ライフサイエンスコーパス: triosephosphate

1 Accumulation of triosephosphates arising from high cytosolic glucose con

2 ate in the liver, one involved in generating triosephosphate from glycerol and the other involved in

3 e benfotiamine countered the accumulation of triosephosphates in experimental diabetes and inhibited

4 We apply MPAX to the triosephosphate isomerase (beta/alpha)(8) barrel, accura

5 r the effect of the S96P mutation in chicken triosephosphate isomerase (cTIM) has been analyzed using

6 ructose-bisphosphate aldolase (EC 4.1.2.13), triosephosphate isomerase (EC 5.3.1.1), and glycerol-3-p

7 Loop 6 in the active site of Triosephosphate Isomerase (Saccharomyces cerevisiae) mov

8 e kinetic parameters for activation of yeast triosephosphate isomerase (ScTIM), yeast orotidine monop

9 e origin for the functional specificities of triosephosphate isomerase (TIM) and methylglyoxal syntha

10 At one end of the HydG (betaalpha)8 triosephosphate isomerase (TIM) barrel, a canonical [4Fe

11 n of (R)-glyceraldehyde 3-phosphate (GAP) by triosephosphate isomerase (TIM) can be attributed to the

12 D-Xylose isomerase (XI) and triosephosphate isomerase (TIM) catalyze the aldose-keto

13 Three mechanisms proposed for the triosephosphate isomerase (TIM) catalyzed reactions were

14 Triosephosphate isomerase (TIM) catalyzes the interconve

15 Triosephosphate isomerase (TIM) catalyzes the reversible

16 Triosephosphate isomerase (TIM) catalyzes the reversible

17 side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to b

18 phate (DHAP) in D(2)O at pD 7.9 catalyzed by triosephosphate isomerase (TIM) from chicken and rabbit

19 te (GAP) in D(2)O at pD 7.5-7.9 catalyzed by triosephosphate isomerase (TIM) from chicken and rabbit

20 more likely to be stabilizing in our model, triosephosphate isomerase (TIM) from Saccharomyces cerev

21 We report that the K12G mutation in triosephosphate isomerase (TIM) from Saccharomyces cerev

22 GAP) to dihydroxyacetone phosphate (DHAP) by triosephosphate isomerase (TIM) from Trypanosoma brucei

23 The L232A mutation in triosephosphate isomerase (TIM) from Trypanosoma brucei

24 simulations of the folding and unfolding of triosephosphate isomerase (TIM) from yeast were conducte

25 transfer steps in the reactions catalyzed by triosephosphate isomerase (TIM) has been studied.

26 The enzyme triosephosphate isomerase (TIM) has been used as a model

27 imulations are used to study the dynamics of triosephosphate isomerase (TIM) in complex with glycerol

28 carbonyl carbon ([1-(13)C]-GA) catalyzed by triosephosphate isomerase (TIM) in D(2)O at pD 7.0 in th

29 s for many enzymes, the enzymatic pathway of triosephosphate isomerase (TIM) includes the partially r

30 The enzyme triosephosphate isomerase (TIM) is a model of catalytic

31 Triosephosphate isomerase (TIM) is a proficient catalyst

32 The Omega loop of triosephosphate isomerase (TIM) is important for prevent

33 talline uniformly (13)C,(15)N-enriched yeast triosephosphate isomerase (TIM) is sequentially assigned

34 The K12G mutation at yeast triosephosphate isomerase (TIM) results in a 5.5 x 10(5)

35 Methylglyoxal synthase (MGS) and triosephosphate isomerase (TIM) share neither sequence n

36 The tunnel region at triosephosphate isomerase (TIM)'s dimer interface, dista

37 e, we designed several consensus variants of triosephosphate isomerase (TIM), a large, diverse family

38 Unfolding and refolding of rabbit muscle triosephosphate isomerase (TIM), a model for (betaalpha)

39 xtent to which sites evolve codependently in triosephosphate isomerase (TIM), a ubiquitous glycolytic

40 Results are featured for three enzymes: triosephosphate isomerase (TIM), aldose reductase (AR),

41 nalysis of the catalytic cycle of the enzyme triosephosphate isomerase (TIM), including both the reac

42 G is a competitive inhibitor of both MGS and triosephosphate isomerase (TIM), the carboxylate groups

43 In the case of the human triosephosphate isomerase (TPI gene), nonsense codons lo

44 in MS, we identified the glycolytic enzymes, triosephosphate isomerase (TPI) and GAPDH, using Igs fro

45 t causes phenotypes analogous to symptoms of triosephosphate isomerase (TPI) deficiency, a human fami

46 ilies with the inherited glycolytic disorder triosephosphate isomerase (TPI) deficiency.

47 Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have bee

48 We examine the evolution of the triosephosphate isomerase (TPI) gene family in fishes fo

49 >A), and -24 (TPI 573 T-->G) variants in the triosephosphate isomerase (TPI) gene occurred frequently

50 including position 192 of the human gene for triosephosphate isomerase (TPI) have been found to reduc

51 erited deficiency of the housekeeping enzyme triosephosphate isomerase (TPI) is the most severe clini

52 constructs containing a portion of the rice triosephosphate isomerase (tpi) promoter, the first tpi

53 extracts of PV4-8 had 3-fold higher level of triosephosphate isomerase (TPI) specific activities than

54 affected gene encodes the glycolytic enzyme, triosephosphate isomerase (Tpi).

