ライフサイエンスコーパス: trisubstituted

1 for the cis to trans epimerization of 1,2,3-trisubstituted 1,2,3,4-tetrahydro-beta-carbolines, while

2 rapid and stereoselective synthesis of 2,3,4-trisubstituted 1,2,3,4-tetrahydropyridines.

3 thods for the synthesis of enantiopure 1,4,5-trisubstituted 1,2,3-triazoles where the chiral componen

4 A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from r

5 - and site-selective formation of tetra- and trisubstituted 1,3-dienes results from use of Ag(2)O and

6 ic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent

7 The challenging C12-C16 bis-trisubstituted 1,4-diene was installed with a complex re

8 ries of nucleoside analogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized u

9 benzene have been examined, leading to 1,4,5-trisubstituted-1,2,3-triazoles.

10 d chiroptical properties of nonracemic 1,6,7-trisubstituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole

11 ation of the absolute configuration of 1,6,7-trisubstituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole

12 rd synthetic protocol for constructing 2,3,5-trisubstituted 2-aminothiophenes.

13 approach leading to the discovery of a 3,4,5-trisubstituted-2-aminopyridine series and present the ap

14 that details the synthesis of stable acyclic trisubstituted [3]dendralenes and deciphers their struct

15 esis of a series of diversely functionalized trisubstituted 4(5)het(aroyl)-2,5(4)-het(aryl)/alkylimid

16 zole-4-carboxamides were elaborated to novel trisubstituted 4,2'-bisoxazoles through DAST/DBU-mediate

17 fficient straightforward synthesis of 2,5,4'-trisubstituted 4,5'-bisoxazoles via copper(I)-catalyzed

18 4-oxopiperidines then gave the 2,4,6-cis,cis-trisubstituted 4-hydroxypiperidines in high diastereosel

19 s to an efficient one-pot synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones (5).

20 elationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines with potent

21 he synthesis is reported of a group of 3,6,9-trisubstituted acridine compounds as telomeric quadruple

22 -assisted methodology has been developed for trisubstituted acridine synthesis.

23 Oxidizable olefins, such as styrenes, trisubstituted aliphatic alkenes, and enamides, can be e

24 synthesis is the asymmetric hydroboration of trisubstituted alkene 6.

25 yclic ring-closing metathesis that affords a trisubstituted alkene and is catalyzed by a Mo bis(arylo

26 The enol silane and a trisubstituted alkene are both formed with >98:2 stereos

27 ethyl groups and an adjacent phenyl group or trisubstituted alkene are exceptionally diastereoselecti

28 es that typically deliver the stereoisomeric trisubstituted alkene containing products.

29 f other enantiomerically pure, stereodefined trisubstituted alkene intermediates not easily accessibl

30 l-substituted electrophiles bearing a di- or trisubstituted alkene may be employed.

31 In contrast, the trisubstituted alkene moieties contained within the fram

32 ivatized via Stille coupling to a variety of trisubstituted alkene products.

33 alkenes give nearly identical results, and a trisubstituted alkene substrate is also shown to undergo

34 ed CAHB of alkyl-substituted methylidene and trisubstituted alkene substrates by pinacolborane (pinBH

35 Trisubstituted alkene substrates can be hydrogenated wit

36 effects, determined the configuration of the trisubstituted alkene target.

37 yl sulfone affords the construction of the Z-trisubstituted alkene with high efficiency and stereosel

38 ting groups, and delivers each nonconjugated trisubstituted alkene with high levels of stereoselectio

39 ult; hence, it would be favorable to use the trisubstituted alkene.

40 substrate for the same product, the isomeric trisubstituted alkenes (D in the text).

41 chiral homoallylic amines possessing di- or trisubstituted alkenes and anti- or syn- relative stereo

42 ion between a range of 1,1'-disubstituted or trisubstituted alkenes and ethyl trifluoropyruvate catal

43 s-metathesis reactions that generate Z- or E-trisubstituted alkenes are disclosed.

