ライフサイエンスコーパス: triene

1 3-dienimidoyl)sulfanyl]acetates (1-aza-1,3,4-trienes).

2 ated with the generation of megastigma-4,6,8-triene.

3 mino carboxylic acid containing a conjugated triene.

4 ide values, conjugated dienes and conjugated trienes.

5 roxide value, acidity, conjugated dienes and trienes.

6 the most stable conformation of each of the trienes.

7 LF revealed the most peroxides but the least trienes.

8 of 1,5-allenynes to produce cross-conjugated trienes.

9 c fragments distinguishable from homoallylic trienes.

10 Trienes 1 and 3 were obtained in five steps from ethyl 4

11 thyl 5,7-difluoro-4-azaspiro[2.4]hepta-1,4,6-triene-1-carboxylate, presumably via the corresponding k

12 produces 4,5-benzobicyclo[4.1.0]hepta-2,4,6-triene (11) at lambda = 670 or >613 nm, but without dete

13 -catalyzed coupling with triflate 13 to give triene 16 without the formation of Heck products, a nove

14 Thermolysis of spiro[2.4]hepta-1,4,6-triene (1a) at 50 degrees C yielded bicyclo[3.2.0]hepta-

15 24b and 24C) as the acid components provided trienes 22, 25b, and 25c, respectively, which upon heati

16 te (>4000-fold), C11-alcohol (250-fold), and triene (220-fold) contribution to PP2A inhibition.

17 rature without any trace of initially formed trienes 28a-c.

18 -tetrahydroxy-9-methyl-19-norlanosta-1,5,2 3-triene-3,11,22-trione], JSI-124, or the extracellular si

19 45384), (17beta)-2,4-dibromo-estra-1,3,5(10)-triene-3,17-diol (NSC103054), and methyl N-(pyridine-4-c

20 trile) or 8beta-VE2 (8-vinylestra-1,3,5 (10)-triene-3,17beta-diol).

21 ), 2-ethoxy-17-(1'-methylene)estra-1,3,5(10)-triene-3-ol (50) and 2-ethoxy-17alpha-methylestradiol (5

22 tetracyclo[5.2.2.1.(3,5)0(2,6)]dodec-2,8,10-triene (33, psi = 14.4 degrees ).

23 ding 1-aza-benzo[d]bicyclo[4.1.0]hepta-2,4,6-triene 34 and 3-aza-benzo[d]cyclohepta-2,3,5,7-tetraene

24 tural product than are the IMDA reactions of trienes 4 and 7.

25 ed the epoxy dienes 10 and 22, the diacetoxy triene 42, and the heavily functionalized cyclohexane 48

26 affords 6-azabicyclo[3.2.0]cyclohepta-1,3,5-triene 43.

27 Triene 5 has been prepared by the E-selective olefinatio

28 degrees C yielded bicyclo[3.2.0]hepta-1,3,6-triene (5), which dimerized in two different fashions to

29 rene ((3)PN), 2-azabicyclo[3.2.0]hepta-1,3,6-triene (6), and 4-azaspiro[2.4]hepta-1,4,6-triene (7).

30 -dien-2-ylidene, 10, and thiacyclohexa-2,3,5-triene, 6.

31 ions of hepta-1,2,4,6-tetraene 5, hexa-1,3,5-triene 7, Z and E-1-aza-1,3,5-hexatrienes 9 and 10, and

32 6-triene (6), and 4-azaspiro[2.4]hepta-1,4,6-triene (7).

33 btained substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols and their keto derivatives showed high

34 esis of substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols, which form the key structural moietie

35 primarily 2,3-benzobicyclo[4.1.0]hepta-2,4,6-triene (9) accompanied by small amounts of triplet 4,5-b

36 The bioactive molecules contain conjugated triene and diene double bonds, carry an alcohol at C13 a

37 ich a chiral cyclopropyl group is flanked by triene and enal chromophores, and hence would clarify th

38 Reactions between (E)-hexa-1,3,5-triene and s-trans-buta-1,3-diene are shown to have subs

39 Smaller amounts of H2O lead to mixtures of triene and vinylallene products, where the latter is for

40 previously utilized and produce mixtures of trienes and cyclohexadienes.

41 -dialkylanilino) donor-substituted push-pull trienes and tetraenes showed better electron-accepting p

42 Hydantoins containing trienes and tetraenes undergo selective RCM and cross me

43 allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthes

44 ular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, represen

45 t positional isomerizations of the diene and triene are facilitated by simultaneous proton transfers

46 The ring closures of these bridged bicyclic trienes are up to a million-fold faster (DeltaDeltaG() =

47 of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed.

