ライフサイエンスコーパス: triskelion

1 pes of complex with the dissociated clathrin triskelions.

2 and conformational variability of individual triskelions.

3 dral organization consisting of two distinct triskelion and globular motifs interacting extensively w

4 of clathrin-coated vesicles are the clathrin triskelion and heterotetrameric associated protein (AP)

5 resolution to detect arrival of the clathrin triskelions and AP2 adaptors that initiate coat assembly

6 hat AP-2 stabilizes helical structure in the triskelion, and we propose that this increases triskelio

7 h indicates that the elastic properties of a triskelion arm are approximately constant over the entir

8 by clathrin baskets nor did soluble clathrin triskelions at pH 7 significantly activate the ATPase ac

9 heavy chains which form a protrusion on free triskelions at the vertex.

10 Triskelion-based spherical architectures offer an opport

11 auxilin can then migrate to another clathrin triskelion before the ATPase cycle is complete.

12 iskelion, linking that vertex to 'ankles' of triskelions centred two vertices away.

13 Three Hsc70s remain bound to the dissociated triskelion, close to its trimerization hub.

14 a recycling synaptic vesicle is the clathrin triskelion, composed of clathrin light chain (Clc) and c

15 A triskelion comprises three clathrin heavy chains joined

16 Thus, each triskelion contributes to two connecting edges of the po

17 in-coated pits and vesicles are comprised of triskelions, each consisting of three oligomerized heavy

18 Clathrin triskelions form the lattice that organizes recruitment

19 skelia in solution showed that an individual triskelion has an intrinsic pucker similar to, but diffe

20 support the notion that the three arms of a triskelion have statistically identical properties and e

21 condary structure content, but a 10% loss of triskelion helical content accompanies assembly in the a

22 spars of the clathrin lattice, close to the triskelion hubs and (ii) there is another interaction at

23 tively consistent with the conformation of a triskelion in a "D6 barrel" cage assembly measured by cr

24 from a high resolution cryoEM structure of a triskelion in a clathrin basket.

25 fic with auxilin first binding to a clathrin triskelion in the baskets and then Hsc70-ATP strongly bi

26 beta'-COP core of coatomer crystallizes as a triskelion in which three copies of a beta'-COP beta-pro

27 omplex reforms, suggesting that the clathrin triskelions in the steady-state complex rebind to the me

28 a 1 to 1 molar ratio of auxilin to clathrin triskelion independent of the Hsc70 concentration sugges

29 The clathrin triskelion is a trimer of heavy-chain subunits (1,675 re

30 rsistence length of the assumed semiflexible triskelion is close to that previously estimated from th

31 The proximal domains of each triskelion leg depart from a cage vertex in a skewed ori

32 and the linker that joins it to the end of a triskelion leg.

33 interactions along the extended parts of the triskelion 'legs'.

34 rom the vertex of each three-legged clathrin triskelion, linking that vertex to 'ankles' of triskelio

35 We propose that individual triskelions may be extricated from the clathrin lattice

36 ucleoporin interactions forming the central "triskelion" of the Y.

37 ology capable of autocatalytically producing triskelion peptides that self-associate into spherical b

38 c70 acts by dissociating individual clathrin triskelions rather than cooperatively destabilizing clat

39 iskelion, and we propose that this increases triskelion rigidity, restricting the range of coat sizes

40 The clathrin triskelion self-assembles into a polyhedral coat surroun

41 RNA viruses, the VP2 attachment trimer has a triskelion shape composed of three tip domains branching

42 The distinctive triskelion shape of clathrin allows assembly into polyhe

43 Clathrin is a triskelion-shaped cytoplasmic protein that polymerizes i

44 This structure reveals whole HA to be a huge triskelion-shaped molecule.

45 rms undecameric rings, and AT assembles into triskelion-shaped trimers.

46 ns based on rigid molecular bead models of a triskelion show that the measured values can be accounte

47 owledge of the way in which assembly affects triskelion structure would be valuable for assessing the

48 bly requires no detectable reorganization of triskelion structure.

49 ittle is known of the effects of assembly on triskelion structure.

50 as a three-legged heteropolymer (known as a triskelion) that assembles into polyhedral cages princip

51 ld occur through simple addition of clathrin triskelions to the edges of growing clathrin-coated pits

52 pose a new model for the organization of the triskelion vertex which provides a structural basis for

53 mutations in the trimerization domain at the triskelion vertex, as well as mutations in the adjacent

54 ns based on flexible bead-spring models of a triskelion, which generate time-averaged scattering func

55 The clathrin triskelion, which is a three-legged pinwheel-shaped hete

56 The channel is a triskelion with arms consisting of repeated arrays of 4-

57 etected as two sequential steps, each of one triskelion with two adaptors.