ライフサイエンスコーパス: tristetraprolin

1 ent in cells (e.g., TIA-1) or induced (e.g., tristetraprolin).

2 d the non-ARE-containing RNAs GADD45beta and tristetraprolin.

3 otein HuA and the mRNA-destabilizing protein tristetraprolin.

4 or c-myc mRNA that were poorly recognized by tristetraprolin.

5 e activity of the mRNA-destabilizing protein tristetraprolin.

6 y changed and included the mRNA decay factor Tristetraprolin.

7 egulates meprin alpha expression by inducing tristetraprolin.

8 ta provoked an increase in the expression of tristetraprolin, a homeostatic zinc finger protein that

9 Previous studies have demonstrated that Tristetraprolin, a human protein of the TIS11 family, in

10 Tristetraprolin, a negative regulator of ARE mRNA stabil

11 lly bound to ARE(TNF) mRNA and competed with tristetraprolin, a protein known to bind and destabilize

12 Among the latter was the RNA encoding tristetraprolin, a protein that binds AREs and is known

13 hat are targeted by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (Z

14 Nase binds both to mRNA cap structure and to tristetraprolin, an inducible host protein that sequeste

15 In contrast, tristetraprolin, an mRNA destabilizing protein, strongly

16 se in expression and RNA binding activity of tristetraprolin, an mRNA-binding protein that destabiliz

17 Tristetraprolin, an mRNA-binding protein that promotes m

18 f PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins

19 In contrast, human TZF homologs tristetraprolin and ERF-2 bind with high specificity to

20 interaction of ARE-binding proteins such as tristetraprolin and the four AUF1 isoforms.

21 mined the status of the ARE binding proteins tristetraprolin and TIA-1/TIAR in infected cells.

22 Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding dom

23 oup of RNA-binding proteins (including TIS11/tristetraprolin and TIS11D) that share characteristic ta

24 The protein Nup475 (also known as Tristetraprolin and TS11) binds to AU-rich sequence elem

25 he activity of the mRNA-destabilizing factor tristetraprolin, and thereby inhibits the expression of

26 Regulation of mRNAs by Tristetraprolin appears to function as one of several cr

27 However, the truncated transcript escaped tristetraprolin binding and downregulation.

28 Earlier, this laboratory reported that tristetraprolin binds VHS RNase.

29 cytotoxic T lymphocyte function mediated by tristetraprolin, contributing to regulation of antitumou

30 In addition, an antibody to tristetraprolin coprecipitated the Vhs protein from lysa

31 Tristetraprolin-deficient [TTP (-/-)] mice exhibit a com

32 IFN-gamma production by naive wild type and tristetraprolin-deficient CD8(+) T-cells is comparable.

33 IL-27 is overproduced by tristetraprolin-deficient macrophages and increased syst

34 rtantly, deletion of IL-27 receptor WSX-1 in tristetraprolin-deficient mice (WSX-1/tristetraprolin do

35 er, tumor growth is accelerated, not only in tristetraprolin-deficient mice after cytotoxic T lymphoc

36 nt macrophages and increased systemically in tristetraprolin-deficient mice.

37 To test the hypothesis that tristetraprolin directs VHS RNase to the AU-rich element

38 ic T lymphocyte depletion, but also in WSX-1/tristetraprolin double knockout mice, with substantial r

39 X-1 in tristetraprolin-deficient mice (WSX-1/tristetraprolin double knockout) leads to a reduction in

40 Here we show that the RNA-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+)

41 on of other mRNAs exemplified by GADD45beta, tristetraprolin, etc.

42 Restoring tristetraprolin expression in an aggressive tumor cell l

43 array data sets revealed that suppression of tristetraprolin expression is a negative prognostic indi

44 Collectively, these data establish that tristetraprolin expression is frequently suppressed in h

45 However, the cellular consequences of tristetraprolin expression varied across different cell

46 Moreover, reducing tristetraprolin expression via short hairpin RNA transfe

47 cripts contained potential binding sites for tristetraprolin family member proteins that were conserv

48 bout a recently discovered placenta-specific tristetraprolin family member, ZFP36L3.

