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1                       At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol lev
2                                                     The 156 trials had a median sample size of 91.5 (range, 13-2593) pati
3                                            Several clinical trials have already demonstrated that combinations of nonchem
4              Grave faults in design and conduct of clinical trials have also substantially contributed to the failure of
5                                        Unfortunately, these trials have been designed without a strong foundational knowl
6                                                    No large trials have been done to investigate the efficacy of an inter
7                                  An unprecedented number of trials have been done, initiated, or are planned to test new
8  cirrhosis, but no adequately powered randomised controlled trials have been done.
9 ive in specific Ph-like ALL subsets, and precision medicine trials have been initiated for this high-risk ALL subset.
10                                           Existing clinical trials have been limited by short duration, low doses of vita
11  yet been conclusively determined as no randomized clinical trials have been published on this issue, and their effective
12                                                    However, trials have been relatively scarce and limited in sample size
13                                              Few randomized trials have compared disease-free survival outcomes for surgi
14                                                   All three trials have completed 2 years of follow-up.
15                                                  Randomized trials have demonstrated increased morbidity with liberal flu
16   Recent exploratory subgroup analyses of the large phase 3 trials have demonstrated that patients with chronic hepatitis
17                                             Recent clinical trials have demonstrated that the immense majority of acute p
18                                       Randomized controlled trials have demonstrated that the newest latent tuberculosis
19                                                    Clinical trials have demonstrated the clinical efficacy of early ART;
20  first- and second-generation EGFR TKI, and recent clinical trials have documented their efficacy in patients with EGFR-m
21 es in cardiovascular medicine fueled by innovative clinical trials have dramatically improved the lives of patients world
22                             Purpose Two previous single-arm trials have drawn conflicting conclusions regarding the activ
23                                                    Clinical trials have established the average benefit of cardiac resync
24         The successes and failures of biologics in clinical trials have facilitated our ability to better understand whic
25         However, meta-analyses of vitamin D supplementation trials have failed to show clear improvements in blood pressu
26             Although case series and controlled prospective trials have found the procedure to be safe, it is unclear whe
27                                              SWOG treatment trials have had a substantial impact on population survival f
28                                                    Clinical trials have investigated the effects of agents designed to ta
29 blood cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this final week of st
30 relatively rare disorder, and as such, large-scale clinical trials have not been completed, rendering management decision
31                                However, prior OXT treatment trials have produced equivocal results, perhaps because of va
32                                           However, clinical trials have produced inconsistent results.
33                                                      Recent trials have produced promising results for HSCT and mesenchym
34 Successes achieved in both animal models and human clinical trials have proven ASOs both safe and effective.
35 esults from large cohort studies and randomized, controlled trials have provided conflicting messages about the benefits
36                                                      Recent trials have provided evidence of benefit in reduction of card
37                                             No high-quality trials have provided evidence of effectiveness and cost-effec
38                           Recently, 3 randomized controlled trials have published contradictory conclusions.
39 al infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety.
40 mprove outcomes for patients with hepatorenal syndrome, but trials have reported variable efficacy.
41                                              Dengue vaccine trials have revealed deficits in our understanding of the mec
42                                                    Clinical trials have showed no relationship between nonsteroidal anti-
43                                                    Clinical trials have shown cardiovascular benefits and potential risks
44                                                    Clinical trials have shown that administration of the nematode Trichur
45                                                      Recent trials have shown that avoiding peanuts during infancy increa
46                    However, to date, no randomized clinical trials have studied this proposition.
47                                          Data from previous trials have suggested that patients receiving clopidogrel mon
48 ds to oligodendrocyte death and demyelination, and clinical trials have tested glial transplants to promote myelin repair
49                                                    Eligible trials had to start randomisation on or after Jan 1, 1970, an
50                               However, prospective clinical trials have yet to demonstrate significant efficacy.

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