001), (2) higher transition to transversion ratio than would be expected if mutations w

242 rate and the mutational spectrum (transition/transversion ratio) of non-CpG residues change in parall

243 in the nucleotide composition and transition/transversion ratio.

244 e variant sets when comparing the transition/transversion ratios (p = 1.0), percentage of novel varia

245 ide screens of paralog groups and transition/transversion ratios highlighted genes including: green f

246 ty shift assays demonstrated that these same transversions reduced the affinity of the toxT promoter

247 show that MNMs exhibit a high percentage of transversions relative to transitions, findings that are

248 dAMP and dGMP (encoding G --> T and G --> C transversions, respectively).

249 r X family polymerases: a high proportion of transversions resulting from T.dTTP, T.dCTP, and C.dTTP

250 transversions and GC-->AT transitions, with transversions showing a strong strand bias and a remarka

251 B(1)-exposed cells that contained the G to T transversion signature mutation at their third base posi

252 itions occurred at roughly twice the rate of transversions, similar to results from sequence comparis

253 r the first time, we detected transition and transversion single nucleotide polymorphisms, as well as

254 uttle vector in COS-7 cells produces G --> T transversions slightly more frequently than does OxodG.

255 T promoter derivatives with single-base-pair transversions spanning the TcpP-binding site were genera

256 , promoter derivatives with single-base-pair transversions spanning the ToxR-footprinted region were

257 A single nucleotide transversion (T --> A) at the second position of intron

258 or mutations that were observed were G --> T transversions targeting the cross-linked dG located in t

259 alyses and showed a stronger relationship to transversion than transition mutations.

260 prints have a higher ratio of transitions to transversions than expected at random and a higher GC co

261 rsion bias, which is the preference for some transversions than others in nucleotide substitutions.

262 One transversion that abolishes secretion, uridyl 9 to adeny

263 report here that Dilp2 is caused by a T-to-A transversion that converts a tyrosine codon to a stop co

264 The single LF1 mutant allele is caused by a transversion that produces an amber stop at codon 87.

265 beta(2)m genes contained a single nucleotide transversion that would mutate a conserved alanine to pr

266 rized by predominant induction of G:C to T:A transversions that occurred within CpG sequence contexts

267 Homozygous mutant embryos carry a C->A transversion, that changes a threonine to a lysine, in a

268 ses in the relative frequency of G:C --> T:A transversions, the signature mutations of oxidative DNA

269 ifferent mechanisms generate transitions and transversions, these results indicate that both mutation

270 The transition/transversion (Ti/Tv) ratio and heterozygous/nonreference

271 the preponderance of transitions relative to transversions to the higher rate of mutation at CpG dinu

272 motifs = 25.6%) and favored transitions over transversions (transition-transversion ratio = 1.29).

273 ase that increases the mutation rate and the transversion/transition ratio compared to the signal seq

274 is there evidence of an increased mutational transversion/transition ratio or coordinated evolution.

275 as scanned for causative mutations and a C>A transversion was identified at c.10063 (human ref NM_000

276 Moreover, the ratio of transitions to transversions was markedly increased compared with norma

277 an unusually high rate of G to C and C to G transversions was observed at the third (silent) positio

278 Saturation of synonymous transversions was predicted to be minimal at 20 years an

279 ns produced by B(a)PDE i.e., "G-->T + C-->A" transversions, was significantly enhanced when the B(a)P

280 sitions generally occur more frequently than transversions, we find that the most frequent transversi

281 A:T-to-G:C transitions and G:C-to-T:A transversions were 3.8 and 2.0 times, respectively, more

282 ucleotide CpG and the neighboring effects on transversions were complex.

283 in a recA730 lexA(Def) mutL background most transversions were dependent upon pols IV and V.

284 In addition, G to T transversions were induced significantly, at frequencies

285 n the frequency of alkylation-induced C to A transversions were observed, consistent with a mutator t

286 > T transversions were the only mutations observed above bac

287 For the C-glycosylase, GC>CG transversions were the predominant mutations, followed b

288 s such as ErrASE preferentially corrects C/G transversions whereas T7 Endonuclease I preferentially c

289 However, the C-->A transversion, which causes a T94K mutation in the NST1 p

290 This results in the propagation of G to T transversions, which are commonly observed somatic mutat

291 V mutations are dC --> dG/dA or dG --> dC/dT transversions, which are proposed to result from replica

292 ost frequently induced mutations were A to T transversions, which were 43.9% for (+)-syn- and 38.8% f

293 3 mutation spectrum, dominated by A:T to T:A transversions with mutations at dA residues located almo

294 tations, i.e., T to C transitions and T to A transversions with significant site-specificities, i.e.,

295 Transition mutations were favored over transversions, with C-->T and G-->A replacements togethe

296 ed targeted mutations, predominantly G --> T transversions, with overall frequencies of approximately

297 generated by both stereoisomers were G --> T transversions, with some G --> A transitions.

298 p deletions, UV induced both transitions and transversions, with the latter type more highly represen

299 P1 was heterozygous for a transversion within the TBXA2R gene predictive of a D304

300 y polymerase with regard to the induction of transversions within specific sequence contexts.