ライフサイエンスコーパス: triazole

1 iazo compound lying ca. 5 kcal/mol above the triazole.

2 acetamido) and several R substituents on the triazole.

3 a-amino esters and C-O bond cleavage to give triazoles.

4 the selective C-5 arylation of N-aryl 1,2,3-triazoles.

5 re also performed on 1,4-disubstituted 1,2,3-triazoles.

6 d to be higher than that of 5-amino-1H-1,2,4-triazoles.

7 r the 3-amino- than for the 5-amino-1H-1,2,4-triazoles.

8 nyl compounds, and 3-alkylthio-5-amino-1,2,4-triazoles.

9 synthesis of 1,4-disubstituted 5-allyl-1,2,3-triazoles.

10 azides to afford enantiopure trisubstituted triazoles.

11 n with organic azides, yielding the expected triazoles.

12 FVP of triazole 13T affords an IR absorption at 2080 cm(-1) asc

13 azole, 9H-purine, 1H-benzotriazole, 1H-1,2,3-triazole, 1H-1,2,4-triazole, and 1H-pyrazole were succes

14 e types, such as 1H-benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazol

15 benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazoles, and 1H-benzimida

16 3,5-Dinitrimino-1,2,4-triazole (2) with three protons has the potential of dep

17 multiple urea moieties [L2 = 3,3'-(1H-1,2,4-triazole-3,5-diyl)dipyridine].

18 heterocycles viz.　4,5-disubstituted 1,2,4-triazole-3-thiones and 4,5-disubstituted 1,2,4-triazoles

19 the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides

20 Desulfurization of 1,2,4-triazole-3-thiones is assisted by thiophilic Cu to provi

21 mpd101; 3-[[[4-methyl-5-(4-pyridyl)-4H-1,2,4-triazole-3-yl] methyl] amino]-N-[2-(trifuoromethyl) benz

22 ting in the formation of 5-sulfonamido-1,2,3-triazole-4-carbothioamide sodium salts as the only produ

23 identify a novel hit series of 5-amino-1,2,3-triazole-4-carboxamides (ATC).

24 The 5-amino-1,2,3-triazole-4-carboxylic acid is a suitable molecule for th

25 at (18)F-N-(methyl-(2-fluoroethyl)-1H-[1,2,3]triazole-4-yl)glucosamine ((18)F-NFTG) annotates glycoge

26 bistriazole at the expense of 5-protio-1,2,3-triazole (5-protiotriazole).

27 esponding 1- and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazole-5(4H)-thiones are formed in high yields.

28 ]benzothiadiazole, 5,6-dicyanobenzo[d][1,2,3]triazole, 6,7-dicyanoquinoxaline, and 6,7-dinitroquinoxa

29 p-F3C-phenyl-triazole 65 (32) was more potent than a corresponding al

30 ydrophilic spacer, and either an alkyne (6), triazole (7), or piperazine (8) link to the PBD.

31 2O2 insult, cells treated with 3-amino-1,2,4-triazole (a catalase inhibitor) were the most sensitive.

32 Isavuconazole is a triazole active in vitro and in animal models against mo

33 In addition, triazoles active as HSP90 inhibitors (as compound 41, IC

34 alogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized using a straightforwar

35 in B deoxycholate, 4/12 (33%) treated with a triazole alone, and none of 8 (0%) who received no antif

36 cts against HIV-1 than corresponding peptide triazoles alone.

37 Here we show that posaconazole, another triazole, also blocks cholesterol export from lysosomes.

38 Using electrospray ionization, oligo(triazole amide)s were best ionized as protonated molecul

39 crypted in monodisperse sequence-coded oligo(triazole amide)s.

40 orward characterization of any encoded oligo(triazole amide)s.

41 eveloped to give a protected version of this triazole amino acid.

42 agreed with predicted binding of alkynyl and triazole analogues.

43 the differences between imidazole and 1,2,4-triazole analogues.

