ライフサイエンスコーパス: trichloro

1 furanosyl) benzimidazole (1263W94) and 2,5,6-trichloro-1(beta-D-ribofuranosyl)benzimidazole (TCRB) we

2 of 2,4,6-triamino-1,3,5-triazine with 2,4,6-trichloro-1,3,5-triazine at 1.0-1.5 GPa and 500-550 degr

3 was observed when 2,4,6-trifluoro- or 2,4,6-trichloro-1,3,5-triazine were used--1,3,5-triazines that

4 eloped an efficient cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for th

5 none (OH-DCMBQ) from DCMBQ, 5-hydroxyl-2,3,6-trichloro-1,4-benzoquinone (OH-TCBQ) from TCBQ, and 3-hy

6 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl

7 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl

8 oro-3-methyl-1,4-benzoquinone (DCMBQ), 2,3,6-trichloro-1,4-benzoquinone (TCBQ), and 2,6-dibromobenzoq

9 furanose to give, after deprotection, 2,5, 6-trichloro-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)be

10 e resulting low overall yield (5%) of 2,5, 6-trichloro-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)be

11 ed with DAST and deprotected to yield 2,5, 6-trichloro-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)be

12 fluorinated benzimidazole nucleosides 2,5, 6-trichloro-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)be

13 In addition, 3-acetyl-2,5,6-trichloro-1-(2-deoxy-beta-d-ribofuranosyl)indole was als

14 -D-arabinofuranosyl)benzimidazole and 2,5, 6-trichloro-1-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)benzi

15 ta-D-arabinofuranosyl)benzimidazole , 2,5, 6-trichloro-1-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)benzi

16 ing compounds [e.g., CMP1 (4-methyl-N-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide)]

17 The D-nucleosides 2,5, 6-trichloro-1-(beta-D-erythrofuranosyl)benzimidazole (8a)

18 for the corresponding ribofuranosides 2,5, 6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (4a), it

19 esized as ring-contracted analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) a

20 nd the fact that 5'-deoxy analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) a

21 2,5,6-Trichloro-1-(beta-d-ribofuranosyl)benzimidazole (TCRB) a

22 2,5,6-Trichloro-1-(beta-d-ribofuranosyl)benzimidazole (TCRB) a

23 2,5,6-Trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) a

24 halogenated benzimidazole nucleosides 2,5, 6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) a

25 ity in vivo of the glycosidic bond of 2,5, 6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) p

26 y, 5'-ethoxy, and 5'-butoxy analogs of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB) w

27 bofuranosyl)indole (FTCRI) and 3-cyano-2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole (CTCRI) were sy

28 y derivatives of the reported 3-formyl-2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole (FTCRI) and 3-c

29 The previously reported 3-formyl-2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole (FTCRI) and its

30 difications of the previously reported 2,5,6-trichloro-1-(beta-d-ribofuranosyl)indole at the 3-positi

31 ents at the 3-position (e.g., 3-methyl-2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole) were much less

32 re active against HCMV (e.g., 3-formyl-2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole, FTCRI, IC50 =

33 The analogue 2,5,6-trichloro-1-(beta-D-ribofuranosyl)indole-3-carboxamide o

34 yethoxy)methyl]benzimidazole (11a) and 2,5,6-trichloro-1-[(1,3-dihydroxy-2-propoxy)methyl] benzimidaz

35 d 19a, which on debenzylation afforded 2,5,6-trichloro-1-[(2-hydroxyethoxy)methyl]benzimidazole (11a)

36 2,5,6-Trichloro-1-beta-D-ribofuranosyl benzimidazole (TCRB) is

37 was followed by deprotection to afford 2,4,5-trichloro-1-beta-D-ribofuranosylbenzimidazole (20a), and

38 eprotection afforded the corresponding 2,4,6-trichloro-1-beta-D-ribofuranosylbenzimidazole (7a) and 2

39 osyl benzimidazole riboside) and TCRB (2,5,6-trichloro-1-beta-D-riborfuranosyl benzimidazole riboside

40 el lentiviral shRNAs or blocker 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoro

41 We also identified 2,3,6-trichloro-(1,4)benzoquinone (TriCBQ), 2,3-dibromo-5,6-di

42 2,5, 6-Trichloro-(1-beta-D-ribofuranosyl)indole (19) was prepar

43 te glass coverslips were functionalized with trichloro(1H,1H,2H,2H-perfluorooctyl)silane on one side,

44 of the antimicrobial triclosan (TCS; 2,4,4'-trichloro-2'-hydroxydiphenyl ether) was developed.

45 4-metoxybenzophenone); and triclosan (2,4,4'-trichloro-2'-hydroxyphenyl ether).

46 agricultural use of the organochlorine 1,1,1-trichloro-2,2'bis(p-chlorophenyl)ethane (DDT) and increa

47 henyls (PBBs), hexabromobenzene (HBB), 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), and tris

48 DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane), a contact inse

49 the ubiquitous global contaminant DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane), have since de

50 specific for the insecticidal p.p'DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane].