49 Partial deficiency of 1 of the 4 mouse tristetraprolin family members, Zfp36l2, resulted in com

50 Members of the tristetraprolin family of CCCH tandem zinc finger protei

51 Members of the mammalian tristetraprolin family of CCCH tandem zinc finger protei

52 Members of the tristetraprolin family of tandem CCCH finger proteins ca

53 -containing mRNA stability by competing with tristetraprolin for mRNA binding.

54 Both HuA and tristetraprolin, however, recognized AU-rich sequences f

55 cytoplasmic accumulation, and persistence of tristetraprolin in infected cells.

56 formed to evaluate the expression of HuA and tristetraprolin in purified human T lymphocytes and to e

57 binds the destabilizing ARE-binding protein tristetraprolin induced following activation of HVS-tran

58 ooxygenase-2 transcript, and transfection of tristetraprolin into HCA-7 cells reduced the level of fu

59 Tristetraprolin is a vertebrate CCCH tandem zinc finger

60 modulation of the phosphorylation status of tristetraprolin is an important physiological mechanism

61 Our studies have also shown that tristetraprolin is one of the key players in regulating

62 were examined for the presence of potential tristetraprolin-like binding sites.

63 amino acid in each MEX-5 zinc finger confers tristetraprolin-like specificity to this protein.

64 ripts following T lymphocyte activation, and tristetraprolin may subsequently mediate their degradati

65 crophages, GILZ levels are downregulated via tristetraprolin-mediated GILZ mRNA destabilization.

66 east cancer, because patients with low tumor tristetraprolin mRNA levels were more likely to present

67 ematically dysregulated in cancers; however, tristetraprolin mRNA levels were significantly decreased

68 ell growth and confluence, the expression of tristetraprolin mRNA was inversely correlated with that

69 Still a third, exemplified by tristetraprolin mRNA, is not degraded, allowing its prot

70 These data demonstrate that neither tristetraprolin nor HuR is required for TNF-alpha mRNA e

71 lves the association of ARE-binding proteins tristetraprolin or AUF1 and proteasome activity, of whic

72 Nup475 (also known as tristetraprolin, or TIS11) is the prototype for a family

73 cted cells, the mutant but not the wild-type tristetraprolin precluded the degradation of the AU-rich

74 Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells i

75 Tristetraprolin promotes the decay of MyoD mRNA, which e

76 lthough absent in resting cells, cytoplasmic tristetraprolin protein was detected 3-6 h following act

77 In contrast, tristetraprolin recognized an AU-rich sequence in interl

78 Here we show that tristetraprolin recruits VHS RNase to the AU-rich elemen

79 several viral and at least one host protein (tristetraprolin) regulate its activity.

80 h elements, we mapped the domains of VHS and tristetraprolin required for their interactions.

81 esulting from decreased activity of TTP, the tristetraprolin RNA-binding protein responsible for mRNA

82 MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA.

83 Tristetraprolin suppresses IL-27 production by promoting

84 The amounts of tristetraprolin that accumulated in the cytoplasm of cel

85 We report that VHS binds to the domain of tristetraprolin that enables its interaction with RNA.

86 shed TNF-alpha ARE-binding proteins, HuR and tristetraprolin, that shuttle between the nucleus and cy

87 th the exception of the destabilizing factor tristetraprolin, the identity and function of the protei

88 to AU-rich elements via its interaction with tristetraprolin, the RNase deadenylates and cleaves the

89 The enhanced binding of tristetraprolin to the MEP1A 3'-UTR results in destabili

90 Tristetraprolin (TTP) acts by binding to AU-rich element

91 complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylat

92 nt evidence that in human cells the proteins Tristetraprolin (TTP) and BRF-1 deliver ARE-mRNAs to pro

93 ucleolytic decay, associate with the protein tristetraprolin (TTP) and its homolog BRF-1, which bind