48 ta-2,4-diene (BCH), bicyclo[6.1.0]nona-2,4,6-triene (BCN), and 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-tr

49 its valence isomer, bicyclo[4.2.0]octa-2,4,7-triene (BCOT, 3a) and that the iron tricarbonyl complex

50 henylcarbene (PC), bicyclo[4.1.0]hepta-2,4,6-triene (BCT), and 1,2,4,6-cycloheptatetraene (CHTE) has

51 Partially conjugated trienes behave similarly to monoenes and conjugated dien

52 show that a variety of conjugated dienes and triene can be enantioselectively diaminated using di-ter

53 Various dienes and a triene can be regioselectively diaminated at the interna

54 A wide variety of conjugated dienes and trienes can be effectively diaminated in good yields wit

55 ed derivatives of s-cis,s-cis (E)-hexa-1,3,5-trienes can lead to derivatives of (Z,Z,E)-cyclodeca-1,3

56 as measured by the conjugated autoxidizable triene (CAT) assay.

57 These two compounds possess a rigid triene chain conjugated to one of the cyclopentadienyl r

58 s of Alzheimer's patients and [(125)I]9, the triene compounds showed excellent binding affinities.

59 steps shorter than any prior synthesis of a triene-containing C17-benzene ansamycin.

60 The triene-containing C17-benzene ansamycins trienomycins A

61 essful synthesis of the ripostatin A skipped triene core.

62 A triene cyclization precursor generated in 12 steps under

63 d [cmpd LA, (22R)-1 alpha, 25-(OH)2-16,22,23-triene-D3] had an ED50 of 2 x 10(-11) mol/L; it was also

64 he synthesis is enabled by a new dendrimeric triene (Danishefsky [3]-dendralene) and a new method for

65 CN), and 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene (DCBCN).

66 Unlike conjugated dienes, fully conjugated triene diagnostic ion signal ratios did not follow any p

67 hexaenoic acid and sulfido-conjugate (SC) of triene double bonds that proved to be 13-glutathionyl, 1

68 ement of 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene-exo-15N.

69 Triene FAME with both methylene and ethylene interruptio

70 The preparation of phosphorus-containing trienes featuring two diastereotopic vinyl moieties foll

71 of the latter to give a 1,5-diazahexa-1,3,5-triene, followed by 1,6-cyclization.

72 The two possible cis-dienes and a cis-triene formally derived from the tetraazaeicosane skelet

73 Photooxidation of this triene forms a cyclopropanone and subsequent photoextrus

74 llene precursor, and the construction of the triene framework by a palladium-catalyzed intramolecular

75 pling reactions are capable of forming E,E,E-trienes from cinnamaldehydes in good yield.

76 guishes between the two allowed, disrotatory triene geometries at the transition state.

77 e first topochemical 1,6-polymerization of a triene has been observed.

78 s (ARCM) of a challenging class of prochiral trienes has also been achieved.

79 der cycloaddition of N-substituted oxazolone triene I allows direct entry to the functionalized octah

80 iels-Alder reaction of an amino acid derived triene in acetic acid.

81 mediacy of 2-methylbicyclo[4.1.0]hepta-2,4,6-triene in the 3b to 18 rearrangement.

82 ing of simple (E)-1,3-dienes to give (E,Z,E)-trienes in high yield and with high Z selectivities.

83 Fragmentation of fully conjugated trienes in the MS-1 spectra yields ratios of [M + 54]+/[

84 allows rapid access to various 1,4-dienes or trienes including the biologically active natural produc

85 (IMDA) reaction of the camphanate-containing triene intermediate.

86 clization of common (5Z)-1,4-diazahexa-1,3,5-triene intermediates.

87 the thermal conversion of 1-azidohepta-3,4,6-trienes into cyclopentennelated dihydropyrroles are pres

88 alytic ring-closing metathesis of an achiral triene is used to establish the all-carbon quaternary st

89 While thermolysis of the macrobicyclic triene lactone 12 did not produce the expected bicyclic

90 closing metathesis (ARCM) of various achiral trienes leads to the formation of medium-ring unsaturate

91 on the TADA reactions of 14-membered cyclic triene macrocycles to yield A.B.C[6.6.6] tricycles using

92 g macrocycle containing the critical (Z,Z,E)-triene moieties.

