ライフサイエンスコーパス: triterpene

1 ctra even allowed for the discovery of a new triterpene.

2 re accumulate abnormally high levels of this triterpene.

3 glycosylates flavonoids, isoflavonoids, and triterpenes.

4 ubsequent conversion of PSPP to a mixture of triterpenes.

5 nt ursane-type and oleanane-type pentacyclic triterpenes.

6 a hydroxylation of oleanane- and ursane-type triterpenes.

7 egies for enhanced production of pentacyclic triterpenes.

8 The chromium-catalyzed allylic oxidation of triterpene 1 with O2 and N-hydroxyphthalimide (NHPI, 5 e

9 non-amorphadiene sesquiterpene, monoterpene, triterpene, 2-C-methyl-D-erythritol 4-phosphate and meva

10 and transgenic lines selected for high-level triterpene accumulation.

11 Ursolic acid, a pentacyclic triterpene acid, has been shown to suppress the expressi

12 /100g), tocopherols (8.83mg/100g), and three triterpene acids (mangiferolic, isomangiferolic and mang

13 focusing on acyl groups, squalene, sterols, triterpene acids/esters, fatty alcohols, wax esters and

14 s putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), s

15 la are glycosides of at least five different triterpene aglycones: soyasapogenol B, soyasapogenol E,

16 30 different saponins based on at least five triterpene aglycones; soyasapogenols B and E, medicageni

17 osperm and the embryo had similar sterol and triterpene alcohol contents and compositions.

18 a previously undescribed xanthone and three triterpenes: ambonic acid, mangiferonic acid and a mixtu

19 racteristics of celastrol, a quinone methide triterpene and an active component from Chinese herbal m

20 micals including phenolic acids, flavonoids, triterpenes and other common dietary phytochemicals, as

21 ased on their bioactive components including triterpenes and polysaccharides by using chromatographic

22 corresponding 50% increase in the levels of triterpenes and the main storage carbohydrate, inulin.

23 rce of different secondary metabolites, i.e. triterpenes and their derivates, which possess not only

24 Pentacyclic triterpenes are minor, but very relevant compounds found

25 Triterpenes are structurally complex plant natural produ

26 of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cuc

27 This represents as many triterpenes as have been reported for all other Arabidop

28 (Avena spp.) make root-derived antimicrobial triterpenes (avenacins) that provide protection against

29 A series of triterpene-based gamma-secretase modulators is optimized

30 e cyclization products, including the simple triterpene beta-amyrin.

31 Avenacins are synthesized from the simple triterpene, beta-amyrin.

32 trol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit inflammation and indu

33 and MAKIBISHI1, the rate-limiting enzyme for triterpene biosynthesis and an E3 ubiquitin ligase that

34 hat mechanistic diversity is the default for triterpene biosynthesis and that product accuracy result

35 the spatiotemporal regulation of pentacyclic triterpene biosynthesis in sweet basil.

36 ms (C31 and C32) by cotargeting the TMTs and triterpene biosynthesis to the chloroplasts, whereas onl

37 is incompatible with prevailing concepts of triterpene biosynthesis, which posit tight control over

38 B-family transcription factors, and specific triterpene biosynthetic genes.

39 the total squalene was methylated, and total triterpene (C30+C31+C32) content was elevated 7-fold.

40 The quinone methide triterpene celastrol, derived from a traditional Chinese

41 -oic acid), a cell-permeable dienonephenolic triterpene compound, revealed its potent inhibitory acti

42 ed by benzoate and cinnamate derivatives and triterpenes consistent with a styrax-type resin (Styrax

43 Up to 91% of the total triterpene contents could be converted to methylated for

44 To test if methylated triterpenes could be produced in tobacco, we also engine

45 Our discoveries provide new insights into triterpene cyclization, revealing hidden functional dive

46 of this residue results in a major change in triterpene cyclization, with production of tetracyclic r

47 evidence for volatile compound formation via triterpene degradation in plants.

48 In our continuing study of triterpene derivatives as potent anti-HIV agents, differ

49 p study of potent anti-HIV agents, seven new triterpene derivatives were designed, synthesized, and e

50 he structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design

51 ynthesize DMNT by the degradation of the C30 triterpene diol, arabidiol.