44 impair the copying process, yet some radical triazole and amide DNA backbones perform surprisingly we

45 ation of an appropriate linker between 1,2,4-triazole and benzimidazolone moieties, whereby a cyclobu

46 t partially explaining the elevated rates of triazole and multi-drug resistance associated with C. gl

47 ion of two types of peptides, one containing triazole and the other with native peptide bonds, on a g

48 An NMR comparative study of 1,2,3-triazole and triazolium anion recognition units containi

49 s based on bidentate halogen bonding by halo-triazoles and -triazoliums is presented.

50 give substituted 1-(1H-pyrrol-3-yl)-4H-1,2,4-triazoles and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazoles in h

51 was utilized in the preparation of mixed bis-triazoles and derivatization of the protein BSA with flu

52 zoles as well as C-beta-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as

53 ion indicated the necessity of unsubstituted triazoles and leucine linker to obtain maximal growth in

54 The triazoles and terbinafine exhibited low MICs against all

55 sistance to multiple drug classes, including triazoles and/or echinocandins.

56 H-benzotriazole, 1H-1,2,3-triazole, 1H-1,2,4-triazole, and 1H-pyrazole were successfully employed for

57 llest stabilizing effect is seen for the 1,5-triazole, and this is attributed to the triazole group b

58 o afford high-molecular-weight polymers with triazole- and urea-type interchain links, respectively.

59 ough equimolar binding of CO2 with the 1,2,4-triazole anion.

60 uconazole (ISAV) is a novel, broad-spectrum, triazole antifungal agent (IV and by mouth [PO]) develop

61 idia production, increased susceptibility to triazole antifungal drugs, and is avirulent in a murine

62 Voriconazole is a triazole antifungal medication used for prophylaxis or t

63 ed in the para-position, the 1,4 and the 2,4-triazoles are cation-stabilizing, whereas the 1,5-triazo

64 Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker betwee

65 These triazoles are formed in a regioselective manner, and sev

66 nimines, and cyclization products, and 1,2,4-triazoles are precursors of nitrile ylides.

67 Triazoles are the mainstay of therapy against Aspergillu

68 ned by introducing a 1,4-disubstituted 1,2,3-triazole as a proteolysis-resistant amide mimic and a se

69 ntroduced the use of 1,4-disubstituted 1,2,3-triazoles as metabolically stable trans-amide bond surro

70 enabled the synthesis of vinyl sulfone-based triazoles as potential nonpeptidic cysteine protease inh

71 yl substituted 1-(beta-d-glucosaminyl)-1,2,3-triazoles as well as C-beta-d-glucosaminyl 1,2,4-triazol

72 ulting click-linked iLOV gene contains eight triazoles at the sites of chemical ligation, and yet is

73 ine boranecarbonitriles is accomplished with triazole-Au(I) complexes.

74 old nanoparticle-conjugated forms of peptide triazoles (AuNP-PT) exhibit substantially more potent an

75 n this class, leading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 </= 20 nM).

76 disubstituted 3-amino- and 3,5-diamino-1,2,4-triazoles based on quaternization of readily available 1

77 3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-ni

78 ssifications, including alkyl CH, phenyl CH, triazole-based CH, imidazolium (CH)(+) and triazolium (C

79 rk, we evaluate the inhibition of InhA by 14 triazole-based diphenyl ethers and use a combination of

80 Triazole-based IL moieties were synthesized using click

81 ctron-withdrawing in character, with the 1,5-triazole being the most electron-withdrawing.