44 Rhodium-catalyzed hydroborations of trisubstituted alkenes are generally slow and often suff

45 otherwise difficult-to-access linear E- or Z-trisubstituted alkenes can be synthesized efficiently an

46 nantioselectively, and ones that can produce trisubstituted alkenes diastereoselectively, are central

47 or the stereoselective generation of acyclic trisubstituted alkenes in either the E or the Z isomeric

48 or the conversion of allylic alcohols to (Z)-trisubstituted alkenes is presented.

49 tioselective boronate conjugate additions to trisubstituted alkenes of acyclic alpha,beta-unsaturated

50 containing regio- and stereodefined di- and trisubstituted alkenes of all conceivable types will be

51 dicate that certain substituents proximal to trisubstituted alkenes seriously affect the course of th

52 rmolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary st

53 mplex was used to catalyze hydrogenations of trisubstituted alkenes to give terminal and internal 1,3

54 ubstituted, (Z)-1,2-disubstituted, and 1,1,2-trisubstituted alkenes undergo dihydroxylation with anti

55 ion of more hindered internal and endocyclic trisubstituted alkenes was achieved through hydroxyl gro

56 aining 1,1- and 1,2-disubstituted as well as trisubstituted alkenes were achieved with enantioselecti

57 Roche ester derivatives were converted to trisubstituted alkenes with allylic chiral centers.

58 Efficient, stereocontrolled access to Z-trisubstituted alkenes with two different substitution p

59 ctions may be performed on the corresponding trisubstituted alkenes, affording quaternary carbon ster

60 nyl phosphorus compounds, and in the case of trisubstituted alkenes, regio- and stereocontrolled olef

61 ners giving rise to the corresponding di- or trisubstituted alkenes, typically in high yield and with

62 phatic and aromatic imines, allylic silanes, trisubstituted alkenes, vinyl- and aryl halides, trifluo

63 cross-metathesis reactions involving E- or Z-trisubstituted alkenes, which are easily prepared from c

64 resulting in a general synthetic strategy to trisubstituted alkenes.

65 e couplings, providing an efficient route to trisubstituted alkenes.

66 method is compatible with terminal, di-, and trisubstituted alkenes.

67 protodeboronation with TBAF3 H(2)O to give Z-trisubstituted alkenes.

68 ion reaction of a variety of mono-, di-, and trisubstituted alkenes.

69 and diastereoselective synthesis of complex trisubstituted alkenes.

70 o the formation of skipped dienes containing trisubstituted alkenes.

71 rious combinations of indole derivatives and trisubstituted alkenes.

72 action between alkenyl triflates and acyclic trisubstituted alkenols of varying chain-lengths.

73 ive redox-relay Heck alkynylation of di- and trisubstituted alkenols to construct propargylic stereoc

74 For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cy

75 bstituted alkenyl-, acyclic, or heterocyclic trisubstituted alkenyl groups may be added in up to >98%

76 lective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids.

77 uted alkene and an easily functionalizable Z-trisubstituted alkenylboron group, are obtained in up to

78 ere subtly tuned to form either a primary or trisubstituted alkyl complex as the more thermodynamical

79 An X-ray crystal structure of the trisubstituted alkyl-palladium complex is presented and

80 reospecific amine-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocycli

81 re compatible with various 1,1-di- and 1,1,3-trisubstituted allenes and N-hydroxyaniline derivatives.

82 The efficient hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings

83 viability established for the conversion of trisubstituted allenes to bicyclo[4.3.0] and -[5.3.0] sk

84 e first epoxidation of 1,3-disubstituted and trisubstituted allenes was found to be >20:1 with dimeth

85 ction can provide silyl-substituted allenes, trisubstituted allenes, and terminal allenes.

86 e transfer of chirality was obtained for all trisubstituted allenes, but loss of chiral information w

87 pounds and terminal alkynes provides di- and trisubstituted allenes.