52 Results demonstrated that sterols and triterpene diols can be used as indicators of variety an

53 Sterols and triterpene diols in olive oil as indicators of variety a

54 xamined for its mechanism, we found that the triterpene down-regulated the expression of cell surviva

55 icins are proapoptotic and anti-inflammatory triterpene electrophiles isolated from an Australian des

56 we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilf

57 entical to those previously reported for the triterpenes extracted from the algae.

58 indings can be attributed to the presence of triterpenes, flavonoids and sterols in Z. album, which a

59 The distinction of oxidized di- and triterpenes, for example, is hindered by the superpositi

60 UA is a pentacyclic triterpene found too in several traditional plants, and

61 Maslinic acid, a pentacyclic triterpene from Olea europaea L., exerts hypoglycemic, a

62 Whether celastrol, a triterpene from traditional Chinese medicine, can modula

63 aneous determination of the main pentacyclic triterpenes from Olea europaea L. in rat plasma.

64 Using the triterpenes from various Actaea (syn.

65 Lupeol, a pentacyclic triterpene, from the hexane extract of Solanum melongena

66 synthesis in land plants via the assembly of triterpene gene clusters and present biochemical and gen

67 diate 2 for the synthesis of the pentacyclic triterpene germanicol 1 have been developed.

68 oots also synthesize the beta-amyrin-derived triterpene glycoside avenacin A-1, which provides protec

69 eptor activity-modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), a novel corecept

70 eptor activity modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), was previously f

71 l as well as the binding properties of three triterpene glycosides (cimicifugoside, cimiracemoside F,

72 e needed to fully characterize whether these triterpene glycosides as well as other components of bla

73 ntermediate in the synthesis of more complex triterpene glycosides associated with plant defense.

74 and modifies its pharmacology to respond to triterpene glycosides found in sponges that serve as a p

75 were then employed to show that neither the triterpene glycosides nor their enzymatically prepared a

76 ously found to be involved in recognition of triterpene glycosides, a family of naturally occurring c

77 eceptor involved in signaling in response to triterpene glycosides.

78 d targeted metabolite profiling, to identify triterpene glycosyltransferases (GTs) from among the mor

79 sent crystal structures of the UDP flavonoid/triterpene GT UGT71G1 from Medicago truncatula bound to

80 Celastroid natural products, triterpenes, have been and continue to be investigated i

81 avonol quercetin with higher efficiency than triterpenes; however, integrated transcript and metaboli

82 e in the absence of NADPH gives a mixture of triterpene hydrocarbons and alcohols, including botryoco

83 es allowed in silico identification of known triterpenes in enriched fractions obtained from an extra

84 Linear, branch-chained triterpenes, including squalene (C30), botryococcene (C3

85 st drastically rearranged of the pentacyclic triterpenes, involves a complex nonstop process, with no

86 Lupeol, a triterpene, is the principal constituent of common fruit

87 Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the white birch tre

88 gions of structure-activity relationship for triterpene maslinic acid and its analogs.

89 Together these findings suggest that simple triterpenes may have widespread and as yet largely unrec

90 r specific role as regulators of specialized triterpene metabolism in M. truncatula.

91 xidosqualene to a diverse array of secondary triterpene metabolites in plants.

92 -18-en-3beta-ol methyl ether), a pentacyclic triterpene methyl ether that is enriched in grains of co

93 d be produced in tobacco, we also engineered triterpene methyltransferases (TMTs) from B. braunii int

94 s screened computationally assuming that the triterpene methyltransferases (TMTs) might resemble the

95 The availability of closely related triterpene methyltransferases exhibiting distinct substr

96 This study examines the effect of a triterpene mixture (F094) and a single molecular species

97 nthesis (for the triterpene synthase SAD1, a triterpene-modifying cytochrome P450 SAD2, and the serin

98 We found that (20S)-Rg3, a triterpene natural compound known as ginsenoside, reduce

99 Betulinic acid is a pentacyclic triterpene natural product initially identified as a mel

100 axanes, epothilones, statins, retinoids, di-/triterpenes, noviose deoxysugar, and antibiotics derived

101 and evolved interdependently for specialized triterpene oil production greater than 500 MYA.

102 colony-forming, green algae that accumulates triterpene oils in excess of 30% of its dry weight.