82 Further synthesis of various triazole bioisosteres demonstrated clear structure-activ

83 We reported a series of triazole bisphosphonate GGDPS inhibitors, of which the m

84 A mixture of homogeranyl and homoneryl triazole bisphosphonates has previously demonstrated pot

85 One of the analogues, containing a B26-B29 triazole bridge, was highly active in binding to both IR

86 gen cycloaddition allowed obtaining of novel triazole-bridged antibiotics (6-16) with the reconstruct

87 ubstituted 3-amino- and 3,5-diamino-1H-1,2,4-triazoles by many alkyl halides proceeds with low select

88 from 5-alkoxyisoxazoles and 1-sulfonyl-1,2,3-triazoles by tuning the Rh(II) catalyst and the reaction

89 the chemical nature of the newly introduced triazole C(5) arm in the presence of attractive antibact

90 N(2)-Aryl-1,2,3-triazole C-nucleoside compounds that could be obtained b

91 iazole-3-thiones and 4,5-disubstituted 1,2,4-triazoles can be synthesized from arylidenearylthiosemic

92 N2 elimination from monocyclic 1,2,3-triazoles can generate iminocarbenes, 1H-azirines, keten

93 esized by reaction of the melampomagnolide-B-triazole carbamate synthon 6 with various terminal diami

94 Four novel triazole carboxamide analogues, 24d, 24e, 24f, and 39c,

95 Some 1,4,5-trisubstituted triazole carboxamides induced dramatic depletion of the

96 es gave a new family of 1,4,5-trisubstituted triazole carboxylic acid derivatives that showed high af

97 n, we explore the 5-(methylchalcogeno)-1,2,3-triazole (chalcogen = Se, Te) motif as a novel ChB donor

98 azole (ITZ) is an FDA-approved member of the triazole class of antifungal agents.

99 evelopment of a series of 1,4-diphenyl-1,2,3-triazole compounds that inhibit the Nrf2-Keap1 protein-p

100 The most cytotoxic active triazole conjugates having a hydrophobic and bulky C(5)

101 lectivity, and PK parameters for a series of triazole containing 4,6- or 1,7-disubstituted-3,4-dihydr

102 vity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR)

103 2(1H)-ones resulted in the identification of triazole containing mTOR kinase inhibitors with improved

104 d the materials in vivo and identified three triazole-containing analogs that substantially reduce fo

105 o the first reported in situ generation of a triazole-containing anticancer agent from two benign com

106 ted and fully characterized nine non-natural triazole-containing cyclic peptides, a further ten molec

107 o acids were employed for the preparation of triazole-containing dipeptides having the structural mot

108 This led to the discovery of a triazole-containing diphenyl ether with an increased res

109 Unprecedented pyrrole- and 1,2,4-triazole-containing ensembles, substituted 1-(1H-pyrrol-

110 The present study has characterized a triazole-containing inducer of NRF2 and elucidated the m

111 ion of the two IGF-1 precursor chains by the triazole-containing moieties, and variation of its neigh

112 on demonstrated that the introduction of the triazole core in the scaffold of nonsteroidal antiandrog

113 Cyclic peptide triazoles (cPTs) retained the gp120 inhibitory and virus

114 reas posaconazole (POS), and NTLA-1 (a nitro-triazole) cured approximately 90% and 20% of mice, respe

115 n of seven frequently used azole fungicides (triazoles: cyproconazole, epoxiconazole, fluconazole, pr

116 omeric forms of [1,2,4]triazolo[3,2-c][1,2,4]triazole derivatives in acidic conditions has been achie

117 is developed from N-sulfonyl-4-biaryl-1,2,3-triazole derivatives via Rh-catalyzed denitrogenative cy

118 , other opioids [tramadol], glucocorticoids, triazole derivatives, and combinations of penicillins, i

119 These triazoles, designed through a structure-based approach,

120 coupling was performed with total control of triazole (Dimroth) isomerization based on the judicious

121 Furthermore, the feasibility of triazole dose escalation, combination therapy, and proph

122 We designed aryl-triazole-ether macrocycles (MC) to be semiflexible, whic

123 dipeptide surrogates in the form of Xaa-psi[triazole]-F2Gly building blocks were established, and se

124 f compounds belonging to the 5-alkynyl-1,2,3-triazole family that exhibits potent antileukemic effect

125 es, including testing with amphotericin B or triazoles for non-Aspergillus molds (Mucoromycotina and

126 cases, C-O bond cleavage occurred via either triazole formation and/or hydrolysis of the ester bond i

127 The extent of triazole formation correlated with ribosome affinity for

128 The extent of triazole formation depends upon leaving group ability.

129 Some C-O bond cleavage via triazole formation was also found to occur when a resin-

130 XRD experiments, and the regiospecificity of triazole formation was evidenced from various NMR techni

131 e AChE toward a transient state favoring syn-triazole formation.