55 etermined to be a mutated glycolytic enzyme, triosephosphate isomerase (TPI).

56 essfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in maligna

57 ng enzymes sponsoring glycolysis (enolase 1, triosephosphate isomerase 1, and hexokinase 2), were red

58 that observed in other gene families (e.g., triosephosphate isomerase and lactate dehydrogenase).

59 vate kinase muscle isozyme, beta-enolase and triosephosphate isomerase and phosphoglucomutase-1.

60 r of the isomerization reaction catalyzed by triosephosphate isomerase and present the crystal struct

61 alytic efficiency of the H95N mutant chicken triosephosphate isomerase and the 60-fold regain of cata

62 Each monomer consists of a triosephosphate isomerase barrel and contains an active

63 to the putative active site of a neighboring triosephosphate isomerase barrel domain, while simultane

64 ypeptide chain of the Rossmann domain to the triosephosphate isomerase barrel domain.

65 h subunit of the MoaA dimer is an incomplete triosephosphate isomerase barrel formed by the N-termina

66 The lateral opening of the incomplete triosephosphate isomerase barrel is covered by the C-ter

67 ology with aldo-keto reductases, including a triosephosphate isomerase barrel structure, conservation

68 etention of the C3 deuterium at the level of triosephosphate isomerase due to a kinetic isotope effec

69 inding, paving the way for future studies of triosephosphate isomerase dynamics and mechanism.

70 hoglucose isomerase, phosphoglucomutase, and triosephosphate isomerase fail to show any decline in fl

71 ate synthase is an alpha/beta protein with a triosephosphate isomerase fold.

72 ase provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacet

73 Glu-167 of triosephosphate isomerase from Trypanosoma brucei brucei

74 (GAP) in D2O at pD 7.9 catalyzed by wildtype triosephosphate isomerase from Trypanosoma brucei brucei

75 opulations of the chemical entities bound to triosephosphate isomerase have been probed by using soli

76 e motion of the active site loop (loop 6) in triosephosphate isomerase is investigated in solution by

77 vent the mutant protein from complementing a triosephosphate isomerase knockout in Escherichia coli.

78 Finally, we show that backrub sampling of triosephosphate isomerase loop 6 can capture the millise

79 tabilizing reagents were used to encapsulate triosephosphate isomerase mRNA of Arabidopsis thaliana.

80 In the glycolysis pathway, triosephosphate isomerase was up-regulated, whereas pyru

81 seven-letter amino acid alphabet produces a triosephosphate isomerase with wild-type activity.

82 a larger charge differential among members (triosephosphate isomerase) indicates that the smaller ch

83 se), pgk (phosphoglycerate kinase), and tpi (triosephosphate isomerase).

84 This approach has also shown that triosephosphate isomerase, aconitate hydratase, M-protei

85 bolism (alpha-enolase, malate dehydrogenase, triosephosphate isomerase, and F1 ATPase, alpha subunit)

86 f typical cytosolic proteins, such as GAPDH, triosephosphate isomerase, and M2-type pyruvate kinase i

87 Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB

88 ding proteins involved in energy metabolism (triosephosphate isomerase, glycerol-3-phosphate-dehydrog

89 The highly efficient glycolytic enzyme, triosephosphate isomerase, is expected to differentially

90 A mutated form of triosephosphate isomerase, isolated by a biochemical met

91 inases, farnesyltransferase, gyrase, prions, triosephosphate isomerase, nitric oxide synthase, phosph

92 g in the isomerization reaction catalyzed by Triosephosphate Isomerase, the conversion of dihydroxyac

93 pe effects in D2O have been measured for the triosephosphate isomerase-catalyzed conversion of dihydr

94 Values of (k(cat)/K(m))GAP for triosephosphate isomerase-catalyzed reactions of (R)-gly

95 selected using in vivo complementation of a triosephosphate isomerase-deficient strain of Escherichi

96 E8 manifested very low affinity for mutant triosephosphate isomerase-HLA-DR1 despite the highly tum

97 n of the operation of a hydrophobic clamp in triosephosphate isomerase.

98 of highly optimized natural enzymes such as triosephosphate isomerase.

99 3-phosphate, a substrate analogue, to yeast triosephosphate isomerase.

100 molecule HLA-DR1 and an epitope from mutant triosephosphate isomerase.

101 s of the prototypical (beta/alpha)(8) barrel triosephosphate isomerase.

102 tial intermediates on the folding pathway of triosephosphate isomerase.

103 base-pair mutation in the glycolytic enzyme triosephosphate isomerase.

104 inal protein hinge of the active-site lid of triosephosphate isomerase.

105 e prototypical (beta/alpha)(8) barrel enzyme triosephosphate isomerase.

106 sequences could serve as a protein hinge in triosephosphate isomerase.

107 , including the functionally similar protein triosephosphate isomerase.

108 ad cDNA highly homologous to plant cytosolic triosephosphate isomerases (cTPI).

109 l phosphate is in rapid equilibrium with the triosephosphate pool, resulting in rapid labeling of the

110 Because the rate of flux of triosephosphate to glucose during fasting far exceeds th

111 mediate in the alkaline decomposition of the triosephosphates to methylglyoxal is now observed by UV

112 renal glomeruli, increased the conversion of triosephosphates to ribose-5-phosphate, and strongly inh

113 genic parasites expressing an epitope-tagged triosephosphate transporter and immunopurified on magnet