ライフサイエンスコーパス: trimethylamine N-oxide

1 alpha-MG (methyl-alpha-glucoside), and TMAO (trimethylamine n-oxide).

2 ic reduction of either dimethyl sulfoxide or trimethylamine N-oxide.

3 fatty acids and degradation products such as trimethylamine N-oxide.

4 ine, but not nitrite, dimethyl sulfoxide, or trimethylamine N-oxide.

5 tive decarbonylation with the bulky reactant trimethylamine-N-oxide.

6 ones such as ethanol, dimethyl sulfoxide, or trimethylamine-N-oxide.

7 ergent, above its CMC ( approximately 0.2%), trimethylamine N-oxide, a folding inducing organic osmol

8 such as urea, sugars, guanidinium salts, and trimethylamine N-oxide affect the stability, solubility,

9 rom dietary choline and L-carnitine, such as trimethylamine N-oxide and betaine, have recently been i

10 cceptors, e.g., nitrite, dimethyl sulfoxide, trimethylamine-N-oxide and fumerate, and azide, an inhib

11 We used four solutes, glycerol, sucrose, trimethylamine-N-oxide and poly(ethylene glycol) 8000, w

12 e that of urea, which is about twice that of trimethylamine-N-oxide and sucrose.

13 ic oxide, nitrous oxide, 1-azido adamantane, trimethylamine n-oxide, and 1,4-benzoquinone quantitativ

14 erature (30 degrees C), osmolytes (glycerol, trimethylamine N-oxide, and dimethyl sulfoxide), and the

15 levels of liver glycogen, choline, taurine, trimethylamine N-oxide, and glucose and by elevated leve

16 ne, glycine, choline, cysteine, glutathione, trimethylamine N-oxide, and the ratios glycine:serine, 3

17 e consisting of aconitic acid, hypoxanthine, trimethylamine N-oxide, and threonine differentiated pat

18 nicotinamide N-oxide, methionine sulfoxide, trimethylamine-N-oxide, and dimethyl sulfoxide, although

19 f enzyme-monitored turnover experiments with trimethylamine N-oxide as substrate reveal that no subst

20 lamine (TMA) and its subsequent oxidation to trimethylamine N-oxide by hepatic flavin-containing mono

21 at protecting osmolytes such as sorbitol and trimethylamine N-oxide can counteract the denaturing eff

22 ature and high concentrations of glycerol or trimethylamine N-oxide can partially counteract the proc

23 eased the lag time, whereas the stabilizers, trimethylamine N-oxide dihydrate (TMAO) and sucrose, inc

24 E'0 [NO2-, U(VI), dimethyl sulfoxide, TMAO (trimethylamine N-oxide), fumarate, gamma-FeOOH, SO3(2-),

25 unrelated protective osmolytes, sorbitol and trimethylamine-n-oxide, function by marginally decelerat

26 ted here, the gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the d

27 phenyl derivative [(tpa(Ph))Fe(II)](-) with trimethylamine N-oxide in acetonitrile solution produces

28 Addition of trimethylamine N-oxide increases T(m) by approximately 5

29 The folding agent trimethylamine N-oxide induced only a small increase in

30 or S-oxides and an increased specificity for trimethylamine-N-oxide (Me(3)NO), with a greater change

31 the urine profiles included higher levels of trimethylamine-N-oxide, N,N'-dimethylglycine, m-hydroxyp

32 nideality arising from molecular crowding by trimethylamine N-oxide on the self-association behaviour

33 39.5 degrees C) in the presence of glycerol, trimethylamine N-oxide or deuterated water.

34 formation upon the addition of the osmolyte trimethylamine N-oxide or the cosolvent 2,2,2-trifluoroe

35 ther in the presence of the natural osmolyte trimethylamine-N-oxide or through a direct interaction w

36 many pathways, including the trimethylamine/trimethylamine N-oxide pathway, short-chain fatty acids

37 al interest, such as urea (good solvent) and trimethylamine N-oxide (poor solvent), are known to affe

38 Flow cytometric screening of trimethylamine N-oxide reductase (TorA) leader peptide l

39 rophobic (h-) region of the Escherichia coli trimethylamine N-oxide reductase (TorA) signal peptide i

40 t the green fluorescent protein fused to the trimethylamine N-oxide reductase (TorA) signal sequence

41 , such as the model (NiFe) hydrogenase-2 and trimethylamine N-oxide reductase (TorA) systems, acquire

42 and a truncated version of the Tat substrate trimethylamine N-oxide reductase (TorA502) bearing an RR

43 sulfoxide reductase, and Shewanella massilia trimethylamine N-oxide reductase as the templates.