132 cally induced cycloreversion for a series of triazoles formed via strain-promoted azide-alkyne cycloa

133 -functionalized 1,2,3-thiadiazoles and 1,2,3-triazoles from 2-cyanothioacetamides and sulfonyl azides

134 ide, azo, sulfoximine, 1-pyrazole, and 1,2,3-triazole functionalities.

135 Our overall results suggest that the triazole functionality is required for ITZ-mediated inhi

136 Thus, agricultural use of triazole fungicides may put bees at risk of being unable

137 rcetin-metabolizing activity, identified six triazole fungicides, all fungal P450 inhibitors, that do

138 ts an azide moiety into a photocaged form of triazole-fused dibenzo[a,e]cyclooctyne (3).

139 nyl sulfones makes use of a combination of a triazole gold complex and gallium triflate.

140 The combination of triazole/gold (TA-Au) and Cu(OTf)2 is identified as the

141 1,5-triazole, and this is attributed to the triazole group being twisted out of conjugation in the d

142 These studies all suggest that the 1,5-triazole group exerts a strong electron-withdrawing effe

143 Furthermore, the triazole group in a linear (L) monomer unit complexed Cu

144 gamma(+) values indicate that the 1,4 triazole group is cation-stabilizing relative to the phe

145 Finally, the anionic triazole group is the most effective radical-stabilizing

146 er between the biaryl pyrazole and imidazole/triazole group.

147 The three triazole groups all enhance the methylenecyclopropane re

148 Computational studies indicate that these triazole groups all stabilize benzylic radicals by a spi

149 nd (19)F chemical shifts indicate that these triazole groups are all inductively electron-withdrawing

150 Three fluorobenzenes substituted with meta-triazole groups have been prepared, and (19)F chemical s

151 Specifically, 1,2,3-triazole groups, when incorporated onto polypeptide side

152 ve Zn(OAc)2-mediated method toward propargyl triazoles has been developed for the first time from com

153 of furazan-functionalized 5-nitroimino-1,2,4-triazoles has been explored.

154 atalyzed denitrogenation of 1-sulfonyl-1,2,3-triazoles has emerged as a powerful strategy for the syn

155 sigma(+) values for these three triazoles have also been determined from solvolysis rate

156 e manner, and several pairs of regioisomeric triazoles have also been synthesized.

157 aminotetrazoles and N,4-diaryl-3-amino-1,2,4-triazoles have been described with good functional group

158 ds that could be obtained by selective 1,2,3-triazole heterocycle N(2) arylation in 1-beta-d-ribofura

159 In addition, triazole heterocycles are well employed as a strategy to

160 l experience increases, the role of this new triazole in the treatment of invasive fungal infections

161 triazole leads to unique N- and C-linked bis-triazoles in excellent yields.

162 ,4-triazoles and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazoles in high yields.

163 tion (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more establish

164 he presence of CO and1-aryl-(1H)-benzo-1,2,3-triazoles in the absence of CO through a common intermed

165 hemical families, oxazoles, strobilurins and triazoles, in water and fruit samples, using dispersive

166 Advantages of this triazole include the availability of a water-soluble int

167 5-Iodo-1,2,3-triazole (iodotriazole) can be prepared from a copper(I)

168 lectrodes based on covalently attached 1,2,3 triazole ionic liquid (IL) were prepared and investigate

169 Triazole is a well-recognized bio-isostere for peptide b

170 oles are cation-stabilizing, whereas the 1,5-triazole is carbocation-destabilizing.