103 The composition of the triterpene oils is dominated by dimethylated to tetramet

104 investigate the effect of lupeol, a dietary triterpene, on (a) apoptosis of tumor necrosis factor-re

105 es (e.g., artemisinin), 26 monoterpenes, two triterpenes, one diterpene and 38 other non-polar metabo

106 Phenolic compounds, sterols, triterpenes, organic acids, fatty acids and volatiles pr

107 Molecular verification of induction of the triterpene pathway in a cell culture system provides a n

108 The occurrence of triterpene pentacyclic acids in plants is extensive, but

109 -Delta(1,4)-cyclohexadien-3-one A-rings from triterpene precursors has been demonstrated beginning wi

110 ffect and associated mechanisms of Lupeol, a triterpene present in fruits and vegetables, in androgen

111 Triterpene resin has also been deployed for defense of l

112 of oleanane-type and ursane-type pentacyclic triterpenes, respectively.

113 Unique quercetin-rich (QAE) and triterpene-rich (TAE) apple peel extracts, their constit

114 ogy platform for the production of bioactive triterpene sapo(ge)nins.

115 us nonvolatile hydrophobic terpenes, such as triterpene sapogenins, from engineered yeast cells into

116 actors of the basic helix-loop-helix family, TRITERPENE SAPONIN BIOSYNTHESIS ACTIVATING REGULATOR1 (T

117 G REGULATOR1 (TSAR1) and TSAR2, which direct triterpene saponin biosynthesis in Medicago truncatula.

118 cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago.

119 pathways including isoflavonoid, lignin and triterpene saponin biosynthesis were modified or added b

120 ulted in elevated transcript levels of known triterpene saponin biosynthetic genes and strongly incre

121 nt patterns of transactivation of downstream triterpene saponin biosynthetic genes, hinting at distin

122 time, we assessed the non-toxic doses of the triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd)

123 Triterpene saponins are important bioactive constituents

124 Here, we profiled triterpene saponins from the skin and flesh of red beetr

125 The biosynthesis of triterpene saponins is poorly characterized in spite of

126 f the steps specific for the biosynthesis of triterpene saponins remain uncharacterized at the molecu

127 osaponins comprise oleanane- and ursane-type triterpene saponins that are abundantly present in the r

128 We tentatively identified 44 triterpene saponins, of which 37 had not been detected p

129 s and strongly increased the accumulation of triterpene saponins.

130 ng both the C and D rings of the pentacyclic triterpene scaffold to give 12,13beta-epoxy-3beta,16beta

131 p opportunities to engineer novel oxygenated triterpene scaffolds by manipulating the precursor suppl

132 e enzyme(s) responsible for decorating these triterpene scaffolds with methyl substituents were unkno

133 n precursor 2,3-oxidosqualene into different triterpene scaffolds.

134 tion of mono- and dimethylated forms of both triterpene scaffolds.

135 ion, hydroxylation, and glycosylation of the triterpene skeleton in the model legume Medicago truncat

136 In addition, another triterpene skeleton, moronic acid (MA, 3), was also empl

137 al, the metabolic fate for most of the major triterpene synthase products in Arabidopsis is now at le

138 three genes for avenacin synthesis (for the triterpene synthase SAD1, a triterpene-modifying cytochr

139 sidue that determines product specificity in triterpene synthases from diverse plant species.

140 likely progenitor to the other Botryococcus triterpene synthases, catalyzes a two-step reaction with

141 ights into the phylogenetic relationships of triterpene synthases.

142 revealing hidden functional diversity within triterpene synthases.

143 mic region that includes two S. lycopersicum triterpene synthases.

144 oids, and carotenoids; the betagamma di- and triterpene synthases; the zeta head-to-tail cis-prenyl t

145 nt Arabidopsis thaliana that is required for triterpene synthesis (the thalianol pathway).

146 nt assembly of operon-like gene clusters for triterpene synthesis has occurred independently in diver

147 overning the regio- and stereospecificity of triterpene synthesis.

148 Three additional triterpenes, the allylic isomers of HSQ and HBO, and an

149 his genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone,

150 ely induced, associated with accumulation of triterpenes, upon exposure of M. truncatula cell suspens

151 ormation of the fatty acid moiety and of the triterpene via the mevalonate route.

152 hloroplasts, whereas only 4% to 14% of total triterpenes were methylated when this metabolism was dir

153 a family of naturally occurring glycosylated triterpenes with a molecular weight > 2,000, exhibit ski