88 All-catalytic route to trisubstituted allenes: The first examples of catalytic

89 In the case of trisubstituted allylboronates with different substituent

90 % of a Ru catechothiolate complex and afford trisubstituted allylic alcohols and ethers in up to 81%

91 riched aldehyde substrates are employed, (Z)-trisubstituted allylic alcohols are isolated with high d

92 (Z)-trisubstituted allylic alcohols are widespread structura

93 Alpha-ethyl and alpha-cyclohexyl (Z)-trisubstituted allylic alcohols can now be synthesized w

94 od for the synthesis of (Z)-alpha,alpha,beta-trisubstituted allylic alcohols.

95 f prochiral aldehydes to produce racemic (Z)-trisubstituted allylic alcohols.

96 ated isomerization process that gives di- or trisubstituted allylic boronic esters with high E select

97 alkyl- (linear as well as branched) and aryl-trisubstituted allylic carbonates serve as effective sub

98 Ir-catalyzed enantioselective allylation of trisubstituted allylic electrophiles has been developed.

99 roup of allylic electrophiles, we found that trisubstituted allylic phosphates are suitable electroph

100 rated [Pd-H] was demonstrated using isomeric trisubstituted alpha,beta-unsaturated esters.

101 to provide facile access to highly hindered trisubstituted alpha-branched olefins, which when couple

102 Oxidation of the BC bond provides trisubstituted alpha-hydroxycyclopropyl carbinols as sin

103 ities were tolerated at this position, alpha-trisubstituted amines possessed markedly decreased inhib

104 ecular aminohydroxylations of functionalized trisubstituted and 1,1-disubstituted alkenes employing b

105 oamidation and iodo-imidation of ynamides to trisubstituted and tetrasubstituted ketene aminals is ex

106 lar and diastereoselective approach to 2,3,4-trisubstituted and tetrasubstituted tetrahydrofurans is

107 ach to the synthesis of one library of 3,4,5-trisubstituted and two libraries of constitutional isome

108 zed dialkylzincs, and (E)-disubstituted, (E)-trisubstituted, and (Z)-disubstituted vinylzinc reagents

109 ed (cis and trans), 2,2-disubstituted, 2,2,3-trisubstituted, and 2,3,3-trisubstituted epoxy alcohols

110 Various olefins, mono-, di-, and trisubstituted, are epoxidized chemoselectively in high

111 tive coupling of 1,3-disubstituted and 1,2,3-trisubstituted arenes (aryl-H) with cyclometalating subs

112 n and cyanation, 1,3-disubstituted and 1,2,3-trisubstituted arenes and heteroarenes containing halide

113 Mono-, di-, and trisubstituted arenes lacking a directing group undergo

114 ly versatile and nicely differentiated 1,2,3-trisubstituted arenes that are difficult to access by ot

115 s and selectivities, especially with di- and trisubstituted arenes.

116 r the synthesis of highly sought after 1,2,4-trisubstituted arenes.

117 ied with substitutions of the Br atom on the trisubstituted aryl ring by various functional groups.

118 2,2,3-Trisubstituted aziridines are known to undergo ring open

119 the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compound

120 and alpha-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and

121 Several trisubstituted aziridines, with different substitution p

122 and enantioselective construction of complex trisubstituted aziridines.

123 ed a short, general synthetic route to 1,3,6-trisubstituted azulenes.

124 d diynes under cobalt-catalysis led to 1,2,3-trisubstituted benzene derivatives in good yields.

125 yptands based on 1,3-dioxane decorated 1,3,5-trisubstituted-benzene building blocks, connected by dif

126 wing up the identification of two lead 2,5,6-trisubstituted benzimidazoles, 1 and 2, targeting Mtb-Ft

127 lpha-tripeptides comprising a central chiral trisubstituted beta(2,2,3)*-amino acid residue form unus

128 esign combines (ortho-tolyl)amide and o,o,o'-trisubstituted biphenyl structural units to provide a ge

129 s in formation of a completely unsymmetrical trisubstituted BODIPY.