171 relative to the phenyl group, albeit the 1,5 triazole is significantly destabilizing relative to phen

172 d evaluation of stereochemically defined des-triazole ITZ analogues also provides key information as

173 Postfunctionalization of this triazole leads to unique N- and C-linked bis-triazoles i

174 Reaction of the polysulfonated triazole ligand L = 4-(1,2,4-triazol-4-yl)ethanedisulfon

175 f the five different azine-substituted 1,2,4-triazole ligands employed, L(azine) = 4-(4-methylphenyl)

176 ough an amide bond in one case and through a triazole linkage ('click chemistry') in the other.

177 s side chain-cyclized peptides bearing a bis-triazole linkage, it is referred to as 'double-click' st

178 t of DNA polymerase to accept templates with triazole linkages in place of phosphodiesters, we have d

179 A dansyl derivatized triazole linked glucopyranosyl conjugate ((NO2)L) has be

180 y(G)) sequence with the quadruplex-targeting triazole-linked acridine ligand GL15 were investigated u

181 ates ssDNA molecules containing an unnatural triazole-linked DNA backbone that is sufficiently biocom

182 e cycloaddition (TAAC) polymerization to 1,4-triazole-linked oligopeptides.

183 rystal-to-crystal polymerization, giving 1,4-triazole-linked pseudo-proteins.

184 Dansyl-derivatized, triazole-linked, glucopyranosyl conjugates, (5F)LOH, (2F

185 xycoumarin-derived antennae attached through triazole linkers were modest sensitizers for Eu(III) and

186 e bonds' rich proteins with intra main-chain triazole links.

187 Animal models confirmed that a high triazole minimal inhibitory concentration corresponded w

188 The distribution of the triazole modification creates a unique hydrogel surface

189 rigid spatial arrangement of the quaternized triazole moieties above and below the Pc core, as confir

190 The triazole moieties thus formed two "cationic donuts" that

191 compounds that incorporate the phenyl-1,2,3-triazole moieties.

192 ith one, two, or three 1,4-substituted 1,2,3-triazole moieties.

193 backbone-fluorinated 1,4-disubstituted 1,2,3-triazole moieties.

194 olyheterocycles containing pyrrole and 1,2,4-triazole moieties.

195 The 1,2,3-triazole moiety can be incorporated as a peptide bond bi

196 presence of iodide as the counterion in the triazole moiety has direct influence on the membrane's f

197 The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibio

198 bone with an isosteric nonhydrolyzable 1,2,3-triazole moiety.

199 ts based on the 3,5-bis(dinitromethyl)-1,2,4-triazole monoanion and dianion were controllably synthes

200 We show that the triazole motif slows the rate of formation for the final

201 adults fed combinations of quercetin and the triazole myclobutanil, the expression of five of six mit

202 le to generate the first pyrrole-substituted triazole NHC.

203 1,2,4-triazoles was first accomplished under triazole-NHC control to give unknown fused heterocyclic

204 folds through selective functionalization of triazole nucleosides.

205 On the other hand, the triazole offers several N-coordination modes including c

206 the 5'-silyl group and the substituent of 3'-triazole or its bioisosteres.

207 st appealing series contain imidazole, 1,2,4-triazole, or benzimidazole rings fused to the 2,3-positi

208 Docking simulations suggested that the triazoles penetrate the Hsp90 ATP binding site.

209 Here, the authors design a triazole peptide that self-replicates and then self-asse

210 /Delta mutant was resistant to 3-amino-1,2,4-triazole, perhaps because of increased expression of the

211 s been demonstrated for benzyl phosphate and triazole phosphate monomers.

212 oligomeric benzyl phosphates (Si-OBP(n)) and triazole phosphates (Si-OTP(n)) using ring-opening metat

213 ynthesis leads to the continual formation of triazole phospholipids and membrane-bound oligotriazole

214 The conformational change of triazole polypeptides in response to the donor-acceptor

215 The fluorescent quantum yield of a triazole product T10 is enhanced by 52-fold as compared

216 of an iodinating agent, with 5-protio-1,2,3-triazole (protiotriazole) as the side product.