94 Tristetraprolin (TTP) and its two known mammalian family

95 Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that comp

96 We validate Tristetraprolin (TTP) as a major regulator of RNA degrad

97 We have identified the RNA-binding protein Tristetraprolin (TTP) as a negative regulator of NLRP3 i

98 RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP) bind AU-rich elements in the 3' un

99 Tristetraprolin (TTP) binds AU-rich elements (AREs) enco

100 The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manne

101 The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present

102 Tristetraprolin (TTP) binds to the 3'-untranslated regio

103 The zinc finger protein tristetraprolin (TTP) destabilizes several proinflammato

104 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

105 lacenta- and yolk sac-specific member of the tristetraprolin (TTP) family of CCCH tandem zinc finger

106 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

107 Zfp36l2 is a member of the tristetraprolin (TTP) family of CCCH tandem zinc finger

108 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

109 Members of the tristetraprolin (TTP) family of proteins participate in

110 protein 36-like 1 (Zfp36L1), a member of the tristetraprolin (TTP) family of tandem CCCH finger prote

111 sponse factor 1 (TIS11b/BRF1) belongs to the tristetraprolin (TTP) family of zinc-finger proteins, wh

112 The zinc-finger protein tristetraprolin (TTP) has been demonstrated to regulate

113 d uridine-rich element (ARE)-binding protein tristetraprolin (TTP) in influencing mRNA stability of I

114 or T-cell intracellular antigen-1 (TIA-1) or tristetraprolin (TTP) initially do not colocalize with t

115 Tristetraprolin (TTP) is a CCCH tandem zinc finger prote

116 Tristetraprolin (TTP) is a CCCH zinc finger-containing p

117 Tristetraprolin (TTP) is a hyperphosphorylated protein t

118 Tristetraprolin (TTP) is a member of the CCCH tandem zin

119 es diverse antiproliferative activities, and tristetraprolin (TTP) is a mitogen-induced RNA-binding p

120 Tristetraprolin (TTP) is a mRNA-destabilizing protein th

121 Tristetraprolin (TTP) is a regulator of TNF-alpha mRNA s

122 Tristetraprolin (TTP) is a tandem CCCH zinc finger prote

123 Tristetraprolin (TTP) is a widely expressed potential tr

124 Tristetraprolin (TTP) is a zinc finger protein that can

125 ere, we report that the destabilizing factor tristetraprolin (TTP) is also ubiquitously expressed in

126 Tristetraprolin (TTP) is an AU-rich element binding prot

127 Tristetraprolin (TTP) is an inducible zinc finger AU-ric

128 Tristetraprolin (TTP) is an inducible, tandem zinc-finge

129 Tristetraprolin (TTP) is an RNA-binding protein required

130 yeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phospho

131 Expression of the immediate early protein tristetraprolin (TTP) is induced by numerous stimuli, in

132 The immediate early gene tristetraprolin (TTP) is induced transiently in many cel

133 lowing TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF

134 The immediate early protein tristetraprolin (TTP) is required to prevent inappropria

135 Tristetraprolin (TTP) is the only trans-acting factor sh

136 Tristetraprolin (TTP) is the prototype of a family of CC

137 Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory

138 Furthermore, IFN-gamma enhances LPS-induced tristetraprolin (TTP) mRNA expression and protein produc

139 studied the role that Hu antigen R (HuR) and tristetraprolin (TTP) play in regulating the expression

140 The RNA-binding protein tristetraprolin (TTP) plays a central role in PTR by bin

141 of being a negative regulator, we found that tristetraprolin (TTP) positively correlates with HIF-1 t

142 c conditions, the mRNA-destabilizing protein tristetraprolin (TTP) regulates apoptosis and the number

143 Tristetraprolin (TTP) regulates expression at the level

144 Tristetraprolin (TTP) regulates pro-inflammatory process

145 We hypothesized that the ARE-binding protein tristetraprolin (TTP) regulates T lymphocyte IL-2 mRNA d

146 TNF-alpha mRNA stability via the binding of tristetraprolin (TTP) to the adenosine/uridine-rich elem

147 Association of tristetraprolin (TTP) with mRNAs containing selected AU-

148 o impacts on the anti-inflammatory protein - tristetraprolin (TTP), a destabilizing RNA binding prote

149 Tristetraprolin (TTP), a member of the tandem CCCH zinc

150 e degradation of the E47 mRNA and found that tristetraprolin (TTP), a physiological regulator of mRNA