130 The 2,3-trans, 2,4-cis trisubstituted chroman moiety was formed via highly effi

131 nic as it is made of a thallium cation and a trisubstituted cluster anion.

132 Among the trisubstituted compounds, (-)-4b exhibited the highest p

133 c 5-substituted indole moiety in both di and trisubstituted compounds, significantly increased their

134 a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 gr

135 nters involves a decarbonylative coupling of trisubstituted cyclic olefins and benzocyclobutenones th

136 boxamides and the syntheses of several novel trisubstituted cyclobutanecarboxamide scaffolds having a

137 1,2,4-Trisubstituted cyclohexadienals can be prepared syntheti

138 oselective (ee value up to 98%) synthesis of trisubstituted cyclohexanols was achieved by using a tan

139 nics was also demonstrated for a diene and a trisubstituted cyclohexene.

140 The trisubstituted cyclohexenone 12, generated through a pal

141 Reductive cyclization of the 2,4,5-trisubstituted cyclohexenone 16 using dihydogen in the p

142 We have found that 1,1,2-trisubstituted cyclopent-3-enes were exclusively obtaine

143 A trisubstituted cyclopentane chiron has been prepared by

144 nthesis of spiro(cyclopentene)oxindoles with trisubstituted cyclopentene units.

145 ative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes from enals and chalcone der

146 verse array of annulation products including trisubstituted cyclopentenes, gamma-lactams, and bicycli

147 th a concise stereocontrolled preparation of trisubstituted cyclopentenes.

148 Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thioph

149 s, enesulfones, and enamides to afford 1,2,3-trisubstituted cyclopropanes.

150 synthesis of either diastereomer of di- and trisubstituted cyclopropanes.

151 ivity in the cycloisomerization of enynes to trisubstituted cyclopropanes.

152 These trisubstituted diarylcyclopropanehydroxamic acids were d

153 zed via Diels-Alder cycloaddition of a 1,2,3-trisubstituted diene to a symmetrical dienophile obtaine

154 d C, we have discovered the formation of a Z-trisubstituted double bond.

155 d dienes forms allylborane products with (E)-trisubstituted double bonds exclusively.

156 n alkynes for the synthesis of stereodefined trisubstituted (E,E)-1,3-dienes-structural motifs common

157 upling strategy was utilized to assemble the trisubstituted (E,E)-diene.

158 rboxylic anydrides or silyl triflates yields trisubstituted enol esters or silanes, respectively.

159 The catalytic asymmetric hydrogenation of trisubstituted enol esters using Rh catalysts bearing ch

160 ion leading to N-heterocycles via control of trisubstituted enolate intermediates.

161 ygenated with peroxyzinc species to generate trisubstituted enolates.

162 akes place at room temperature and affords E-trisubstituted enones in moderate to good yields with hi

163 problem of ECA of alkenyl groups to acyclic trisubstituted enones, an advance achieved by adopting a

164 The trisubstituted epoxide gave low yields of adducts with a

165 based on an early stage introduction of the trisubstituted epoxide group is reported, allowing acces

166 s demonstrated using four diastereomers of a trisubstituted epoxide.

167 ve promoter of the endo-selective opening of trisubstituted epoxides, enabling related cascades leadi

168 d oxepane-containing polyethers from di- and trisubstituted epoxides.

169 substituted, 2,2,3-trisubstituted, and 2,3,3-trisubstituted epoxy alcohols rendered prominent ECCD si

170 odomethyltrifluoroborate resulted in di- and trisubstituted ethyltrifluoroborates in good to excellen

171 ure described for the formation of the 2,3,5-trisubstituted furan (option B) takes approximately 52.5

172 saturated alcohol and formation of the 2,3,5-trisubstituted furan adduct.

