ライフサイエンスコーパス: trichothecene

1 the keto group at C-8 and hence is a type A trichothecene.

2 about cellular protection mechanisms against trichothecenes.

3 t not in related species that do not produce trichothecenes.

4 sphate, the immediate molecular precursor of trichothecenes.

5 llected in Hawaii, was a source of three new trichothecenes, 3-hydroxyroridin E (1a), 13'-acetyltrich

6 e infested seeds are often contaminated with trichothecene and estrogenic mycotoxins that pose a seri

7 NK/p38 kinases and induction of apoptosis by trichothecenes and anisomycin.

8 ses and induction of apoptosis) of apoptotic trichothecenes and anisomycin.

9 lready reported for legislated mycotoxins as trichothecenes and zearalenone (ZON) separately, we desc

10 otein synthesis inhibitor that competes with trichothecenes (and anisomycin) for ribosome binding, al

11 Trichothecenes are isoprenoid mycotoxins produced in whe

12 Trichothecenes are phytotoxic sesquiterpenic mycotoxins

13 Trichothecenes are terpene-derived secondary metabolites

14 Some fungal genes for trichothecene biosynthesis (Tri genes) are known to be u

15 Trichothecene biosynthetic enzymes accumulate in organiz

16 ium graminearum and F. sporotrichioides have trichothecene biosynthetic genes (TRI) at three loci: a

17 first metabolic intermediate specific to the trichothecene biosynthetic pathway.

18 Fluorescence tagged trichothecene biosynthetic proteins co-localize with the

19 n the parental strain treated with different trichothecenes, but not in a petite version of the paren

20 ient mutants, suggesting that elimination of trichothecene-damaged mitochondria by mitophagy improves

21 the occurrence of eighteen mycotoxins, nine trichothecenes (deoxynivalenol, 3-acetyl-deoxynivalenol,

22 revealed the presence of 4 out of 12 studied trichothecenes: DON (deoxynivalenol), 15AcDON (15-acetyl

23 f beer a combined solid phase extraction for trichothecenes, enniatins, beauvericin and zearalenone w

24 The trichothecene family of mycotoxins inhibit protein synth

25 s and toxin evolution, a 19-kb region of the trichothecene gene cluster was sequenced in 39 strains c

26 ichodiene synthase) and probably maps in the trichothecene gene cluster.

27 nt and evidence of adaptive evolution within trichothecene genes are also reported.

28 used as a representative compound for type-B trichothecenes in this detection scheme.

29 l protein synthesis as a novel mechanism for trichothecene-induced cell death.

30 y is a cellular protection mechanism against trichothecene-induced mitochondrial oxidative stress and

31 le and sensitive method for the screening of trichothecenes is important to prevent economic loss and

32 To understand the trichothecene mechanism of action, we screened the yeast

33 Strain-specific differences in trichothecene metabolite profiles (chemotypes) are not w

34 To determine the effect of trichothecene metabolites on gene expression, cultures w

35 In rice cultures, a new trichothecene mycotoxin (named NX-2) was characterized b

36 nome-wide insight into the mode of action of trichothecene mycotoxins and uncover a critical role for

37 Trichothecene mycotoxins are natural contaminants of sma

38 e isolated, which produced none of the known trichothecene mycotoxins despite causing normal disease

39 expensive method for the detection of type-B trichothecene mycotoxins has been developed in our labor

40 Trichothecene mycotoxins in animal feed and human food c

41 Trichothecene mycotoxins synthesized by Fusarium species

42 ion, scabby grain is often contaminated with trichothecene mycotoxins that act as virulence factors o

43 , these findings support the hypothesis that trichothecene mycotoxins, and in particular NIV, have th

44 nzyme A to the C3 hydroxyl moiety of several trichothecene mycotoxins.

45 or both of these enzymes with coenzyme A and trichothecene mycotoxins.

46 When triggered to produce sesquiterpene (trichothecene) mycotoxins, the endoplasmic reticulum (ER

47 total of 12 mycotoxins simultaneously, nine trichothecenes (NIV, DON, FUS-X, DAS, 15-AcDON, 3-AcDON,

48 graminearum, a fungus able to produce type B trichothecenes on cereals, including deoxynivalenol (DON

49 ety in DON is common to virtually all type-B trichothecenes, our approach may be ideal for type-speci

50 uccessfully applied for the determination of trichothecenes, patulin and zearalenone in 182 milled gr

51 The locus governing the type of trichothecene produced (nivalenol or deoxynivalenol) cos

52 Harzianum A (HA) is a non-phytotoxic trichothecene produced by Trichoderma arundinaceum.

53 Cotreatment with rapamycin and trichothecenes reduced ROS levels and cytotoxicity in th

54 To identify cellular functions involved in trichothecene resistance, we screened the Saccharomyces

55 oxidative stress and a potential target for trichothecene resistance.

56 gesting that oxidative stress contributes to trichothecene sensitivity.

57 We have found that selected trichothecenes strongly activate JNK/p38 kinases and ind

58 uce systemic defences indicates that complex trichothecene structures may not be necessary for induci

59 s in activity of these enzymes toward B-type trichothecenes such as deoxynivalenol.

60 Trichothecenes that inhibit protein synthesis without ac

61 Among trichothecenes that strongly activate JNK/p38 kinases, i

62 Among trichothecenes that strongly inhibit protein synthesis,

63 Artificially inoculated grasses accumulated trichothecenes to a much lesser extent than wheat, and n

64 Although the ability of individual trichothecenes to inhibit protein synthesis and activate

65 less than 10(0.7) L/kg(oc) (e.g., all type B trichothecenes) to 10(4.0) L/kg(oc) (positively charged

66 ting a role for fully active mitochondria in trichothecene toxicity.

67 Loci governing trichothecene toxin amount and type (deoxynivalenol or n

68 AG42R in Fusarium sporotrichioides increases trichothecene (TR) mycotoxin production and alters TR ge

69 icity in the parental strain relative to the trichothecene treatment alone, but not in mitophagy defi

70 idated for the simultaneous extraction of 12 trichothecenes (type A and type B) from baby foods, foll

71 Cytotoxicity of trichothecenes was alleviated after treatment of the par