217 A peptide triazole (PT) class of entry inhibitor has previously be

218 mechanism of Env gp120 encounter by peptide triazole (PT) inactivators of HIV-1.

219 meantime, showdomycin, formycin, and various triazole, pyrazine, pyridine, dihydroxyphenyl, thienopyr

220 f the azide and alkyne reactants to form the triazole remains a likely limiting step.

221 The development of multiple triazole resistance in pathogenic filamentous fungi has

222 candins, was not affected by the presence of triazole resistance mutations.

223 Samples of plant bulbs were positive for triazole-resistant A. fumigatus with CYP51A mutations.

224 Infections caused by triazole-resistant Aspergillus fumigatus are associated

225 to Ireland from the Netherlands might harbor triazole-resistant Aspergillus fumigatus.

226 dditional study of molecularly characterized triazole-resistant Aspergillus isolates is required to c

227 demiology is evolving, with the emergence of triazole-resistant Aspergillus spp. and multidrug-resist

228 p guide treatment decisions in patients with triazole-resistant invasive aspergillosis.

229 selective formation of the 1,4-disubstituted triazole, respectively.

230 s showed additional interactions between the triazole ring and lectin amino acid residues, suggesting

231 An insight into the mechanism of the triazole ring cleavage was achieved by performing a DFT

232 [3,4-a]isoquinolines, in good yields without triazole ring cleavage.

233 ion starts with a hydrolytic cleavage of the triazole ring followed by oxidative cyclization.

234 beta-lactam ring of carbapenems and that the triazole ring generated by this reaction is well tolerat

235 ence of sulfur as a trap, the opening of the triazole ring occurs with the formation of derivatives o

236 The primary products underwent a triazole ring opening under the basic arylation conditio

237 lo[3,4-a]isoquinolines involves, besides the triazole ring opening, the unusual migration of the cyan

238 omers were composed of monomers containing a triazole ring, a short ethylene oxide segment, and an am

239 on of a substituent at the 3-position of the triazole ring, made it possible to generate the first py

240 probability of attack at the N-4 atom of the triazole ring, whereas increasing softness should enhanc

241 le ring but not by those tested containing a triazole ring.

242 The binaphthyl amine containing two triazole rings shows higher affinity for c-MYC G-quadrup

243 s recyclable nanoreactor with intradendritic triazole rings strongly also activates the simple Sharpl

244 pper-free 'click' reaction, leading to a VPg-triazole-RNA construct that was 'non-cleavable' by TDP2.

245 ns catalyzes the formation of 5,5'-bis(1,2,3-triazole)s (5,5'-bistriazoles) from organic azides and t

246 neous alkylation of the resulting poly(1,2,3-triazole)s with a series of difunctional cross-linking a

247 r biologically active compounds based on the triazole scaffold.

248 ld the corresponding 1-aryl-(1H)-benzo-1,2,3-triazoles selectively in good yields.

249 The imidazole and triazole series with the short -CH2- linker displayed pr

250 While the N-beta-d-glucosaminyl 1,2,3-triazoles showed weak or no inhibition, the C-beta-d-glu

251 We further compared triazole stability to the mechanical stability of polyme

252 F2 complex, we have developed first-in-class triazole-stapled peptides that block the protein-protein

253 The regioselectivity in triazole substitution at the C-5 position was confirmed

254 he studied bombesin peptide bearing multiple triazole substitutions.

255 arylation in 1-beta-d-ribofuranosyl-2H-1,2,3-triazole substrate were designed in this study.

256 or oxidative N-N bond formation in the 1,2,4-triazole synthesis.

257 splayed higher persistence (e.g., terbutryn, triazoles: T1/2 >> 120 days).

258 is enhanced set, we identified the carbamoyl triazole TCMDC-134379 (1), a known serine protease inhib

259 approach, as a very large variety of complex triazole-tethered substrates can potentially be integrat

260 t is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug.