173 enones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substit

174 of this gamma-hydroxyenone to afford a 2,3,5-trisubstituted furan.

175 eses of various aromatic and aliphatic 2,3,5-trisubstituted furans from acetylenic epoxides are descr

176 e at room temperature gave 2,5-di- and 2,3,5-trisubstituted furans in high yields (85-97%).

177 ogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.

178 siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditio

179 Herein, we report that trisubstituted haloimidazoles not only display ferroelec

180 -alkylation at position 1 afforded the 1,7,7-trisubstituted hexahydropyrazolo[1,5-a]pyridin-2(1H)-one

181 catalyzed aminations which transform di- and trisubstituted homoallylic carbamates into [4.1.0]-carba

182 emoved by heating, leading to precursors for trisubstituted hydrazines.

183 lective hydrogenation of enantioenriched (E)-trisubstituted hydroxy enamines to generate 1,2-disubsti

184 p53-MDM2/MDMX inhibitors based on the 1,4,5-trisubstituted imidazole scaffold which are appended wit

185 upling with haloarenes furnished the desired trisubstituted imidazole scaffolds.

186 a subsequent two-fold cross-coupling to give trisubstituted imidazoles in good yields.

187 of the resulting alpha-hydroxyiminoimines to trisubstituted imidazoles in high yields under mild cond

188 We have prepared a set of trisubstituted imidazoles with a rigidized 7-azaindole h

189 n trisubstituted styryl azides to form 1,2,3-trisubstituted indoles.

190 rther extended to the preparation of a 1,2,3-trisubstituted indoline.

191 clude twenty-five 5,8-disubstituted or 5,6,8-trisubstituted indolizidines; one 1,4-disubstituted quin

192 ctor of the cembranoid skeleton containing a trisubstituted iodoalkene attached to an alpha-phenylsel

193 an internal alkyne for the preparation of a trisubstituted iodoalkene, allene formation using the My

194 forded a C(1)-symmetric and a C(3)-symmetric trisubstituted isomer, with the former being the major p

195 benzothiazole carboxylic acid moiety onto a trisubstituted isoxazole scaffold.

196 A variety of trisubstituted isoxazoles are prepared in moderate to ex

197 palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles, including valdecoxib.

198 ses the yield of the desired 4-alkenyl-3,4,5-trisubstituted isoxazoles.

199 actions, and the preparation of chiral 3,4,4-trisubstituted isoxazolines.

200 Enantioenriched trisubstituted lactones were obtained in good yields and

201 Mono-, di- and trisubstituted lanthanide amidinate and guanidinate comp

202 acid with 3 equiv of a primary amine yields trisubstituted mellitic triimides via dehydration and im

203 K4Ge9 with {Si(SiMe3)3}Cl which produces the trisubstituted monoanions [Ge9{Si(SiMe3)3}](-).

204 ransferase inhibitor, which contains a 2,6,6-trisubstituted morpholine system, can be accomplished.

205 novo palladium carbon-catalyzed synthesis of trisubstituted nicotinonitriles from easily synthesized

206 ive addition to and nitronate protonation of trisubstituted nitroalkenes to produce highly enantioenr

207 Here, a novel class of ANPs containing trisubstituted nitrogen (aza-ANPs) has been synthesized.

208 silyl)vinyl substituent to produce the 3,5,7-trisubstituted octahydro[2]pyrindene as a single diaster

209 ethyl allylmethylallylmalonate) that forms a trisubstituted olefin product is used to further delinea

210 the Z-vinylsilane a variety of stereodefined trisubstituted olefin products can be accessed including

211 xidation reaction illustrate a generalizable trisubstituted olefin scope, identify alternatives to O(

212 ough carboacylation of a sterically hindered trisubstituted olefin with benzocyclobutenone.