93 ile moieties located on a single macrocyclic triene molecule have been recognized as effective synthe

94 formation of diazabicyclo[4.1.0]hepta-2,4,6-triene N-oxide and diazacycloheptatetraene N-oxide inter

95 Thus, the all-cis 1,5,9-triene natural product was prepared in 15 steps from com

96 The formation of triene occurs only in the presence of ArB(OH)2.

97 DCBCN to 9,9-dicyanobicyclo[4.2.1]nona-2,4,7-triene occurs with a preferred stereochemistry correspon

98 sahexaenoate backbone and sulfido-conjugated triene or tetraene double-bond systems.

99 acid core component, a cyclohexane ring, two triene polyketide chains, and a 2-amino-3-hydroxycyclope

100 The conjugated triene present in alpha-eleostearic acid constitutes an

101 With an excess of H2O, a triene product is selectively formed via allenic C-H act

102 energies than those involving (Z)-hexa-1,3,5-triene reacting with either s-cis- or s-trans-buta-1,3-d

103 on-10 alcohol and geometry of the conjugated triene, required for bioactivity remained to be assigned

104 +pi4s] cycloadditions with cyclic dienes and trienes, respectively, to generate novel bridged azabicy

105 analogue lacking the entire C12-C18 (Z,Z,E)-triene segment, which were used to define the magnitude

106 Synthesis of the C(15)-C(25) skipped triene side chain fragment makes use of a [2,3]-Wittig-S

107 The C45-C48 segment of the eventual triene side chain was introduced by addition of a functi

108 e reactivity of the unique 4,9,11 conjugated triene structure of trenbolone.

109 Olefin metathesis of the triene substrate 12 afforded the product diene macrolide

110 e is demonstrated in the direct synthesis of triene substrates for silicon-tethered intramolecular Di

111 dified Julia protocol to elaborate the E,E,E-triene subunit in a stereo-controlled fashion, (d) an ef

112 The triene system was introduced by the Pd-catalyzed tandem

113 (7 and 8) with an unprecedented non-natural triene system were synthesized by thermal isomerization

114 ll as the parent vitamin with the "reversed" triene system, 9-methylene-19-nor-1alpha,25-(OH)2D3, wer

115 oximation of an intact vitamin D conjugated triene system.

116 he B-ring opening, leading to the conjugated triene system.

117 earomatization and on the replacement of the triene tail of the natural product by an aromatic ring.

118 etraazabicyclo[9.3.1]-pentadeca-1(15),11,13 -triene (Tb-PCTMB) has also been shown to exhibit strongl

119 bstituted, pi-conjugated polycyanohexa-1,3,5-trienes (TCHTs and PCHTs) and polycyanoocta-1,3,5,7-tetr

120 ad to derivatives of (Z,Z,E)-cyclodeca-1,3,7-triene that are stable to Cope rearrangement, and reacti

121 cycloaddition of tethered diynes with cyclic trienes that generates five rings and six stereogenic ce

122 roxy diastereomers with all-trans-conjugated trienes that incorporated (18)O from H(2)(18)O at C-8, i

123 trocyclizations of chiral 1-azahexa-1E,3Z,5E-trienes that yield functionalized dihydropyridines.

124 e characteristic chromophore of a conjugated triene, the other with a chromophore characteristic of a

125 ective installation of the sensitive (Z,Z,E)-triene through a beta-chelation-controlled nucleophilic

126 [4-(trimethylamino)phenyl]-6-phenyhexa-1,3,5-triene (TMA-DPH), which probes the upper region of the b

127 4-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene (TMA-DPH).

128 esis (RC-RO-RC-CM) occurred with a hydantoin triene to give a bicyclic hydantoin dimer in high yield.

129 d concentrations and 22% had a high ratio of triene to tetraene.

130 24 mol %, CH2Cl2, reflux) give the cage-like trienes trans- Fe(CO)3(P((CH2)mCH horizontal lineCH(CH2)

131 ular diene cyclozirconation of the resulting triene under equilibrating conditions led to the tricycl

132 gle-step installation of the sensitive Z,Z,E-triene unit through a chelation-controlled cuprate addit

133 ective monoepoxidation of conjugated di- and trienes using 30% H2O2 at or below room temperature.

134 Boland semireduction, to create the (E,E,Z)-triene via an (E,E)-ynediene, and a selective deprotecti

135 e IMDA reaction of the camphanate-containing triene were obtained from density functional theory calc

136 The requisite starting trienes were prepared stereoselectively in just three st

137 out 50 kcal/mol lower than norborna-1(7),2,5-triene, which was thus excluded as a reaction intermedia

138 as used as the key transformation to prepare trienes with a carboxamide substituent on the tether.

139 vinyl borate ester, possessing the all-trans triene, with an advanced C(1-19) vinyl iodide followed b