261 that of other dibenzocyclooctynes, fusion of triazole to the dibenzocyclooctyne system in 3 results i

262 pplied to alkenyl imidazoles, pyrazoles, and triazoles to provide products with nitrogen incorporated

263 l inhibitory concentration corresponded with triazole treatment failure and that the efficacy of othe

264 he first-in-human study of (18)F-fluoroethyl triazole [Tyr(3)] octreotate ((18)F-FET-betaAG-TOCA) in

265 peptide bonds, and peptides with one or more triazole units are of great interest for different appli

266 odextrins composed of d-glucose residues and triazole units bound together through alpha-(1,4) linkag

267 (ethylene glycol) or chains containing 1,2,3-triazole units to present flexibility in the chemical an

268 the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.

269 TZ2PA6 and TZ2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne

270 gnaling in GABAergic synapses, we used 1,2,3-triazole urea compounds to selectively inhibit 2-AG bios

271 We have previously reported that triazole ureas can act as selective and CNS-active inhib

272 Triazole ureas constitute a versatile class of irreversi

273 does not inhibit DAGL), which indicates the triazole ureas may affect the energy balance in mice thr

274 We found that 2,4-substituted triazole ureas with a biphenylmethanol group provided th

275 ree-step process from 5,5'-dinitro-bis,1,2,4-triazole via a di-N-amino compound.

276 s are transformed to 4,5-disubstituted 1,2,4-triazoles via a desulfurization process.

277 rylation at the C-5 position of N-aryl 1,2,3-triazoles via a direct palladium catalyzed arylation rea

278 activated by conversion to the corresponding triazoles via click chemistry.

279 cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles via copper-mediated intramolecular direct C-ar

280 d intramolecular direct C-arylation of 1,2,4-triazoles was first accomplished under triazole-NHC cont

281 ilicity of 3-amino- and 3,5-diamino-1H-1,2,4-triazoles was predicted to be higher than that of 5-amin

282 A series of new 4,5-dihydro-1H-1,2,4-triazoles was synthesized from amidrazones and acetylene

283 ty functional theory calculations, and these triazoles were compared to the 1,4- and 1,5-regioisomers

284 Although triazoles were less potent than 3 (6), simpler synthesis

285 A variety of C-5 substituted N-aryl 1,2,3-triazoles were prepared using these conditions with yiel

286 action using alkyl azides, and the resulting triazoles were quaternized providing well-defined multit

287 s, derivatives of 4, 4'-bis(5-nitro-1,2,3-2H-triazole) were designed, synthesized, and characterized.

288 itroamino-functionalized mono- and bis(1,2,4-triazoles) were synthesized and characterized by infrare

289 4-(4-methylphenyl)-3-phenyl-5-(azine)-1,2,4-triazole, where azine = pyridine, pyridazine, 4-pyrimidi

290 (1H-pyrazol-4-yl)-1,3-phenylene)bis(1H-1,2,3-triazole)), which demonstrates markedly higher yet still

291 The approach affords densely functionalized triazoles, which are amenable to further modifications b

292 Isavuconazole is a new extended-spectrum triazole with activity against yeasts, molds, and dimorp

293 Isavuconazole is a novel triazole with broad-spectrum antifungal activity.

294 The reaction of 3-amino-5-nitro-1,2,4-triazole with nitrous acid produces the corresponding di

295 hesis of a metal-free [2]rotaxane containing triazole with other functionalities in the axle was achi

296 of a small library of novel 1,4-substituted triazoles with AR antagonistic activity.

297 s assisted by thiophilic Cu to provide 1,2,4-triazoles with concomitant formation of CuS and polynucl

298 onships in the reactions of C-amino-1H-1,2,4-triazoles with electrophiles.

299 available 1-substituted 3-acetylamino-1,2,4-triazoles with subsequent removal of the acetyl protecti

300 cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles with TTMSS/AIBN under neutral conditions allow