213 A catalytic asymmetric bromocyclization of trisubstituted olefinic amides that uses a C(2)-symmetri

214 ding while the homogeneous analogue degrades trisubstituted olefins and produces trans-epoxide produc

215 catalyst in the hydrogenation of unactivated trisubstituted olefins and superior activity in the hydr

216 A range of mono-, di-, and trisubstituted olefins as well as alkyl- and arylthioami

217 tions, selective hydrogenation of one of two trisubstituted olefins can be achieved.

218 Furthermore, trisubstituted olefins can be selectively hydrogenated i

219 ave been obtained for a variety of trans and trisubstituted olefins including electron-deficient alph

220 yst for asymmetric epoxidation of trans- and trisubstituted olefins was efficiently prepared from L-s

221 with pendant 1,2-disubstituted olefins form trisubstituted olefins with control of both absolute con

222 ikov-type hydroarylation of vinyl arenes and trisubstituted olefins with indoles.

223 sts, is an effective catalyst for trans- and trisubstituted olefins, and up to 97% ee has been achiev

224 array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated

225 tes allowed the stereoselective synthesis of trisubstituted olefins, while allylic substitution of th

226 s for the syntheses of geometrically defined trisubstituted olefins.

227 ated cyclization of enamides to afford 2,4,5-trisubstituted oxazoles.

228 In almost all cases the 2,3,5-trisubstituted p-benzoquinones were obtained.

229 This base induced reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazo

230 Trisubstituted perfluoroalkenes can be obtained in a hig

231 sition as well as 3,5-disubstituted or 3,4,5-trisubstituted phenols were also effective activators of

232 rans-quinolizidine (+)-myrtine and cis-2,4,6-trisubstituted piperidine alkaloid (+)-241D are reported

233 text] The asymmetric synthesis of the 2,3,6-trisubstituted piperidine core of the antitumor Nuphar a

234 d by tributyltin hydride to afford the 2,4,5-trisubstituted piperidine or undergo a second 5-endo cyc

235 adical addition/cyclization reaction to give trisubstituted piperidines 4ab.

236 eral and efficient method to construct 2,3,6-trisubstituted piperidines in a substituent-independent

237 A novel approach to 2,4,5-trisubstituted piperidines is reported, involving the 6-

238 rectly converted to the diastereomeric 2,4,5-trisubstituted piperidines syn-5m, -5n, -5o and anti-5m,

239 s the only detectable binding motif when the trisubstituted porphyrin H2Tri4 combines with [poly(dA-d

240 arylation of very hindered alpha,alpha,alpha-trisubstituted primary amines.

241 native synthetic approach for selected 2,6,9-trisubstituted purine CDK inhibitor conjugates with foli

242 (R)-Roscovitine, a trisubstituted purine, has been shown to inhibit L-curre

243 Trisubstituted purines could become a new class of drugs

244 The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-co

245 In the present study, we introduce 1,3,5-trisubstituted pyrazolines as potent and selective allos

246 rt the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-b

247 al alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.

248 Acids to bases: The synthesis of 2,4,6-trisubstituted pyridines from (phenylthio)acetic acid an

249 report an efficient means to access di- and trisubstituted pyridines in an efficient and highly cont

250 l access to various previously unknown 2,3,6-trisubstituted pyridines.

251 tions yielded the synthesis of 4-amino-2,6,8-trisubstituted pyrido[3,2-d]pyrimidine derivatives, with

252 The trisubstituted pyrimidine 1 was identified through high-

253 it against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold.

254 e SAR of a new series of water-soluble 2,4,6-trisubstituted pyrimidines where R1 is an aromatic heter

255 curs prior to enolization to produce a 2,3,5-trisubstituted pyrrole after cyclization.

256 However, the 2,3,5-trisubstituted pyrrole group, which is connected to the

257 by a Paal-Knorr cyclization provides a 2,3,4-trisubstituted pyrrole; when enolization is disfavored,

258 regioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles has been achieved via [3,3] and

259 thod allows the synthesis of mono-, di-, and trisubstituted pyrroles with appropriate substitutions.