44 of the native Esherichia coli Tat substrate trimethylamine N-oxide reductase with a twin-lysine subs

45 MSOR = dimethyl sulfoxide reductase, TMAOR = trimethylamine N-oxide reductase)

46 DMSOR = dimethylsulfoxide reductase, TMAOR = trimethylamine N-oxide reductase) members of the title e

47 Dimethyl sulfoxide reductase (DMSOR), trimethylamine-N-oxide reductase (TMAOR), and biotin sul

48 of S. cerevisiae with the chemical chaperone trimethylamine-N-oxide resulted in near complete restora

49 es T(m) by approximately 5 degrees C per 1 M trimethylamine N-oxide, resulting in stable triple-helix

50 the naturally occurring protecting osmolytes trimethylamine N-oxide, sarcosine, sucrose, and proline

51 d to be specific for chicken intake, whereas trimethylamine-N-oxide showed good specificity for fish.

52 lamines (glycerophosphocholine, betaine, and trimethylamine N-oxide), substrates (DL-glyceraldehyde a

53 Other osmolytes such as trimethylamine N-oxide, sucrose, and betaine also reacti

54 conditions (pH 5.7-8.2, 0-40% sucrose, 0-2 M trimethylamine N-oxide) suggest that the salt-induced di

55 complements the action of osmolytes, such as trimethylamine N-oxide, that favor more compact protein

56 acids, select unsaturated lipid species, and trimethylamine-N-oxide), thus in effect linking diverse

57 the fluctuations of the native state, while trimethylamine N-oxide (TMAO) affects function in the op

58 dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identifi

59 include the cellular osmolytes glycerol and trimethylamine N-oxide (TMAO) and the organic solvent di

60 tion in the presence of the natural osmolyte trimethylamine N-oxide (TMAO) and the solvent trifluoroe

61 tions of the gut bacteria choline metabolite trimethylamine N-oxide (TMAO) are associated with athero

62 Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocea

63 ium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source;

64 grow on either dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO) as the sole terminal elect

65 (arc) and anaerobic respiration (dms), using trimethylamine N-oxide (TMAO) as the terminal electron a

66 esent study, we show that a natural osmolyte trimethylamine N-oxide (TMAO) at the optimal 1 m concent

67 perature (T(F)) changes linearly as urea and trimethylamine N-oxide (TMAO) concentrations increase.

68 lt and urea increase the Km's of enzymes and trimethylamine N-oxide (TMAO) counteracts these effects

69 The osmolyte trimethylamine N-oxide (TMAO) did not affect the structu

70 sus belief that protective osmolytes such as trimethylamine N-oxide (TMAO) favor protein folding by b

71 We have found that the natural osmolyte trimethylamine N-oxide (TMAO) induces secondary structur

72 Trimethylamine N-oxide (TMAO) is a biologically active m

73 Trimethylamine N-oxide (TMAO) is a common osmolyte found

74 Trimethylamine n-oxide (TMAO) is a naturally occurring o

75 Trimethylamine N-oxide (TMAO) is a solute concentrated i

76 ectron acceptor dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO) is manifested by the molyb

77 , we detect associations with fasting plasma trimethylamine N-oxide (TMAO) levels, a gut microbiota-d

78 ctate as the sole carbon source, with either trimethylamine N-oxide (TMAO) or fumarate as an electron

79 Trimethylamine N-oxide (TMAO) reductases are widespread

80 We show that the osmolytes urea and trimethylamine N-oxide (TMAO) shift the population of ID

81 in aqueous solutions of urea, methanol, and trimethylamine N-oxide (TMAO) show clearly the effects o

82 The common osmolyte trimethylamine N-oxide (TMAO) stabilizes proteins agains

83 urally occurring protein-protective osmolyte trimethylamine N-oxide (TMAO) that stabilizes cellular p

84 The protective osmolyte trimethylamine N-oxide (TMAO) was used to induce folding

85 association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcom

86 Trimethylamine N-oxide (TMAO), a gut microbe-dependent m

87 Trimethylamine N-oxide (TMAO), a gut microbiota metaboli

88 atomic force microscopy measurements, unless trimethylamine N-oxide (TMAO), a natural occurring osmol

89 The molecular orientation of trimethylamine N-oxide (TMAO), a powerful protein stabil

90 g osmolyte, shifts the equilibrium toward U; trimethylamine N-oxide (TMAO), a protecting osmolyte, sh

