ライフサイエンスコーパス: triosephosphate isomerase

1 se), pgk (phosphoglycerate kinase), and tpi (triosephosphate isomerase).

2 n of the operation of a hydrophobic clamp in triosephosphate isomerase.

3 of highly optimized natural enzymes such as triosephosphate isomerase.

4 3-phosphate, a substrate analogue, to yeast triosephosphate isomerase.

5 molecule HLA-DR1 and an epitope from mutant triosephosphate isomerase.

6 s of the prototypical (beta/alpha)(8) barrel triosephosphate isomerase.

7 tial intermediates on the folding pathway of triosephosphate isomerase.

8 base-pair mutation in the glycolytic enzyme triosephosphate isomerase.

9 inal protein hinge of the active-site lid of triosephosphate isomerase.

10 e prototypical (beta/alpha)(8) barrel enzyme triosephosphate isomerase.

11 sequences could serve as a protein hinge in triosephosphate isomerase.

12 , including the functionally similar protein triosephosphate isomerase.

13 ng enzymes sponsoring glycolysis (enolase 1, triosephosphate isomerase 1, and hexokinase 2), were red

14 This approach has also shown that triosephosphate isomerase, aconitate hydratase, M-protei

15 that observed in other gene families (e.g., triosephosphate isomerase and lactate dehydrogenase).

16 vate kinase muscle isozyme, beta-enolase and triosephosphate isomerase and phosphoglucomutase-1.

17 r of the isomerization reaction catalyzed by triosephosphate isomerase and present the crystal struct

18 alytic efficiency of the H95N mutant chicken triosephosphate isomerase and the 60-fold regain of cata

19 bolism (alpha-enolase, malate dehydrogenase, triosephosphate isomerase, and F1 ATPase, alpha subunit)

20 f typical cytosolic proteins, such as GAPDH, triosephosphate isomerase, and M2-type pyruvate kinase i

21 Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB

22 Each monomer consists of a triosephosphate isomerase barrel and contains an active

23 to the putative active site of a neighboring triosephosphate isomerase barrel domain, while simultane

24 ypeptide chain of the Rossmann domain to the triosephosphate isomerase barrel domain.

25 h subunit of the MoaA dimer is an incomplete triosephosphate isomerase barrel formed by the N-termina

26 The lateral opening of the incomplete triosephosphate isomerase barrel is covered by the C-ter

27 ology with aldo-keto reductases, including a triosephosphate isomerase barrel structure, conservation

28 We apply MPAX to the triosephosphate isomerase (beta/alpha)(8) barrel, accura

29 pe effects in D2O have been measured for the triosephosphate isomerase-catalyzed conversion of dihydr

30 Values of (k(cat)/K(m))GAP for triosephosphate isomerase-catalyzed reactions of (R)-gly

31 r the effect of the S96P mutation in chicken triosephosphate isomerase (cTIM) has been analyzed using

32 ad cDNA highly homologous to plant cytosolic triosephosphate isomerases (cTPI).

33 selected using in vivo complementation of a triosephosphate isomerase-deficient strain of Escherichi

34 etention of the C3 deuterium at the level of triosephosphate isomerase due to a kinetic isotope effec

35 inding, paving the way for future studies of triosephosphate isomerase dynamics and mechanism.

36 ructose-bisphosphate aldolase (EC 4.1.2.13), triosephosphate isomerase (EC 5.3.1.1), and glycerol-3-p

37 hoglucose isomerase, phosphoglucomutase, and triosephosphate isomerase fail to show any decline in fl

38 ate synthase is an alpha/beta protein with a triosephosphate isomerase fold.

39 ase provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacet

40 Glu-167 of triosephosphate isomerase from Trypanosoma brucei brucei

41 (GAP) in D2O at pD 7.9 catalyzed by wildtype triosephosphate isomerase from Trypanosoma brucei brucei

42 ding proteins involved in energy metabolism (triosephosphate isomerase, glycerol-3-phosphate-dehydrog

43 opulations of the chemical entities bound to triosephosphate isomerase have been probed by using soli

44 E8 manifested very low affinity for mutant triosephosphate isomerase-HLA-DR1 despite the highly tum

45 a larger charge differential among members (triosephosphate isomerase) indicates that the smaller ch

46 e motion of the active site loop (loop 6) in triosephosphate isomerase is investigated in solution by

47 The highly efficient glycolytic enzyme, triosephosphate isomerase, is expected to differentially

48 A mutated form of triosephosphate isomerase, isolated by a biochemical met

49 vent the mutant protein from complementing a triosephosphate isomerase knockout in Escherichia coli.

50 Finally, we show that backrub sampling of triosephosphate isomerase loop 6 can capture the millise

51 tabilizing reagents were used to encapsulate triosephosphate isomerase mRNA of Arabidopsis thaliana.