51 e authors explored whether exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its is

52 The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still u

53 evious studies of pregnancy losses and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) were limit

54 , the main metabolite of the pesticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), are hormo

55 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), the first

56 nant, is a metabolite of the pesticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).

57 The primary 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane metabolite, p,p'

58 DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) is highly effec

59 levels of plasma DDE (a metabolite of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane), numbers and ty

60 traction was used to extract 4,4'-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] and its metabol

61 gstD1 encodes a 1,1,1-trichloro-2,2-bis-(P-chlorophenyl)ethane dehydrochlorina

62 1,1-trichloro-2,2-di(4-chlorophenyl)ethane (DDT) and its met

63 rine from chloropentafluorobenzene and 1,3,5-trichloro-2,4,6-trifluorobenzene.

64 lotrinitrobenzene explosives: 1:1 DADP/1,3,5-trichloro-2,4,6-trinitrobenzene (TCTNB), 1:1 DADP/1,3,5-

65 o alpha-aryloxyisobutyric acid 2 using 1,1,1-trichloro-2-methyl-2-propanol (chloretone) was developed

66 trations of pyrethroid metabolites and 3,5,6-trichloro-2-pyridinol (TCPy) in samples collected in 200

67 henone, perfluoroheptanesulfonic acid, 3,5,6-trichloro-2-pyridinol, and 2,4,5-trichlorophenoxyacetic

68 2,4,5-Trichloro-, 2-bromo-4,5-dichloro-, and 2,4,5-tribromoimi

69 l]): 2,2,2-tribromo-(267% [240-294]) > 2,2,2-trichloro-(215% [196-234]) > chloral hydrate (165% [161-

70 ch include 2,5-dichloro, 3,4-dichloro, 3,4,5-trichloro, 3-methoxy, and 2,5-dimethoxy analogues 13-17

71 ive 80-90% yields of 2,6-dichloro- and 2,6,7-trichloro-3-(2,3-dideoxy-2,3-didehydro-d/l-erythrofurano

72 HSV-1 activity, the alpha-d anomer of 2,6,7-trichloro-3-(erythrofuranosyl)imidazo[1,2-a]pyridine pro

73 m TriCHQ-2 and subsequent formation of 3,5,6-trichloro-4-hydroxycyclohexa-2,4-dienone (TriCHQ*).

74 e also produces substantial amounts of 2,3,5-trichloro-6-S-glutathionylhydroquinone (GS-TriCHQ) and a

75 First, the product of such a reaction, 2,3,5-trichloro-6-S-glutathionylhydroquinone, is not a kinetic

76 ess toxic surrogate standard for TCDD [2,3,7-trichloro-8-methyl-dibenzo-p-dioxin (TMDD; XVII)] which

77 Moreover, the trichloro acetimidamide directing group was found to be

78 The readily synthesized trichloro acetimidamide was found to be an excellent dir

79 Similar to the previously reported 2,5,6-trichloro analog (TCRB), the 5,6-dibromo ribonucleoside

80 The 4',7,8-trichloro analogue (38) of mazindol was the most potent

81 erpes simplex virus type 1 revealed that the trichloro analogues of TCRB (2a, 3a) were nearly as acti

82 onality of intermediate reactivity (chloro-, trichloro-, and trifluoroethyl esters), allowed quinone

83 .g., 4,4'-dichloro-biphenyl-2,5-diol, 3,6,4'-trichloro-biphenyl-2,5-diol, 3,4,6,-trichloro-biphenyl-2

84 , 3,6,4'-trichloro-biphenyl-2,5-diol, 3,4,6,-trichloro-biphenyl-2,5-diol, and their corresponding qui

85 Treatment with BF3.Et2O gives a 3,5,8-trichloro-BODIPY that readily undergoes regioselective S

86 respectively, and 0.68 ng mL(-1) (n = 1) for trichloro-BPA.

87 ynthesized and converted to its trinitro and trichloro derivatives (see scheme; R=NO(2), Cl).

88 immunomodulating tellurium compound ammonium trichloro (dioxoethylene-o,o') tellurate (AS101) on dext

89 Second, AS101 [ammonium trichloro(dioxoethylene-o,o')tellurate], a compound that

90 Among the HNQs tested, 5,6,7-trichloro HNQ (8i) was the most potent antagonist with a

91 2,4,6-Trichlorophenol (2) and 2,4,6-trichloro-m-cresol (5) react with calcium hypochlorite (

92 yzes the GSH-dependent conversion of TeCH to trichloro-p-hydroquinone (TriCH) and then to dichloro-p-

93 Since GS-trichloro-p-hydroquinone is uncommon in nature, the exte

94 glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone.

95 reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone.

96 increased risk associated with use of 2,4,5-trichloro-phenoxypropionic acid (2,4,5-TP) and possibly

97 asal medium in the presence of 4-amino-3,5,6,trichloro-picolinic acid (picloram) inducing the formati

98 5,6,7-Trichloro-QTO also had a Kb of 180 nM for AMPA receptors

99 Among the derivatives evaluated, 5,6,7-trichloro-QTO was the most potent antagonist with an IC5

100 moderately strong acids in aqueous solution (trichloro-, trifluoro-, chlorodifluoro-, and dichloroace