91 We have used trimethylamine N-oxide (TMAO), a protecting osmolyte, to

92 The use of trimethylamine N-oxide (TMAO), an osmolyte that stabiliz

93 Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by natur

94 nvestigating the effects of three osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on

95 Chemical chaperones, such as trimethylamine N-oxide (TMAO), can prevent formation of

96 ats with active or relapsing vasculitis were trimethylamine N-oxide (TMAO), citrate and 2-oxoglutarat

97 now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to pl

98 umarate, nitrate, dimethyl sulfoxide (DMSO), trimethylamine N-oxide (TMAO), nitrite, and insoluble ir

99 the presence of dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO), R. sphaeroides 2.4.1T uti

100 t in buffers containing the natural osmolyte trimethylamine N-oxide (TMAO), recombinant AF1 folds int

101 ectron acceptor dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO), Rhodobacter sphaeroides 2

102 ectron acceptors tested, including fumarate, trimethylamine N-oxide (TMAO), thiosulfate, dimethyl sul

103 traordinary capability of one such osmolyte, trimethylamine N-oxide (TMAO), to force two thermodynami

104 apability of the naturally occurring solute, trimethylamine N-oxide (TMAO), to force two unfolded pro

105 We study the effect of the osmolyte, Trimethylamine N-Oxide (TMAO), which accumulates in cell

106 FMO3 produces trimethylamine N-oxide (TMAO), which has recently been s

107 ing transition upon addition of the osmolyte trimethylamine N-oxide (TMAO).

108 ine, glycine betaine), and also glycerol and trimethylamine N-oxide (TMAO).

109 olism of certain dietary nutrients producing trimethylamine N-oxide (TMAO).

110 nhibited by the naturally occurring osmolyte trimethylamine N-oxide (TMAO).

111 ate anions (ligands) as well as the osmolyte trimethylamine N-oxide (TMAO).

112 m to counteract the effects of urea by using trimethylamine N-oxide (TMAO).

113 tra acquired in the presence of the osmolyte trimethylamine N-oxide (TMAO).

114 lism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and colorectal cancer ris

115 ined the relationship between fasting plasma trimethylamine-N-oxide (TMAO) and all-cause mortality ov

116 cing effects between the protecting osmolyte trimethylamine-N-oxide (TMAO) and denaturing osmolyte ur

117 Trimethylamine-N-oxide (TMAO) and urea represent the ext

118 growth to anaerobic respiratory growth with trimethylamine-N-oxide (TMAO) as the terminal electron a

119 tent with clinical data, and discovered that trimethylamine-N-oxide (TMAO) crosses the blood-brain ba

120 Trimethylamine-N-oxide (TMAO) in the cells of sharks and

121 Trimethylamine-N-Oxide (TMAO) is a microbiome-related me

122 Although it is not clear whether trimethylamine-N-oxide (TMAO) is directly transported, t

123 Trimethylamine-N-oxide (TMAO) levels in blood predict fu

124 sted the influence of trehalose, sucrose and trimethylamine-N-oxide (TMAO) on Abeta aggregation and f

125 mulation study of the effect of the osmolyte trimethylamine-N-oxide (TMAO) on hydrophobic phenomena a

126 ne, dimethylamine (DMA), trimethylamine, and trimethylamine-N-oxide (TMAO) with the use of liquid chr

127 Trimethylamine-N-oxide (TMAO), a gut microbial-dependent

128 ucture and compactness is also observed with trimethylamine-N-oxide (TMAO), a naturally occurring osm

129 ations of the naturally occurring osmolytes, trimethylamine-N-oxide (TMAO), sarcosine, betaine, proli

130 ficacy of naturally occurring osmolytes like trimethylamine-N-oxide (TMAO), to offset the deleterious

131 ary source for the gut microbiota metabolite trimethylamine-N-oxide (TMAO), which has been related to

132 ry choline, results in increased exposure to trimethylamine-N-oxide (TMAO), which is purported to be

133 oduction of a proatherosclerotic metabolite, trimethylamine-N-oxide (TMAO).

134 her metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).

135 subsequent host-driven conversion of TMA to trimethylamine-N-oxide (TMAO).

136 g osmolytes glycerol, proline, sarcosine and trimethylamine-N-oxide (TMAO).

137 ratures, in acidic pH, or in the presence of trimethylamine N-oxide, trifluoroethanol, or a cationic

138 TMAO (trimethylamine-N-oxide) was used to stabilize the tetram