52 inases, farnesyltransferase, gyrase, prions, triosephosphate isomerase, nitric oxide synthase, phosph

53 Loop 6 in the active site of Triosephosphate Isomerase (Saccharomyces cerevisiae) mov

54 e kinetic parameters for activation of yeast triosephosphate isomerase (ScTIM), yeast orotidine monop

55 g in the isomerization reaction catalyzed by Triosephosphate Isomerase, the conversion of dihydroxyac

56 e origin for the functional specificities of triosephosphate isomerase (TIM) and methylglyoxal syntha

57 At one end of the HydG (betaalpha)8 triosephosphate isomerase (TIM) barrel, a canonical [4Fe

58 n of (R)-glyceraldehyde 3-phosphate (GAP) by triosephosphate isomerase (TIM) can be attributed to the

59 D-Xylose isomerase (XI) and triosephosphate isomerase (TIM) catalyze the aldose-keto

60 Three mechanisms proposed for the triosephosphate isomerase (TIM) catalyzed reactions were

61 Triosephosphate isomerase (TIM) catalyzes the interconve

62 Triosephosphate isomerase (TIM) catalyzes the reversible

63 Triosephosphate isomerase (TIM) catalyzes the reversible

64 side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to b

65 phate (DHAP) in D(2)O at pD 7.9 catalyzed by triosephosphate isomerase (TIM) from chicken and rabbit

66 te (GAP) in D(2)O at pD 7.5-7.9 catalyzed by triosephosphate isomerase (TIM) from chicken and rabbit

67 more likely to be stabilizing in our model, triosephosphate isomerase (TIM) from Saccharomyces cerev

68 We report that the K12G mutation in triosephosphate isomerase (TIM) from Saccharomyces cerev

69 GAP) to dihydroxyacetone phosphate (DHAP) by triosephosphate isomerase (TIM) from Trypanosoma brucei

70 The L232A mutation in triosephosphate isomerase (TIM) from Trypanosoma brucei

71 simulations of the folding and unfolding of triosephosphate isomerase (TIM) from yeast were conducte

72 transfer steps in the reactions catalyzed by triosephosphate isomerase (TIM) has been studied.

73 The enzyme triosephosphate isomerase (TIM) has been used as a model

74 imulations are used to study the dynamics of triosephosphate isomerase (TIM) in complex with glycerol

75 carbonyl carbon ([1-(13)C]-GA) catalyzed by triosephosphate isomerase (TIM) in D(2)O at pD 7.0 in th

76 s for many enzymes, the enzymatic pathway of triosephosphate isomerase (TIM) includes the partially r

77 The enzyme triosephosphate isomerase (TIM) is a model of catalytic

78 Triosephosphate isomerase (TIM) is a proficient catalyst

79 The Omega loop of triosephosphate isomerase (TIM) is important for prevent

80 talline uniformly (13)C,(15)N-enriched yeast triosephosphate isomerase (TIM) is sequentially assigned

81 The K12G mutation at yeast triosephosphate isomerase (TIM) results in a 5.5 x 10(5)

82 Methylglyoxal synthase (MGS) and triosephosphate isomerase (TIM) share neither sequence n

83 The tunnel region at triosephosphate isomerase (TIM)'s dimer interface, dista

84 e, we designed several consensus variants of triosephosphate isomerase (TIM), a large, diverse family

85 Unfolding and refolding of rabbit muscle triosephosphate isomerase (TIM), a model for (betaalpha)

86 xtent to which sites evolve codependently in triosephosphate isomerase (TIM), a ubiquitous glycolytic

87 Results are featured for three enzymes: triosephosphate isomerase (TIM), aldose reductase (AR),

88 nalysis of the catalytic cycle of the enzyme triosephosphate isomerase (TIM), including both the reac

89 G is a competitive inhibitor of both MGS and triosephosphate isomerase (TIM), the carboxylate groups

90 In the case of the human triosephosphate isomerase (TPI gene), nonsense codons lo

91 in MS, we identified the glycolytic enzymes, triosephosphate isomerase (TPI) and GAPDH, using Igs fro

92 t causes phenotypes analogous to symptoms of triosephosphate isomerase (TPI) deficiency, a human fami

93 ilies with the inherited glycolytic disorder triosephosphate isomerase (TPI) deficiency.

94 Individuals with 50% of expected triosephosphate isomerase (TPI) enzyme activity have bee

95 We examine the evolution of the triosephosphate isomerase (TPI) gene family in fishes fo

96 >A), and -24 (TPI 573 T-->G) variants in the triosephosphate isomerase (TPI) gene occurred frequently

97 including position 192 of the human gene for triosephosphate isomerase (TPI) have been found to reduc

98 erited deficiency of the housekeeping enzyme triosephosphate isomerase (TPI) is the most severe clini

99 constructs containing a portion of the rice triosephosphate isomerase (tpi) promoter, the first tpi

100 extracts of PV4-8 had 3-fold higher level of triosephosphate isomerase (TPI) specific activities than

101 affected gene encodes the glycolytic enzyme, triosephosphate isomerase (Tpi).

102 etermined to be a mutated glycolytic enzyme, triosephosphate isomerase (TPI).

103 essfully verified, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in maligna

104 In the glycolysis pathway, triosephosphate isomerase was up-regulated, whereas pyru

105 seven-letter amino acid alphabet produces a triosephosphate isomerase with wild-type activity.