151 Tristetraprolin (TTP), a protein involved in the degrada

152 We report here that mice deficient in tristetraprolin (TTP), a protein with known anti-inflamm

153 We investigated the possibility that tristetraprolin (TTP), a tandem CCCH zinc finger protein

154 In the case of one member of this family, tristetraprolin (TTP), absence of the protein in knockou

155 Here we show that tristetraprolin (TTP), an ARE-binding protein that desta

156 Tristetraprolin (TTP), an mRNA-binding protein, plays a

157 We found that overexpression of tristetraprolin (TTP), but not its RNA binding mutant or

158 ein, Zfp36l2, like its better-known relative tristetraprolin (TTP), can decrease the stability of AU-

159 One ARE binding protein, tristetraprolin (TTP), has been implicated in regulating

160 ities and show that the RNA-binding protein, tristetraprolin (TTP), interacts with these elements.

161 ne encoding the putative zinc finger protein tristetraprolin (TTP), is rapidly induced in fibroblasts

162 Here we show that a key destabilizing AUBP, tristetraprolin (TTP), is repressed by the p38 mitogen-a

163 mRNA coding for tumor necrosis factor (TNF), tristetraprolin (TTP), suppressor of cytokine signaling-

164 Tristetraprolin (TTP), the best known member of a class

165 Tristetraprolin (TTP), the prototype of a class of CCCH

166 Tristetraprolin (TTP), the prototype of a class of Cys-C

167 Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH

168 Tristetraprolin (TTP), the prototype of a small family o

169 Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc fi

170 nduced expression of the ARE-binding protein tristetraprolin (TTP), which colocalized to P bodies.

171 transcriptionally by the RNA-binding protein tristetraprolin (TTP), which destabilizes IL-10 mRNA in

172 he latter is regulated, at least in part, by tristetraprolin (TTP), which is increased in aged B cell

173 Macrophages derived from tristetraprolin (TTP)-deficient mice exhibited increased

174 owever, bone marrow-derived macrophages from tristetraprolin (TTP)-deficient mice were less sensitive

175 pecific and requires the ARE binding protein tristetraprolin (TTP).

176 e/threonine phosphoprotein, XRN1, eIF4E, and tristetraprolin (TTP).

177 lecule farther downstream of p38 MAPK, i.e., tristetraprolin (TTP).

178 ation of the AU-rich element-binding protein tristetraprolin (TTP).

179 at are recognized by the RNA binding protein tristetraprolin (TTP).

180 The protein tristetraprolin (TTP, also known as NUP475 and TIS11) is

181 n the expression of the RNA-binding proteins tristetraprolin (TTP, ZFP36) and HuR (ELAVL1).

182 nt with its role in moderating inflammation, tristetraprolin (TTP, ZFP36) was among the most highly e

183 Tristetraprolin (TTP, Zfp36, Nup475, Tis11) dramatically

184 The RBP tristetraprolin (TTP/Zfp36) is a signal-induced phosphor

185 ly, Myc directly suppresses transcription of Tristetraprolin (TTP/ZFP36), an mRNA-destabilizing AUBP,

186 in AU-rich cis-elements (AREs) recognized by tristetraprolin (TTP/Zfp36), an RNA-binding protein prev

187 gulation/activity of HuR and inactivation of tristetraprolin, two AU-rich element-binding proteins.

188 Interestingly, the RNA destabilizing protein tristetraprolin was induced following IgE cross-linkage

189 We report that tristetraprolin was made and accumulated in the cytoplas

190 The localization of tristetraprolin was not modified in cells infected with

191 n inhibitory transcription factor, and ZFP36/Tristetraprolin, which binds to AU-rich elements within

192 nactivation of the mRNA-destabilizing factor tristetraprolin, which we show is able to target the IFN

193 estabilizing protein Tis11b, a member of the tristetraprolin/ZFP36 family, and thereby, decreases MR

194 Tristetraprolin, ZFP36L1, and ZFP36L2 have been shown to

195 rated roles for three of the family members, tristetraprolin, ZFP36L1, and ZFP36L2, in inflammation,

196 tein containing the critical features of the tristetraprolin zinc finger domain.