260 minals, followed by ring opening to generate trisubstituted pyrroles.

261 es for the oxidative synthesis of penta- and trisubstituted pyrroles: a nitrenoid analogue to classic

262 fficient assembly of the kaitocephalin 2,2,5-trisubstituted pyrrolidine core.

263 potency and pharmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two

264 2,6-Disubstituted pyridines and 2,6,7-trisubstituted quinuclidines are screened as potential s

265 The selectivity change for the trisubstituted rings is attributed to a distortion of th

266 crossover reactions of internal olefins via trisubstituted ruthenacyclobutane intermediates.

267 We report a tunable library of N,N,N'-trisubstituted selenourea precursors and their reaction

268 te the selective migration of acyl groups in trisubstituted styryl azides to form 1,2,3-trisubstitute

269 with anti-diastereoselectivity, while 1,2,2-trisubstituted systems afford syn-diastereoisomers.

270 tem shows ortho selectivity, while the 1,3,4-trisubstituted systems show para, meta (instead of ortho

271 tereoselectivity with which terminal di- and trisubstituted tetraenes are known to react biosynthetic

272 potentially diastereoselective, and di- and trisubstituted tetraenes often undergo cascade reactions

273 Computations indicate that di- and trisubstituted tetraenes undergo facile but less exergon

274 mechanism of the epimerization of cis-1,2,3-trisubstituted tetrahydro-beta-carbolines into the trans

275 ved in the Pictet-Spengler reaction of 1,2,3-trisubstituted tetrahydro-beta-carbolines.

276 e first acetogenin containing a hydroxylated trisubstituted tetrahydrofuran (THF) ring.

277 An oxonium ylide rearrangement formed the trisubstituted tetrahydrofuran core found in the natural

278 A trisubstituted tetrahydrofuran representing C10-C18 of t

279 nthesis of complex stereocomplementary 1,3,4-trisubstituted tetrahydroisoquinolines (THIQs) with thre

280 ariety of 2,6-disubstituted as well as 2,4,6-trisubstituted tetrahydropyrans that could be considered

281 y have been achieved in a synthesis of 2,4,5-trisubstituted tetrahydropyrans, which proceeds under th

282 The 2,3,5-trisubstituted THF portion (C13-C17) was accessed using

283 thieno[3,2-b]pyrroles and the discovery of a trisubstituted thieno[3,2-b]pyrrole 5-carboxamide 15c th

284 Some 1,4,5-trisubstituted triazole carboxamides induced dramatic de

285 aryl propiolates gave a new family of 1,4,5-trisubstituted triazole carboxylic acid derivatives that

286 ange of organic azides to afford enantiopure trisubstituted triazoles.

287 4-Substituted piperidine-derived trisubstituted ureas are reported as highly potent and s

288 nthesis of unsymmetrical N,N'-di- and N,N,N'-trisubstituted ureas in one pot and is tolerant of a wid

289 The insertion of trisubstituted ureas in the main chain of N,N'-linked ol

290 ymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trif

291 also yielded a stereoselective synthesis of trisubstituted vinyl aziridines from these chiral sulfin

292 The trisubstituted vinyl boronate esters are formed as the (

293 ds to the formation of 1,1-disubstituted and trisubstituted vinyl boronate esters with moderate to go

294 ynes is also achieved using BCl3 to generate trisubstituted vinyl boronate esters.

295 of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with

296 whereas the cis-disubstituted and the trans-trisubstituted vinylepoxide linchpins proceed to deliver

297 (Z)-trisubstituted vinylzinc reagents are formed in situ by

298 for the catalytic asymmetric addition of (Z)-trisubstituted vinylzinc reagents to prochiral aldehydes

299 complished with palladium NHC catalysts, and trisubstituted Z alkenylsilanes are accessed with nickel

300 rrangement for efficient installation of the trisubstituted Z-double bond.